Déshydrogénase
Les déshydrogénases sont des enzymes impliquées dans les réactions d'oxydoréduction des voies métaboliques, jouant un rôle central dans la production d'énergie et la respiration cellulaire. Ces enzymes sont cruciales pour des processus tels que le cycle de l'acide citrique, la glycolyse et l'oxydation des acides gras. Les inhibiteurs de déshydrogénases sont des outils importants dans l'étude des maladies métaboliques, du cancer et du stress oxydatif. Chez CymitQuimica, nous proposons une sélection complète d'inhibiteurs de déshydrogénases pour soutenir vos recherches en métabolisme, biologie du cancer et biochimie.
302 produits trouvés pour "Déshydrogénase"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
DHODH-IN-13
CAS :<p>DHODH-IN-13 is an inhibitor of DHODH with IC50 of 4.3 μM for rat liver. DHODH-IN-13 can be used in studies about rheumatoid arthritis.</p>Formule :C10H6F3N3O3Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :273.17DHODH-IN-15
CAS :DHODH-IN-15, a hydroxyfuran analogue of A771726, inhibits rat liver DHODH with an IC50 of 11 μM, and is used for rheumatoid arthritis.Formule :C15H11N3O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :281.27DHODH-IN-1
CAS :<p>DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.</p>Formule :C21H20F3N3O2Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :403.4DHODH-IN-17
CAS :DHODH-IN-17 is a human DHODH inhibitor with an IC50 of 0.40 μM.Formule :C12H9ClN2O2Degré de pureté :99.52% - 99.99%Couleur et forme :SolidMasse moléculaire :248.67DHODH-IN-4
CAS :DHODH-IN-4 inhibits human & Plasmodium DHODH; IC50: 4 μM (Pf), 0.18 μM (Hs). It has antimalarial properties.Formule :C17H12Cl2N2O2Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :347.2DHODH-IN-8
CAS :DHODH-IN-8 is a DHODH inhibitor with antimalarial properties, IC50: 0.13 μM (human), 47.4 μM (P. falciparum); Ki: 0.016 μM (human), 5.6 μM (P. falciparum).Formule :C17H13ClN2O2Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :312.75BRD9185
CAS :BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.Formule :C23H21F6N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :485.42ML-148
CAS :ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM).Formule :C20H21N3ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :319.4hDHODH-IN-5
CAS :hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).Formule :C21H21F3N2O2Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :390.411β-HSD1-IN-1
CAS :11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1, IC50: 52 nM), and used for the treatment of pain.Formule :C18H14ClF4N3ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :399.77hDHODH-IN-4
CAS :hDHODH-IN-4, a potent DHODH inhibitor, has a pIC50 of 7.8 and blocks measles virus replication with a pMIC50 of 8.8.Formule :C21H24N4O2Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :364.44AZD8329
CAS :AZD8329 is an 11β-HSD1 inhibitor that inhibits 11β-HSD2, 17β-HSD1, 17β-HSD3, and can be used to study allergic reactions in humans.Formule :C25H31N3O3Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :421.53ALDH1A1-IN-2
CAS :ALDH1A1-IN-2 is an aldehyde dehydrogenase 1a1 inhibitor with anticancer activity.ALDH1A1-IN-2 may be used in the study of breast cancer, inflammation or obesityFormule :C25H23ClN4O3SDegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :494.99Manitimus
CAS :Manitimus is a potent immunosuppressive drug, and is an inhibitor of dehydroorotate dehydrogenase,.Formule :C15H11F3N2O2Degré de pureté :99.75% - 99.75%Couleur et forme :SolidMasse moléculaire :308.26NCT-506
CAS :NCT-506 is an orally bioavailable inhibitors of aldehyde dehydrogenase 1A1 (ALDH1A1) (IC50 of 7 nM).Formule :C25H23FN4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :478.54Metapramine
CAS :Metapramine, a tricyclic antidepressant, blocks norepinephrine reuptake and is a low-affinity NMDA antagonist.Formule :C16H18N2Degré de pureté :99.03% - 99.67%Couleur et forme :SolidMasse moléculaire :238.33DS18561882
