Neuroscience
Les inhibiteurs en neurosciences sont des composés conçus pour moduler l'activité de protéines, d'enzymes ou de récepteurs spécifiques au sein du système nerveux. Ces inhibiteurs sont cruciaux pour étudier les mécanismes moléculaires sous-jacents au fonctionnement neuronal, à la transmission synaptique et aux maladies neurodégénératives. En ciblant les récepteurs des neurotransmetteurs, les canaux ioniques et les voies de signalisation, les inhibiteurs en neurosciences facilitent l'exploration du fonctionnement cérébral et le développement de stratégies thérapeutiques pour des troubles neurologiques tels que la maladie d'Alzheimer, de Parkinson et l'épilepsie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs en neurosciences de haute qualité pour soutenir vos recherches en neurobiologie, neuropharmacologie et sciences cognitives.
Sous-catégories appartenant à la catégorie "Neuroscience"
- récepteur 5-HT(1.025 produits)
- ACK(1 produits)
- AChR(647 produits)
- ATP Citrate Lyase(17 produits)
- Récepteur adrénergique(3.027 produits)
- BACE(37 produits)
- Bêta-amyloïde(230 produits)
- CaMK(73 produits)
- COX(602 produits)
- Récepteur de la dopamine(445 produits)
- Récepteur GABA(373 produits)
- Gamma-sécrétase(62 produits)
- GluR(265 produits)
- GlyT(26 produits)
- Récepteur de l'histamine(385 produits)
- LRRK2(43 produits)
- Récepteur de la mélatonine(26 produits)
- NMDAR(10 produits)
- Récepteur OX(41 produits)
- Récepteur opioïde(327 produits)
Affichez 12 plus de sous-catégories
5639 produits trouvés pour "Neuroscience"
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Xenopus orexin B
CAS :Xenopus orexin B, a neuropeptide identified as an endogenous ligand for an orphan G-protein-coupled receptor, acts as a potent agonist of OX2R [1].Formule :C130H219N45O40S2Couleur et forme :SolidMasse moléculaire :3116.54Lon 954
CAS :Lon 954, also known as Harmine, is a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds.Formule :C9H10Cl3N3OCouleur et forme :SolidMasse moléculaire :282.55α-Conotoxin imi
CAS :alpha-Conotoxin imi is a nicotinic acetylcholine receptor ligand.Formule :C52H78N20O15S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1351.56UCM 549
CAS :UCM 549 is a bioactive chemical.Formule :C19H21NO2Couleur et forme :SolidMasse moléculaire :295.385H-Pyrido[4,3-b]indole
CAS :5H-Pyrido[4,3-b]indole is a potential AchE/ChE inhibitor with potential antiviral activity for the study of neurodegenerative diseases.Formule :C11H8N2Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :168.2AChE/BChE-IN-20
AChE/BChE-IN-20 (compound 3m) serves as an inhibitor for both acetylcholinesterase (AChE, IC50=34.81 µM) and butyrylcholinesterase (BChE, IC50=20.66 µM). The affinity for the critical enzyme pockets and the favorable interaction profiles were established through molecular docking and kinetics simulation, making it relevant for the study of Alzheimer's disease.Couleur et forme :Odour Solid5-Hydroxymethyl tolterodine formate
CAS :5-Hydroxymethyl tolterodine (formate) (PNU-200577 (formic)) is an active metabolite of the muscarinic acetylcholine receptor antagonists Tolterodine and Fesoterodine. It is synthesized by the cytochrome P450 (CYP) isoenzyme CYP2D6 and plasma esterases.Formule :C23H33NO4Couleur et forme :SolidMasse moléculaire :387.51Atagabalin
CAS :Atagabalin (PD 0200390), a gabamimetic for insomnia treatment and related to gabapentin, was halted due to poor trial outcomes.Formule :C10H19NO2Couleur et forme :SolidMasse moléculaire :185.26Eletriptan
CAS :Eletriptan, second-generation triptans used to treat migraines, is used as an abortion drug.Formule :C22H26N2O2SCouleur et forme :SolidMasse moléculaire :382.52Sulamserod
