FAAH
L'hydrolase des amides d'acides gras (FAAH) est une enzyme qui décompose les amides d'acides gras, y compris les endocannabinoïdes comme l'anandamide. Ces composés sont impliqués dans la régulation de la douleur, de l'humeur, de l'appétit et de la mémoire. L'inhibition de la FAAH peut augmenter les niveaux de ces molécules de signalisation, offrant ainsi des bénéfices thérapeutiques potentiels pour la douleur, l'anxiété et les maladies neurodégénératives. Chez CymitQuimica, nous proposons une sélection d'inhibiteurs de la FAAH pour soutenir vos recherches en neurosciences, gestion de la douleur et signalisation endocannabinoïde.
64 produits trouvés pour "FAAH"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
OMDM-5
CAS :OMDM-5 is a potent vanilloid receptor type 1 (TRPV1, EC50 = 75 nM) agonist, showing weak ligand activity at cannabinoid type 1 receptor (CB1, Ki=4.9 μM).Formule :C26H44N2O3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :432.64Ref: TM-T12306
1mg93,00€5mg177,00€1mL*10mM (DMSO)210,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€JP104
CAS :JP104 is an aryl carbamate that irreversibly inhibits fatty acid amide hydrolase (FAAH) with a pIC50 value of approximately 8 [1].Formule :C25H30N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.523-Decyl-5,5'-diphenyl-2-thioxo-4-imidazolidinone
CAS :3-Decyl-5,5'-diphenyl-2-thioxo-4-imidazolidinone (compound 45), having a pI50 of 5.89, shows promise as an inhibitor of fatty acid amide hydrolase (FAAH). Despite its activity, it demonstrates a lack of affinity for cannabinoid receptors CB(1) and CB(2) [1].Formule :C25H32N2OSCouleur et forme :SolidMasse moléculaire :408.6PDP-EA
CAS :PDP-EA is an activator of fatty acid amide hydrolase(FAAH) and enhances the amidohydrolase activity of FAAH.Formule :C25H43NO3Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :405.61Ref: TM-T28353
1mL*10mM (DMSO)À demander2mg33,00€5mg48,00€10mg75,00€25mg110,00€50mg166,00€100mg245,00€200mg353,00€NRMA-8
CAS :NRMA-8 is a small-molecule nuclear receptor modulator capable of penetrating the brain. It holds potential for research into central nervous system (CNS) diseases, including Alzheimer's disease, Parkinson's disease, demyelinating diseases, and glioblastoma.Formule :C20H23ClN2O3Couleur et forme :SolidMasse moléculaire :374.86Sob-AM2
CAS :Sob-AM2 is an effective substrate targeting the fatty acid amide hydrolase (FAAH) expressed in the brain, with a Km of 1.3 μM. It delivers higher concentrations of Sobetirome to the central nervous system at minimal peripheral systemic doses, thereby activating the central thyroid hormone receptor β (TRβ).Formule :C21H27NO3Couleur et forme :SolidMasse moléculaire :341.44FAAH/MAGL-IN-1
FAAH/MAGL-IN-1 (SIH 3) inhibits FAAH & MAGL with IC50 of 31 & 29 nM, useful in neuropathic pain research.Formule :C15H9Cl2N3O3Couleur et forme :SolidMasse moléculaire :350.16AZ513
CAS :AZ513 is a reversible FAAH inhibitor, exhibiting an IC50 of 551 nM for human FAAH and 27 nM for rat FAAH. It inhibits the hydrolysis of arachidonoyl ethanolamide in HEK293 cells transfected with human FAAH, with an IC50 of 360 nM.Formule :C14H9Cl2N3OCouleur et forme :SolidMasse moléculaire :306.147MK-3168 (12C)
CAS :MK-3168 (12C) functions as a FAAH inhibitor, exhibiting IC50 values of 1.0 nM, 5.5 nM, and 1.7 nM for human, rhesus, and rat respectively. It demonstrates effective brain uptake and FAAH-specific signaling. Additionally, 11 C MK-3168 is applicable as a FAAH PET tracer.Formule :C21H21ClN4OSCouleur et forme :SolidMasse moléculaire :412.94Irafamdastat
CAS :Irafamdastat (BMS-986368) [Example 74] is an inhibitor of FAAH and MAGL, with IC50 values of ≤ 100 nM for human FAAH and 100 nM-1 μM for human MAGL. It exhibits anticonvulsant properties.Formule :C20H21F3N4O4Couleur et forme :SolidMasse moléculaire :438.40FAAH/MAGL-IN-2
CAS :FAAH/MAGL-IN-2: potent, reversible, oral FAAH & MAGL inhibitor, IC50: 11/36 nM, may research neuropathic pain, no locomotion issue.Formule :C15H13Cl2N3O3SCouleur et forme :SolidMasse moléculaire :386.25FAAH/MAGL-IN-3
FAAH/MAGL-IN-3 irreversibly inhibits FAAH (IC50: 179 nM) & MAGL (IC50: 759 nM) with low PAMPA permeability.Formule :C21H25N3O6SCouleur et forme :SolidMasse moléculaire :447.5Dual FAAH/sEH-IN-1
CAS :Dual FAAH/sEH-IN-1 inhibits both sEH (IC50: 9.6 nM) and FAAH (IC50: 7 nM), offering potent anti-inflammatory effects.
Formule :C25H22ClN3O3S2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :512.04TC-F 2
CAS :TC-F 2 is a FAAH inhibitor.Formule :C26H25N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :439.51
