Déshydrogénase
Les déshydrogénases sont des enzymes impliquées dans les réactions d'oxydoréduction des voies métaboliques, jouant un rôle central dans la production d'énergie et la respiration cellulaire. Ces enzymes sont cruciales pour des processus tels que le cycle de l'acide citrique, la glycolyse et l'oxydation des acides gras. Les inhibiteurs de déshydrogénases sont des outils importants dans l'étude des maladies métaboliques, du cancer et du stress oxydatif. Chez CymitQuimica, nous proposons une sélection complète d'inhibiteurs de déshydrogénases pour soutenir vos recherches en métabolisme, biologie du cancer et biochimie.
303 produits trouvés pour "Déshydrogénase"
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MTHFD2-IN-2
MTHFD2-IN-2 (compound 13) serves as a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].Formule :C22H18N4O5Couleur et forme :SolidMasse moléculaire :418.4WQQ-345
WQQ-345, a BCAT1 inhibitor, exhibits an IC50 of 10.8 mM. In 67R cells, it reduces α-KG levels and upregulates H3K27me3 expression while downregulating the expression of glycolytic enzymes (PFKP and LDHA), leading to impaired glycolytic activity. Additionally, WQQ-345 demonstrates tumor-suppressive activity in a 67R subcutaneous xenograft model.Formule :C10H17NO2Couleur et forme :SolidMasse moléculaire :183.25PDK-IN-1
CAS :PDK-IN-1, a PDK inhibitor, IC50: 0.03μM (PDK1), 0.1μM (HSP90), reduces tumor mass.Formule :C20H16BrN7OCouleur et forme :SolidMasse moléculaire :450.29LDHA-IN-3
CAS :LDHA-IN-3 is a potent selenobenzene-based LDHA inhibitor with a 145.2 nM IC50, useful in cancer research.Formule :C13H9F3SeDegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :301.17Ref: TM-T39805
1mg52,00€5mg113,00€1mL*10mM (DMSO)124,00€10mg177,00€25mg371,00€50mg517,00€100mg707,00€200mg973,00€Methyl Diethyldithiocarbamate
CAS :Methyl diethyldithiocarbamate, a disulfiram metabolite, inhibits rat ALDH (ID50=15.5mg/kg) and affects MAP and heart rate during ethanol challenge.Formule :C6H13NS2Couleur et forme :SolidMasse moléculaire :163.311β-HSD1 inibitor 17
CAS :11β-HSD1 inibitor 17 is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).Formule :C22H20F3N3O2SDegré de pureté :99.26% - 99.72%Couleur et forme :SoildMasse moléculaire :447.47Crelosidenib
CAS :Crelosidenib is a potent and selective mutant IDH inhibitor for IDH1 R132H, IDH1 R132C, IDH2 R140Q, and IDH2 R172K mutases.Formule :C28H36N6O3Degré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :504.62IGUANA-1 free base
CAS :IGUANA-1: selective ALDH1 B1 inhibitor, IC50=30 nM, hinders SW480 cell growth with IC50=2.46/0.39 μM in adherent/spheroid forms, for cancer research.Formule :C26H24ClN3O2Couleur et forme :SolidMasse moléculaire :445.94Octanoyl Coenzyme A (sodium salt)
Octanoyl Coenzyme A (sodium salt) inhibits citrate synthase and glutamate dehydrogenase with an IC50 of 0.4–1.6 mM.Formule :C29H49N7NaO17P3SCouleur et forme :SolidMasse moléculaire :915.7111β-HSD1 inibitor 19
CAS :3-chloro-4-sulfonyl-Benzonitrile inhibits hHSD1/mHSD1, IC50: 16nM/10nM.Formule :C19H16ClF4N3O2SDegré de pureté :99.58%Couleur et forme :SoildMasse moléculaire :461.8617β-HSD10-IN-1
CAS :17β-HSD10-IN-1 is a 17β-hydroxysteroid dehydrogenase type 10 inhibitor with blood-brain permeability and potency for the study of Alzheimer's disease.Formule :C16H13ClN4O3SDegré de pureté :98.47%Couleur et forme :SoildMasse moléculaire :376.82hDHODH-IN-17
hDHODH-IN-17 (Compound 10) is an inhibitor of human dihydroorotate dehydrogenase (hDHODH), with an IC50 value of 0.188 μM. It fits well with the hDHODH active site and interacts effectively with amino acid residues. hDHODH-IN-17 is a potential broad-spectrum antiviral drug.DHODH-IN-23
CAS :DHODH-IN-23 is a DHODH inhibitor with oral activity. DHODH-IN-23 is often used in cancer research.
