PDE
Les phosphodiestérases (PDE) sont des enzymes qui hydrolysent les nucléotides cycliques, tels que l'AMPc et le GMPc, en leurs formes inactives, jouant un rôle clé dans la régulation des voies de signalisation intracellulaire. Les inhibiteurs de PDE sont utilisés dans le traitement de diverses affections, notamment les maladies cardiovasculaires, la dysfonction érectile et les troubles respiratoires, en raison de leur capacité à moduler les niveaux de nucléotides cycliques. Chez CymitQuimica, nous proposons une gamme d'inhibiteurs de PDE pour soutenir vos recherches en signalisation cellulaire, pharmacologie et développement thérapeutique.
165 produits trouvés pour "PDE"
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K134
CAS :<p>K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.</p>Formule :C22H29N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :399.48PAT-048
CAS :<p>PAT-048 is an effective and selective autotaxin inhibitor.</p>Formule :C22H18ClF2N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.91Propentofylline
CAS :<p>Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.</p>Formule :C15H22N4O3Degré de pureté :99.76% - 99.86%Couleur et forme :Off-White SolidMasse moléculaire :306.36Deltasonamide 2
CAS :<p>Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.</p>Formule :C30H39ClN6O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.25Deltasonamide 2 (TFA)
CAS :<p>Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.</p>Formule :C32H40ClF3N6O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :761.28PDE9-IN-1
CAS :<p>PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).</p>Formule :C17H23FN6O2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :362.4Tilivapram
CAS :<p>Tilivapram is a PDE4 (phosphodiesterase IV) inhibitor that can be used in the study of mental illness.</p>Formule :C16H15Cl2N3O4Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :384.21AN3199
CAS :<p>AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.</p>Formule :C17H18BNO5Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :327.14Imazodan hydrochloride
CAS :<p>Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.</p>Formule :C13H13ClN4ODegré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :276.72BAY 73-6691
CAS :<p>BAY 73-6691 is an inhibitor of brain penetrant PDE9A.</p>Formule :C15H12ClF3N4OCouleur et forme :SolidMasse moléculaire :356.73Lirimilast
CAS :<p>Lirimilast: oral PDE4 inhibitor (IC50: 49 nM), anti-inflammatory, treats asthma/COPD.</p>Formule :C17H12Cl2N2O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.26WAY127093B racemate
CAS :<p>WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.</p>Formule :C23H28N4O4Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :424.49PDE7-IN-2
CAS :<p>PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.</p>Formule :C14H11ClN2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :322.77(R)-DNMDP
CAS :<p>(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.</p>Formule :C15H20N4O3Couleur et forme :SolidMasse moléculaire :304.34Autotaxin-IN-1
CAS :<p>Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.</p>Formule :C21H23N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.45Senazodan hydrochloride
CAS :<p>Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.</p>Formule :C15H15ClN4ODegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :302.76KD-027
CAS :<p>KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.</p>Formule :C25H35N7O6SDegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :561.65ATX inhibitor 5
CAS :<p>ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.</p>Formule :C22H18ClF3N6ODegré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :474.87PF-04822163
CAS :<p>PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.</p>Formule :C19H17ClN2O2Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :340.8Imazodan
CAS :<p>Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.</p>Formule :C13H12N4ODegré de pureté :98% - 98.31%Couleur et forme :SolidMasse moléculaire :240.26PDE IV-IN-1
CAS :<p>PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary disease</p>Formule :C20H23ClN4O2Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :386.88Tanimilast
CAS :<p>Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.</p>Formule :C30H30Cl2F2N2O8SDegré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :687.54uk-50001
CAS :<p>UK-50001 is a PDE4 inhibitor for treating inflammation, allergies, respiratory issues, and wounds.</p>Formule :C26H24F3N3O4Degré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :499.48PDE4B-IN-2
CAS :<p>PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.</p>Formule :C19H18ClN3O2SDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :387.88Nanterinone
CAS :<p>Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.</p>Formule :C15H15N3ODegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :253.3Dovramilast
CAS :<p>Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus erythematosus.</p>Formule :C24H28N2O6SDegré de pureté :98.75% - 99.62%Couleur et forme :SolidMasse moléculaire :472.55Verofylline
CAS :<p>Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 for the</p>Formule :C12H18N4O2Degré de pureté :98.33% - 98.83%Couleur et forme :SolidMasse moléculaire :250.3Carbazeran
CAS :<p>Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases.</p>Formule :C18H24N4O4Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :360.41AWD 12-281
CAS :<p>AWD 12-281 is a PDE4 inhibitor with anti-inflammatory activity and bronchodilator activity for the study of chronic obstructive pulmonary disease (COPD).</p>Formule :C22H14Cl2FN3O3Degré de pureté :99.25% - 99.85%Couleur et forme :SolidMasse moléculaire :458.27Autotaxin-IN-3
CAS :<p>Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.</p>Formule :C22H21N9O2Degré de pureté :99.54% - 99.79%Couleur et forme :SolidMasse moléculaire :443.46Filaminast
CAS :<p>Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.</p>Formule :C15H20N2O4Degré de pureté :98.53% - 98.93%Couleur et forme :SolidMasse moléculaire :292.33MK-0873
