Prolyl-Hydroxylase de HIF/HIF
Le facteur inductible par l'hypoxie (HIF) est un facteur de transcription qui joue un rôle crucial dans les réponses cellulaires aux faibles niveaux d'oxygène (hypoxie). L'activité de HIF est étroitement régulée par les prolyl-hydroxylases de HIF, qui ciblent HIF pour sa dégradation dans des conditions normoxiques. Les inhibiteurs de la prolyl-hydroxylase de HIF peuvent stabiliser HIF, favorisant l'expression de gènes impliqués dans l'angiogenèse, l'érythropoïèse et le métabolisme. Ces inhibiteurs sont d'un grand intérêt pour le traitement de conditions telles que l'anémie, les maladies ischémiques et le cancer. Chez CymitQuimica, nous proposons des inhibiteurs de HIF/prolyl-hydroxylase HIF pour soutenir vos recherches en biologie de l'hypoxie, en thérapie anticancéreuse et en régulation métabolique.
142 produits trouvés pour "Prolyl-Hydroxylase de HIF/HIF"
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Deferoxamine Mesylate
CAS :<p>Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.</p>Formule :C26H52N6O11SDegré de pureté :94.68% - 99.8%Couleur et forme :SolidMasse moléculaire :656.79Tilorone dihydrochloride
CAS :<p>Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.</p>Formule :C25H36Cl2N2O3Degré de pureté :98% - 99.86%Couleur et forme :Orange Yellow Crystal PowderMasse moléculaire :483.47Hydralazine hydrochloride
CAS :<p>Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.</p>Formule :C8H9ClN4Degré de pureté :99.85% - 99.86%Couleur et forme :Yellow Crystals White Crystalline SolidMasse moléculaire :196.64Chloramphenicol
CAS :<p>Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.</p>Formule :C11H12Cl2N2O5Degré de pureté :99.6% - 99.84%Couleur et forme :Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidMasse moléculaire :323.13Glucosamine hydrochloride
CAS :<p>Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.</p>Formule :C6H13NO5·HClDegré de pureté :99.77%Couleur et forme :White Solid CrystallineMasse moléculaire :215.63EHP-101
CAS :<p>EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.</p>Formule :C28H35NO3Degré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :433.58Molidustat
CAS :<p>Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。</p>Formule :C13H14N8O2Degré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :314.3PT2399
CAS :<p>PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.</p>Formule :C17H10F5NO4SDegré de pureté :98.8% - 99.45%Couleur et forme :SolidMasse moléculaire :419.32Oltipraz
CAS :<p>Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.</p>Formule :C8H6N2S3Degré de pureté :98.79% - 99.77%Couleur et forme :SolidMasse moléculaire :226.34Citric acid trilithium salt tetrahydrate
CAS :<p>Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of</p>Formule :C6H13Li3O11Degré de pureté :99.88%Couleur et forme :White Crystalline PowderMasse moléculaire :281.98Hydroxycitric acid tripotassium hydrate
CAS :<p>Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor effects.</p>Formule :C6H7K3O8Degré de pureté :99.85%Couleur et forme :White Solid CrystallineMasse moléculaire :324.41(-)-Hydroxycitric acid lactone
CAS :<p>(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, which</p>Formule :C6H6O7Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :190.11Minocycline hydrochloride
CAS :<p>Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.</p>Formule :C23H28ClN3O7Degré de pureté :99.28% - >99.99%Couleur et forme :Bright Yellow-Orange Amorphous Solid Crystalline YellowMasse moléculaire :493.94Amifostine
CAS :<p>Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.</p>Formule :C5H15N2O3PSDegré de pureté :99.88%Couleur et forme :White SolidMasse moléculaire :214.22Glucosamine
CAS :<p>Glucosamine (Chitosamine) is used as a dietary supplement. Glucosamine has pharmacological effects on osteoarthritis cartilage. High-Quality, Low-Cost!</p>Formule :C6H13NO5Degré de pureté :99.8% - 99.8%Couleur et forme :CoaMasse moléculaire :179.17Vadadustat
CAS :<p>Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.</p>Formule :C14H11ClN2O4Degré de pureté :99.02% - 99.80%Couleur et forme :SolidMasse moléculaire :306.7Roxadustat
CAS :<p>Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.</p>Formule :C19H16N2O5Degré de pureté :99% - 99.88%Couleur et forme :SolidMasse moléculaire :352.34SYP-5
CAS :<p>SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.</p>Formule :C18H16O3SDegré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :312.38Albendazole
CAS :<p>Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.</p>Formule :C12H15N3O2SDegré de pureté :98.21% - 98.76%Couleur et forme :Colorless Crystals SolidMasse moléculaire :265.33HIF-2α-IN-2
CAS :<p>HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).</p>Formule :C17H13F2NO4SDegré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :365.35Enarodustat
CAS :<p>Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.</p>Formule :C17H16N4O4Degré de pureté :99.73% - 99.75%Couleur et forme :SolidMasse moléculaire :340.33ISM012-042
<p>ISM012-042 is an orally active inhibitor of PHD1 and PHD2, with IC50 values of 1.9 and 2.5 nM, respectively. At a concentration of 2.5 μM, ISM012-042 protects Caco-2 cells from DSS-induced barrier damage. Additionally, in LPS-induced bone marrow-derived dendritic cells (BMDC) from mice, ISM012-042 exhibits anti-inflammatory properties by dose-dependently reducing the expression of IL-12 subunit IL-12p35 and TNF. It also restores intestinal barrier function and alleviates intestinal inflammation in various experimental colitis models. ISM012-042 is useful for studying intestinal mucosal repair and immune disorders.</p>Formule :C26H28N6O4Couleur et forme :SolidMasse moléculaire :488.538HIF-1α-IN-6
