Prolyl-Hydroxylase de HIF/HIF
Le facteur inductible par l'hypoxie (HIF) est un facteur de transcription qui joue un rôle crucial dans les réponses cellulaires aux faibles niveaux d'oxygène (hypoxie). L'activité de HIF est étroitement régulée par les prolyl-hydroxylases de HIF, qui ciblent HIF pour sa dégradation dans des conditions normoxiques. Les inhibiteurs de la prolyl-hydroxylase de HIF peuvent stabiliser HIF, favorisant l'expression de gènes impliqués dans l'angiogenèse, l'érythropoïèse et le métabolisme. Ces inhibiteurs sont d'un grand intérêt pour le traitement de conditions telles que l'anémie, les maladies ischémiques et le cancer. Chez CymitQuimica, nous proposons des inhibiteurs de HIF/prolyl-hydroxylase HIF pour soutenir vos recherches en biologie de l'hypoxie, en thérapie anticancéreuse et en régulation métabolique.
142 produits trouvés pour "Prolyl-Hydroxylase de HIF/HIF"
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Albendazole
CAS :<p>Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.</p>Formule :C12H15N3O2SDegré de pureté :98.21% - 98.76%Couleur et forme :Colorless Crystals SolidMasse moléculaire :265.33Hydralazine hydrochloride
CAS :<p>Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.</p>Formule :C8H9ClN4Degré de pureté :99.85% - 99.86%Couleur et forme :Yellow Crystals White Crystalline SolidMasse moléculaire :196.64Amifostine
CAS :<p>Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.</p>Formule :C5H15N2O3PSDegré de pureté :99.88%Couleur et forme :White SolidMasse moléculaire :214.22(-)-Hydroxycitric acid lactone
CAS :<p>(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, which</p>Formule :C6H6O7Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :190.11Minocycline hydrochloride
CAS :<p>Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.</p>Formule :C23H28ClN3O7Degré de pureté :99.28% - >99.99%Couleur et forme :Bright Yellow-Orange Amorphous Solid Crystalline YellowMasse moléculaire :493.94Vadadustat
CAS :<p>Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.</p>Formule :C14H11ClN2O4Degré de pureté :99.02% - 99.80%Couleur et forme :SolidMasse moléculaire :306.7PT2399
CAS :<p>PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.</p>Formule :C17H10F5NO4SDegré de pureté :98.8% - 99.45%Couleur et forme :SolidMasse moléculaire :419.32Deferoxamine Mesylate
CAS :<p>Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.</p>Formule :C26H52N6O11SDegré de pureté :94.68% - 99.8%Couleur et forme :SolidMasse moléculaire :656.79Roxadustat
CAS :<p>Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.</p>Formule :C19H16N2O5Degré de pureté :99% - 99.88%Couleur et forme :SolidMasse moléculaire :352.34Oltipraz
CAS :<p>Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.</p>Formule :C8H6N2S3Degré de pureté :98.79% - 99.77%Couleur et forme :SolidMasse moléculaire :226.34Glucosamine
CAS :<p>Glucosamine (Chitosamine) is used as a dietary supplement. Glucosamine has pharmacological effects on osteoarthritis cartilage. High-Quality, Low-Cost!</p>Formule :C6H13NO5Degré de pureté :99.8% - 99.8%Couleur et forme :CoaMasse moléculaire :179.17HIF-2α-IN-2
CAS :<p>HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).</p>Formule :C17H13F2NO4SDegré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :365.35Enarodustat
CAS :<p>Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.</p>Formule :C17H16N4O4Degré de pureté :99.73% - 99.75%Couleur et forme :SolidMasse moléculaire :340.33Tilorone dihydrochloride
CAS :<p>Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.</p>Formule :C25H36Cl2N2O3Degré de pureté :98% - 99.86%Couleur et forme :Orange Yellow Crystal PowderMasse moléculaire :483.47SYP-5
CAS :<p>SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.</p>Formule :C18H16O3SDegré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :312.38Chloramphenicol