CAS :DS18561882: Potent MTHFD2 inhibitor (IC50=0.0063), inhibits MTHFD1 (IC50=0.57), good oral kinetics.Formule :C28H31F3N4O6SDegré de pureté :98.19% - >99.99%Couleur et forme :SolidMasse moléculaire :608.63PBRM
CAS :PBRM (17β-HSD1-IN-2) is a selective covalent inhibitor of 17β-HSD1, used in breast cancer and endometriosis research.Formule :C28H34BrNO2Degré de pureté :99.56% - 99.59%Couleur et forme :SolidMasse moléculaire :496.48CPS-11
CAS :CPS-11, a Thalidomide analogue, shows potent, broad antitumor activity, especially in multiple myeloma cells.Formule :C14H12N2O5Degré de pureté :99.8% - 99.98%Couleur et forme :SolidMasse moléculaire :288.26IDH2R140Q-IN-2
CAS :IDH2R140Q-IN-2 is an IDH2R140Q inhibitor indicated for the study of acute myeloid leukaemia (AML).Formule :C21H18F6N6ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :484.4ALDH1A3-IN-2
CAS :ALDH1A3-IN-2 is a potent ALDH1A3 inhibitor with an IC50 of 0.30 μM.ALDH1A3-IN-2 has potential for cancer disease research.Formule :C13H17NODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :203.28BMS-823778
CAS :<p>BMS-823778 is a potent inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) for the study of type 2 diabetes.</p>Formule :C18H18ClN3ODegré de pureté :99.39% - 99.75%Couleur et forme :SolidMasse moléculaire :327.81HSD-016
CAS :HSD-016: Oral 11β-HSD1 inhibitor, active in humans, mice, rats (IC50: 11, 1, 8 nM), potential for type 2 diabetes research.Formule :C21H21F7N2O3SDegré de pureté :99.40% - >99.99%Couleur et forme :SolidMasse moléculaire :514.46Qc1
CAS :Qc1 is an inhibitor of threonine dehydrogenase (TDH) inhibitor and can be used in studies about metabolic diseases.Formule :C23H16F3N3O2SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :455.45G6PD activator AG1
CAS :G6PD activator AG1 is a G6PD agonist that promotes G6PD oligomerization to a catalytically competent form.Formule :C24H30N4S2Degré de pureté :98.38% - 99.51%Couleur et forme :SolidMasse moléculaire :438.65Olorofim
CAS :Olorofim（F-901318）is a new selective antifungal compound that inhibits Aspergillus fumigatus DHODH (IC50: 44 nM). Cost-effective and quality-assured.Formule :C28H27FN6O2Degré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :498.55IGP-1
CAS :iGP-1 is a cell-permeable mitochondrial sn-Glycerol 3-phosphate dehydrogenase (mGPDH) inhibitor.Formule :C17H15N3O3Degré de pureté :99.12% - 99.15%Couleur et forme :SolidMasse moléculaire :309.32CM037
CAS :CM037 (A-37) is a selective ALDH1A1 (acetaldehyde dehydrogenase 1A1) inhibitor (IC50; 4.6 µM) with antitumor activity and may be used in studies to eliminateFormule :C21H25N3O3S2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :431.57DSM421
CAS :DSM421 (DSM-421) is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shownFormule :C14H11F5N6Degré de pureté :99.67% - 99.82%Couleur et forme :SolidMasse moléculaire :358.27IMPDH2-IN-2
CAS :IMPDH2-IN-2 is an IMPDH inhibitor with antimicrobial activity and potential anti-tuberculosis activity for the study of inflammation and immune dysfunction.Formule :C21H15Cl2N3O3Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :428.27PHGDH-IN-3
CAS :PHGDH-IN-3, an oral PHGDH blocker with 2.8 μM IC50, may help in cancer research.Formule :C24H18FN3O4S2Degré de pureté :97.24% - 99.1%Couleur et forme :SolidMasse moléculaire :495.55PKUMDL-WQ-2101
CAS :PKUMDL-WQ-2101 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase with anti-tumor activity.Formule :C14H11N3O6Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :317.25hDHODH-IN-7
CAS :hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor.Formule :C21H23FN4ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :366.4315-PGDH-IN-2
CAS :15-PGDH-IN-2 (Compound 2) is an inhibitor of 15-PGDH with an IC50 value of 0.274 nM. This compound is useful for research into hair loss, bone formation, gastric ulcer healing, and dermal wound healing [1].Formule :C16H13NO3S2Couleur et forme :SolidMasse moléculaire :331.41Tetrahydro-11-dehydrocorticosterone