CAS :<p>MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.</p>Formule :C25H18N4O3Degré de pureté :98.40%Couleur et forme :SolidMasse moléculaire :422.44Mopidamol
CAS :<p>Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimental</p>Formule :C19H31N7O4Degré de pureté :99.05% - 99.78%Couleur et forme :SolidMasse moléculaire :421.49Isomazole
CAS :<p>Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.</p>Formule :C14H13N3O2SDegré de pureté :98.66%Couleur et forme :SolidMasse moléculaire :287.34Tofimilast
CAS :<p>Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.</p>Formule :C18H21N5SDegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :339.46Dasantafil
CAS :<p>Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and study erectile dysfunction.</p>Formule :C22H28BrN5O5Degré de pureté :99.4% - 99.50%Couleur et forme :SolidMasse moléculaire :522.39PF-04447943
CAS :<p>PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory properties.</p>Formule :C20H25N7O2Degré de pureté :99.36% - 99.59%Couleur et forme :SolidMasse moléculaire :395.46GSK356278
CAS :<p>GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.</p>Formule :C21H25N7O2SDegré de pureté :99.90% - 99.97%Couleur et forme :SolidMasse moléculaire :439.53MK-8189
CAS :<p>MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.</p>Formule :C19H22N6OSDegré de pureté :99.38% - 99.67%Couleur et forme :SolidMasse moléculaire :382.48Autotaxin-IN-5
CAS :<p>Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.</p>Formule :C30H29N9O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :547.61Gisadenafil
CAS :<p>Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.</p>Formule :C23H33N7O5SDegré de pureté :98.82% - 99.50%Couleur et forme :SolidMasse moléculaire :519.62PDE5-IN-2
CAS :<p>PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)</p>Formule :C25H21N3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :491.52CI-1044
CAS :<p>CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).</p>Formule :C23H19N5O2Couleur et forme :SolidMasse moléculaire :397.43BIO-32546
CAS :<p>BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.</p>Formule :C28H31F6NO3Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :543.54Gisadenafil besylate
CAS :<p>Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor, for lower urinary tract symptoms associated with benign prostatic hyperplasia.</p>Formule :C29H39N7O8S2Couleur et forme :SolidMasse moléculaire :677.79Difamilast
CAS :<p>Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).</p>Formule :C23H24F2N2O5Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :446.44Siguazodan
CAS :<p>Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.</p>Formule :C14H16N6ODegré de pureté :99.62% - 99.87%Couleur et forme :SolidMasse moléculaire :284.32Adibendan
CAS :<p>Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.</p>Formule :C16H14N4ODegré de pureté :99.52% - >99.99%Couleur et forme :SolidMasse moléculaire :278.31Autotaxin-IN-4
CAS :<p>Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.</p>Formule :C22H21N9O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.46PF-04957325
CAS :<p>PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can be used for the study of autoimmune encephalomyelitis.</p>Formule :C14H15F3N8OSDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :400.38PDE9-IN-(S)-C33
CAS :<p>PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.</p>Formule :C18H20ClN5ODegré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :357.84Enpp-1-IN-16
CAS :<p>Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.</p>Formule :C23H32N4O4Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :428.52TPN171
CAS :<p>TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary</p>Formule :C24H35N5O3Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :441.57AMG 579
CAS :<p>AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).</p>Formule :C25H23N5O3Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :441.48Cudetaxestat
CAS :<p>Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.</p>Formule :C21H15Cl2F2N3O2SDegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :482.33TP-10
CAS :<p>TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.</p>Formule :C26H19F3N4ODegré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :460.45Thioquinapiperifil dihydrochloride
CAS :<p>Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.</p>Formule :C24H29ClN6OSDegré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :485.05PF-00489791
CAS :<p>PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.</p>Formule :C20H28N8O4SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :476.55Deltasonamide 2 hydrochloride
<p>Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.</p>Formule :C30H40Cl2N6O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :683.71ASP9831
CAS :<p>ASP9831 is an orally active PDE4 inhibitor. It suppresses LPS-induced TNF-α production and exhibits anti-inflammatory properties. ASP9831 is useful in the study of steatohepatitis.</p>Formule :C20H23N3O3Couleur et forme :SolidMasse moléculaire :353.42Tovinontrine
CAS :<p>Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.</p>Formule :C21H26N6O2Degré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :394.47BMS-341400 mesylate
CAS :<p>BMS-341400 mesylate (Compound 6) is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM and is useful in the study of erectile dysfunction.</p>Formule :C24H26ClN9O5SCouleur et forme :SolidMasse moléculaire :588.039TAK-915
CAS :<p>TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.</p>Formule :C19H18F4N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.36Z21090
CAS :<p>Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].</p>Formule :C12H14ClN3O3Couleur et forme :SolidMasse moléculaire :283.71NHTD
CAS :<p>NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).</p>Formule :C24H26N2O5Couleur et forme :SolidMasse moléculaire :422.47
