Déshydrogénase
Les déshydrogénases sont des enzymes impliquées dans les réactions d'oxydoréduction des voies métaboliques, jouant un rôle central dans la production d'énergie et la respiration cellulaire. Ces enzymes sont cruciales pour des processus tels que le cycle de l'acide citrique, la glycolyse et l'oxydation des acides gras. Les inhibiteurs de déshydrogénases sont des outils importants dans l'étude des maladies métaboliques, du cancer et du stress oxydatif. Chez CymitQuimica, nous proposons une sélection complète d'inhibiteurs de déshydrogénases pour soutenir vos recherches en métabolisme, biologie du cancer et biochimie.
267 produits trouvés pour "Déshydrogénase"
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ML-148
CAS :<p>ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM).</p>Formule :C20H21N3ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :319.4DS18561882
CAS :<p>DS18561882: Potent MTHFD2 inhibitor (IC50=0.0063), inhibits MTHFD1 (IC50=0.57), good oral kinetics.</p>Formule :C28H31F3N4O6SDegré de pureté :98.19% - >99.99%Couleur et forme :SolidMasse moléculaire :608.63Olorofim
CAS :<p>Olorofim（F-901318）is a new selective antifungal compound that inhibits Aspergillus fumigatus DHODH (IC50: 44 nM). Cost-effective and quality-assured.</p>Formule :C28H27FN6O2Degré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :498.55Qc1
CAS :<p>Qc1 is an inhibitor of threonine dehydrogenase (TDH) inhibitor and can be used in studies about metabolic diseases.</p>Formule :C23H16F3N3O2SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :455.45CPS-11
CAS :<p>CPS-11, a Thalidomide analogue, shows potent, broad antitumor activity, especially in multiple myeloma cells.</p>Formule :C14H12N2O5Degré de pureté :99.8% - 99.98%Couleur et forme :SolidMasse moléculaire :288.26ALDH1A3-IN-2
CAS :<p>ALDH1A3-IN-2 is a potent ALDH1A3 inhibitor with an IC50 of 0.30 μM.ALDH1A3-IN-2 has potential for cancer disease research.</p>Formule :C13H17NODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :203.28PHGDH-IN-3
CAS :<p>PHGDH-IN-3, an oral PHGDH blocker with 2.8 μM IC50, may help in cancer research.</p>Formule :C24H18FN3O4S2Degré de pureté :97.24% - 98.55%Couleur et forme :SolidMasse moléculaire :495.55HSD-016
CAS :<p>HSD-016: Oral 11β-HSD1 inhibitor, active in humans, mice, rats (IC50: 11, 1, 8 nM), potential for type 2 diabetes research.</p>Formule :C21H21F7N2O3SDegré de pureté :99.40% - >99.99%Couleur et forme :SolidMasse moléculaire :514.46CM037
CAS :<p>CM037 (A-37) is a selective ALDH1A1 (acetaldehyde dehydrogenase 1A1) inhibitor (IC50; 4.6 µM) with antitumor activity and may be used in studies to eliminate</p>Formule :C21H25N3O3S2Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :431.57IDH2R140Q-IN-2
CAS :<p>IDH2R140Q-IN-2 is an IDH2R140Q inhibitor indicated for the study of acute myeloid leukaemia (AML).</p>Formule :C21H18F6N6ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :484.4IGP-1
CAS :<p>iGP-1 is a cell-permeable mitochondrial sn-Glycerol 3-phosphate dehydrogenase (mGPDH) inhibitor.</p>Formule :C17H15N3O3Degré de pureté :99.12% - 99.15%Couleur et forme :SolidMasse moléculaire :309.32PKUMDL-WQ-2101
CAS :<p>PKUMDL-WQ-2101 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase with anti-tumor activity.</p>Formule :C14H11N3O6Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :317.25hDHODH-IN-7
CAS :<p>hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor.</p>Formule :C21H23FN4ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :366.43BMS-823778
CAS :<p>BMS-823778 is a potent inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) for the study of type 2 diabetes.</p>Formule :C18H18ClN3ODegré de pureté :99.39% - 99.75%Couleur et forme :SolidMasse moléculaire :327.81IMPDH2-IN-2