CAS :<p>Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.</p>Formule :C11H12Cl2N2O5Degré de pureté :99.6% - 99.84%Couleur et forme :Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidMasse moléculaire :323.13Citric acid trilithium salt tetrahydrate
CAS :<p>Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of</p>Formule :C6H13Li3O11Degré de pureté :99.88%Couleur et forme :White Crystalline PowderMasse moléculaire :281.98Hydroxycitric acid tripotassium hydrate
CAS :<p>Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor effects.</p>Formule :C6H7K3O8Degré de pureté :99.85%Couleur et forme :White Solid CrystallineMasse moléculaire :324.41EHP-101
CAS :<p>EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.</p>Formule :C28H35NO3Degré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :433.58Glucosamine hydrochloride
CAS :<p>Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.</p>Formule :C6H13NO5·HClDegré de pureté :99.77%Couleur et forme :White Solid CrystallineMasse moléculaire :215.63Molidustat
CAS :<p>Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。</p>Formule :C13H14N8O2Degré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :314.3ZG-2033
CAS :<p>ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity (EC50 = 490 nM) in a luciferase reporter assay. It demonstrates an anti-anemic effect and shows synergistic effects with AKB-6548 in anemia, making it useful for the study of renal anemia.</p>Formule :C15H14N2O2SCouleur et forme :SolidMasse moléculaire :286.35NF-κB/HIF-1α-IN-1
<p>NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.</p>Formule :C24H27N7O4Couleur et forme :SolidMasse moléculaire :477.21245Adaptaquin
CAS :<p>Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].</p>Formule :C21H16ClN3O2Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :377.821,4-DPCA
CAS :<p>1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting</p>Formule :C13H8N2O3Degré de pureté :97.77%Couleur et forme :SolidMasse moléculaire :240.21(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
CAS :<p>(S,R,S)-AHPC-C2-amide targets Smad3 degradation and boosts HIF-α; it has anti-fibrotic and renal protective roles.</p>Formule :C41H46N6O6SCouleur et forme :SolidMasse moléculaire :750.91Sirtuin modulator 2
CAS :<p>Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.</p>Formule :C19H15N3O2SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :349.41ISM012-042
<p>ISM012-042 is an orally active inhibitor of PHD1 and PHD2, with IC50 values of 1.9 and 2.5 nM, respectively. At a concentration of 2.5 μM, ISM012-042 protects Caco-2 cells from DSS-induced barrier damage. Additionally, in LPS-induced bone marrow-derived dendritic cells (BMDC) from mice, ISM012-042 exhibits anti-inflammatory properties by dose-dependently reducing the expression of IL-12 subunit IL-12p35 and TNF. It also restores intestinal barrier function and alleviates intestinal inflammation in various experimental colitis models. ISM012-042 is useful for studying intestinal mucosal repair and immune disorders.</p>Formule :C26H28N6O4Couleur et forme :SolidMasse moléculaire :488.538Zifcasiran
CAS :<p>Zifcasiran reduces HIF synthesis, has antitumor properties, useful in renal carcinoma studies.</p>Formule :C737H972F20N211O349P43S8Couleur et forme :SolidMasse moléculaire :20339.137-Hydroxyneolamellarin A
CAS :<p>7-Hydroxyneolamellarin A, from Dendrilla nigra, inhibits HIF-1α and VEGF in cancer research.</p>Formule :C24H19NO5Couleur et forme :SolidMasse moléculaire :401.41Fibrostatin C
CAS :<p>Fibrostatin C is an inhibitor of prolyl 4-hydroxylase. It is produced by Streptomyces catenulae subsp.</p>Formule :C18H19NO8SCouleur et forme :SolidMasse moléculaire :409.41HIF-1 inhibitor-5
<p>HIF-1 inhibitor-5 (Compound 16e) is a potent inhibitor of HIF-1, exhibiting an IC50 value of 2.38 μM and demonstrating significant anti-angiogenic potential [1</p>Formule :C28H35NO5Couleur et forme :SolidMasse moléculaire :465.58HIF1-IN-3
CAS :<p>HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in</p>Formule :C26H24N2O3Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :412.48HIF-1α-IN-6
