Phospholipase
Les phospholipases sont un groupe d'enzymes qui hydrolysent les phospholipides en acides gras et autres substances lipophiles, jouant un rôle crucial dans la biologie des membranes et la génération de molécules de signalisation. Les inhibiteurs des phospholipases sont utilisés pour étudier leur rôle dans les maladies inflammatoires, les troubles cardiovasculaires et la neurodégénérescence. Ces inhibiteurs sont également précieux pour explorer les voies de signalisation lipidique et leurs implications dans les mécanismes des maladies. Chez CymitQuimica, nous fournissons une variété d'inhibiteurs de phospholipases pour soutenir vos recherches en inflammation, métabolisme lipidique et signalisation cellulaire.
82 produits trouvés pour "Phospholipase"
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Omeprazole
CAS :<p>Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor.</p>Formule :C17H19N3O3SDegré de pureté :98.43% - 98.48%Couleur et forme :White SolidMasse moléculaire :345.42Niflumic acid
CAS :<p>Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.</p>Formule :C13H9F3N2O2Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :282.22Tris(2,4-di-tert-butylphenyl)phosphate
CAS :<p>Tris(2,4-di-tert-butylphenyl)phosphate (TDTBPP) inhibits secretory phospholipase A2 (sPLA2) with anti-inflammatory effect. Cost-effective and quality-assured.</p>Formule :C42H63O4PDegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :662.92Lp-PLA2-IN-1
CAS :<p>Lp-PLA2-IN-1 suppresses Lp-PLA2, aiding in treating atherosclerosis and Alzheimer's.</p>Formule :C21H17F5N4O3Degré de pureté :99.60%Couleur et forme :SolidMasse moléculaire :468.38Lansoprazole
CAS :<p>Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON</p>Formule :C16H14F3N3O2SDegré de pureté :99.18% - 99.84%Couleur et forme :White Crystalline PowderMasse moléculaire :369.36ML349
CAS :<p>ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM).</p>Formule :C23H22N2O4S2Degré de pureté :99.59% - 99.88%Couleur et forme :SolidMasse moléculaire :454.561-Myristoyl-2-Linoleoyl-sn-glycero-3-PC
CAS :<p>1-Myristoyl-2-Linoleoyl-sn-glycero-3-PC is a phospholipid identified in human plasma, characterized by the presence of Myristic acid and Linoleic acid at the sn-1 and sn-2 positions, respectively.</p>Formule :C40H76NO8PCouleur et forme :SolidMasse moléculaire :730.01VU533
CAS :<p>VU533 is a NAPE-PLD activator, EC50=0.30 µM, boosts macrophage activity, potential in cardiometabolic diseases.</p>Formule :C21H22FN3O3S2Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :447.55AACOCF3
CAS :<p>AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid.</p>Formule :C21H31F3ODegré de pureté :99% - 99%Couleur et forme :Yellow LiquidMasse moléculaire :356.47A3373
CAS :<p>A3373 is a novel inhibitor targeting both Phospholipase D1 (PLD1) and Phospholipase D2 (PLD2), demonstrating half maximal inhibitory concentrations (IC50) of</p>Formule :C17H9F7N2ODegré de pureté :98%Couleur et forme :SoildMasse moléculaire :390.26Compound 48/80 trihydrochloride
CAS :<p>Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺和甲醛发生缩合反应后的混合物。Compound 48/80 trihydrochloride 是一种肥大细胞 (mast cell) 脱颗粒剂和组胺 (histamine) 释放剂。Compound 48/80 trihydrochloride 对人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性有抑制作用。</p>Formule :C32H48Cl3N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :629.1ASM-IN-3
CAS :<p>ASM-IN-3 (Compound 21b) is a selective acid sphingomyelinase (ASM) inhibitor that can penetrate the blood-brain barrier, with an IC50 of 3.37 μM against purified human ASM. By inhibiting ASM activity in the hippocampus and promoting neurogenesis, ASM-IN-3 alleviates depressive-like behavior in reserpine-induced depressive rats.</p>Formule :C17H13ClN2O4Couleur et forme :SolidMasse moléculaire :344.75BIRM 271
CAS :<p>BIRM 271 is a novel arachidonic acid release inhibitor that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils.</p>Formule :C21H25N3ODegré de pureté :99.64%Couleur et forme :SoildMasse moléculaire :335.44SB-435495