Formule :C24H21ClFNO4Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :441.88MTHFD2-IN-4 sodium
MTHFD2-IN-4 sodium, a potent inhibitor of MTHFD2 and a tricyclic coumarin derivative, is applicable in cancer research [1].Formule :C26H21F6N2NaO5Couleur et forme :SolidMasse moléculaire :578.44PTOTAC HSD17B13 degrader 1
CAS :PTOTAC HSD17B13 Degrader 1, a PROTAC designed to target 17β-HSD 13 (HSD17B13), incorporates several key components. These include the PROTAC target protein ligand HSD17B13 Degrader 2, the PROTAC Linker tert-Butyl 5-bromoisoindoline-2-carboxylate, and the E3 ubiquitin ligase ligand E3 Ligase Ligand 31. Notably, the conjugate formed by the E3 ubiquitin ligase ligand and the linker is recognized as E3 Ligase Ligand-linker Conjugate 114.Formule :C45H45ClF3N7O5Couleur et forme :SolidMasse moléculaire :856.33D-Lactate dehydrogenase
CAS :D-LDH is an oxidoreductase turning D-lactate into pyruvate, using NAD+/NADP+; prevalent in bacteria and fungi, key for biochemical research.Couleur et forme :SolidHSD17B13-IN-71
CAS :HSD17B13-IN-71 (Compound 149), an effective inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), displays potent activity with an IC 50 value of ≤ 0.1 μM against estradiol. This compound is applicable in the study of various disorders including liver diseases, metabolic diseases, and cardiovascular conditions such as NAFLD or NASH, in addition to drug-induced liver injury (DILI) [1].Formule :C25H16Cl2F5N3O4Couleur et forme :SolidMasse moléculaire :588.31MTHFD2-IN-1
MTHFD2-IN-1 (compound 12) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].Formule :C24H21NO6Couleur et forme :SolidMasse moléculaire :419.43LDHA-IN-8
CAS :LDHA-IN-8, an inhibitor, inhibits the proliferation of pancreatic and lung cancer cells, decreasing the intracellular lactate content and increasing ROS levels.Formule :C15H14N4O2Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :282.3Necroptosis-IN-3
CAS :Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis.Formule :C12H17NOSDegré de pureté :99.85%Couleur et forme :SoildMasse moléculaire :223.33DSM1465
DSM1465 (Compound 82) is a potent and selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM. It inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM and demonstrates significant in vivo efficacy in humanized P. falciparum mouse models.Formule :C17H12ClF6N5O2Couleur et forme :SolidMasse moléculaire :467.753SCD1 inhibitor-3
CAS :SCD1 inhibitor-3 (ML-270) is a highly effective and orally available compound that inhibits SCD1 with remarkable safety.Formule :C19H16FN7O2Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :393.37Ref: TM-T38683
1mg87,00€5mg177,00€1mL*10mM (DMSO)195,00€10mg281,00€25mg480,00€50mg692,00€100mg973,00€D34-919
CAS :D34-919 is a potent inhibitor of the ALDH1A3-PKM2 interaction, effectively inhibiting the ALDH1A3-mediated tetramerization enhancement of PKM2. Treatment mediated by D34-919 both in vitro and in vivo enhances and restores apoptosis and sensitivity in glioblastoma (GBM) cells induced by radiochemotherapy.Formule :C22H27N5OSCouleur et forme :SolidMasse moléculaire :409.55BMS-770767
CAS :BMS-770767 is a novel 11-betahydroxysteroid dehydrogenase type I (11ß-HSD1) inhibitor.Formule :C19H18ClN3O2Couleur et forme :SolidMasse moléculaire :355.82HSD17B13-IN-89