<p>HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively.</p>Degré de pureté :98%Couleur et forme :Odour SolidHIF-1α-IN-2 hydrochloride
<p>HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM in</p>Formule :C21H20ClN3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :397.92VHL-IN-1
<p>VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and</p>Formule :C28H37FN4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :544.68ML228
CAS :<p>ML228 activates HIF pathway and VEGF, with EC50 of 1μM, effective in vitro.</p>Formule :C27H21N5Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :415.49Mersalyl
CAS :<p>Mersalyl is an organic mercurial diuretic.</p>Formule :C13H16HgNNaO6Couleur et forme :SolidMasse moléculaire :505.854IOX2-NH2-Methyl
<p>IOX2-NH2-Methyl is a modified form of IOX2. IOX2 is a specific inhibitor of PHD2 (prolyl-hydroxylase-2), capable of upregulating HIF-1α expression and suppressing ROS production. IOX2-NH2-Methyl is employed in investigations of platelet and thrombus formation.</p>Formule :C20H19N3O5Degré de pureté :97.64% - 99.31%Couleur et forme :SolidMasse moléculaire :381.39HIF-1 inhibitor-4
CAS :<p>HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM.</p>Formule :C18H19IN2O2Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :422.26Izilendustat
CAS :<p>Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.</p>Formule :C22H28ClN3O4Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :433.93TAT-cyclo-CLLFVY
CAS :<p>Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).</p>Formule :C111H188N42O24S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2559.1Daprodustat
CAS :<p>Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor.</p>Formule :C19H27N3O6Degré de pureté :97% - 99.82%Couleur et forme :SolidMasse moléculaire :393.43HIF-PHD-IN-4
<p>HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.</p>Couleur et forme :Odour SolidAxl-IN-16
<p>Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptor</p>Formule :C14H19ClO8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.75HIF-1 α (556-574)
CAS :<p>HIF-1 alpha (556-574) is a 19-mer fragment vital for gene expression in low oxygen; it binds VHL with critical proline 564 for stability.</p>Formule :C101H150D2N20O34S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2254.6HSP90-IN-30
<p>HSP90-IN-30 (compound 3e) inhibits the activity of the HSP90 molecular chaperone. Under hypoxic conditions, HSP90-IN-30 suppresses HIF-1 transcriptional activity with an IC50 value of 2.16 μM.</p>Formule :C20H39B12N4O2Masse moléculaire :499.41897ZG-2305
<p>ZG-2305 is an effective, selective, and orally active inhibitor of FIH (factor inhibiting hypoxia-inducible factor (FIH)), with Ki values of 79.6 nM for FIH and 2786 nM for PHD2. This compound enhances the expression of the EGLN3 gene, reduces cellular triglyceride levels, and decreases lipid accumulation. ZG-2305 holds potential for research into obesity and fatty liver disease.</p>Formule :C17H11Cl2N3O5Couleur et forme :SolidMasse moléculaire :408.19HIV-IN-7
<p>Axl-IN-16 (Compound 4), an Axl inhibitor, not only suppresses Axl expression and HIF activity but also triggers fruiting body formation in Flammulina velutipes.</p>Formule :C32H61N3O10P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :709.79KG-548
CAS :<p>KG-548 is a dual inhibitor of ARNT/TACC3 and HIF-1α, inhibiting lactate production, and can be used in cancer research.</p>Formule :C9H4F6N4Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :282.15HIF-IN-1
CAS :<p>HIF-IN-1 is a inhibitor of hypoxia-inducible factor, which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.</p>Formule :C17H12N2ODegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :260.29HIF-1α-IN-2
CAS :<p>HIF-1α-IN-2 is a HIF-1α inhibitor with anticancer activity that inhibits the expression of HIF-1α and VEGF, and inhibits cell migration.</p>Formule :C21H19N3OSDegré de pureté :99.90% - >99.99%Couleur et forme :SolidMasse moléculaire :361.461,4-DPCA ethyl ester
