Neuroscience

<p>Fluxametamide, an isoxazoline insecticide, targets insect chloride channels with IC50s of 1.95 nM (GABA) and 225 nM (glutamate).</p>

<p>Acetamiprid: nAChR agonist, global neonicotinoid insecticide linked to neuromuscular/reproductive issues.</p>

<p>CI 169369 is a selective 5-HT2 receptor antagonist used in the study of anxiety and depression.</p>

<p>Org-26576 is a positive allosteric modulator of the AMPA receptor.</p>

<p>Pizotifen is a serotonin antagonist with mild anticholinergic effects, used in migraine prevention. Not available in the USA.</p>

<p>Mianserin HCl (Org GB 94): a tetracyclic antidepressant; blocks alpha-adrenergic, H1, serotonin receptors; may induce drowsiness, hematological issues.</p>

<p>Promazine hydrochloride, a phenothiazine less potent than chlorpromazine, treats disturbed behavior and nausea.</p>

<p>Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine.</p>

<p>Levodropropizine ((S)-(-)-Dropropizine) is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug.</p>

<p>Dexchlorpheniramine Maleate, an antihistamine with anticholinergic effects, treats allergies like hay fever. It's the active isomer of chlorpheniramine.</p>

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PGD2S. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PGD2S. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human PGD2S, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PGD2S in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Human NEFL protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human NEFL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human NEFL in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Human NRGN protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human NRGN. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human NRGN in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Human BNP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human BNP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human BNP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>YKP 10811 (Relenopride) is a novel 5-HT4 receptor partial agonist, which can be used to study irritable bowel syndrome with constipation.</p>

<p>Molindone hydrochloride (EN-1733A) is an indole derivative effective in schizophrenia and other psychoses by blocking the effects of dopamine in the brain.</p>

<p>SSR 180 is a potent and subtype-selective α7 agonist with applications in the study of Alzheimer;s disease and schizophrenia.</p>

<p>NEO 376 (SPI-376) is a selective 5-HT1 receptor, GABA receptor and dopamine receptor modulator, showing anti-psychotic actively.</p>

<p>Vigabatrin (Sabril), an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate Transaminase responsible for the catabolism of γ-</p>

<p>Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.</p>

<p>Sumatriptan succinate (GR 43175), a serotonin1 (5-HT1) receptor agonist, is used in the acute treatment of a migraine headache.</p>

<p>Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties.</p>

<p>Propantheline bromide (Pro-Banthine) competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle</p>