Canal calcique
Les canaux calciques sont des protéines membranaires qui régulent le flux d'ions calcium dans et hors des cellules, ce qui est essentiel pour diverses fonctions cellulaires, y compris la contraction musculaire, la libération de neurotransmetteurs et l'expression génique. La dysrégulation de l'activité des canaux calciques est associée à des conditions telles que l'hypertension, les arythmies cardiaques et les troubles neurologiques. Chez CymitQuimica, nous proposons une large sélection de modulateurs des canaux calciques pour soutenir vos recherches en santé cardiovasculaire, neurobiologie et transduction du signal.
578 produits trouvés pour "Canal calcique".
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ω-Conotoxin CVIE
ω-Conotoxin CVIE selectively inhibits voltage-gated Ca^2+ channels (Ca_v 2.2) [1].Formule :C98H164N40O34S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2638.99SB-237376
CAS :SB-237376 is a calcium and potassium channel antagonist used to treat cardiac arrhythmias.Formule :C20H25N3O5Degré de pureté :98.88% - 99.47%Couleur et forme :SolidMasse moléculaire :387.43Nurr1 Agonist 14
Nurr1 Agonist 14 (Compound 32) is a Nurr1 agonist with an EC50 of 0.09 μM for Nurr1. It exhibits significant neuroprotective activity without being hindered by residual DHODH inhibition. This compound can upregulate neuroprotective genes in dopaminergic neurons, such as SOD2, SESN3, BIRC5, XIAP, FLRT2, and CRMP4. Nurr1 Agonist 14 is useful for studying neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS).ω-Conotoxin MVIIC
CAS :Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.Formule :C106H178N40O32S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2749Flosatidil
CAS :Flosatidil is a small molecule voltage-gated calcium channel complex (VDCCs) blocker for the treatment of neurological disorders and cardiovascular diseases,Formule :C26H34F3N3O3SDegré de pureté :99.87% - 99.99%Couleur et forme :SolidMasse moléculaire :525.63Levamlodipine besylate Hemipentahydrate
CAS :Levamlodipine besylate hemipentahydrate is the besylate hemipentahydrate salt form of Levamlodipine. It is an orally effective calcium channel blocker with antioxidative and vasodilatory properties. This compound can reduce serum malondialdehyde (MDA) levels, enhance the activity of superoxide dismutase (SOD), and alleviate oxidative stress. Levamlodipine besylate hemipentahydrate is relevant for research in vascular dementia, hypertension, and cerebrovascular diseases.Formule :C20H25ClN2O5·C6H6O3SH2OCouleur et forme :SolidMasse moléculaire :1224.18Triphenylethylene
CAS :Triphenylethylene ,with CAS No. 58-72-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Triphenylethylene provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C20H16Couleur et forme :White PowderMasse moléculaire :256.34ω-Conotoxin FVIA
ω-Conotoxin FVIA is an inhibitor of N-type Ca²⁺ channels (Caᵥ2.2), shown to alleviate mechanical and thermal pain abnormalities in a rat model of caudal nerveFormule :C98H164N36O33S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2566.96MCU-i11
CAS :MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.Formule :C28H28N4O5SDegré de pureté :98.3%Couleur et forme :White SolidMasse moléculaire :532.61Ref: TM-T9960
1mg152,00€5mg340,00€1mL*10mM (DMSO)400,00€10mg485,00€25mg802,00€50mg1.099,00€100mg1.485,00€L-Phenylalanine-13C6
CAS :L-Phenylalanine-13C6 is a carbon-13 labeled version of L-Phenylalanine. L-Phenylalanine (T3377) ( (S)-2-Amino-3-phenylpropionic acid) is an essential amino acid derived from Escherichia coli. It acts as a voltage-dependent α2δ subunit Ca2+ channel antagonist with a Ki of 980 nM. Additionally, it is a competitive antagonist at the glycine and glutamate binding sites of NMDARs (KB 573 μM) and non-NMDARs. L-Phenylalanine (T3377) is extensively utilized in the production of food flavors and pharmaceuticals.Formule :C9H11NO2Couleur et forme :SolidMasse moléculaire :171.15KT-362 free base
CAS :KT-362 is a calcium channel blocker with antihypertensive properties that can be used in the study of cardiovascular disease.Formule :C22H28N2O3SDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :400.53Caloxin 3A1
Caloxin 3A1, a biologically active peptide, is a member of the caloxins, which are inhibitors of the extracellular plasma membrane (PM) Ca2+ pumps.Formule :C83H126N22O30Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1912.02Sulcardine 2HCl
CAS :Sulcardine 2HCl is a multi-ion channel blocker that blocks the properties of hERG and hNav1.5 channels and can be used to study atrial fibrillation.Formule :C24H35Cl2N3O4SDegré de pureté :98.85% - 99.33%Couleur et forme :SolidMasse moléculaire :532.523BTT-266