CAS :<p>1,4-DPCA ethyl ester is a form of 1,4-DPCA modified, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.</p>Formule :C15H12N2O3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :268.27UNC6934
CAS :<p>UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.</p>Formule :C24H21N5O4Degré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :443.45TP0463518
CAS :<p>TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).</p>Formule :C20H18ClN3O6Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :431.83HNHA
CAS :<p>HNHA is an inhibitor of HDAC.</p>Formule :C17H21NO2SDegré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :303.42Ethyl 3,4-dihydroxybenzoate
CAS :<p>Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.</p>Formule :C9H10O4Degré de pureté :99.88%Couleur et forme :White Crystal Or PowderMasse moléculaire :182.17Fraxinellone
CAS :<p>1.</p>Formule :C14H16O3Degré de pureté :99.35% - 99.92%Couleur et forme :SolidMasse moléculaire :232.27AKBA
CAS :<p>AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.</p>Formule :C32H48O5Degré de pureté :97.85% - 99.77%Couleur et forme :SolidMasse moléculaire :512.72Izilendustat hydrochloride
CAS :<p>Izilendustat hydrochloride inhibits prolyl hydroxylase, stabilizing HIF-1α/HIF-2, with potential to treat various HIF-1α diseases.</p>Formule :C22H29Cl2N3O4Couleur et forme :SolidMasse moléculaire :470.39FG-2216
CAS :<p>FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.</p>Formule :C12H9ClN2O4Degré de pureté :97.1% - >99.99%Couleur et forme :SolidMasse moléculaire :280.66N-Oxalylglycine
CAS :<p>N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.</p>Formule :C4H5NO5Degré de pureté :99.23%Couleur et forme :Colourless SolidMasse moléculaire :147.09IDF-11774
CAS :<p>IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).</p>Formule :C23H32N2O2Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :368.51IOX2
CAS :<p>IOX2 is a selective HIF PHD inhibitor, active in cells with 21 nM IC50 for PHD2/ELGN-1, not inhibiting FIH at 20uM.</p>Formule :C19H16N2O5Degré de pureté :98% - 99.59%Couleur et forme :SolidMasse moléculaire :352.34ZINC13466751
CAS :<p>ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).</p>Formule :C20H21N5O2Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :363.41Glucosamine sulfate
CAS :<p>Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.</p>Formule :C6H13NO5·H2SO4Degré de pureté :99.64%Couleur et forme :White CrystalMasse moléculaire :277.25M1001
CAS :<p>M1001 is a HIF-2α agonist.</p>Formule :C17H17N3O2SDegré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :327.4Deoxyshikonin
CAS :<p>1.</p>Formule :C16H16O4Degré de pureté :99.36% - ≥95%Couleur et forme :SolidMasse moléculaire :272.3VH-298
CAS :<p>VH-298 blocks VHL:HIF-α interaction, stabilizes HIF-α, and triggers hypoxic response differently by inhibiting VHL post-HIF-α PHD hydroxylation.</p>Formule :C27H33N5O4SDegré de pureté :99.17% - >99.99%Couleur et forme :SolidMasse moléculaire :523.65PHD-1-IN-1
CAS :<p>PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).</p>Formule :C13H8N4Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :220.23GN44028
CAS :<p>GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.</p>Formule :C18H15N3O2Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :305.33B2
CAS :<p>B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease</p>Formule :C20H17ClN4O3Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :396.83BAY 87-2243
CAS :<p>BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).</p>Formule :C26H26F3N7O2Degré de pureté :98% - 99.95%Couleur et forme :SolidMasse moléculaire :525.53Chlorogenic Acid
CAS :<p>Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective and quality-assured.</p>Formule :C16H18O9Degré de pureté :98.84% - 99.67%Couleur et forme :SolidMasse moléculaire :354.31JNJ-42041935
