IDO
L'indoleamine 2,3-dioxygénase (IDO) est une enzyme impliquée dans le catabolisme du tryptophane, conduisant à la production de kynurénine et d'autres métabolites. L'IDO joue un rôle dans la tolérance immunitaire et est souvent surexprimée dans le cancer et les maladies inflammatoires chroniques. Les inhibiteurs de l'IDO sont explorés comme agents immunothérapeutiques potentiels dans le cancer et les maladies auto-immunes. Chez CymitQuimica, nous fournissons des inhibiteurs de l'IDO pour soutenir vos recherches en immunologie, oncologie et régulation métabolique.
84 produits trouvés pour "IDO"
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IDO-IN-6
CAS :IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.Formule :C18H21FN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :316.37IDO1-IN-2
CAS :IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.Formule :C15H17FN6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.33IDO-IN-3
CAS :IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).Formule :C11H12BrFN6O2Couleur et forme :SolidMasse moléculaire :359.15IDO-IN-11
CAS :IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).Formule :C19H23BrFN7O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :544.4IDO1/TDO-IN-3
CAS :IDO1/TDO-IN-3 inhibits IDO1 (IC50: 0.005 μM) and TDO (IC50: 0.004 μM) with strong anti-tumor activity and low toxicity.Formule :C16H6ClF2N3O2Couleur et forme :SolidMasse moléculaire :345.69IDO-IN-4
CAS :IDO-IN-4 is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor.Formule :C26H35N3O3Couleur et forme :SolidMasse moléculaire :437.57IDO1-IN-16
CAS :IDO1-IN-16 (I-1) is an IDO1 inhibitor that targets holo-IDO1 (IC50: 127 nM).Formule :C25H35BrFN5O2Couleur et forme :SolidMasse moléculaire :536.48IACS-8968 R-enantiomer
CAS :IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).Formule :C17H18F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :381.35IDO1/TDO-IN-2
CAS :IDO1/TDO-IN-2: IDO1/TDO inhibitor; IC50s: IDO1, 0.1μM; TDO, 0.07μM; potential for cancer research.Formule :C16H9N3O2Couleur et forme :SolidMasse moléculaire :275.26IDO/TDO-IN-1
CAS :IDO/TDO-IN-1 is an orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50s: 9.7 and 47 nM).Formule :C25H24FN5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :413.49IDO1-IN-15
CAS :IDO1-IN-15 is an effective IDO1 inhibitor with IC50 of 127 nM. The potency of IDO1-IN-15 against IDO1 enzyme is comparable with Epacadostat in vitro.Formule :C13H14BrFN6O3Couleur et forme :SolidMasse moléculaire :401.19IDO-IN-16
CAS :IDO-IN-16 (compound 5) is an IDO inhibitor (IC50: 36 nM).Formule :C22H21F3N4OCouleur et forme :SolidMasse moléculaire :414.42IDO1-IN-17
CAS :IDO1-IN-17 (I-4) is an IDO1 inhibitor, with an IC 50 of 0.44 μM in hela cells .Formule :C28H32BrClFN5O2Couleur et forme :SolidMasse moléculaire :604.94IDO-IN-14
CAS :IDO-IN-14 is an IDO inhibitor (IC50: 0.6928 nM).Formule :C23H23ClN4O2Couleur et forme :SolidMasse moléculaire :422.91MMG-0358
CAS :MMG-0358 is a novel potent IDO1 inhibitor, showing low cytotoxicity and higher selectivity for IDO1 over TDO enzyme.Formule :C8H6ClN3OCouleur et forme :SolidMasse moléculaire :195.61IDO1-IN-21
CAS :IDO1-IN-21 (compound 10m), with an IC50 of 0.64 μM, acts as an IDO1 inhibitor and has demonstrated efficacy in suppressing tumor growth in murine models [1].Formule :C21H19F2N3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :479.45IDO-IN-5
CAS :IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).Formule :C18H21FN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :316.37Roxyl-9
