Prolyl-Hydroxylase de HIF/HIF
Le facteur inductible par l'hypoxie (HIF) est un facteur de transcription qui joue un rôle crucial dans les réponses cellulaires aux faibles niveaux d'oxygène (hypoxie). L'activité de HIF est étroitement régulée par les prolyl-hydroxylases de HIF, qui ciblent HIF pour sa dégradation dans des conditions normoxiques. Les inhibiteurs de la prolyl-hydroxylase de HIF peuvent stabiliser HIF, favorisant l'expression de gènes impliqués dans l'angiogenèse, l'érythropoïèse et le métabolisme. Ces inhibiteurs sont d'un grand intérêt pour le traitement de conditions telles que l'anémie, les maladies ischémiques et le cancer. Chez CymitQuimica, nous proposons des inhibiteurs de HIF/prolyl-hydroxylase HIF pour soutenir vos recherches en biologie de l'hypoxie, en thérapie anticancéreuse et en régulation métabolique.
142 produits trouvés pour "Prolyl-Hydroxylase de HIF/HIF"
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HIF-PHD-IN-2
CAS :<p>HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].</p>Formule :C17H15N5O3SCouleur et forme :SolidMasse moléculaire :369.4Angiogenesis agent 1
CAS :<p>Compound C-31, a salidroside-based glycoside, activates HIF-1α and may aid in diabetic limb ischemia studies.</p>Formule :C20H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.4BNS
CAS :<p>BNS is a potent, prolyl-hydroxylase 2 (PHD2)-selective inhibitor.</p>Formule :C18H16N2O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.46M1002
CAS :<p>M1002, a HIF-2 agonist, boosts HIF-2alpha/ARNT activation and alters HIF-281alpha PAS-B, working with PHD inhibitors.</p>Formule :C15H8F6N2O2SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :394.29103D5R
CAS :<p>103D5R selectively inhibits hif-1α, reducing its levels in hypoxia or with cobalt ions, dose- and time-dependently.</p>Formule :C20H21N3O2Couleur et forme :SolidMasse moléculaire :335.4HIF-IN-33
CAS :<p>HIF-IN-33 is an inhibitor of HIF pathway.</p>Formule :C21H17F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.38Langkamide
CAS :<p>Langkamide is a HIF-2 inhibitor with EC₅₀ values of 14.0 uM.</p>Formule :C16H17NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :303.31ENMD-1198
CAS :<p>ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.</p>Formule :C20H25NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :311.42HIF-1/2α-IN-2
CAS :<p>HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α.</p>Formule :C16H11FN4O2SCouleur et forme :SolidMasse moléculaire :342.35THS-044
CAS :<p>THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activity</p>Formule :C11H12F3N3O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :291.23KCN1
CAS :<p>KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.</p>Formule :C26H27NO5SCouleur et forme :SolidMasse moléculaire :465.56TM6089
CAS :<p>TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.</p>Formule :C13H14N4O3SDegré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :306.34HIF-1α inhibitor-1
CAS :<p>HIF-1α inhibitor-1 is a HIF-1 alpha inhibitor.</p>Formule :C15H11N3O4Couleur et forme :SolidMasse moléculaire :297.27KRH102140
CAS :<p>KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.</p>Formule :C25H24FNODegré de pureté :98.31% - 99.61%Couleur et forme :SolidMasse moléculaire :373.46HIF-2α-IN-3
CAS :<p>HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.</p>Formule :C12H6ClN5O5Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :335.66TC-S 7009
CAS :<p>TC-S 7009: Strong HIF-2α inhibitor (Kd 81 nM), weak for HIF-1α; disrupts dimerization & gene expression.</p>Formule :C12H6ClFN4O3Degré de pureté :99.46% - 99.71%Couleur et forme :SolidMasse moléculaire :308.65HIF-2α-IN-13
CAS :<p>HIF-2α-IN-13 (18) acts as a HIF-2α inhibitor and exhibits an IC 50 value of 2.7 μM.</p>Formule :C15H14ClF4NO2Couleur et forme :SolidMasse moléculaire :351.72PHD-IN-2
CAS :<p>PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 of</p>Formule :C26H27N7O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.54Prolyl Hydroxylase inhibitor 1
CAS :<p>Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).</p>Formule :C19H18ClN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.83PHD2-IN-1