CAS :<p>JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.</p>Formule :C12H6ClF3N4O3Degré de pureté :99.58% - ≥95%Couleur et forme :SolidMasse moléculaire :346.65dencichine
CAS :<p>Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.</p>Formule :C5H8N2O5Degré de pureté :99.93% - ≥95%Couleur et forme :SolidMasse moléculaire :176.13Dapagliflozin
CAS :<p>Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.</p>Formule :C21H25ClO6Degré de pureté :99.5% - 99.93%Couleur et forme :SolidMasse moléculaire :408.87DMOG
CAS :<p>DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.</p>Formule :C6H9NO5Degré de pureté :80.23% - 99.98%Couleur et forme :SolidMasse moléculaire :175.14MK-8617
CAS :<p>MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).</p>Formule :C24H21N5O4Degré de pureté :99.38% - >99.99%Couleur et forme :SolidMasse moléculaire :443.45KC7F2
CAS :<p>KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.</p>Formule :C16H16Cl4N2O4S4Degré de pureté :98% - 99.11%Couleur et forme :SolidMasse moléculaire :570.382,4-DPD
CAS :<p>2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)</p>Formule :C11H13NO4Degré de pureté :99.74%Couleur et forme :Yellow Solid CrystallineMasse moléculaire :223.23HIF-2α-IN-4
CAS :<p>HIF-2a translation inhibitor is a compound used as a molecular building block.</p>Formule :C9H9N3O4S2Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :287.32PT-2385
CAS :<p>PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).</p>Formule :C17H12F3NO4SDegré de pureté :98.91% - 99.55%Couleur et forme :SolidMasse moléculaire :383.34Oroxylin A
CAS :<p>Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.</p>Formule :C16H12O5Degré de pureté :98.72% - 99.55%Couleur et forme :SolidMasse moléculaire :284.26IOX4
CAS :<p>IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)</p>Formule :C15H16N6O3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :328.33Panaxadiol
CAS :<p>Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.</p>Formule :C30H52O3Degré de pureté :98% - 99.9%Couleur et forme :SolidMasse moléculaire :460.73LW6
CAS :<p>LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.</p>Formule :C26H29NO5Degré de pureté :98.1% - 98.22%Couleur et forme :SolidMasse moléculaire :435.51Belzutifan
CAS :<p>"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."</p>Formule :C17H12F3NO4SDegré de pureté :99.34% - 99.88%Couleur et forme :SolidMasse moléculaire :383.34Amifostine trihydrate
CAS :<p>Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.</p>Formule :C5H15N2O3PS·3H2ODegré de pureté :99.71% - 99.80%Couleur et forme :SolidMasse moléculaire :268.27PX-478
CAS :<p>PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.</p>Formule :C13H20Cl4N2O3Degré de pureté :97% - 99.79%Couleur et forme :SolidMasse moléculaire :394.12Diethyl bipy55'DC
CAS :<p>"Diethyl bipy55'DC blocks CP4H, crucial for collagen stability via hydroxylation in cells."</p>Formule :C16H16N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :300.31E3330
CAS :<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Formule :C21H30O6Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :378.46OHM1
CAS :<p>OHM1, an analog of HIF1α CTAD, effectively inhibits the interaction between HIF1α CTAD and p300/CBP by targeting the CH1 domain with a binding affinity of 0.53</p>Formule :C24H42N6O5Couleur et forme :SolidMasse moléculaire :494.63CL67
CAS :<p>CL67 is a hypoxia-inducible factor pathway inhibitor. It acts by binding to a G-quadruplex higher-order structure in the HIF promoter sequence in vitro.</p>Formule :C38H42N10O2Couleur et forme :SolidMasse moléculaire :670.81ZK-261991
CAS :<p>ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).</p>Formule :C24H25N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.5Dimethyl-bisphenol A
CAS :<p>DMBPA inhibits HIF-1α, promotes its degradation by detaching Hsp90, and reduces Vegfa mRNA expression.</p>Formule :C17H20O2Couleur et forme :SolidMasse moléculaire :256.34FM19G11