CAS :Sulamserod (RS 100302) is a potent 5-HT4 receptor antagonist with antiarrhythmic activity for the study of atrial fibrillation and cardiovascular relatedFormule :C19H28ClN3O5SDegré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :445.96RA306
RA306 is an orally active CAMK2 inhibitor that effectively disrupts the PEAK1/CAMK2 signaling pathway. It demonstrates anti-tumor activity by inhibiting proliferation, migration, and invasion of breast cancer cells. Additionally, RA306 shows potential in cardiac disease research, as it improves dilated cardiomyopathy in mice.Couleur et forme :Odour SolidOXA(17-33)
CAS :Potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A.Formule :C79H125N23O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1749β-Amyloid (1-16) acetate
β-Amyloid (1-16) acetate, Fragment of β-Amyloid, N-terminal amino group coordinates metal ions (Cu/Zn), used for Alzheimer's disease research.Formule :C84H119N27O28·xC2H4O2Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :1955.04 (free base)Amyloid-Forming peptide GNNQQNY
CAS :Amyloid-Forming peptide GNNQQNY, a biologically active heptapeptide derived from the N-terminal prion-determining domain of yeast Sup35, is instrumental inFormule :C33H48N12O14Couleur et forme :SolidMasse moléculaire :836.81N-Ethyl-N-(3-pyridylmethyl)amine
CAS :N-Ethyl-N-(3-pyridylmethyl)amine has affinity for nAChR (Ki = 0.97 µM) and can be used in related research in the field of life sciences.Formule :C8H12N2Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :136.19Rasagiline 13C3 mesylate racemic
CAS :Rasagiline 13C3 mesylate racemic is the deuterium labeled Rasagiline, which is an irreversible monoamine oxidase inhibitor.Formule :C13H17NO3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :270.32Anticonvulsant agent 8
Anticonvulsant agent 8 (compound D4) is a chemical used in treating epilepsy by inhibiting GABAA currents. In mouse models, its ED50 values are 2.23 mg/kg for the maximal electroshock (MES) test and 24.60 mg/kg for the pentylenetetrazol (PTZ) test.Formule :C15H11N5OCouleur et forme :SolidMasse moléculaire :277.28α5-GABAA receptor modulator 1
α5-GABAA receptor modulator 1 (Compound A-4) is a selective silent allosteric modulator (SAM) targeting the α5 subunit of GABAA receptors, useful for research into central nervous system (CNS) disorders.Formule :C21H20FN3O4Couleur et forme :SolidMasse moléculaire :397.4p-MPPF
CAS :p-MPPF is a 5-HT antagonist that can be used to study neurological diseases.Formule :C25H27FN4O2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :434.51BuChE-IN-16
BuChE-IN-16 (Compound 6a) is an orally active, blood-brain barrier-permeable, and selective BuChE inhibitor with an IC50 of 0.33 μM. It exhibits anti-inflammatory and neuroprotective effects, improves cognitive function in Alzheimer's disease (AD) zebrafish models, and alleviates scopolamine-induced memory impairment in mice. BuChE-IN-16 is applicable for Alzheimer's disease research.Formule :C16H22N2O3Couleur et forme :SolidMasse moléculaire :290.36K1833
K1833 is an inhibitor and reactivator of human acetylcholinesterase (hrAChE), exhibiting an inhibition concentration (IC50) of 58$.Couleur et forme :Odour Solid2'-O-Succinyl-cAMP
CAS :2'-O-Monosuccinyladenosine-3',5'-cyclic monophosphate is an immunogenic derivative of cAMP that has been used to generate anti-cAMP antisera and antibodies.1,2Formule :C14H16N5O9PCouleur et forme :SolidMasse moléculaire :429.282AC 253
CAS :Amylin (AMY3) receptor antagonist; blocks cAMP, Ca2+, PKA, MAPK, Akt, and cFOS activity; prevents Aβ-induced neuronal death. Cyclic AC 253 variant exists.Formule :C122H196N40O39Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2847.11Polyglutamine binding peptide 1