CAS :<p>SB-435495 is a compound characterized by its potent, selective, reversible, and non-covalent inhibition of Lp-PLA2, demonstrating an IC50 value of 0.06 nM.</p>Formule :C38H40F4N6O2SDegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :720.82DPTIP hydrochloride
CAS :<p>DPTIP hydrochloride is a potent inhibitor of neutral sphingomyelinase (N-SMase 2) that can cross the blood-brain barrier. It acts as an exosome inhibitor with an IC50 value of 30 nM.</p>Formule :C21H19ClN2O3SCouleur et forme :SolidMasse moléculaire :414.91PLA2-IN-1
<p>PLA2-IN-1 (Compound 7) is a potent and selective inhibitor of phospholipase A (PLA2) with an IC50 value of 1 nM. It effectively inhibits PLA2-induced coagulation disorders in vitro and shows potential for use as an antidote for snake bites caused by cobra venom.</p>Couleur et forme :Odour SolidnSMase2-IN-1
<p>nSMase2-IN-1 is an orally active inhibitor of Neutral sphingomyelinase 2 (nSMase2) with a potent IC50 value of 0.13 ± 0.06 μM.</p>Formule :C12H17N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :247.3LEI110
CAS :<p>LEI110 inhibits PLA2G16 and HRASLS enzymes, Ki 20 nM, selectively targets related thiol hydrolases.</p>Formule :C25H23F3N2O3Degré de pureté :98.66% - 98.8%Couleur et forme :SolidMasse moléculaire :456.46A4333
<p>A4333, a biotinylated derivative of A3373, selectively inhibits Phospholipase D1 (PLD1) while sparing PLD2.</p>Degré de pureté :98%Couleur et forme :Odour SolidDPTIP
CAS :<p>DPTIP is an effective inhibitor of neutral sphingomyelinase 2 with an IC50 value of 30 nM.</p>Formule :C21H18N2O3SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :378.44BMS493
CAS :<p>BMS493 is an inverse agonist of RAR that inhibits retinoic acid-induced differentiation and inhibits the increase in phospholipase A2 activity.</p>Formule :C29H24O2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :404.5Bromoenol lactone
CAS :<p>NeurokininBromoenol lactone ((6E)-Bromoenol lactone) is an iPLA2β and serine protease inhibitor that attenuates nicotine-induced breast cancer cell proliferation.</p>Formule :C16H13BrO2Couleur et forme :SolidMasse moléculaire :317.18PACOCF3
CAS :<p>PACOCF3, a phospholipase A2 inhibitor, hinders Ca2+ signaling with an IC50 of 3.8 μM in renal cells.</p>Formule :C17H31F3ODegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :308.42MJ33 lithium salt
CAS :<p>MJ33 lithium salt is an inhibitor of NADPH oxidase type 2-mediated ROS generation, inhibits PLA2 activity, and can be used to study acute lung injury.</p>Formule :C22H43F3LiO6PDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :498.48LEI-401
CAS :<p>LEI-401 is a NAPE-PLD inhibitor.LEI-401 reduces the level of n-acyl ethanolamines in the brain of free-ranging mice and modulates their emotional behaviour.</p>Formule :C24H31N5O2Degré de pureté :99.79% - 99.79%Couleur et forme :SolidMasse moléculaire :421.54ML-211
CAS :<p>ML-211 is a carbamate-based dual inhibitor of LYPLA1 (IC50 = 17 nM) and the related LYPLA2 (IC50 = 30 nM)</p>Formule :C25H30N4O2Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :418.53N-(p-amylcinnamoyl) Anthranilic Acid
CAS :<p>N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker.</p>Formule :C21H23NO3Degré de pureté :99.35% - 99.67%Couleur et forme :SolidMasse moléculaire :337.41Rhamnetin
CAS :<p>Rhamnetin (beta-Rhamnocitrin), a quercetin derivative found in Coriandrum sativum, has antioxidant and anti-inflammatory activities.</p>Formule :C16H12O7Degré de pureté :99.61% - 99.905%Couleur et forme :SolidMasse moléculaire :316.26hnps-PLA Inhibitor
CAS :<p>Hnps-PLA Inhibitor is an inhibitor of human nonpancreatic secretory Phospholipase A (hnps-PLA).</p>Formule :C21H21N3O4Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :379.41Varespladib
CAS :<p>Varespladib (LY315920) inhibits hnsPLA2 effectively (IC50=7 nM), studied for sickle cell, VOC, and acute coronary syndrome.</p>Formule :C21H20N2O5Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :380.39BAPTA
CAS :<p>BAPTA is a neuroprotective agent in cerebral ischemia, acting as an intercellular Ca2+ chelator.</p>Formule :C22H24N2O10Degré de pureté :96.28% - ≥95%Couleur et forme :White SolidMasse moléculaire :476.43Rapanone