CAS :<p>FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).</p>Formule :C23H17N3O8Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :463.4GSK360A
CAS :<p>GSK360A is a novel prolyl hydroxylase (PHD) domain-containing enzyme inhibitor.</p>Formule :C17H17FN2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.33HIF-1α-IN-3
CAS :<p>HIF-1α-IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-1α. It exhibits potent antiestrogenic activity [1].</p>Formule :C19H17N5O2Couleur et forme :SolidMasse moléculaire :347.37TM6008
CAS :<p>TM6008 is an inhibitor of prolyl hydroxylase that protects against cell death after hypoxia.</p>Formule :C21H17N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.39HIF-PHD-IN-2
CAS :<p>HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].</p>Formule :C17H15N5O3SCouleur et forme :SolidMasse moléculaire :369.4Angiogenesis agent 1
CAS :<p>Compound C-31, a salidroside-based glycoside, activates HIF-1α and may aid in diabetic limb ischemia studies.</p>Formule :C20H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.4BNS
CAS :<p>BNS is a potent, prolyl-hydroxylase 2 (PHD2)-selective inhibitor.</p>Formule :C18H16N2O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.46M1002
CAS :<p>M1002, a HIF-2 agonist, boosts HIF-2alpha/ARNT activation and alters HIF-281alpha PAS-B, working with PHD inhibitors.</p>Formule :C15H8F6N2O2SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :394.29103D5R
CAS :<p>103D5R selectively inhibits hif-1α, reducing its levels in hypoxia or with cobalt ions, dose- and time-dependently.</p>Formule :C20H21N3O2Couleur et forme :SolidMasse moléculaire :335.4HIF-IN-33
CAS :<p>HIF-IN-33 is an inhibitor of HIF pathway.</p>Formule :C21H17F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.38Langkamide
CAS :<p>Langkamide is a HIF-2 inhibitor with EC₅₀ values of 14.0 uM.</p>Formule :C16H17NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :303.31ENMD-1198
CAS :<p>ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.</p>Formule :C20H25NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :311.42HIF-1/2α-IN-2
CAS :<p>HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α.</p>Formule :C16H11FN4O2SCouleur et forme :SolidMasse moléculaire :342.35THS-044
CAS :<p>THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activity</p>Formule :C11H12F3N3O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :291.23KCN1
CAS :<p>KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.</p>Formule :C26H27NO5SCouleur et forme :SolidMasse moléculaire :465.56TM6089
CAS :<p>TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.</p>Formule :C13H14N4O3SDegré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :306.34HIF-1α inhibitor-1
CAS :<p>HIF-1α inhibitor-1 is a HIF-1 alpha inhibitor.</p>Formule :C15H11N3O4Couleur et forme :SolidMasse moléculaire :297.27KRH102140
CAS :<p>KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.</p>Formule :C25H24FNODegré de pureté :98.31% - 99.61%Couleur et forme :SolidMasse moléculaire :373.46HIF-2α-IN-3
CAS :<p>HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.</p>Formule :C12H6ClN5O5Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :335.66TC-S 7009
CAS :<p>TC-S 7009: Strong HIF-2α inhibitor (Kd 81 nM), weak for HIF-1α; disrupts dimerization & gene expression.</p>Formule :C12H6ClFN4O3Degré de pureté :99.46% - 99.71%Couleur et forme :SolidMasse moléculaire :308.65HIF-2α-IN-13
CAS :<p>HIF-2α-IN-13 (18) acts as a HIF-2α inhibitor and exhibits an IC 50 value of 2.7 μM.</p>Formule :C15H14ClF4NO2Couleur et forme :SolidMasse moléculaire :351.72PHD-IN-2
CAS :<p>PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 of</p>Formule :C26H27N7O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.54Prolyl Hydroxylase inhibitor 1
CAS :<p>Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).</p>Formule :C19H18ClN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.83PHD2-IN-1