CAS :BTT-266 is a blocker of voltage-gated calcium channel for pain management.Formule :C34H28N4O4Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :556.61Ref: TM-T60010
1mg73,00€5mg146,00€10mg212,00€1mL*10mM (DMSO)212,00€25mg374,00€50mg572,00€100mg858,00€Huwentoxin I
CAS :Huwentoxin I (HWTX-I) is a peptide toxin that targets and inhibits both voltage-gated sodium channels and N-type calcium channels.Formule :C161H246N48O44S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3750.36Calcicludine
CAS :Calcicludine, a protein toxin derived from the green mamba (Dendroaspis angusticeps) venom, selectively inhibits high-voltage-activated, particularly L-type,Formule :C321H476N86O78S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :6980.13Vesnarinone HCl
Vesnarinone HCl is an oral PDE3 inhibitor improving heart contractility, affecting calcium and potassium flux. Used in heart failure research.Formule :C22H26ClN3O4Degré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :431.91Candidalysin
CAS :Candidalysin is a cytolytic peptide toxin initially isolated from *Candida albicans*, exhibiting both toxic and non-toxic properties. It activates epithelial cell signaling pathways by interacting with the epithelial growth factor receptor (EGFR) on host cells, leading to the activation of matrix metalloproteinases (MMP) and calcium ion influx, which results in inflammatory responses and immune cell recruitment. Additionally, Candidalysin exhibits cytotoxicity by causing membrane damage to host cells.Formule :C153H266N38O38S2Couleur et forme :SolidMasse moléculaire :3310.111-(aminomethyl)cyclopropanecarboxylic acid hydrochloride
CAS :1-(aminomethyl)cyclopropanecarboxylic acid hydrochloride inhibits L amino acid transporter proteins and the α2δ subunit of voltage-gated calcium channels.1-(Formule :C5H10ClNO2Degré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :151.59FS-2
FS-2 is a potent, specific inhibitor of L-type CaV channels, effectively impeding high K+ or glucose-induced L-type Ca2+ influx in RIN beta cells [1].Formule :C297H462N92O86S10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :7018.06Budiodarone tartrate
CAS :Budiodarone tartrate (ATI-2042 tartrate) is an antiarrhythmic agent that inhibits calcium channels, and can be used in atrial fibrillation research.Formule :C31H37I2NO11Degré de pureté :97.44%Couleur et forme :Yellow ViscousMasse moléculaire :853.44Ref: TM-T74678
1mg154,00€5mg371,00€1mL*10mM (DMSO)587,00€10mg612,00€25mg1.161,00€50mg1.873,00€100mg2.637,00€Maurocalcine TFA
Maurocalcine TFA acts as an agonist for ryanodine receptor (RyR) channels 1, 2, and 3, demonstrating cell-penetrating capabilities. It induces binding of [3H]ryanodine to RyR1 with an EC50 of 2558 nM and exhibits an apparent affinity of 14 nM for RyR2. This compound is applicable for in vivo cell tracking or other cellular imaging techniques.Formule :C156H270N56O46S6·xC2HF3O2Couleur et forme :SolidMasse moléculaire :3858.55 (free base)ProTx-I
CAS :Selective blocker for CaV3.1 (IC50 = 0.2 μM), CaV3.2 (31.8 μM), also inhibits NaV1.8 and blocks KV2.1 channels.Formule :C171H245N53O47S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3987.5117R(18S)-EpETE
CAS :17R(18S)-EpETE: Oxylipin, eicosapentaenoic acid metabolite, activates BKCa channels, has negative chronotropic effects.Formule :C20H30O3Couleur et forme :SolidMasse moléculaire :318.457PDDHV
CAS :PDDHV: a capsaicin-like vanilloid selective for rat TRPV1; induces Ca2+ uptake in neurons, EC50 of 70 nM.Formule :C49H72O11Couleur et forme :SolidMasse moléculaire :837.09MMK 1
CAS :Potent hFPR2 agonist; EC50: 1 nM (mFPR2), 2 nM (hFPR2), >10,000 nM (hFPR1). Induces monocyte/neutrophil migration, boosts IL-1β/IL-6, activates NADPH-oxidase.Formule :C75H123N19O18SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1610.97NSC156529
CAS :NSC156529 suppresses AKT1, reduces cancer cell growth in vitro, and inhibits prostate tumors in vivo.Formule :C28H21ClS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :457.05Lyso-Globotriaosylceramide (d18:1)
CAS :Lyso-Gb3, lacking fatty acyl, binds Stx1 with cholesterol and phosphatidylcholine, not Stx2; lowers neutrophil viability; accumulates in Fabry disease.Formule :C36H67NO17Couleur et forme :SolidMasse moléculaire :785.922Lnd 796
CAS :Lnd 796 is an aminosteroid related to LND 623.Formule :C27H45NO7Couleur et forme :SolidMasse moléculaire :495.65Flunarizine
CAS :Flunarizine is an orally administered peripheral vasodilator, a dual blocker of voltage-gated Na+/Ca2+ channels and a D2 dopamine receptor antagonist.Formule :C26H26F2N2Degré de pureté :99.9%Couleur et forme :White SolidMasse moléculaire :404.50Imperatoxin A
CAS :Imperatoxin A, a peptide toxin sourced from the African scorpion Pandinus imperator, functions as an activator of Ca2+-release channels/ryanodine receptors (Formule :C148H254N58O45S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3758.35Ion Channel Targeted Library