CAS :Tetrahydro-11-dehydrocorticosterone is an inhibitor of 11β-hydroxysteroid dehydrogenase [1].Formule :C21H32O4Couleur et forme :SolidMasse moléculaire :348.48AKR1C3-IN-6
CAS :AKR1C3-IN-6: Strong AKR1C3 inhibitor (IC50: 0.31 μM); weak on AKR1C2 (IC50: 73.23 μM); shows antitumor effects.Formule :C18H15F3N4O3Couleur et forme :SolidMasse moléculaire :392.33Anticancer agent 121
CAS :Anticancer agent 121, a human lactate dehydrogenase A (hLDHA) inhibitor, exhibits potent anticancer activities, suitable for use in anticancer research [1].Formule :C19H18N2O3SCouleur et forme :SolidMasse moléculaire :354.42YG1702
CAS :YG1702, a potent inhibitor specific to ALDH18A1, suppresses the proliferation of MYCN-amplified neuroblastoma (NB) and reduces MYCN expression.Formule :C23H30N2O7SCouleur et forme :SolidMasse moléculaire :478.56MK-0736 hydrochloride
CAS :MK-0736 hydrochloride is a potent and selective 11β-HSD-1 inhibitor.Formule :C23H31ClF3N3O2SCouleur et forme :SolidMasse moléculaire :506.03DHODH-IN-22
CAS :DHODH-IN-22: potent, selective DHODH inhibitor, orally active, IC50: 0.3 nM, for AML research.Formule :C21H21ClF4N6O5Couleur et forme :SolidMasse moléculaire :548.88CHK-336
CAS :CHK-336 (Example 1), an orally active LDHA inhibitor (IC50 <1 nM), suppresses lactate production in mouse hepatocytes and is applicable in hyperoxaluriaFormule :C24H20F2N4O4S2Couleur et forme :SolidMasse moléculaire :530.57MK-0736
CAS :MK-0736 is a potent and selective 11β-HSD-1 inhibitor.Formule :C23H30F3N3O2SCouleur et forme :SolidMasse moléculaire :469.56PF-915275
CAS :PF-915275 inhibits 11βHSD1 in humans (Ki=2.3 nM, EC50=15 nM) and affects cortisone-cortisol conversion in hepatocytes.Formule :C18H14N4O2SDegré de pureté :99.58% - 99.61%Couleur et forme :SolidMasse moléculaire :350.39DHODH-IN-14
CAS :DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.Formule :C15H7F4N3O3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :353.23S07-1066
CAS :S07-1066, an aldo-keto reductase 1C3 (AKR1C3) inhibitor, enhances doxorubicin (DOX) cytotoxicity by selectively inhibiting AKR1C3-mediated reduction of DOX andFormule :C16H11Cl2FO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :325.16hDHODH-IN-1
CAS :hDHODH-IN-1 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an anti-inflammatory effect.Formule :C17H14N2O2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :278.31IDH889
CAS :IDH889: Brain-penetrant, mutant-specific IDH1 inhibitor; selective for IDH1 R132* mutations. IC50: 0.02μM (R132H), 0.072μM (R132C), 1.38μM (wild-type).Formule :C23H25FN6O2Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :436.4811α-Hydroxyprogesterone
CAS :11alpha-Hydroxyprogesterone, an inactive analogue of 11beta-Hydroxyprogesterone, serves as an experimental control. Meanwhile, 11beta-Hydroxyprogesterone functions as a potent inhibitor of 11β-Hydroxysteroid dehydrogenase and activates the human mineralocorticoid receptor in COS-7 cells, with an effective dose (ED)50 of 10 nM.Formule :C21H30O3Couleur et forme :SolidMasse moléculaire :330.468HSD17B13-IN-2
CAS :HSD17B13-IN-2 (compound 1) serves as a potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) with demonstrable activity in cellular experiments [1Formule :C21H23F2NO4Couleur et forme :SolidMasse moléculaire :391.41IDH1 Inhibitor 2
CAS :IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).Formule :C26H22N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.48AZD 4017
CAS :AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).Formule :C22H33N3O3SDegré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :419.58Anticancer agent 122
CAS :Anticancer agent 122, a potent inhibitor of human lactate dehydrogenase A (h LDHA), exhibits significant anticancer activities, rendering it suitable for use inFormule :C18H15ClN2O2SCouleur et forme :SolidMasse moléculaire :358.84α-Pyridoin