CAS :<p>PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].</p>Formule :C21H23ClN4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.88HIF-2α-IN-9
CAS :<p>HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes within</p>Formule :C12H13F5O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.35PHD-IN-1
CAS :<p>PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.</p>Formule :C24H23N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.49AKB-6899
CAS :<p>AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated</p>Formule :C14H11FN2O4Degré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :290.25HIF-2α-IN-1
CAS :<p>HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.</p>Formule :C16H8F5NO4SDegré de pureté :97.99%Couleur et forme :SolidMasse moléculaire :405.3CLB-016
CAS :<p>CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.</p>Formule :C17H20N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.38HIF-2α-IN-6
CAS :<p>HIF-2α-IN-6 (117) is a HIF-2α inhibitor [1].</p>Formule :C15H13F4NO3SCouleur et forme :SolidMasse moléculaire :363.33NPAS3-IN-1
CAS :<p>NPAS3-IN-1 is an NPAS3-ARNT heterodimerization inhibitor that regulates NPAS3 transcription by modulating the heterodimerization of NPAS3 with ARNT.</p>Formule :C10H5N3O2S3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :295.36HIF-2α agonist 2
CAS :<p>HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α.</p>Formule :C13H8Br2N2O2SDegré de pureté :98.87%Couleur et forme :SoildMasse moléculaire :416.09HIF-2α-IN-7
CAS :<p>HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor.</p>Formule :C18H9F6NO2Couleur et forme :SolidMasse moléculaire :385.26HIF-2α-IN-5
CAS :<p>HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of < 50 nM [1].</p>Formule :C15H12F4O3S2Couleur et forme :SolidMasse moléculaire :380.38(Rac)-PT2399
CAS :<p>(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).</p>Formule :C17H10F5NO4SCouleur et forme :SolidMasse moléculaire :419.32JTZ-951 HCl
CAS :<p>JTZ-951 is a potent and orally active inhibitor of hypoxia inducible factor prolyl hydroxylase (PHD).</p>Formule :C17H17ClN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.79AFP464 free base
CAS :<p>AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.</p>Formule :C22H23F3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.44HIF-1α-IN-5
<p>HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A.</p>Formule :C16H15N3O2Couleur et forme :SolidMasse moléculaire :281.31DDO-3055
CAS :<p>DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.</p>Formule :C17H13ClN2O5Couleur et forme :SolidMasse moléculaire :360.749JPHM-2-167
CAS :<p>PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD). It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.</p>Formule :C30H28N6O2Couleur et forme :SolidMasse moléculaire :504.582HIF-1α-IN-4
<p>HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects.</p>Formule :C16H12N2O3Couleur et forme :SolidMasse moléculaire :280.28DS44470011
CAS :<p>DS44470011 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) with oral bioavailability. It enhances the release of erythropoietin (EPO) from cells and is utilized in research related to renal anemia.</p>Formule :C21H19N3O4Couleur et forme :SolidMasse moléculaire :377.39PHD2-IN-4
CAS :<p>PHD2-IN-4 (compound 1) is an inhibitor of PHD2, with an IC50 of 4 nM. It is utilized in research related to chronic kidney disease.</p>Formule :C21H19N5O3Couleur et forme :SolidMasse moléculaire :389.407HIF-1/2α-IN-1
<p>HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α.</p>Formule :C17H16N6O4Couleur et forme :SolidMasse moléculaire :368.35HIF-PHD-IN-1
CAS :<p>HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therapeutic agent for renal anemia is highly promising.</p>Formule :C17H12Cl2N6O3Couleur et forme :SolidMasse moléculaire :419.22Desidustat
CAS :<p>Desidustat is an inhibitor of HIF hydroxylase.</p>Formule :C16H16N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :332.31Ref: TM-T5176
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