CAS :<p>IMPDH2-IN-2 is an IMPDH inhibitor with antimicrobial activity and potential anti-tuberculosis activity for the study of inflammation and immune dysfunction.</p>Formule :C21H15Cl2N3O3Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :428.27G6PD activator AG1
CAS :<p>G6PD activator AG1 is a G6PD agonist that promotes G6PD oligomerization to a catalytically competent form.</p>Formule :C24H30N4S2Degré de pureté :98.38% - 99.51%Couleur et forme :SolidMasse moléculaire :438.65DSM421
CAS :<p>DSM421 (DSM-421) is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shown</p>Formule :C14H11F5N6Degré de pureté :98.23% - 99.82%Couleur et forme :SolidMasse moléculaire :358.27HSD17B13-IN-2
CAS :<p>HSD17B13-IN-2 (compound 1) serves as a potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) with demonstrable activity in cellular experiments [1</p>Formule :C21H23F2NO4Couleur et forme :SolidMasse moléculaire :391.41α-Pyridoin
CAS :<p>α-Pyridoin (α-pyridoin) is an enediol (enediol) compound that acts as a unique antioxidant.</p>Formule :C12H12N2O2Couleur et forme :SolidMasse moléculaire :216.24IDH1 Inhibitor 2
CAS :<p>IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).</p>Formule :C26H22N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.48AZD 4017
CAS :<p>AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).</p>Formule :C22H33N3O3SDegré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :419.5815-PGDH-IN-1
CAS :<p>15-PGDH-IN-1: potent oral 15-PGDH inhibitor, IC50=3nM, useful for tissue repair research.</p>Formule :C24H22N4O2Couleur et forme :SolidMasse moléculaire :398.46GSK321
CAS :<p>GSK321 is an IDH1 inhibitor that prevents cytoplasmic glutamine reductive carboxylation.GSK321 is used in the study of leukemia.</p>Formule :C28H28FN5O3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :501.55CHK-336
CAS :<p>CHK-336 (Example 1), an orally active LDHA inhibitor (IC50 <1 nM), suppresses lactate production in mouse hepatocytes and is applicable in hyperoxaluria</p>Formule :C24H20F2N4O4S2Couleur et forme :SolidMasse moléculaire :530.5715-PGDH-IN-2
CAS :<p>15-PGDH-IN-2 (Compound 2) is an inhibitor of 15-PGDH with an IC50 value of 0.274 nM. This compound is useful for research into hair loss, bone formation, gastric ulcer healing, and dermal wound healing [1].</p>Formule :C16H13NO3S2Couleur et forme :SolidMasse moléculaire :331.41hDHODH-IN-1
CAS :<p>hDHODH-IN-1 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an anti-inflammatory effect.</p>Formule :C17H14N2O2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :278.31YG1702
CAS :<p>YG1702, a potent inhibitor specific to ALDH18A1, suppresses the proliferation of MYCN-amplified neuroblastoma (NB) and reduces MYCN expression.</p>Formule :C23H30N2O7SCouleur et forme :SolidMasse moléculaire :478.56PF-915275
CAS :<p>PF-915275 inhibits 11βHSD1 in humans (Ki=2.3 nM, EC50=15 nM) and affects cortisone-cortisol conversion in hepatocytes.</p>Formule :C18H14N4O2SDegré de pureté :99.58% - 99.61%Couleur et forme :SolidMasse moléculaire :350.39Anticancer agent 121
CAS :<p>Anticancer agent 121, a human lactate dehydrogenase A (hLDHA) inhibitor, exhibits potent anticancer activities, suitable for use in anticancer research [1].</p>Formule :C19H18N2O3SCouleur et forme :SolidMasse moléculaire :354.42MK-0736
CAS :<p>MK-0736 is a potent and selective 11β-HSD-1 inhibitor.</p>Formule :C23H30F3N3O2SCouleur et forme :SolidMasse moléculaire :469.56HSD17B13-IN-3
CAS :<p>HSD17B13-IN-3 (compound 2) is a potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13), lacking cellular experimental activity [1].</p>Formule :C22H21NO6S2Couleur et forme :SolidMasse moléculaire :459.54Tetrahydro-11-dehydrocorticosterone
CAS :<p>Tetrahydro-11-dehydrocorticosterone is an inhibitor of 11β-hydroxysteroid dehydrogenase [1].</p>Formule :C21H32O4Couleur et forme :SolidMasse moléculaire :348.48DHODH-IN-22