CAS :Polyglutamine binding peptide 1 (QBP1) is a peptide inhibitor of polyglutamine (polyQ). It effectively inhibits polyQ protein aggregation in vitro and prevents polyQ-induced cell death in cell cultures.Formule :C72H90N16O16Couleur et forme :SolidMasse moléculaire :1435.58PSEN1-IN-1
PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50Formule :C20H19ClF3NO3SCouleur et forme :SolidMasse moléculaire :445.88Salvianolic acid H
CAS :Salvianolic acid H is a strong inhibitor of acetylcholinesterase (AChE) [1].Formule :C27H22O12Couleur et forme :SolidMasse moléculaire :538.46mHTT-IN-1
CAS :mHTT-IN-1 is a potent inhibitor of toxic mHTT, linked to Huntington's disease, with an EC50 of 46 nM.Formule :C18H19N7OSCouleur et forme :SolidMasse moléculaire :381.45C175-0062
CAS :C175-0062, a monoamine oxidase B (MAO-B) inhibitor, is applicable in research focused on neurodegenerative disorders such as Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS) [1].Formule :C21H18N2O5Couleur et forme :SolidMasse moléculaire :378.38Xanthohumol I
Xanthohumol I is a natural product that can be used as a reference standard.Formule :C21H22O6Couleur et forme :SolidMasse moléculaire :370.401BuChE-IN-11
BuChE-IN-11 (Compound 3b-1) is a selective inhibitor of BuChE with an IC50 of 0.44 μM for hBuChE. The compound demonstrates high brain-blood barrier permeability and possesses free radical scavenging capabilities, indicating significant antioxidant activity. BuChE-IN-11 interacts with the choline binding site, the acyl binding site, and the peripheral anionic site, showing submicromolar inhibitory activity against BuChE and preventing the self-aggregation of β-amyloid protein (Aβ). This compound holds promise for research in the field of Alzheimer's disease.Formule :C28H27FN4O2Masse moléculaire :470.2118AChE-IN-70
AChE-IN-70 (compound 4) is an acetylcholinesterase inhibitor. It exhibits larvicidal activity against mosquito larvae (Culex pipiens L.), making it useful for mosquito control research.Couleur et forme :Odour Solid5-MeO-pyr-T
CAS :5-MeO-pyr-T (5-Methoxy pyrrolidinyltryptamine) acts as a 5-HT1AR agonist, exhibiting Ki values of 0.577 μM and 373 μM for 5-HT1AR and 5-HT2AR, respectively. It inhibits the reuptake of 5-HT and triggers its release. Additionally, 5-MeO-pyr-T can induce reduced motor activity.Formule :C15H20N2OCouleur et forme :SolidMasse moléculaire :244.33Notch 1 TFA
Notch 1 TFA encodes a member of the NOTCH family of proteins.Formule :C64H98N15F3O25S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1614.81AChE/BChE-IN-15
AChE/BChE-IN-15 (Compound 6d) serves as an inhibitor for both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), presenting inhibition constants (Formule :C29H30N6O3Couleur et forme :SolidMasse moléculaire :510.59BChE-IN-21
BChE-IN-21, a potent inhibitor of butyrylcholinesterase (BChE), exhibits an inhibition constant (IC50) of 0.14 ± 0.02 μM, indicating promise for research inCouleur et forme :Odour Solid(Rac)-5-Hydroxymethyl Tolterodine hydrochloride
CAS :(Rac)-5-Hydroxymethyl Tolterodine HCl, or (Rac)-Desfesoterodine HCl, is a potent mAChR blocker researched for overactive bladder.
Formule :C22H32ClNO2Couleur et forme :SolidMasse moléculaire :377.95AChE-IN-29
AChE-IN-29, a 3-OH pyrrolidine derivative, acts as a cholinesterase (ChE) inhibitor with potent activity against human acetylcholinesterase (hAChE), electricFormule :C18H19BrN2O2Couleur et forme :SolidMasse moléculaire :375.26(-)-Coclaurine hydrochloride
CAS :(-)-Coclaurine hydrochloride is an antagonist of nAChRs isolated from Sarcopetalum harveyanum.Formule :C17H20ClNO3Degré de pureté :99.07%Couleur et forme :SoildMasse moléculaire :321.8Ref: TM-TN1519L
1mg109,00€5mg235,00€1mL*10mM (DMSO)235,00€10mg349,00€25mg532,00€50mg745,00€100mg999,00€200mg1.333,00€DAA-1106