A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;Couleur et forme :Odour SolidRef: TM-L2300
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderPACAP-38 (31-38), human, mouse, rat
CAS :PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine productionFormule :C47H83N17O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1062.27Calcium Channel antagonist 4
CAS :Calcium Channel antagonist 4 is a voltage-gated calcium channel inhibitor (IC50 : 5-20 μM).Formule :C23H26N2O4SDegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :426.53Imperatoxin A TFA
Imperatoxin A TFA, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, acts as an activator of Ca2+-release channels/ryanodine receptors (RyRs). It facilitates the influx of Ca2+ from the sarcoplasmic reticulum into the cell.Formule :C148H254N58O45S6·xC2HF3O2Couleur et forme :SolidMasse moléculaire :3758.35 (free base)ω-Hexatoxin-Hv1a
CAS :ω-Hexatoxin-Hv1a, a neurotoxin extracted from the venom of the spider Hadronyche versuta, inhibits voltage-gated calcium channels [1] [2].Formule :C162H247N49O61S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4049.38Capa-2
CAS :Capa-2 is a neuropeptide that induces calcium ion influx and stimulates nitric oxide (NO) production, which activates soluble guanylate cyclase (sGC) and increases intracellular cGMP levels, thereby driving ion and fluid secretion. Capa-2 is utilized in diuretic research.Formule :C47H78N14O11Masse moléculaire :1015.23YM-244769 dihydrochloride
CAS :YM-244769 dihydrochloride is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM.Formule :C26H24Cl2FN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :516.39MRS1845
CAS :MRS1845 is a selective inhibitor of store-operated calcium (SOC) channel (IC50 of 1.7 μM).Formule :C21H22N2O6Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :398.41Almorexant hydrochloride
CAS :Almorexant hydrochloride (ACT 078573 hydrochloride) is a dual orexin receptor antagonist that induces apoptosis and can be used to study sleep disorders.Formule :C29H32ClF3N2O3Degré de pureté :99.85%Couleur et forme :White SolidMasse moléculaire :549.02YM-244769
CAS :YM-244769 (3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-) is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3)Formule :C26H22FN3O3Degré de pureté :95.62%Couleur et forme :SolidMasse moléculaire :443.47(R)-(+)-Bay-K-8644
CAS :(R)-(+)-Bay-K-8644, a Ca2+ channel agonist, is a dihydropyridine agonist that induces central respiratory depression and inhibits platelet activation in cats.Formule :C16H15F3N2O4Degré de pureté :96.51% - 96.57%Couleur et forme :SolidMasse moléculaire :356.3Catharanthine
CAS :Catharanthine ((+)-3,4-Didehydrocoronaridine) suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).Formule :C21H24N2O2Degré de pureté :99.11%Couleur et forme :White SolidMasse moléculaire :336.43(S)-Lercanidipine-D3 hydrochloride
CAS :(S)-Lercanidipine D3 hydrochloride is a deuterium labeled Lercanidipine D3 hydrochloride. (S)-Lercanidipine hydrochloride is an agent of antihypertensive.Formule :C36H42ClN3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :651.21CCT129957
CAS :CCT129957 is a novel and potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of about 3 μM and a GC50 of 15 μM.CCT129957 exhibits anticancer activity andFormule :C17H15N3O3Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :309.32Ref: TM-T14903
1mg44,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg126,00€25mg220,00€50mg330,00€100mg497,00€500mg1.054,00€(R)-Nicardipine
CAS :(R)-Nicardipine is the less active R enantiomer of Nicardipine. Nicardipine is a blocker of calcium channel(IC50 of 1 μM for blocking cardiac calcium channels).Formule :C26H29N3O6Couleur et forme :SolidMasse moléculaire :479.53Norverapamil-D7
CAS :Norverapamil D7 is a deuterium labeled Norverapamil . Norverapamil is a blocker of L-type calcium channel and an inhibitor of P-glycoprotein (P-gp) function .Formule :C26H36N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :447.62TPC2-A1-N
CAS :TPC2-A1-N is a TPC2 small molecule agonist that can be used to detect different functions of TPC2 channels in intact cells.Formule :C17H9Cl2F3N2O2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :401.17Norverapamil-D7 hydrochloride
CAS :Norverapamil-d7 HCl (D591-d7 HCl) is a 2H-labeled Norverapamil HCl, a calcium channel blocker and P-gp inhibitor, also a coronary vasodilator.Formule :C26H37ClN2O4Couleur et forme :White SolidMasse moléculaire :484.08β-Cyfluthrin
CAS :Produit contrôléβ-Cyfluthrin is a type II synthetic pyrethroid compound commonly utilized as an active ingredient in agricultural insecticide products.Formule :C22H18Cl2FNO3Couleur et forme :SolidMasse moléculaire :434.29
