NAMPT
La nicotinamide phosphoribosyltransférase (NAMPT) est une enzyme impliquée dans la biosynthèse du nicotinamide adénine dinucléotide (NAD+), un coenzyme essentiel au métabolisme cellulaire et à la production d'énergie. Les inhibiteurs de la NAMPT suscitent un intérêt particulier en recherche sur le cancer, en raison de leur capacité à perturber le métabolisme du NAD+ et à induire la mort des cellules cancéreuses. Ces inhibiteurs sont également étudiés dans le contexte des troubles métaboliques et du vieillissement. Chez CymitQuimica, nous proposons des inhibiteurs de la NAMPT pour soutenir vos recherches en biologie du cancer, métabolisme et vieillissement.
40 produits trouvés pour "NAMPT".
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STF-118804
CAS :STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.Formule :C25H23N3O4SDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :461.533GNE-617 hydrochloride
CAS :GNE-617 hydrochloride is a specific inhibitor of NAMPT and inhibits NAMPT activity (IC50: 5 nM).Formule :C21H16ClF2N3O3SCouleur et forme :SolidMasse moléculaire :463.885GNE-617
CAS :GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.Formule :C21H15F2N3O3SDegré de pureté :99.38% - 99.71%Couleur et forme :White SolidMasse moléculaire :427.424Nampt-IN-12
CAS :Nampt-IN-12 (compound 9), a derivative of N-Pyridinylthiophene carboxamid, exhibits activity against peripheral nerve sheath cancer cells. It is metabolized by the enzymes NAMPT and NMNAT1 within the NAD salvage pathway into an adenine dinucleotide (AD) derivative, an analog of NAD that can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) within the cells. Nampt-IN-12's effective blood-brain barrier permeability makes it suitable for research into cancers of the central and peripheral nervous system.Formule :C10H8N2OSCouleur et forme :SolidMasse moléculaire :204.25Nampt-IN-7
CAS :Nampt-IN-7 (GF8) inhibits NAMPT (IC50: 7.31 μM) and kills HepG2 cells (IC50: 24.28 μM).Formule :C20H21N5O3Couleur et forme :SolidMasse moléculaire :379.41Teglarinad chloride
CAS :Teglarinad chloride (GMX-1777 chloride) is an inhibitor of NAMPT with antitumor activity that acts by interfering with DNA repair and inhibiting angiogenesis.Formule :C30H43Cl2N5O8Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :672.597Nampt-IN-9
CAS :Nampt-IN-9 (Compound 8) is a potent inhibitor of NAMPT with anticancer properties.Nampt-IN-9 can be used to study ductal adenocarcinoma of the pancreas.Formule :C26H33N3O4Couleur et forme :SolidMasse moléculaire :451.56Nampt activator-3
CAS :NAMPT activator-3: a NAT derivative, EC50 of 2.6 μM, KD 132 nM, protects cells, prevents FK866 toxicity, and is neuroprotective in CIPN mice.Formule :C19H20N2O3Couleur et forme :SolidMasse moléculaire :324.37Nampt activator-2
CAS :Nampt activator-2: Potent NAMPT activator (EC50: 0.023 μM), binds CYP2C9 (0.060 μM), 2D6 (0.41 μM), 2C19 (0.59 μM); useful in metabolic disease research.Formule :C17H15ClN4O3SDegré de pureté :98.59% - 98.88%Couleur et forme :SolidMasse moléculaire :390.844GNE-618
CAS :GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM).Formule :C21H15F3N4O3SCouleur et forme :SolidMasse moléculaire :460.429Nampt-IN-10 TFA
CAS :Nampt-IN-10 TFA, a NAMPT inhibitor, shows potency in A2780 (IC50: 5 nM) and CORL23 (IC50: 19 nM), suitable for ADC payloads.Formule :C29H29F4N5O4Couleur et forme :SolidMasse moléculaire :587.21557JGB-1-155
CAS :JGB-1-155 is a positive allosteric modulator of nicotinamide phosphoribosyltransferase that enhances NAMPT enzymatic activity, elevates intracellular NAD⁺ levels in human monocytes, counteracts oxidative stress, and attenuates TNFα-induced reactive oxygen species production, supporting its application in studies of redox balance and inflammatory signaling.Formule :C26H38N2O3Degré de pureté :99.33%Couleur et forme :White SolidMasse moléculaire :426.59LB-60-OF61
CAS :LB-60-OF61 is a NAMPT inhibitor, a NAMPT inhibitor that displays antiproliferative activity against MYC oncogene-dependent cancer cell lines.Formule :C29H30N6O2Degré de pureté :99.99%Couleur et forme :White SolidMasse moléculaire :494.5875NAMPT activator-6
CAS :NAMPT activator-6 regulates NAMPT/NAD⁺ optogenetic systems, used to construct PS-PROTACs for light-dependent reversible regulation and reduced toxicity.Formule :C17H21N5O3SDegré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :375.45Nampt-IN-15
CAS :Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.Formule :C24H30N4O2Couleur et forme :SolidMasse moléculaire :406.52Nampt activator-4
CAS :Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].Formule :C26H22F3N7OSCouleur et forme :SolidMasse moléculaire :537.56Nampt-IN-14
CAS :Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).Formule :C33H35N7O2Couleur et forme :SolidMasse moléculaire :561.68Nampt-IN-13
CAS :Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).Formule :C24H30N6O2Couleur et forme :SolidMasse moléculaire :434.53PD-L1/Nampt-IN-1
CAS :PD-L1/Nampt-IN-1 is an orally active inhibitor that targets both PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase), with IC50 values of 63 nM and 582 nM, respectively. It exhibits cross-species affinity, with KD values of 52.6 nM for hPD-L1 and 49.1 nM for mPD-L1. This compound effectively suppresses tumor growth by activating the tumor immune microenvironment and is applicable in melanoma research.Formule :C28H28N4O2Couleur et forme :SolidMasse moléculaire :452.55CB30865
CAS :CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.Formule :C26H22BrN5O2Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :516.389