CAS :DAA-1106 is a potent and selective ligand for PBR, acting as a potent and selective agonist at the peripheral benzodiazepine receptor.Formule :C23H22FNO4Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :395.42CDD0102 HCl
CAS :CDD0102 HCl is a selective and potent M1 muscarinic receptor agonist for the treatment of Alzheimer's disease.Formule :C8H13ClN4ODegré de pureté :99.7%Couleur et forme :SoildMasse moléculaire :216.67Amyloid β-Protein (1-24)
CAS :Amyloid β-Protein (1-24) is a peptide identified through peptide screening. This tool predominantly employs immunoassays to gather and analyze active peptides. Peptide screening is utilized in studies involving protein interactions, functional analysis, and epitope screening, particularly relevant in the research and development of active molecules.Formule :C130H183N35O40Masse moléculaire :2876.05(Iso)-Landipirdine
CAS :(Iso)-Landipirdine((Iso)-RO5025181) is a selective and potent 5-HT6R antagonist.Formule :C18H19FN2O3SDegré de pureté :98.94%Couleur et forme :SoildMasse moléculaire :362.425-HT1AR/5-HT6R ligand-1
5-HT1AR/5-HT6R ligand-1 (Compound PP13) functions as a ligand for the 5-HT receptor, demonstrating high affinity for 5-HT1AR, 5-HT6R, and 5-HT7R with Ki values of 19, 69, and 198 nM, respectively. In HEK293 cells, it inhibits cAMP production with EC50 values of 1535, 488, and 53 nM for these receptors. Additionally, 5-HT1AR/5-HT6R ligand-1 exhibits antiproliferative effects on several cancer cell lines, including 1321N1, U87MG, MCF7, and AsPC-1, with IC50 values of 9.6, 13.6, 19.3, and 14.6 μM, respectively. The compound also shows antagonistic activity towards the dopamine receptor D2R, with a Ki of 1903 nM.Formule :C25H29ClN4O2SCouleur et forme :SolidMasse moléculaire :485.04CUR-IPA
CUR-IPA is a cholinesterase inhibitor with IC50 values of 5.99 μM for eAChE (electric eel), 59.30 μM for hAChE (human), and 60.66 μM for hBChE (human). It has free radical scavenging and antioxidant activity and is useful for researching cognitive dysfunction.Formule :C43H38N2O8Couleur et forme :SolidMasse moléculaire :710.77Perlapine
CAS :Perlapine is an effective and selective HM3DQ DREADD agonist (EC50 = 2.8 nM).Formule :C19H21N3Couleur et forme :SolidMasse moléculaire :291.39Anticonvulsant agent 9
Anticonvulsant agent 9 (compound 4f) is an activator of the α1β2γ2GABA_A receptor, with an EC50 value of 1.24 μM. It inhibits the inactivation of Nav1.2 channels and exhibits significant anticonvulsant activity.Formule :C22H24N4O2Couleur et forme :SolidMasse moléculaire :376.45nAChR agonist CMPI hydrochloride
CAS :CMPI hydrochloride: Potent α4:α4 nAChR PAM; EC50 0.26 μM for (α4)3(β2)2 response to ACh; may aid nicotine dependence, neuropsychiatric research.Formule :C18H20Cl2N4OCouleur et forme :SolidMasse moléculaire :379.29γ-Secretase modulator 10
CAS :γ-Secretase modulator 10 is a novel γ-secretase modulator.Formule :C25H23F3N4O2Couleur et forme :SolidMasse moléculaire :468.48Mesoridazine Besylate
CAS :Mesoridazine Besylate (Serentil), a piperidine antipsychotic and phenothiazine, treats schizophrenia; it's a thioridazine metabolite.Formule :C27H32N2O4S3Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :544.75Flupyradifurone
CAS :Flupyradifurone (flupyradifurone) is a systemic insecticide and nicotinic acetylcholine receptor (nAChR) agonist interfer nervous system of insects.Formule :C12H11ClF2N2O2Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :288.684,4-Difluorobenzhydrol
CAS :Compound PDK0200, with CAS No. 365-24-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0200 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C13H10F2OCouleur et forme :Off-White CrystalsMasse moléculaire :220.21MAO-IN-6