<p>HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively.</p>Degré de pureté :98%Couleur et forme :Odour SolidHIV-IN-7
<p>Axl-IN-16 (Compound 4), an Axl inhibitor, not only suppresses Axl expression and HIF activity but also triggers fruiting body formation in Flammulina velutipes.</p>Formule :C32H61N3O10P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :709.79Axl-IN-16
<p>Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptor</p>Formule :C14H19ClO8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.75(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
CAS :<p>(S,R,S)-AHPC-C2-amide targets Smad3 degradation and boosts HIF-α; it has anti-fibrotic and renal protective roles.</p>Formule :C41H46N6O6SCouleur et forme :SolidMasse moléculaire :750.91HIF-1 α (556-574)
CAS :<p>HIF-1 alpha (556-574) is a 19-mer fragment vital for gene expression in low oxygen; it binds VHL with critical proline 564 for stability.</p>Formule :C101H150D2N20O34S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2254.6ML228
CAS :<p>ML228 activates HIF pathway and VEGF, with EC50 of 1μM, effective in vitro.</p>Formule :C27H21N5Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :415.497-Hydroxyneolamellarin A
CAS :<p>7-Hydroxyneolamellarin A, from Dendrilla nigra, inhibits HIF-1α and VEGF in cancer research.</p>Formule :C24H19NO5Couleur et forme :SolidMasse moléculaire :401.41HIF-1α-IN-2 hydrochloride
<p>HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM in</p>Formule :C21H20ClN3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :397.92Adaptaquin
CAS :<p>Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].</p>Formule :C21H16ClN3O2Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :377.82HIF-1 inhibitor-4
CAS :<p>HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM.</p>Formule :C18H19IN2O2Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :422.26VHL-IN-1
<p>VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and</p>Formule :C28H37FN4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :544.68Daprodustat
CAS :<p>Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor.</p>Formule :C19H27N3O6Degré de pureté :97% - 99.82%Couleur et forme :SolidMasse moléculaire :393.43NF-κB/HIF-1α-IN-1
<p>NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.</p>Formule :C24H27N7O4Couleur et forme :SolidMasse moléculaire :477.21245HIF-1 inhibitor-5
<p>HIF-1 inhibitor-5 (Compound 16e) is a potent inhibitor of HIF-1, exhibiting an IC50 value of 2.38 μM and demonstrating significant anti-angiogenic potential [1</p>Formule :C28H35NO5Couleur et forme :SolidMasse moléculaire :465.58HSP90-IN-30
<p>HSP90-IN-30 (compound 3e) inhibits the activity of the HSP90 molecular chaperone. Under hypoxic conditions, HSP90-IN-30 suppresses HIF-1 transcriptional activity with an IC50 value of 2.16 μM.</p>Formule :C20H39B12N4O2Masse moléculaire :499.41897HIF-PHD-IN-4
<p>HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.</p>Couleur et forme :Odour SolidIzilendustat
CAS :<p>Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.</p>Formule :C22H28ClN3O4Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :433.93Sirtuin modulator 2
CAS :<p>Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.</p>Formule :C19H15N3O2SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :349.41TAT-cyclo-CLLFVY
CAS :<p>Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).</p>Formule :C111H188N42O24S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2559.1HIF1-IN-3
CAS :<p>HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in</p>Formule :C26H24N2O3Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :412.48IOX2-NH2-Methyl
<p>IOX2-NH2-Methyl is a modified form of IOX2. IOX2 is a specific inhibitor of PHD2 (prolyl-hydroxylase-2), capable of upregulating HIF-1α expression and suppressing ROS production. IOX2-NH2-Methyl is employed in investigations of platelet and thrombus formation.</p>Formule :C20H19N3O5Degré de pureté :97.64% - 99.31%Couleur et forme :SolidMasse moléculaire :381.39Zifcasiran
CAS :<p>Zifcasiran reduces HIF synthesis, has antitumor properties, useful in renal carcinoma studies.</p>Formule :C737H972F20N211O349P43S8Couleur et forme :SolidMasse moléculaire :20339.13Mersalyl
CAS :<p>Mersalyl is an organic mercurial diuretic.</p>Formule :C13H16HgNNaO6Couleur et forme :SolidMasse moléculaire :505.854Fibrostatin C
CAS :<p>Fibrostatin C is an inhibitor of prolyl 4-hydroxylase. It is produced by Streptomyces catenulae subsp.</p>Formule :C18H19NO8SCouleur et forme :SolidMasse moléculaire :409.411,4-DPCA
CAS :<p>1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting</p>Formule :C13H8N2O3Degré de pureté :97.77%Couleur et forme :SolidMasse moléculaire :240.21ZG-2305
<p>ZG-2305 is an effective, selective, and orally active inhibitor of FIH (factor inhibiting hypoxia-inducible factor (FIH)), with Ki values of 79.6 nM for FIH and 2786 nM for PHD2. This compound enhances the expression of the EGLN3 gene, reduces cellular triglyceride levels, and decreases lipid accumulation. ZG-2305 holds potential for research into obesity and fatty liver disease.</p>Formule :C17H11Cl2N3O5Couleur et forme :SolidMasse moléculaire :408.19ZG-2033
CAS :<p>ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity (EC50 = 490 nM) in a luciferase reporter assay. It demonstrates an anti-anemic effect and shows synergistic effects with AKB-6548 in anemia, making it useful for the study of renal anemia.</p>Formule :C15H14N2O2SCouleur et forme :SolidMasse moléculaire :286.351,4-DPCA ethyl ester
CAS :<p>1,4-DPCA ethyl ester is a form of 1,4-DPCA modified, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.</p>Formule :C15H12N2O3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :268.27