CAS :<p>DHODH-IN-22: potent, selective DHODH inhibitor, orally active, IC50: 0.3 nM, for AML research.</p>Formule :C21H21ClF4N6O5Couleur et forme :SolidMasse moléculaire :548.88DHODH-IN-14
CAS :<p>DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.</p>Formule :C15H7F4N3O3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :353.23IDH889
CAS :<p>IDH889: Brain-penetrant, mutant-specific IDH1 inhibitor; selective for IDH1 R132* mutations. IC50: 0.02μM (R132H), 0.072μM (R132C), 1.38μM (wild-type).</p>Formule :C23H25FN6O2Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :436.48Anticancer agent 122
CAS :<p>Anticancer agent 122, a potent inhibitor of human lactate dehydrogenase A (h LDHA), exhibits significant anticancer activities, rendering it suitable for use in</p>Formule :C18H15ClN2O2SCouleur et forme :SolidMasse moléculaire :358.84KB-74935
CAS :<p>KB-74935: enzyme inhibitor, mineralocorticoid blocker, treats cholesterol, hypolipidemia, neurological issues, Alzheimer's.</p>Formule :C19H18ClF4N3O3SDegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :479.88ALDH2 modulator 1
CAS :<p>ALDH2 modulator 1 is a potent and orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.</p>Formule :C18H18ClFN2O3Degré de pureté :99.68%Couleur et forme :SoildMasse moléculaire :364.8CB29
CAS :<p>CB29 is a specific inhibitor of aldehyde dehydrogenase 3A1 (ALDH3A1).</p>Formule :C15H15N3O5SDegré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :349.36BI-3231
CAS :<p>BI-3231 is a hydroxysteroid 17ß-dehydrogenase 13 HSD17B13 inhibitor that inhibits hHSD17B13 .BI-3231 can be used to study cirrhosis.</p>Formule :C16H14F2N4O3SDegré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :380.377-Hydroxy-4-phenylcoumarin
CAS :<p>7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.</p>Formule :C15H10O3Couleur et forme :SolidMasse moléculaire :238.238T-3764518
CAS :<p>T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).</p>Formule :C20H17F6N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.37DSM705 hydrochloride
<p>DSM705 hydrochloride: potent antimalarial, pyrrole-based DHODH inhibitor effective against Plasmodium, non-toxic to mammalian DHODH.</p>Formule :C19H20ClF3N6OCouleur et forme :SolidMasse moléculaire :440.85FXR/HSD17B13 modulator 1
CAS :<p>FXR/HSD17B13 modulator 1 (compound 6) is an effective modulator of FXR/HSD17B13, playing a significant role in studies related to metabolic dysfunction-associated steatohepatitis (MASH).</p>Formule :C26H19Cl2NO4Couleur et forme :SolidMasse moléculaire :480.339RORγt/DHODH-IN-3
<p>RORγt/DHODH-IN-3 (compound (S)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.098 μM) and DHODH (IC50: 0.432 μM).RORγt/DHODH-IN-1 has</p>Formule :C24H26ClF6N3O3SCouleur et forme :SolidMasse moléculaire :585.99PHGDH-IN-2
<p>PHGDH-IN-2: potent PHGDH inhibitor, IC50=5.2μM; hinders PHGDH cancer cell growth & serine synthesis in MDA-MB-468.</p>Formule :C22H20N4O3SCouleur et forme :SolidMasse moléculaire :420.48BI-4916
CAS :<p>BI-4916 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor that inhibits SSP and reduces cancer cell migration.</p>Formule :C23H24Cl2N2O6SDegré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :527.42PDHK-IN-4
<p>PDHK-IN-4 inhibits PDHK2 (IC50: 0.0051 μM) & PDHK4 (IC50: 0.0122 μM), with potential for cancer research.</p>Formule :C24H25N5O3Couleur et forme :SolidMasse moléculaire :431.49PDHK-IN-3
<p>PDHK-IN-3 (compound 7) is a potent inhibitor of pyruvate dehydrogenase kinase(PDHK) with IC50s of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively [1].</p>Formule :C17H16N2O2Couleur et forme :SolidMasse moléculaire :280.32BRD7539
