Aminopeptidase
Les aminopeptidases sont un groupe d'enzymes qui catalysent la coupure des acides aminés à partir de l'extrémité N-terminale des peptides et des protéines, jouant un rôle crucial dans la maturation et la dégradation des protéines. Ces enzymes sont impliquées dans divers processus physiologiques, notamment le traitement des antigènes, la régulation des hormones peptidiques et l'homéostasie cellulaire. Les inhibiteurs des aminopeptidases présentent un intérêt pour le traitement de maladies telles que le cancer, l'inflammation et les maladies infectieuses. Chez CymitQuimica, nous proposons une variété d'inhibiteurs d'aminopeptidases pour soutenir vos recherches en protéomique, développement de médicaments et traitement des maladies.
67 produits trouvés pour "Aminopeptidase"
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RB 101
CAS :<p>RB 101 suppresses enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase.</p>Formule :C31H38N2O3S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :582.84MetAP2-IN-1
CAS :<p>MetAP2-IN-1 is a selective inhibitor of MetAP2, a target involved in angiogenesis-related conditions, suitable for research applications [1].</p>Formule :C8H6BrN3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :224.06Arphamenine A
CAS :<p>Arphamenine A is an inhibitor of aminopeptidase B (aminopeptidaseB) found in HMG361-CF4 of Actinomadura azurea. It exhibits inhibitory effects against Sarcoma 180 and invasive micropapillary carcinoma (IMC).</p>Formule :C16H24N4O3Couleur et forme :SolidMasse moléculaire :320.387A-800141
CAS :<p>A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.</p>Formule :C24H30N2O4SCouleur et forme :SolidMasse moléculaire :442.571EC33
CAS :<p>EC33, a selective aminopeptidase A (APA) inhibitor, blocks the pressor response of exogenous Ang II and does not cross the blood-brain barrier, making it a potential candidate for salt-dependent hypertension research [1].</p>Formule :C4H11NO3S2Couleur et forme :SolidMasse moléculaire :185.27LTA4H-IN-3
CAS :<p>LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].</p>Formule :C17H15ClN4O3Couleur et forme :SolidMasse moléculaire :358.78LTA4H-IN-2
CAS :<p>LTA4H-IN-2 (compound (S)-2) acts as an orally active inhibitor targeting Leukotriene A4 Hydrolase, exhibiting potent activity with an IC 50 of less than 3 nM [1].</p>Formule :C20H19FN6O2Couleur et forme :SolidMasse moléculaire :394.4Bestatin methyl ester
CAS :<p>Bestatin methyl ester (600, 900 µM; 24 h) inhibits spore cell differentiation in Dictyostelium discoideum.</p>Formule :C17H26N2O4Couleur et forme :SolidMasse moléculaire :322.4Ketomethylenebestatin
CAS :<p>Ketomethylenebestatin, a weaker carba-analog of aminopeptidase inhibitor bestatin, is 10x less potent.</p>Formule :C17H25NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :307.38SDX-7539
CAS :<p>SDX-7539 is a selective MetAP2 inhibitor that inhibits the proliferation of HUVEC, with an IC50 of 120 μM. It has demonstrated antitumor activity in xenografted NSCLC in athymic nude mice.</p>Formule :C23H38N2O5Masse moléculaire :422.56PPI-2458
CAS :<p>PPI-2458, a fumagillin derivative, irreversibly blocks MetAP2, hindering abnormal cell growth and angiogenesis with improved toxicity.</p>Formule :C22H36N2O6Couleur et forme :SolidMasse moléculaire :424.53QGC583
CAS :<p>QGC583 is an effective and selective AminopeptidaseA (APA) inhibitor, demonstrating an IC50 of 4 nM. It inhibits APA activity in the brain, kidneys, and heart of rats.</p>Formule :C13H20NO5PCouleur et forme :SolidMasse moléculaire :301.284-MDM
CAS :<p>4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H). By promoting the degradation of proline-glycine-proline by LTA4H, 4-MDM reduces neutrophil recruitment in the lungs, alleviating inflammation without affecting the epoxide hydrolase activity of LTA4H. This compound is useful for research in pulmonary diseases.</p>Formule :C14H14OCouleur et forme :SolidMasse moléculaire :198.26ERAP1 modulator-2
CAS :<p>ERAP1 modulator-2 (compound 10) is a potent ERAP1 inhibitor with an IC50 value of less than 100 nM.</p>Formule :C22H25F3N2O4SCouleur et forme :SolidMasse moléculaire :470.505Beloranib
CAS :<p>Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.</p>Formule :C29H41NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :499.64TNP-470
CAS :<p>TNP-470 is a methionine aminopeptidase-2 inhibitor. TNP-470 is also an angiogenesis inhibitor.</p>Formule :C19H28ClNO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.88Actinonin
CAS :<p>Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. It also induces apoptosis and inhibits aminopeptidase M, aminopeptidase N, and leucine aminopeptidase, as well as MMP-1, MMP-3, MMP-8, MMP-9, and meprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin exhibits antiproliferative and antitumor activities [1][2][3][4][5].</p>Formule :C19H35N3O5Couleur et forme :SolidMasse moléculaire :385.5
