PDE
Les phosphodiestérases (PDE) sont des enzymes qui hydrolysent les nucléotides cycliques, tels que l'AMPc et le GMPc, en leurs formes inactives, jouant un rôle clé dans la régulation des voies de signalisation intracellulaire. Les inhibiteurs de PDE sont utilisés dans le traitement de diverses affections, notamment les maladies cardiovasculaires, la dysfonction érectile et les troubles respiratoires, en raison de leur capacité à moduler les niveaux de nucléotides cycliques. Chez CymitQuimica, nous proposons une gamme d'inhibiteurs de PDE pour soutenir vos recherches en signalisation cellulaire, pharmacologie et développement thérapeutique.
165 produits trouvés pour "PDE"
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PQ-10
CAS :<p>PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.</p>Formule :C22H21N5O3Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :403.43Roflumilast N-oxide
CAS :<p>Roflumilast N-oxide is an inhibitor of PDE type 4.</p>Formule :C17H14Cl2F2N2O4Degré de pureté :98.19% - 99.69%Couleur et forme :SolidMasse moléculaire :419.21Balipodect
CAS :<p>Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.</p>Formule :C23H17FN6O2Degré de pureté :98% - 99.79%Couleur et forme :SolidMasse moléculaire :428.42Irsogladine
CAS :<p>Irsogladine (Dicloguamine) is an anti-ulcer agent that promotes gap junction intercellular communication via M1 muscarinic acetylcholine receptor binding.</p>Formule :C9H7Cl2N5Degré de pureté :99.74% - 99.91%Couleur et forme :White Or Colorless Crystal Or Crystalline Powder Odorless Slightly BitterMasse moléculaire :256.09K-Ras-PDEδ-IN-1
CAS :<p>K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).</p>Formule :C25H26FN5O2Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :447.5Cilomilast
CAS :<p>Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.</p>Formule :C20H25NO4Degré de pureté :97.37% - 99.52%Couleur et forme :White SolidMasse moléculaire :343.42ICI 63197
CAS :<p>ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.</p>Formule :C9H13N5ODegré de pureté :99.70%Couleur et forme :White SolidMasse moléculaire :207.23IBMX
CAS :<p>IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μM</p>Formule :C10H14N4O2Degré de pureté :98% - >99.99%Couleur et forme :Off-WhiteMasse moléculaire :222.242,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide
CAS :<p>2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide is a PDE inhibitor.</p>Formule :C9H9Cl2F2NO3SDegré de pureté :98.60%Couleur et forme :SolidMasse moléculaire :320.14Olprinone
CAS :<p>Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate</p>Formule :C14H10N4ODegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :250.26HA130
CAS :<p>HA130 is a selective ATX (autotaxin) inhibitor.</p>Formule :C24H19BFNO5SDegré de pureté :98.26% - ≥95%Couleur et forme :SolidMasse moléculaire :463.29Ro 20-1724
CAS :<p>Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1</p>Formule :C15H22N2O3Degré de pureté :98.82% - 99.79%Couleur et forme :SolidMasse moléculaire :278.35Mardepodect
CAS :<p>Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE.</p>Formule :C25H20N4ODegré de pureté :99.81% - 99.94%Couleur et forme :SolidMasse moléculaire :392.45BW-A 78U
CAS :<p>BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.</p>Formule :C13H12FN5Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :257.27MBCQ
CAS :<p>MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.</p>Formule :C16H12ClN3O2Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :313.74HA 155
CAS :<p>HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.</p>Formule :C24H19BFNO5SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :463.29Ibudilast
CAS :<p>Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.</p>Formule :C14H18N2ODegré de pureté :99.83% - >99.99%Couleur et forme :White SolidMasse moléculaire :230.31ML-030
CAS :<p>ML-030 is a potent PDE4 inhibitor, selective for subtypes (A1, B1, B2, C1, D2) with IC50 ranging from 6.7 to 452 nM.</p>Formule :C20H20N4O4SDegré de pureté :97.93%Couleur et forme :SolidMasse moléculaire :412.46SEP-0372814
CAS :<p>SEP-0372814 is a potent inhibitor of PDE10.</p>Formule :C21H19N7Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :369.42YM976
CAS :<p>YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)</p>Formule :C17H16ClN3ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :313.78Cilostamide
CAS :<p>Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)</p>Formule :C20H26N2O3Degré de pureté :98.87%Couleur et forme :White To Off-White SolidMasse moléculaire :342.43D159687
CAS :<p>D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant benefit.</p>Formule :C21H19ClN2O2Degré de pureté :97.57%Couleur et forme :SolidMasse moléculaire :366.84RS-25344 hydrochloride
