IDO
L'indoleamine 2,3-dioxygénase (IDO) est une enzyme impliquée dans le catabolisme du tryptophane, conduisant à la production de kynurénine et d'autres métabolites. L'IDO joue un rôle dans la tolérance immunitaire et est souvent surexprimée dans le cancer et les maladies inflammatoires chroniques. Les inhibiteurs de l'IDO sont explorés comme agents immunothérapeutiques potentiels dans le cancer et les maladies auto-immunes. Chez CymitQuimica, nous fournissons des inhibiteurs de l'IDO pour soutenir vos recherches en immunologie, oncologie et régulation métabolique.
84 produits trouvés pour "IDO"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
GNF-PF-3777
CAS :<p>GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).</p>Formule :C15H7N3O4Degré de pureté :97.88%Couleur et forme :SolidMasse moléculaire :293.23IDO-IN-13
CAS :<p>IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).</p>Formule :C26H17F3N4ODegré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :458.43LY3381916
CAS :<p>IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.</p>Formule :C23H25FN2O3Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :396.45CAY10581
CAS :CAY10581, a derivative of pyranonaphthoquinone, serves as a highly specific and reversible uncompetitive inhibitor of IDO, demonstrating potency with an IC50Formule :C22H21NO4Couleur et forme :SolidMasse moléculaire :363.41human TDO2-IN-1
<p>Human TDO2-IN-1 (Cpd-2) is a potent inhibitor of human TDO2, with an IC50 of 14.8 nM. It plays a significant role in studies related to metabolism, inflammation, and tumor immune surveillance.</p>Formule :C30H36N4O5Couleur et forme :SolidMasse moléculaire :532.631XW-032
<p>XW-032 is an apo-IDO1 inhibitor with an IC50 of 21 nM. In the CT26 syngeneic mouse model, XW-032 demonstrates significant in vivo antitumor efficacy with a TGI of 63%, showing potential for cancer research applications.</p>Couleur et forme :Odour SolidIDO1-IN-24
IDO1-IN-24 (compound 2c) inhibits the production of IDO1 during cell assays, with an IC50 value of 17 μM.Formule :C18H22N2O4Masse moléculaire :330.15796NLG802
CAS :<p>NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.</p>Formule :C20H30ClN3O3Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :395.92TDO-IN-2
TDO-IN-2 is an orally active TDO inhibitor with an IC50 of 1.25 μM. It exhibits antitumor activity in a Hepa1-6 liver cancer allograft mouse model. Additionally, TDO-IN-2 works synergistically with PD-1/PD-L1 inhibitor BMS-202, making it useful for studying tumor immune tolerance.Formule :C20H15N3O3Couleur et forme :SolidMasse moléculaire :345.11134BMT-297376
CAS :BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.Formule :C23H29F2N3O3Couleur et forme :SolidMasse moléculaire :433.5NU227326
CAS :NU227326 is a PROTAC degrader of indoleamine 2,3-dioxygenase 1 (IDO1) with a DC50 value of 4.5 nM. It effectively degrades IDO1 in U87 and GBM43 cells, with DC50 values of 7.1 nM and 11.8 nM, respectively. NU227326 exhibits favorable pharmacokinetic properties, with a plasma half-life of 5.7 hours and a brain tissue half-life of 11.8 hours. (Pink: ligand for target protein IDO1 ligand-1; Black: linker; Blue: ligand for E3 ligase Cereblon).Formule :C53H61FN8O7Couleur et forme :SolidMasse moléculaire :941.099IDO1-IN-7
CAS :IDO1-IN-7 is a potent IDO1 inhibitor with a 6.1 nM IC50 and immunomodulatory effects for cancer research.Formule :C22H19ClFN3O3Couleur et forme :SolidMasse moléculaire :427.86PROTAC IDO1 Degrader-1
CAS :First potent PROTAC IDO1 degrader; links IDO1 to CRBN E3 ligase for UPS-induced degradation (DC50=2.84 μM), boosts H ER2 CAR-T cell efficacy.Formule :C40H53BrFN9O13Couleur et forme :SolidMasse moléculaire :966.816IDO1-IN-23
<p>IDO1-IN-23 (compound 41) is a potent inhibitor of human indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 of 13 μM [1].</p>Degré de pureté :98%Couleur et forme :Odour SolidIDO-IN-15
CAS :IDO-IN-15 is an IDO1 inhibitor ( IC 50 < 0.51 nM).Formule :C29H39N5O4Couleur et forme :SolidMasse moléculaire :521.662IDO1/TDO-IN-8
<p>IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor capable of crossing the blood-brain barrier, with EC50 values of 0.33 μM and 1.78 μM, respectively. It modulates the kynurenine pathway of tryptophan metabolism, reducing the kynurenine/tryptophan ratio. IDO1/TDO-IN-8 has neuroprotective effects, alleviating motor dysfunction and improving depressive behavior, making it relevant for research into Parkinson's disease with comorbid depression.</p>Formule :C17H14N2SCouleur et forme :SolidMasse moléculaire :278.37IDO1-IN-11
CAS :<p>IDO1-IN-11 is an IDO1 inhibitor with an IC 50 value of 0.6 nM.</p>Formule :C22H17ClFN3O3Couleur et forme :SolidMasse moléculaire :425.84NU223612
CAS :<p>"NU223612 is a potent IDO1-degrading PROTAC with Kd 640 nM, binds CRBN at 290 nM, and crosses the BBB."</p>Formule :C49H55FN6O9Couleur et forme :SolidMasse moléculaire :890.99IDO1-IN-12
CAS :IDO1-IN-12 is a potent and orally available IDO1 inhibitor.Formule :C21H19F3N2O2Couleur et forme :SolidMasse moléculaire :388.39IDO1/TDO-IN-7
<p>IDO1/TDO-IN-7 (Compound 43b), an isochinoline derivative, functions as a potent dual inhibitor of IDO1/TDO with IC50 values of 0.31 μM and 0.08 μM, respectively. Demonstrating favorable pharmacokinetics and strong antitumor efficacy in the B16-F10 tumor model, this compound also exhibits low toxicity.</p>Couleur et forme :Odour Solid