MAO-IN-6 (Compound 3f) is a reversible MAO-B inhibitor that can cross the blood-brain barrier, with an IC50 value of 0.09 μM. It also shows inhibitory activity against AChE and BChE, with IC50 values of 4.48 μM and 17.03 μM, respectively. MAO-IN-6 exhibits low cytotoxicity and is applicable in Alzheimer's disease research.Formule :C22H14F3NO2Couleur et forme :SolidMasse moléculaire :381.35Pyridostigmine bromide
CAS :Pyridostigmine bromide (Mestinon), a cholinesterase inhibitor, is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants.Formule :C9H13BrN2O2Degré de pureté :99.00% - 99.98%Couleur et forme :White Or Practically White Crystalline Powder Pale Yellow To Colorless LiquidMasse moléculaire :261.12BMY-14802
CAS :BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.Formule :C18H22F2N4ODegré de pureté :99.84%Couleur et forme :SoildMasse moléculaire :348.39Ref: TM-T67739
2mg35,00€5mg52,00€1mL*10mM (DMSO)58,00€10mg90,00€25mg164,00€50mg259,00€100mg383,00€200mg545,00€AChE-IN-27
CAS :AChE-IN-27 is a small molecule used for high-throughput assays.Formule :C20H14N2O3Degré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :330.34Multitarget AD inhibitor-1
CAS :Multitarget AD inhibitor-1: reversible, selective BuChE blocker, inhibits β-secretase and amyloid/tau aggregation, promising for Alzheimer's research.Formule :C29H38N2OCouleur et forme :SolidMasse moléculaire :430.636AChE-IN-86
AChE-IN-86 (Compound 6f) is an inhibitor of acetylcholinesterase (AChE) with an IC50 value of 25.33 μg/mL. This compound exerts its inhibitory effects by forming hydrogen bonds, π-π, and π-alkyl interactions with amino acid residues at the key catalytic site of AChE. AChE-IN-86 can be utilized in Alzheimer's disease research.Formule :C28H27N3O6SCouleur et forme :SolidMasse moléculaire :533.595(Rac)-Sclerone
CAS :(Rac)-Sclerone, a natural product isolated from the green husk of Carya illinoinensis, exhibits significant AChE inhibition activity with an IC50 value of 192.Formule :C10H10O3Couleur et forme :SolidMasse moléculaire :178.18Nictide
CAS :Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated form of LRRK2[G2019S], exhibiting a Km value of 10 μM.Formule :C123H193N45O28Couleur et forme :SolidMasse moléculaire :2750.13LY3020371
CAS :LY3020371: potent, selective mGlu 2/3 receptor antagonist with Ki of 5.26 nM (hmGluR2) and 2.50 nM (hmGluR3); key in depression studies.Formule :C15H15F2NO5SCouleur et forme :SolidMasse moléculaire :359.34(-)-Eseroline fumarate
CAS :(-)-Eseroline fumarate, a Physostigmine metabolite and AChE inhibitor, triggers cancer cell LDH release and neuronal cell death.Formule :C17H22N2O5Couleur et forme :SolidMasse moléculaire :334.37nAChR modulator-1
CAS :nAChR modulator-1, a insecticide, is a insect nAChR orthosteric modulator [1] .Formule :C12H8ClN3O2Couleur et forme :SolidMasse moléculaire :261.66Suntinorexton
CAS :Suntinorexton (TAK 861) is an orexin type 2 receptor (OX2R) agonist used in the study of neurologic disorders.Formule :C23H28F2N2O4SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :466.54Ref: TM-T39807
1mg171,00€5mg418,00€1mL*10mM (DMSO)428,00€10mg666,00€25mg1.017,00€50mg1.372,00€100mg1.793,00€200mg2.405,00€BChE-IN-10
CAS :BChE-IN-10, a strong mixed BChE inhibitor (IC50=6.4 μM), comes from Bletilla striata for AD research.Formule :C23H20O5Couleur et forme :SolidMasse moléculaire :376.4Peptide 401
CAS :Peptide 401: AMP from bee/wasp venom, triggers histamine release, reduces paw swelling.Formule :C110H192N40O24S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2587.22BuChE-IN-8
BuChE-IN-8 (compound 19c), a butyrylcholinesterase (BuChE) inhibitor, exhibits an IC50 value of 559 nM and concurrently inhibits human β-secretase (BACE1) andFormule :C28H33ClN4O2SCouleur et forme :SolidMasse moléculaire :525.11Cytidine 5′-diphosphoethanolamine
CAS :Cytidine 5′-diphosphoethanolamine, a key intermediate in phosphatidylethanolamine synthesis, also serves as a stimulant of Ach synthesis [1].