CAS :<p>RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitor</p>Formule :C19H14ClN5O4Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :411.8BRL-50481
CAS :<p>BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.</p>Formule :C9H12N2O4SDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :244.27Piclamilast
CAS :<p>Piclamilast (RP 73401) is a PDE4 inhibitor.</p>Formule :C18H18Cl2N2O3Degré de pureté :98.28% - 99.57%Couleur et forme :SolidMasse moléculaire :381.25Ensifentrine
CAS :<p>Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that</p>Formule :C26H31N5O4Degré de pureté :99.76% - 99.94%Couleur et forme :SolidMasse moléculaire :477.56Z-HA155
CAS :<p>Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.</p>Formule :C24H19BFNO5SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :463.29Crisaborole
CAS :<p>Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.</p>Formule :C14H10BNO3Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :251.05Udenafil
CAS :<p>Udenafil is an inhibitor of PDE5 .</p>Formule :C25H36N6O4SDegré de pureté :99.90%Couleur et forme :Off-White SolidMasse moléculaire :516.66GSK256066
CAS :<p>GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold</p>Formule :C27H26N4O5SDegré de pureté :99.60% - 99.66%Couleur et forme :SolidMasse moléculaire :518.58Nortadalafil
CAS :<p>Nortadalafil, a demethylated form of Tadalafil, is a PDE5 inhibitor used to treat ED and pulmonary arterial hypertension as Adcirca.</p>Formule :C21H17N3O4Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :375.38Homo Sildenafil
CAS :<p>Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.</p>Formule :C23H32N6O4SDegré de pureté :99.88%Couleur et forme :White SolidMasse moléculaire :488.6GEBR-7b
CAS :<p>GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.</p>Formule :C13H16O3Degré de pureté :99.533%Couleur et forme :SolidMasse moléculaire :220.26Enoximone
CAS :<p>Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.</p>Formule :C12H12N2O2SDegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :248.3MY-5445
CAS :<p>MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).</p>Formule :C20H14ClN3Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :331.8Amino Tadalafil
CAS :<p>Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.</p>Formule :C21H18N4O4Degré de pureté :99.85%Couleur et forme :White PowderMasse moléculaire :390.39Sildenafil Mesylate
CAS :<p>Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.</p>Formule :C22H30N6O4S·xCH4O3SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :570.68Lodenafil
CAS :<p>Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)</p>Formule :C23H32N6O5SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :504.6[11C]MP 10
CAS :<p>[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.</p>Formule :C25H20N4ODegré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :391.45Osoresnontrine
CAS :<p>Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.</p>Formule :C16H17N5O2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :311.34CP671305
CAS :<p>CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.</p>Formule :C23H19FN2O7Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :454.4Ziritaxestat
CAS :<p>Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.</p>Formule :C30H33FN8O2SDegré de pureté :97% - 99.85%Couleur et forme :SolidMasse moléculaire :588.7PDE10-IN-1
CAS :<p>PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.</p>Formule :C21H19N7Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :369.42RS-25344
CAS :<p>RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.</p>Formule :C19H13N5O4Degré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :375.34Lotamilast
CAS :<p>Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.</p>Formule :C26H24N4O5Degré de pureté :97.03% - 99.29%Couleur et forme :SolidMasse moléculaire :472.49Enpp-1-IN-1
CAS :<p>Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)</p>Formule :C17H17N3O3SDegré de pureté :97.52%Couleur et forme :SolidMasse moléculaire :343.4GSK256066 Trifluoroacetate
CAS :<p>GSK 256066 Trifluoroacetate: selective PDE4 inhibitor, IC50: 3.2 pM for PDE4B, treats COPD.</p>Formule :C29H27F3N4O7SCouleur et forme :SolidMasse moléculaire :632.61Crisaborole-d4
<p>Crisaborole-d4 (AN-2728-d4) is the deuterated form of Crisaborole. Crisaborole is a PDE4 inhibitor and also a cytokine release inhibitor.</p>Formule :C14H6D4BNO3Couleur et forme :SolidMasse moléculaire :255.07ent-Tadalafil
CAS :<p>ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).</p>Formule :C22H19N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.4Deltarasin
CAS :<p>Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.</p>Formule :C40H37N5ODegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :603.75
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