OAT
Les transporteurs d'anions organiques sont une famille de protéines membranaires qui médiatisent l'absorption et l'excrétion de divers anions organiques endogènes et exogènes, y compris les médicaments, les toxines et les sous-produits métaboliques. Les OAT sont principalement exprimés dans les reins et le foie, où ils jouent un rôle crucial dans la détoxification et l'élimination des médicaments. La dysrégulation de la fonction des OAT peut entraîner une toxicité médicamenteuse et des troubles rénaux. Chez CymitQuimica, nous proposons une variété de modulateurs de OAT pour soutenir vos recherches en pharmacologie, toxicologie et fonction rénale.
32 produits trouvés pour "OAT"
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URAT1 inhibitor 7
CAS :URAT1 inhibitor 7, a uric acid transporter protein URAT1 inhibitor.URAT1 inhibitor 7 inhibits CYP2C9 and can be used in the study of hyperuricemia and gout.Formule :C19H10ClFN4O3SDegré de pureté :97.14%Couleur et forme :SoildMasse moléculaire :428.824'-hydroxy Trazodone
CAS :<p>4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1It is an inhibitor of organic anion transporter 3 (OAT3; Ki= 16.9 μM) and is</p>Formule :C19H22ClN5O2Couleur et forme :SolidMasse moléculaire :387.87Epaminurad HCl
CAS :Epaminurad HCl is a URAT1 inhibitor with partial inhibition of OAT1 and OAT3 (organic anion transporters).Epaminurad HCl is a pro-uric acid excretory agent used for the prevention and treatment of gout and hyperuricemia.Formule :C14H11Br2ClN2O3Degré de pureté :99.01% - 99.42%Couleur et forme :SoildMasse moléculaire :450.51hURAT1 inhibitor 1
Compound 27b, also known as hURAT1 inhibitor 1, is an isomarine-derived, orally active inhibitor that targets both hURAT1 and GLUT9 with IC50 values of 0.16 μM and 4.47 μM, respectively. This compound exhibits significant anti-hyperuricemia effects and has demonstrated potent uric acid-lowering activity in a hyperuricemia mouse model at a dose of 10 mg/kg. Importantly, Compound 27b displays no notable in vitro cytotoxicity or in vivo hepatotoxicity, and possesses favorable pharmacokinetic (PK) characteristics.Formule :C24H19BrO4Masse moléculaire :451.31URAT1 inhibitor 10
URAT1 inhibitor10 (Compound 23a) is a URAT1 inhibitor with an IC50 of 0.052 μM. It exhibits oral efficacy and low cytotoxicity. The compound demonstrates high selectivity for OAT1, with an IC50 of 9.17 μM.URAT1 inhibitor 11
CAS :URAT1 inhibitor11 (Compound 7) is a potent URAT1 inhibitor, exhibiting an IC50 of 0.18 μM. It effectively reduces uric acid levels in zebrafish with hyperuricemia induced by Potassium oxonate and Xanthinesodium salt.Formule :C20H16F4N2O2Couleur et forme :SolidMasse moléculaire :392.35Euphol acetate
CAS :Euphol acetate, a triterpene from Euphorbia broteri, inhibits liver transport proteins OATP1B1/3.Formule :C32H52O2Couleur et forme :SolidMasse moléculaire :468.75URAT1/GLUT9-IN-1
URAT1/GLUT9-IN-1 (compound 29) effectively inhibits urate transporter 1 (URAT1) with an IC50 value of 2.01 μM and glucose transporter 9 (GLUT9) with an IC50 of 18.21 μM. This compound exhibits favorable pharmacokinetic properties and oral bioavailability, making it useful for research in gout and hyperuricemia.Ruzinurad
CAS :Ruzinurad (WO2020088641, compound I) is a potent URAT1 inhibitor, exhibiting high selectivity.Formule :C14H12BrNO2SCouleur et forme :SolidMasse moléculaire :338.22Lesinurad sodium
CAS :Lesinurad sodium (RDEA594 sodium) is a selective inhibitor of uric acid reabsorption and is used in the study of cardiovascular diseases.Formule :C17H13BrN3NaO2SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :426.26Verinurad
CAS :Verinurad (RDEA3170) (RDEA3170) is an organic anion transporter URAT1 (SLC22A12) inhibitor for the treatment of gout and hyperuricemia.Formule :C20H16N2O2SDegré de pureté :97.36% - 99.22%Couleur et forme :SolidMasse moléculaire :348.42Cabotegravir
CAS :Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (Formule :C19H17F2N3O5Degré de pureté :98.55% - 99.92%Couleur et forme :SolidMasse moléculaire :405.35Lesinurad
CAS :Lesinurad (RDEA594), a selective uric acid reabsorption inhibitor, is used to treat gout without causing liver damage.Formule :C17H14BrN3O2SDegré de pureté :99.83% - 99.86%Couleur et forme :SolidMasse moléculaire :404.28Epaminurad
CAS :Epaminurad (UR-1102) is an oral URAT1 inhibitor for gout research with a Ki of 0.057 μM, modestly affects OAT1/3.Formule :C14H10Br2N2O3Couleur et forme :SolidMasse moléculaire :414.05Dotinurad