Formule :C11H20N4O11P2Couleur et forme :SolidMasse moléculaire :446.24hAChE-IN-6
hAChE-IN-6 (compound 51) is a brain-penetrant acetylcholinesterase (AChE) inhibitor exhibiting an IC50 of 0.16 μM.Couleur et forme :Odour SolidMGS0274
CAS :MGS0274, a lipophilic prodrug of mGlu2/3 agonist MGS0008, enhances oral bioavailability, potentially aiding schizophrenia research.Formule :C21H32FNO7Couleur et forme :SolidMasse moléculaire :429.485CVN417
CVN417 is an orally active antagonist of nAChR containing the α6 subunit, modulating phasic dopaminergic neurotransmission in an impulse-dependent fashion.Couleur et forme :Odour SolidRivanicline 2HCl
Rivanicline 2HCl is a selective neuronal nicotinic receptor inhibitor with a high affinity for the α4β2 subtype.Formule :C10H16Cl2N2Degré de pureté :99.4%Couleur et forme :SoildMasse moléculaire :235.15Ref: TM-T12738L1
1mg34,00€5mg71,00€10mg100,00€1mL*10mM (DMSO)110,00€25mg234,00€50mg420,00€100mg617,00€Echimidine N-oxide
CAS :Echimidine N-oxide, a pyrrolizidine alkaloid, exhibits significant inhibitory activity against acetylcholinesterase (AChE) with an IC50 value of 0.347 mM.Formule :C20H31NO8Couleur et forme :SolidMasse moléculaire :413.47Ethylpropyltryptamine
CAS :Ethylpropyltryptamine (EPT) is an orally active novel psychoactive substance. It is predicted to act as a partial agonist of the 5-HT2A receptor.Formule :C15H22N2Couleur et forme :SolidMasse moléculaire :230.35BI 1181181 MZ
BI 1181181 MZ is a potent and selective BACE1 inhibitor. BI 1181181 MZ is applicable to Alzheimer's disease research.Formule :C31H37FN4O5Couleur et forme :SolidMasse moléculaire :564.2748Ro60-0175
CAS :Ro60-0175 is a selective 5-HT2B and 5-HT2C serotonin receptor agonist, often used as fumarate.Formule :C11H12ClFN2Degré de pureté :97.09%Couleur et forme :SolidMasse moléculaire :226.68Ref: TM-T39161
1mg93,00€1mL*10mM (DMSO)187,00€5mg205,00€10mg334,00€25mg587,00€50mg802,00€100mg1.108,00€AChE/BChE-IN-11
CAS :AChE/BChE-IN-11, natural from artichoke leaves, inhibits AChE and BChE (IC50: 70/71 μM) for Alzheimer's research.Formule :C21H22O12Couleur et forme :SolidMasse moléculaire :466.39SC-53116
CAS :SC-53116 HCl can increase the production of serotonin in central nervous system tissues and is a psychoactive agent.Formule :C16H22ClN3O2Couleur et forme :SolidMasse moléculaire :323.82PD25
PD25, an inhibitor of both AChE and BuChE, demonstrates inhibitory constants of hAChE IC50: 1.58 μM, eeAChE IC50: 1.63 μM, and eqBuChE IC50: 2.39 μM.Formule :C25H24N2O4Couleur et forme :SolidMasse moléculaire :416.47β-Amyloid (18-28)
CAS :Intracerebroventricular administration of synthetic peptides Beta-amyloid (12-20), (12-28), and (18-28) causes amnesia in mice.Formule :C55H81N13O18Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1212.31RN341
RN341 is a LRRK2-specific type II kinase inhibitor (IC50 of 296 nM). It prevents the phosphorylation of LRRK2 by stabilizing an open conformation, thereby avoiding S935 dephosphorylation. Additionally, RN341 rescues LRRK2-mediated kinesin motility blockage by preventing microtubule binding. This compound effectively inhibits both wild-type and G2019S LRRK2 at the cellular level, offering a novel avenue for Parkinson's disease research.Couleur et forme :Odour SolidLycoramine hydrobromide
CAS :Lycoramine is a natural alkaloid isolated from Lycoris chinensis.Formule :C17H24BrNO3Couleur et forme :SolidMasse moléculaire :370.28ALEPH hydrochloride
CAS :ALEPH (hydrochloride) acts as a partial agonist of h5-HT2A and h5-HT2B receptors, with EC50 values of 10.3 nM and 19.2 nM, respectively. It can induce head twitch responses in mice, with an ED50 of 0.80 mg/kg.Formule :C12H20ClNO2SCouleur et forme :SolidMasse moléculaire :277.81Flufiprole
CAS :Flufiprole is used as a phenylpyrazole pesticide. It has enantioselective metabolism in human and rat liver microsomes.Formule :C16H10Cl2F6N4OSCouleur et forme :SolidMasse moléculaire :491.24Muscarine
CAS :Muscarine is a toxic alkaloid found in Amanita muscaria and other fungi of the Inocybe species.Formule :C9H20NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :174.26Dual AChE-MAO B-IN-3
Compound C10 is a potent dual AChE/MAO-B inhibitor with IC50s of 0.58μM (AChE) and 0.41μM (MAO-B), useful in Alzheimer's research.Formule :C30H26F3NO3Couleur et forme :SolidMasse moléculaire :505.53Aβ1-14-εK-KKK-MvF5 Th
Aβ1-14-εK-KKK-MvF5 Th (UB311 immunogen I) is a biologically active peptide and one of the Aβ1–14 targeting peptides (B-cell epitope) used in UB-311.