CAS :α-Pyridoin (α-pyridoin) is an enediol (enediol) compound that acts as a unique antioxidant.Formule :C12H12N2O2Couleur et forme :SolidMasse moléculaire :216.24HSD17B13-IN-3
CAS :HSD17B13-IN-3 (compound 2) is a potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13), lacking cellular experimental activity [1].Formule :C22H21NO6S2Couleur et forme :SolidMasse moléculaire :459.5415-PGDH-IN-1
CAS :15-PGDH-IN-1: potent oral 15-PGDH inhibitor, IC50=3nM, useful for tissue repair research.Formule :C24H22N4O2Couleur et forme :SolidMasse moléculaire :398.46GSK321
CAS :GSK321 is an IDH1 inhibitor that prevents cytoplasmic glutamine reductive carboxylation.GSK321 is used in the study of leukemia.Formule :C28H28FN5O3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :501.55CB29
CAS :<p>CB29 is a specific inhibitor of aldehyde dehydrogenase 3A1 (ALDH3A1).</p>Formule :C15H15N3O5SDegré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :349.36ALDH2 modulator 1
CAS :<p>ALDH2 modulator 1 is a potent and orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.</p>Formule :C18H18ClFN2O3Degré de pureté :99.68%Couleur et forme :SoildMasse moléculaire :364.8BI-3231
CAS :BI-3231 is a hydroxysteroid 17ß-dehydrogenase 13 HSD17B13 inhibitor that inhibits hHSD17B13 .BI-3231 can be used to study cirrhosis.Formule :C16H14F2N4O3SDegré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :380.37KB-74935
CAS :KB-74935: enzyme inhibitor, mineralocorticoid blocker, treats cholesterol, hypolipidemia, neurological issues, Alzheimer's.Formule :C19H18ClF4N3O3SDegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :479.88HSD17B13-IN-84
CAS :HSD17B13-IN-84 (182) serves as an inhibitor of 17β-Hydroxysteroid dehydrogenases (HSD17B13), exhibiting an IC50 of less than 0.1 μM for Estradiol. It is primarily utilized in the study of NAFLD (Nonalcoholic fatty liver diseases) [1].Formule :C19H12Cl2F3N3O3SMasse moléculaire :490.28Oxamic acid
CAS :Oxamic acid is an LDHA inhibitor, antitumor, induces apoptosis, downregulates EGFR expression, and inhibits cancer stem cell properties and EMT.Formule :C2H3NO3Couleur et forme :SolidMasse moléculaire :89.05HSD17B13-IN-95
CAS :HSD17B13-IN-95 (1) serves as an inhibitor for 17 β-hydroxysteroid dehydrogenase (HSD17B13), exhibiting an IC50 value of <0.1 μM for estradiol. It is applicable in researching nonalcoholic fatty liver disease [1].Formule :C24H16F6N4O4Masse moléculaire :538.40Mirivadelgat
CAS :Mirivadelgat is an activator of aldehyde dehydrogenase 2 (aldehyde dehydrogenase2). It is anticipated to be useful in research related to interstitial lung disease, pulmonary arterial hypertension, and cancer.Formule :C30H34FN3O5Masse moléculaire :535.607DSM705 hydrochloride
DSM705 hydrochloride: potent antimalarial, pyrrole-based DHODH inhibitor effective against Plasmodium, non-toxic to mammalian DHODH.Formule :C19H20ClF3N6OCouleur et forme :SolidMasse moléculaire :440.85Deamino-NAD sodium
CAS :Deamino-NAD sodium, a structural analog of NAD+, serves as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH) in glycolysis. It exhibits a Km of 2300 pm and a Kd of 112 pm.Formule :C21H25N6NaO15P2Couleur et forme :SolidMasse moléculaire :686.39GSK864
CAS :GSK864 is an inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant. GSK864 inhibits IDH1 mutants R132C, R132H, and R132G (IC50: 8.8, 15.2, and 16.6 nM).Formule :C30H31FN6O4Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :558.6T-3764518
CAS :T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).Formule :C20H17F6N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.37BRD7539
CAS :BRD7539B: PfDHODH inhibitor, IC50 0.033μM; selective vs HsDHODH, IC50 >50μM.Formule :C23H22FN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :391.44BI-4916
CAS :BI-4916 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor that inhibits SSP and reduces cancer cell migration.Formule :C23H24Cl2N2O6SDegré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :527.427-Hydroxy-4-phenylcoumarin