CAS :Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 μM for uric acid).Formule :C14H9Cl2NO4SDegré de pureté :97.43% - 98.04%Couleur et forme :SolidMasse moléculaire :358.2XOR/URAT1-IN-1
CAS :Compound II15, known as XOR/URAT1-IN-1, serves as a dual inhibitor targeting xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1), exhibiting IC50 values of 6 nM and 12.9 μM, respectively. This compound effectively reduces uric acid levels in a mouse model of acute hyperuricemia induced by potassium oxonate and hypoxanthine.Formule :C18H13ClN2O3Masse moléculaire :340.76JTT-552
CAS :JTT-552, a uric acid transporter 1 (URAT1) inhibitor, is used potentially for the treatment of hyperuricemia.Formule :C15H12ClNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :289.71URAT1 inhibitor 4
CAS :URAT1 inhibitor 4 is a potent, orally active Lesinurad derivative with a 7.56 μM IC50, showing greater in vivo efficacy.Formule :C27H20BrN3O4S3Couleur et forme :SolidMasse moléculaire :626.56Xininurad
CAS :Xininurad (XNW3009) is a urate transporter (URAT) inhibitor.Formule :C15H10Br2FN3O2Couleur et forme :SolidMasse moléculaire :443.07Puliginurad
CAS :Puliginurad (YL-90148) is a urate transporter protein inhibitor that inhibits the reabsorption of uric acid.Puliginurad is used in the treatment of gout.Formule :C19H16N2O2SDegré de pureté :99.50% - 99.96%Couleur et forme :SolidMasse moléculaire :336.41URAT1&XO inhibitor 2
CAS :Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM forFormule :C14H12BrNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :322.15Lingdolinurad
CAS :Lingdolinurad is a uric acid transporter protein inhibitor targeting hURAT1 for the study of hyperuricemia or gout.Formule :C17H12BrN3O2Degré de pureté :96.26%Couleur et forme :SolidMasse moléculaire :370.2URAT1 inhibitor 6
CAS :URAT1 inhibitor 6 (Compound 1h), with an IC50 of 35 nM for hURAT1, demonstrates 200-fold and 8-fold greater potency compared to Lesinurad and Benzbromarone,Formule :C9H7BrN3NaO2S2Couleur et forme :SolidMasse moléculaire :356.2URAT1 inhibitor 8
CAS :URAT1 Inhibitor 8 (example 247) serves as a highly potent inhibitor of URAT1, demonstrating an IC50 value of 0.001 μM.Formule :C19H13ClFN3O4SCouleur et forme :SolidMasse moléculaire :433.84URAT1 inhibitor 1
CAS :URAT1 inhibitor 1 (1g) is an inhibitor of uric acid transporter 1 (URAT1) (IC50: 32 nM), has the potential to treat hyperuricemia associated with gout.Formule :C19H15Br2N5O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :569.29TRPV1 antagonist 10
CAS :TRPV1 antagonist 10 is a potent, orally active TRPV1 antagonist with an IC50 of 33.06 nM and serves as a moderate to weak inhibitor of URAT1 (IC50 = 22.51 μM) and GLUT9 (inhibition of 60.25% at 50 μM). It exhibits analgesic and urate-lowering properties and is applicable for research in hyperuricemia and inflammatory pain.Formule :C16H14N2O5Couleur et forme :SolidMasse moléculaire :314.293URAT1 inhibitor 13
CAS :URAT1 inhibitor13 (compound 22k) is a potent inhibitor of URAT1, useful for research related to gout.Formule :C18H14Cl2N2O2Masse moléculaire :361.22KPH2f
CAS :KPH2f: dual URAT1/GLUT9 inhibitor, orally active, IC50: 0.24μM (URAT1), 9.37μM (GLUT9), minimal OAT1/ABCG2 impact.Formule :C24H16N3NaO2SCouleur et forme :SolidMasse moléculaire :433.46hURAT1 inhibitor 2
CAS :hURAT1 inhibitor 2 (Compound 5) is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC50 of 18 nM. It also exhibits some inhibitory activity against OATP1B1, with an IC50 of 0.73 μM. hURAT1 inhibitor 2 can be used in research related to hyperuricemia, gout, and other diseases associated with abnormal uric acid metabolism.Formule :C17H11Br2FO3Couleur et forme :SolidMasse moléculaire :442.074URAT1 inhibitor 3
URAT1 inhibitor 3: potent oral URAT1 blocker, IC50=0.8 nM, for gout/hyperuricemia study.Formule :C14H8Cl2N2O2Couleur et forme :SolidMasse moléculaire :307.13URAT1 inhibitor 2
URAT1 inhibitor 2: oral URAT1/CYP blocker, IC50 of 1.36μM (URAT1), 16.97μM (CYP1A2), 5.22μM (CYP2C9); potential gout treatment.Formule :C21H18BrN3O2SCouleur et forme :SolidMasse moléculaire :456.36URAT1-IN-14
CAS :URAT1-IN-14 is a potent and orally active inhibitor of uric acid transporter 1 (URAT1). It demonstrates an IC50 value of 0.72 μM for inhibiting human URAT1 in HEK293 cells and exhibits low cytotoxicity in Hep-G2 cells. URAT1-IN-14 reduces uric acid levels in a hyperuricemia mouse model and is applicable in research on hyperuricemia and gout.Formule :C19H19NO3SCouleur et forme :SolidMasse moléculaire :341.42