CAS :<p>Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.</p>Formule :C19H30O4Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :322.44U-73343
CAS :<p>U-73343 is an inactive analog of U-73122 and can be used as a negative control. U-73122 dose-dependently inhibits acid secretion irrespective of the stimulant.</p>Formule :C29H42N2O3Degré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :466.66Tanshinone I
CAS :<p>Tanshinone I (Tanshinone A), an active principle isolated from the herbal medicine Salvia miltiorrhiza, displays cytotoxicity against tumor cells.</p>Formule :C18H12O3Degré de pureté :98.31% - 98.70%Couleur et forme :SolidMasse moléculaire :276.29ML348
CAS :<p>ML348 (GNF-Pf-1127) is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM).</p>Formule :C18H17ClF3N3O3Degré de pureté :99% - 99.88%Couleur et forme :SolidMasse moléculaire :415.79FIPI
CAS :<p>FIPI, a halopemide derivative, strongly blocks PLD1 and PLD2 (IC50s: 25 nM, 20 nM) and hinders PLD-mediated cell activity.</p>Formule :C23H24FN5O2Degré de pureté :97.21% - 98.68%Couleur et forme :SolidMasse moléculaire :421.47ML-298
CAS :<p>ML-298 (CID53393915) is a potent, specific inhibitor of Phospholipase D2 (PLD2, IC50 of 355 nM).</p>Formule :C22H23F3N4O2Degré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :432.441-Naphthaleneacetic acid
CAS :<p>1-Naphthaleneacetic acid, an auxin-like synthetic plant hormone, boosts rooting in horticulture.</p>Formule :C12H10O2Degré de pureté :98.67%Couleur et forme :Needles From Water White To Off White CrystalsMasse moléculaire :186.21ST271
CAS :<p>ST271 is an effective protein tyrosine kinase (PTK) inhibitor.</p>Formule :C16H20N2O2Degré de pureté :98.94%Couleur et forme :SolidMasse moléculaire :272.34Darapladib
CAS :<p>Darapladib (SB-480848) is a lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with an IC50 value of 0.25 nM.Cost-effective and quality-assured.</p>Formule :C36H38F4N4O2SDegré de pureté :99.82% - >99.99%Couleur et forme :SolidMasse moléculaire :666.77RHC 80267
CAS :<p>RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)</p>Formule :C20H34N4O4Degré de pureté :99.54%Couleur et forme :White SolidMasse moléculaire :394.51GW4869
CAS :<p>GW4869 (GW69A) is a selective and non-competitive inhibitor of neutral sphingomyelinase N-SMase (IC50=1 μM).</p>Formule :C30H30Cl2N6O2Degré de pureté :98.12% - 98.47%Couleur et forme :SolidMasse moléculaire :577.5RPI-1
CAS :<p>RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.</p>Formule :C17H15NO4Degré de pureté :98.91% - ≥95%Couleur et forme :SolidMasse moléculaire :297.311-Linoleoyl Glycerol
CAS :<p>1-Linoleoyl Glycerol (Monolinolein) is fatty acid glycerol that has been isolated from Saururus Chinensis roots.</p>Formule :C21H38O4Degré de pureté :98.95% - 99.56%Couleur et forme :Less Oil Colourless OilMasse moléculaire :354.52ONO-RS-082
CAS :<p>ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor. </p>Formule :C21H22ClNO3Degré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :371.86AA26-9
CAS :<p>AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.</p>Formule :C7H10N4ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :166.181-Naphthaleneacetic acid potassium salt
CAS :<p>1-Naphthaleneacetic acid potassium salt (1-NAA Potassium Salt) is a synthetic phytogrowth hormone that promotes plant growth and a PLA2 inhibitor.</p>Formule :C12H9O2·KDegré de pureté :97.68%Couleur et forme :Off-White To Beige PowderMasse moléculaire :224.3Difluprednate
CAS :<p>Difluprednate (Myser)(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain.</p>Formule :C27H34F2O7Degré de pureté :99.23% - 99.86%Couleur et forme :SolidMasse moléculaire :508.55Cambinol
CAS :<p>Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.</p>Formule :C21H16N2O2SDegré de pureté :98.02% - 99.83%Couleur et forme :SolidMasse moléculaire :360.43CAY10594
CAS :<p>CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.</p>Formule :C26H28N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.53