CAS :HSD17B13-IN-89 (206) acts as an inhibitor of 17β-Hydroxysteroid dehydrogenases (HSD17B13) and demonstrates potent activity with an IC 50 value of less than 0.1 μM for Estradiol. It is commonly utilized in research related to Nonalcoholic Fatty Liver Diseases (NAFLD) [1].Formule :C23H13Cl2F4N3O3Couleur et forme :SolidMasse moléculaire :526.27PDK-IN-2
PDK-IN-2 (Compound 1F), with an IC50 of 68 nM, is a potent PDK inhibitor that downregulates the expression of PDK1 and PDK4 in cells.Formule :C17H23AsCl2N2O2S2Couleur et forme :SolidMasse moléculaire :497.33DSM705
CAS :DSM705: Pyrrole-based, potent nanomolar Plasmodium DHODH inhibitor with strong antimalarial efficacy; spares mammalian DHODH.Formule :C19H19F3N6OCouleur et forme :SolidMasse moléculaire :404.397Glucose dehydrogenase
CAS :Glucose dehydrogenase (GDH) is a redox enzyme typically occurring as dimeric or tetrameric proteins. GDH utilises external NAD or NADP to oxidise glucose .Couleur et forme :SolidALDH1A2-IN-1
CAS :ALDH1A2-IN-1 is a reversible active-site-directed ALDH1A2 inhibitor preventing spermatogenesis, useful in male contraceptive research.Formule :C21H26N4O4SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :430.52Ref: TM-T39675
1mg50,00€5mg110,00€1mL*10mM (DMSO)126,00€10mg172,00€25mg344,00€50mg537,00€100mg780,00€200mg1.054,00€BMS-566419
CAS :BMS-566419: Acridinone-based IMPDH inhibitor for studying graft rejection.Formule :C28H30FN5O2Couleur et forme :SolidMasse moléculaire :487.57Ketogestin
CAS :Ketogestin is a progestational steroid and an inhibitor of enzyme 11β-hydroxysteroid dehydrogenase, and a weak negative modulator of GABAA receptors.Formule :C21H28O3Degré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :328.45Aldehyde dehydrogenase (NAD(P))
CAS :ALDH catalyzes oxidation of aldehydes to acids, reducing NAD(P) to NAD(P)H, helping alleviate aldehyde stress.Couleur et forme :SolidDSM265
CAS :DSM265 (PfSPZ) is a dihydroorotic acid dehydrogenase inhibitor with antimalarial activity.DSM265 can be used for the treatment of malaria infections.Formule :C14H12F7N5SDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :415.332-Bromoacetamide
CAS :2-Bromoacetamide (α-Bromoacetamide) is a class of disinfection by-products that exhibit developmental toxicity in animals.Formule :C2H4BrNODegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :137.96DSM502
CAS :DSM502 DSM502 is a dihydroorotic acid dehydrogenase (DHODH) inhibitor with antimalarial activity that inhibits Plasmodium DHODH and can be used as a lead for antimalarial compounds.Formule :C16H16F3N3ODegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :323.31Ref: TM-T40087
1mg82,00€5mg177,00€1mL*10mM (DMSO)197,00€10mg285,00€25mg583,00€50mg853,00€100mg1.161,00€PKUMDL-WQ-2201
CAS :PKUMDL-WQ-2201 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) with Anti-tumor Activity, it binds to site II.Formule :C15H14ClN3O3SCouleur et forme :SolidMasse moléculaire :351.81ALDH1A3-IN-1
CAS :ALDH1A3-IN-1 (Compound 14) is a potent inhibitor of ALDH1A3 which can be used in prostate cancer research (IC50 = 0.63 μM; Ki = 0.46 μM) [1].Formule :C13H18BrNOCouleur et forme :SolidMasse moléculaire :284.19Trilostane-d3