CAS :<p>PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].</p>Formule :C21H23ClN4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.88HIF-2α-IN-9
CAS :<p>HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes within</p>Formule :C12H13F5O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.35PHD-IN-1
CAS :<p>PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.</p>Formule :C24H23N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.49AKB-6899
CAS :<p>AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated</p>Formule :C14H11FN2O4Degré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :290.25HIF-2α-IN-1
CAS :<p>HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.</p>Formule :C16H8F5NO4SDegré de pureté :97.99%Couleur et forme :SolidMasse moléculaire :405.3CLB-016
CAS :<p>CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.</p>Formule :C17H20N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.38HIF-2α-IN-6
CAS :<p>HIF-2α-IN-6 (117) is a HIF-2α inhibitor [1].</p>Formule :C15H13F4NO3SCouleur et forme :SolidMasse moléculaire :363.33NPAS3-IN-1
CAS :<p>NPAS3-IN-1 is an NPAS3-ARNT heterodimerization inhibitor that regulates NPAS3 transcription by modulating the heterodimerization of NPAS3 with ARNT.</p>Formule :C10H5N3O2S3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :295.36HIF-2α agonist 2
CAS :<p>HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α.</p>Formule :C13H8Br2N2O2SDegré de pureté :98.87%Couleur et forme :SoildMasse moléculaire :416.09HIF-2α-IN-7
CAS :<p>HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor.</p>Formule :C18H9F6NO2Couleur et forme :SolidMasse moléculaire :385.26HIF-2α-IN-5
CAS :<p>HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of < 50 nM [1].</p>Formule :C15H12F4O3S2Couleur et forme :SolidMasse moléculaire :380.38(Rac)-PT2399
CAS :<p>(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).</p>Formule :C17H10F5NO4SCouleur et forme :SolidMasse moléculaire :419.32JTZ-951 HCl
CAS :<p>JTZ-951 is a potent and orally active inhibitor of hypoxia inducible factor prolyl hydroxylase (PHD).</p>Formule :C17H17ClN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.79AFP464 free base
CAS :<p>AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.</p>Formule :C22H23F3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.44HIF-1α-IN-5
<p>HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A.</p>Formule :C16H15N3O2Couleur et forme :SolidMasse moléculaire :281.31DDO-3055
CAS :<p>DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.</p>Formule :C17H13ClN2O5Couleur et forme :SolidMasse moléculaire :360.749JPHM-2-167
CAS :<p>PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD). It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.</p>Formule :C30H28N6O2Couleur et forme :SolidMasse moléculaire :504.582HIF-1α-IN-4
<p>HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects.</p>Formule :C16H12N2O3Couleur et forme :SolidMasse moléculaire :280.28DS44470011
CAS :<p>DS44470011 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) with oral bioavailability. It enhances the release of erythropoietin (EPO) from cells and is utilized in research related to renal anemia.</p>Formule :C21H19N3O4Couleur et forme :SolidMasse moléculaire :377.39PHD2-IN-4
CAS :<p>PHD2-IN-4 (compound 1) is an inhibitor of PHD2, with an IC50 of 4 nM. It is utilized in research related to chronic kidney disease.</p>Formule :C21H19N5O3Couleur et forme :SolidMasse moléculaire :389.407HIF-1/2α-IN-1
<p>HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α.</p>Formule :C17H16N6O4Couleur et forme :SolidMasse moléculaire :368.35HIF-PHD-IN-1
CAS :<p>HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therapeutic agent for renal anemia is highly promising.</p>Formule :C17H12Cl2N6O3Couleur et forme :SolidMasse moléculaire :419.22Desidustat
CAS :<p>Desidustat is an inhibitor of HIF hydroxylase.</p>Formule :C16H16N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :332.31Ref: TM-T5176
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