CAS :7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.Formule :C15H10O3Couleur et forme :SolidMasse moléculaire :238.238AXKO-0046
AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor.Formule :C25H33N3Couleur et forme :SolidMasse moléculaire :375.55Etamicastat
CAS :Etamicastat can be used in the research of cardiovascular diseases.Formule :C14H15F2N3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :311.3511β-HSD2-IN-2
CAS :<p>11β-HSD2-IN-2 (compound 3) is a selective 17β-HSD2 (17β-hydroxysteroid dehydrogenase type 2) inhibitor with an IC50 of 300 nM, studying osteoporosis.</p>Formule :C22H21NO2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :331.41PDHK-IN-3
PDHK-IN-3 (compound 7) is a potent inhibitor of pyruvate dehydrogenase kinase(PDHK) with IC50s of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively [1].Formule :C17H16N2O2Couleur et forme :SolidMasse moléculaire :280.32MDH1/2-IN-1
CAS :<p>MDH1/2-IN-1 is an MDH1/2 inhibitor with IC50 values of 1.07 nM and 1.06 nM, respectively. It suppresses mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 exhibits significant antitumor potential and offers new avenues for developing drugs targeting cancer metabolism.</p>Formule :C25H33NO4Couleur et forme :SolidMasse moléculaire :411.534FXR/HSD17B13 modulator 1
CAS :FXR/HSD17B13 modulator 1 (compound 6) is an effective modulator of FXR/HSD17B13, playing a significant role in studies related to metabolic dysfunction-associated steatohepatitis (MASH).Formule :C26H19Cl2NO4Couleur et forme :SolidMasse moléculaire :480.339RORγt/DHODH-IN-1
CAS :RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significantFormule :C24H26ClF6N3O3SCouleur et forme :SolidMasse moléculaire :585.99Indoluidin E
Indoluidin E selectively inhibits DHODH and has an inhibitory effect on cancer cell growth.Formule :C28H30N4O2Couleur et forme :SolidMasse moléculaire :454.56PDHK-IN-4
PDHK-IN-4 inhibits PDHK2 (IC50: 0.0051 μM) & PDHK4 (IC50: 0.0122 μM), with potential for cancer research.Formule :C24H25N5O3Couleur et forme :SolidMasse moléculaire :431.49hDHODH-IN-10
hDHODH-IN-10: selective oral inhibitor of hDHODH (IC50: 10.9 nM); blocks cancer cell growth, aids cancer research.Formule :C21H15ClF4N2O4Couleur et forme :SolidMasse moléculaire :470.8PDHK-IN-5
PDHK-IN-5, potent PDHK2 (0.006 μM IC50) & PDHK4 (0.0329 μM IC50) inhibitor, may be explored for cancer and diabetes treatment.Formule :C30H31N5O2Couleur et forme :SolidMasse moléculaire :493.6PHGDH-IN-2
PHGDH-IN-2: potent PHGDH inhibitor, IC50=5.2μM; hinders PHGDH cancer cell growth & serine synthesis in MDA-MB-468.Formule :C22H20N4O3SCouleur et forme :SolidMasse moléculaire :420.48AKR1C3-IN-7
AKR1C3-IN-7 (Compound 13) is an effective and selective AKR1C3 inhibitor (IC50=0.19 μM). AKR1C3-IN-7 has antitumor activity.Formule :C24H20N2O4Couleur et forme :SolidMasse moléculaire :400.43AKR1C3-IN-8
AKR1C3-IN-8 (Compound 5) is an effective and selective AKR1C3 inhibitor (IC50=0.069 μM). AKR1C3-IN-8 has antitumor activity.Formule :C23H20N4O3Couleur et forme :SolidMasse moléculaire :400.43(6S)-CP-470711
CAS :(6S)-CP-470711 (Compound 8) acts as an inhibitor of sorbitol dehydrogenase (SDH) in both humans and rats, exhibiting inhibitory concentrations (IC50) of 19 nM and 27 nM, respectively. Additionally, (6S)-CP-470711 has been shown to ameliorate diabetes in rats induced by Streptozotocin.Formule :C18H26N6O2Couleur et forme :SolidMasse moléculaire :358.44LDHA-IN-5
CAS :LDHA-IN-5 is a novel and potent inhibitor targeting both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), designed for the treatment of primaryFormule :C27H22FN7O6S3Couleur et forme :SolidMasse moléculaire :655.7HSD17B13-IN-28