CAS :Roxyl-9 is an inhibitor of IDO1 (Indoleamine 2,3-dioxygenase 1) [1].Formule :C18H13N3O2Couleur et forme :SolidMasse moléculaire :303.31TDO-IN-1
CAS :<p>TDO-IN-1 is a tryptophan 2,3-dioxygenase (TDO) inhibitor with antitumor activity that acts by reversing local immune tolerance in tumor tissues.</p>Formule :C16H13F3N4O2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :350.3IDO1/2-IN-1
CAS :First potent oral dual IDO1/IDO2 inhibitor with antitumor properties; IC50: 28 nM (IDO1), 144 nM (IDO2).Formule :C16H18BrFN8O4Couleur et forme :SolidMasse moléculaire :485.27(R)-IDO/TDO-IN-1
CAS :(R)-IDO/TDO-IN-1 (compound 25), an indoleamine-2,3-dioxygenase (IDO) inhibitor, demonstrates good pharmacokinetic properties and exerts anti-tumor effects in the MC38 xenograft model. This compound exhibits synergy when combined with the anti-PD-1 monoclonal antibody (SHR-1210) [1].Formule :C25H24FN5Couleur et forme :SolidMasse moléculaire :413.49NUCC-0223619
CAS :NUCC-0223619 is an IDO1 inhibitor that induces the degradation of IDO protein and can be involved in the synthesis of PROTAC.Formule :C24H24ClFN2O2Couleur et forme :SolidMasse moléculaire :426.91IDO1/2-IN-1 hydrochloride
CAS :IDO1/2-IN-1 hydrochloride: Dual IDO1/2 inhibitor, IC50 of 28/144 nM, oral, with antitumor properties.Formule :C16H19BrClFN8O4Couleur et forme :SolidMasse moléculaire :521.73IDO1/TDO-IN-6
CAS :IDO1/TDO-IN-6 (compound 11) is a dual inhibitor targeting IDO1 and TDO, exhibiting IC50 values of 2.25 μM for IDO1 and 2.89 μM for TDO.Formule :C20H17NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.35IDO-IN-9
CAS :IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).Formule :C13H13BrFN7O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.251-Isopropyltryptophan
CAS :1-Isopropyltryptophan (1-IsoPT), an IDO1 inhibitor, suppresses the expression of IDO-1 and IDO-2 mRNA induced by IFN-γ stimulation [1].Formule :C14H18N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :246.3IDO1 ligand-1
CAS :<p>IDO1ligand-1 is the target protein ligand for PROTAC NU227326, which is utilized for degrading IDO1.</p>Formule :C29H34FN3O2Couleur et forme :SolidMasse moléculaire :475.598IDO2-IN-1
CAS :<p>IDO2-IN-1: potent oral IDO2 inhibitor, IC50 = 112 nM, for inflammatory autoimmunity research.</p>Formule :C21H21BrN10O3Couleur et forme :SolidMasse moléculaire :541.36VS-15
CAS :VS-15 is a selective inhibitor of IDO1, specifically binding to its apo-heme form. Additionally, VS-15 serves as an inhibitor of iNOS.Formule :C29H27N5O3Couleur et forme :SolidMasse moléculaire :493.56IDO1-IN-13
IDO1-IN-13 is a potent IDO1 inhibitor (IC50: 61.6 nM, EC50: 30 nM in HeLa) that reduces kyn/trp ratio by 51% in SK-OV-3 tumors.Formule :C20H16BrN5O2SCouleur et forme :SolidMasse moléculaire :470.34IDO1-IN-25
CAS :<p>IDO1-IN-25, a dual inhibitor of IDO1/TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS). Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.</p>Formule :C14H8Cl3NO2SCouleur et forme :SolidMasse moléculaire :360.64IDO1-IN-14
IDO1-IN-14 is an IDO1 enzyme inhibitor with an IC50 of 396.9 nM and suppresses HeLa cell activity with an EC50 of 3393 nM.Formule :C18H12Cl2FN3O2Couleur et forme :SolidMasse moléculaire :392.21IDO antagonist-1
CAS :<p>IDO antagonist-1 (compound 163), an IDO antagonist, effectively inhibits the growth of pancreatic adenocarcinoma cells in C57BL/6 mice [1].</p>Formule :C39H53N7O5Couleur et forme :SolidMasse moléculaire :699.884-Phenyl-1H-1,2,3-triazole
CAS :<p>4-Phenyl-1H-1,2,3-triazole, an inhibitor of the enzyme IDO1 (IC50: 60 µM), is utilized in cancer research [1].</p>Formule :C8H7N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :145.16