Formule :C199H318N56O55Masse moléculaire :4372.38081AChE-IN-35
AChE-IN-35 (compound 5g) serves as an acetylcholinesterase inhibitor, exhibiting an inhibitory concentration 50 (IC50) value of 5.88 μM [1].Formule :C20H16N8O5Couleur et forme :SolidMasse moléculaire :448.39Dicloromezotiaz
CAS :Dicloromezotiaz: Potent insecticide targeting nAChRs, controls various lepidoptera.Formule :C19H12Cl3N3O2SCouleur et forme :SolidMasse moléculaire :452.74Brexpiprazole S-oxide
CAS :Brexpiprazole S-oxide is the main metabolite of Brexpiprazole, a human 5-HT1A and dopamine receptor partial agonist (Ki: 0.12, 0.3 nM).Formule :C25H27N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :449.57hAChE-IN-5
hAChE-IN-5 (compound 49) is a dual inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBuChE), exhibiting inhibitory potency withDegré de pureté :98%Couleur et forme :Odour Solid8-hydroxy Amoxapine
CAS :8-hydroxy Amoxapine is a metabolite of the tetracyclic antidepressant amoxapine .1,2
Formule :C17H16ClN3O2Couleur et forme :SolidMasse moléculaire :329.78Aβ-IN-7
Aβ-IN-7 (compound 5a) acts as a potent inhibitor of Aβ aggregation, stabilizing Aβ monomers at 50 μM concentration to prevent them from forming larger oligomersFormule :C14H10N2SCouleur et forme :SolidMasse moléculaire :238.31LY 344864 racemate
CAS :LY 344864 racemate is a 5-HT1F receptor agonist.Formule :C21H22FN3ODegré de pureté :99.75%Couleur et forme :SoildMasse moléculaire :351.42BChE-IN-12
CAS :BChE-IN-12, non-competitive BChE inhibitor from Bletilla striata, IC50=2.3μM; potential Alzheimer’s research.Formule :C31H30O5Couleur et forme :SolidMasse moléculaire :482.57β-Amyloid (1-11)
CAS :Anionic interaction of Beta-amyloid (1-11) with Factor XII is suspected to cause massive activation of the C4 (complement 4) system in the cerebrospinal fluidFormule :C56H76N16O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1325.3Isobutyryl-L-carnitine
CAS :Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases.Formule :C11H21NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :231.29Aβ-IN-8
Aβ-IN-8, also known as compound 7e, is a potent inhibitor of Aβ aggregation [1].Formule :C22H16F3N3O3SCouleur et forme :SolidMasse moléculaire :459.44Oxatomide
CAS :Oxatomide: Dual H1/P2X7 antagonist, antihistamine, anti-allergic, treats immune diseases, IC50: 0.95 μM (P2X7), 0.43 μM (5-HT).Formule :C27H30N4ODegré de pureté :99.28% - 99.72%Couleur et forme :White PowderMasse moléculaire :426.55Ref: TM-T19839
1mg35,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg114,00€25mg222,00€50mg356,00€100mg557,00€500mg1.153,00€AChE/BuChE/MAO-B-IN-2
AChE/BuChE/MAO-B-IN-2 (compound 4b) is a potent inhibitor of AChE, BuChE, and hu MAO-B, with respective IC50 values of 5.3 μM, 12.4 μM, and 1.9±0.08 μM,Formule :C19H18FNO3Couleur et forme :SolidMasse moléculaire :327.35isomer-Cilansetron
CAS :isomer-Cilansetron is an isomer of Cilansetron.Formule :C20H21N3ODegré de pureté :99.92% - 99.96%Couleur et forme :SoildMasse moléculaire :319.4
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