Trilostane-d3 is a deuterium-substituted isotope-labeled compound of Trilostane, usually used as a quantitative tracer. Trilostane is an inhibitor of 3β-HSD.Formule :C20H24D3NO3Couleur et forme :SolidMasse moléculaire :332.45PS10
CAS :PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2 and significantly increases the activity of the pyruvate dehydrogenase complex.Formule :C14H13NO6SDegré de pureté :98.51% - 99.01%Couleur et forme :SolidMasse moléculaire :323.32ALDH3A1-IN-1
CAS :ALDH3A1-IN-1 (Compound 18) is a potent inhibitor of ALDH3A1 with IC50 of 1.61 μM, outperforms DEAB in prostate cancer cells.Formule :C13H18N2O3Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :250.29XTT sodium
CAS :XTT sodium is a cell viability detector that can be metabolized by mitochondrial dehydrogenase in live cells to produce a highly colored formic acid product.Formule :C22H16N7NaO13S2Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :673.52ABT-384
CAS :ABT-384 is a high-affinity, selective 11β-HSD1 inhibitor capable of suppressing hepatic and central nervous system HSD-1 activity for depressive disorder.Formule :C25H34F3N5O2Degré de pureté :99.863%Couleur et forme :SolidMasse moléculaire :493.58Ref: TM-T26528
1mg109,00€5mg260,00€1mL*10mM (DMSO)281,00€10mg432,00€25mg802,00€50mg1.243,00€100mg1.935,00€200mg2.592,00€4-Isopropoxybenzaldehyde
CAS :ALDH1A3-IN-3 inhibits ALDH1A3 (IC50: 0.26 μM), acts on ALDH3A1, and is used in prostate cancer research.Formule :C10H12O2Degré de pureté :99.00%Couleur et forme :SolidMasse moléculaire :164.2Brequinar
CAS :Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.Formule :C23H15F2NO2Degré de pureté :99.1% - 99.57%Couleur et forme :SolidMasse moléculaire :375.37VER-246608
CAS :VER-246608 inhibits PDK (IC50: 35-91 nM), boosts PDC, reduces glycolysis, causes cancer cell cytostasis, and enhances doxorubicin effects.Formule :C28H23ClF2N4O4Degré de pureté :98.5%Couleur et forme :SolidMasse moléculaire :552.96Ref: TM-T17224
1mg50,00€2mg71,00€5mg105,00€1mL*10mM (DMSO)130,00€10mg166,00€25mg313,00€50mg475,00€100mg692,00€BVT 2733
CAS :BVT 2733 is a new, non-steroidal, isoform-specific inhibitor of 11β-HSD1.Formule :C17H21ClN4O3S2Degré de pureté :98% - 99.64%Couleur et forme :SolidMasse moléculaire :428.96Vidofludimus hemicalcium
CAS :Vidofludimus hemicalcium: oral DHODH inhibitor, FXR modulator, for autoimmune and fatty liver research.Formule :C20H18FNO4CaCouleur et forme :SolidMasse moléculaire :375.4NCT-503
CAS :NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with no activity against other dehydrogenases. NCT-503 has antitumor activity. Cost-effective and quality-assured.Formule :C20H23F3N4SDegré de pureté :98.91% - 99.84%Couleur et forme :SolidMasse moléculaire :408.48Ref: TM-T4213
2mg39,00€5mg59,00€1mL*10mM (DMSO)65,00€10mg95,00€25mg177,00€50mg321,00€100mg477,00€200mg667,00€(E/Z)-Teriflunomide
CAS :(E/Z)-Teriflunomide (Aubagio), a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.Formule :C12H9F3N2O2Degré de pureté :99.49% - 99.76%Couleur et forme :White SolidMasse moléculaire :270.21AGI-6780
CAS :AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.Formule :C21H18F3N3O3S2Degré de pureté :98.19% - 99.7%Couleur et forme :SolidMasse moléculaire :481.51Ref: TM-T1809
1mg34,00€2mg49,00€5mg74,00€1mL*10mM (DMSO)80,00€10mg113,00€25mg208,00€50mg371,00€100mg557,00€500mg1.198,00€