CAS :<p>BRD7539B: PfDHODH inhibitor, IC50 0.033μM; selective vs HsDHODH, IC50 >50μM.</p>Formule :C23H22FN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :391.44PDHK-IN-5
<p>PDHK-IN-5, potent PDHK2 (0.006 μM IC50) & PDHK4 (0.0329 μM IC50) inhibitor, may be explored for cancer and diabetes treatment.</p>Formule :C30H31N5O2Couleur et forme :SolidMasse moléculaire :493.6Deamino-NAD sodium
CAS :<p>Deamino-NAD sodium, a structural analog of NAD+, serves as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH) in glycolysis. It exhibits a Km of 2300 pm and a Kd of 112 pm.</p>Formule :C21H25N6NaO15P2Couleur et forme :SolidMasse moléculaire :686.39Etamicastat
CAS :<p>Etamicastat can be used in the research of cardiovascular diseases.</p>Formule :C14H15F2N3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :311.3511β-HSD2-IN-2
CAS :<p>11β-HSD2-IN-2 (compound 3) is a selective 17β-HSD2 (17β-hydroxysteroid dehydrogenase type 2) inhibitor with an IC50 of 300 nM, studying osteoporosis.</p>Formule :C22H21NO2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :331.41GSK864
CAS :<p>GSK864 is an inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant. GSK864 inhibits IDH1 mutants R132C, R132H, and R132G (IC50: 8.8, 15.2, and 16.6 nM).</p>Formule :C30H31FN6O4Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :558.6MDH1/2-IN-1
CAS :<p>MDH1/2-IN-1 is an MDH1/2 inhibitor with IC50 values of 1.07 nM and 1.06 nM, respectively. It suppresses mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 exhibits significant antitumor potential and offers new avenues for developing drugs targeting cancer metabolism.</p>Formule :C25H33NO4Couleur et forme :SolidMasse moléculaire :411.534AXKO-0046
<p>AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor.</p>Formule :C25H33N3Couleur et forme :SolidMasse moléculaire :375.55Indoluidin E
<p>Indoluidin E selectively inhibits DHODH and has an inhibitory effect on cancer cell growth.</p>Formule :C28H30N4O2Couleur et forme :SolidMasse moléculaire :454.56LDHA-IN-5
CAS :<p>LDHA-IN-5 is a novel and potent inhibitor targeting both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), designed for the treatment of primary</p>Formule :C27H22FN7O6S3Couleur et forme :SolidMasse moléculaire :655.7hDHODH-IN-10
<p>hDHODH-IN-10: selective oral inhibitor of hDHODH (IC50: 10.9 nM); blocks cancer cell growth, aids cancer research.</p>Formule :C21H15ClF4N2O4Couleur et forme :SolidMasse moléculaire :470.8RORγt/DHODH-IN-1
CAS :<p>RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significant</p>Formule :C24H26ClF6N3O3SCouleur et forme :SolidMasse moléculaire :585.99Etamicastat hydrochloride
CAS :<p>Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension.</p>Formule :C14H16ClF2N3OSDegré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :347.81CP-642931
CAS :<p>CP-642931 (Sorbitol dehydrogenase-IN-1) is a sorbitol dehydrogenase inhibitor used in the study of diabetes mellitus and cardiovascular disease.</p>Formule :C17H25N7ODegré de pureté :99.67% - >99.99%Couleur et forme :SolidMasse moléculaire :343.43PS10
CAS :<p>PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2 and significantly increases the activity of the pyruvate dehydrogenase complex.</p>Formule :C14H13NO6SDegré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :323.32GNE-140 racemate
CAS :<p>GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.</p>Formule :C25H23ClN2O3S2Couleur et forme :SolidMasse moléculaire :499.04(S)-GNE-140
CAS :<p>(S)-GNE-140 is the less active enantiomer of GNE-140.</p>Formule :C25H23ClN2O3S2Couleur et forme :SolidMasse moléculaire :499.0511β-HSD1-IN-8
CAS :<p>11β-HSD1-IN-8 is a useful organic compound for research related to life sciences. The catalog number is T65743 and the CAS number is 386704-15-0.</p>Formule :C10H8F3NO3Couleur et forme :SolidMasse moléculaire :247.173