CAS :HSD17B13-IN-28 (compound 47) is a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), with an IC50 of < 0.1 μM using estradiol as a substrate. HSD17B13-IN-28 plays an important role in nonalcoholic fatty liver diseases (NAFLDs), including NASH (nonalcoholic steatohepatitis) [1].Formule :C23H16Cl2FN3O3Couleur et forme :SolidMasse moléculaire :472.3HSD17B13-IN-17
CAS :HSD17B13-IN-17 (compound 9) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13). It demonstrates inhibitory efficacy with IC50 values of ＜0.1 μM for estradiol and ＜1 μM for Leukotriene B3 as substrates. This compound is significant in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Formule :C20H16ClFN2O3SMasse moléculaire :418.87HSD17B13-IN-19
CAS :HSD17B13-IN-19 (compound 16) acts as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting IC50 values under 0.1 μM and under 1 μM when using estradiol and Leukotriene B3 as substrates, respectively. This compound is crucial in the treatment of nonalcoholic fatty liver diseases (NAFLDs), such as nonalcoholic steatohepatitis (NASH) [1].Formule :C23H23FN2O4SMasse moléculaire :442.5HSD17B13-IN-44
CAS :HSD17B13-IN-44 (Compound 23) functions as an inhibitor targeting hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of < 0.1 μM against estradiol. This compound is applicable in the study of liver diseases or metabolic disorders [1].Formule :C18H14FNO5S2Masse moléculaire :407.4417β-HSD1-IN-1
17β-HSD1-IN-1 (Compound 1) can be used in the non-small cell lung cancer (NSCLC) research.Formule :C21H21NO3Couleur et forme :SolidMasse moléculaire :335.4HSD17B13-IN-30
CAS :HSD17B13-IN-30 (compound 64) serves as a potent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), exhibiting an IC 50 value of less than 0.1 μM? with estradiol? as substrates. This compound is significantly implicated in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Formule :C24H16Cl2F3N3O4Couleur et forme :SolidMasse moléculaire :538.315-epi-PGE1
CAS :15-epi-PGE1 (15R-Prostaglandin E1; 15-Epiprostaglandin E1), a stereoisomer of PGE1, exhibits reduced biological activity [2]. This compound acts as a non-competitive inhibitor of human placental 15-Hydroxyprostaglandin dehydrogenase (15-PGDH), with an inhibitory concentration 50 (IC50) value of 170 μM [1].Formule :C20H34O5Masse moléculaire :354.48HSD17B13-IN-32
CAS :HSD17B13-IN-32 (Compound 67) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤0.1 μM for estradiol. It can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) [1].Formule :C23H15Cl2N5O3Masse moléculaire :480.3HSD17B13-IN-40
CAS :HSD17B13-IN-40 (compound 6) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of less than 0.1 μM using estradiol as substrates. This compound is significant in the treatment of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Formule :C23H14Cl2F3N3O3Masse moléculaire :508.28RORγt/DHODH-IN-3
RORγt/DHODH-IN-3 (compound (S)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.098 μM) and DHODH (IC50: 0.432 μM).RORγt/DHODH-IN-1 hasFormule :C24H26ClF6N3O3SCouleur et forme :SolidMasse moléculaire :585.99Etamicastat hydrochloride
CAS :<p>Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension.</p>Formule :C14H16ClF2N3OSDegré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :347.81CP-642931
CAS :CP-642931 (Sorbitol dehydrogenase-IN-1) is a sorbitol dehydrogenase inhibitor used in the study of diabetes mellitus and cardiovascular disease.Formule :C17H25N7ODegré de pureté :99.67% - >99.99%Couleur et forme :SolidMasse moléculaire :343.43GNE-140 racemate
CAS :GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.Formule :C25H23ClN2O3S2Couleur et forme :SolidMasse moléculaire :499.04(S)-GNE-140
CAS :(S)-GNE-140 is the less active enantiomer of GNE-140.Formule :C25H23ClN2O3S2Couleur et forme :SolidMasse moléculaire :499.0511β-HSD1-IN-8
CAS :11β-HSD1-IN-8 is a useful organic compound for research related to life sciences. The catalog number is T65743 and the CAS number is 386704-15-0.Formule :C10H8F3NO3Couleur et forme :SolidMasse moléculaire :247.173
