Neuroscience

Les inhibiteurs en neurosciences sont des composés conçus pour moduler l'activité de protéines, d'enzymes ou de récepteurs spécifiques au sein du système nerveux. Ces inhibiteurs sont cruciaux pour étudier les mécanismes moléculaires sous-jacents au fonctionnement neuronal, à la transmission synaptique et aux maladies neurodégénératives. En ciblant les récepteurs des neurotransmetteurs, les canaux ioniques et les voies de signalisation, les inhibiteurs en neurosciences facilitent l'exploration du fonctionnement cérébral et le développement de stratégies thérapeutiques pour des troubles neurologiques tels que la maladie d'Alzheimer, de Parkinson et l'épilepsie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs en neurosciences de haute qualité pour soutenir vos recherches en neurobiologie, neuropharmacologie et sciences cognitives.

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5398 produits trouvés pour "Neuroscience"

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MAO-B-IN-6
MAO-B-IN-6 is a selective, potent, orally active MAO-B inhibitor (IC50: 0.019 μM). MAO-B-IN-6 is superior to Safinamide both in vitro and in vivo.
Couleur et forme :Solid
Ref: TM-T64271
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5-HT6R/MAO-B modulator 1
5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.
Formule :C₃₃H₃₈N₄O₃S
Couleur et forme :Solid
Masse moléculaire :570.74
Ref: TM-T64036
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hAChE/Aβ1-42-IN-1
CAS :
- 2761149-17-9
Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines and
Formule :C₂₀H₂₄N₆O
Couleur et forme :Solid
Masse moléculaire :364.44
Ref: TM-T61388
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LRRK2-IN-6
LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).
Formule :C₂₃H₂₄F₂N₄O₂S
Couleur et forme :Solid
Masse moléculaire :458.52
Ref: TM-T62871
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Revexepride
CAS :
- 219984-49-3
Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.
Formule :C₂₁H₃₂ClN₃O₄
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :425.95
Ref: TM-T16737
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BChE-IN-5
BChE-IN-5: potent, selective BChE inhibitor (IC50: 2.8 nM), more effective on hBChE, potential in Alzheimer's research.
Formule :C₃₀H₄₂N₄O
Couleur et forme :Solid
Masse moléculaire :474.68
Ref: TM-T63091
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P2X7 receptor antagonist-5
CAS :
- 3046388-16-0
P2X7 receptor antagonist-5 (compound 13a) is a potent, orally active, and long-lasting antagonist of the P2X7 receptor.
Formule :C₂₁H₁₇F₃N₆O₃S₂
Couleur et forme :Solid
Masse moléculaire :522.52
Ref: TM-T201089
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U92016A hydrochloride
CAS :
- 149654-41-1
U92016A hydrochloride: potent, orally active 5-HT1A agonist, metabolically stable, high intrinsic activity, Ki=0.2 nM.
Formule :C₁₉H₂₆ClN₃
Couleur et forme :Solid
Masse moléculaire :331.89
Ref: TM-T60990
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AAK1-IN-2 TFA
AAK1-IN-2 TFA (compound (S)-31) is a selective and potent AAK1 inhibitor (IC50: 5.8 nM) that can cross the blood-brain barrier.
Formule :C₂₄H₂₂F₆N₄O₄
Couleur et forme :Solid
Masse moléculaire :544.45
Ref: TM-T63833
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K203
K203 is a potent tabun-inhibited AChE reactivator and is an important antidote to organophosphorus poisoning.
Formule :C₁₆H₁₈Br₂N₄O₂
Couleur et forme :Solid
Masse moléculaire :458.15
Ref: TM-T62857
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5-IAI hydrochloride
CAS :
- 1782044-60-3
5-IAI hydrochloride is a psychoactive analog of para-iodoamphetamine. 5-IAI hydrochloride significantly reduces serotonin uptake sites and hippocampal serotonin levels in rats.
Formule :C₉H₁₁ClIN
Couleur et forme :Solid
Masse moléculaire :295.548
Ref: TM-T204949
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PXS-5153A monohydrochloride
CAS :
- 2125956-82-1
PXS-5153A is an oral, fast-acting LOXL2/3 inhibitor with IC50 <40 nM for LOXL2 and 63 nM for LOXL3, potentially treating fibrosis.
Formule :C₂₀H₂₅Cl₂FN₄O₂S
Degré de pureté :98%
Couleur et forme :Odour Solid
Masse moléculaire :475.41
Ref: TM-T12585L
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UB 165
CAS :
- 200432-86-6
Subtype-selective nicotinic agonist
Formule :C₁₃H₁₅ClN₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :234.72
Ref: TM-T23485
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1,9-Dideoxyforskolin
CAS :
- 64657-18-7
The compound is an inactive analog of forskolin(an adenylyl cyclase activator).
Formule :C₂₂H₃₄O₅
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :378.5
Ref: TM-T22467
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cSPM
cSPM (Cyclic spermine) is an Aβ42 inhibitor. cSPM inhibits the aggregation of three different peptides, Aβ42, tryptophan and insulin, and reduces cytotoxicity.
Formule :C₂₇H₅₇N₇
Couleur et forme :Solid
Masse moléculaire :479.79
Ref: TM-T63163
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GABAA receptor agonist 1
Compound 3e, a potent GABAA agonist, targets GABA sites and has potential anti-depressive effects in mice.
Formule :C₂₀H₃₀O₃
Couleur et forme :Solid
Masse moléculaire :318.45
Ref: TM-T60842
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Aβ42-IN-1
CAS :
- 2582757-69-3
Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).
Formule :C₂₉H₂₇ClN₄O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :499
Ref: TM-T10211
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CVN636
CAS :
- 2226732-62-1
CVN636, a potent and selective allosteric agonist for the mGluR7 receptor, exhibits oral activity and CNS permeability [1], with an EC50 of 7 nM for human
Formule :C₁₉H₂₀FNO₄S
Couleur et forme :Solid
Masse moléculaire :377.43
Ref: TM-T78090
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Remlifanserin
CAS :
- 2289704-13-6
Remlifanserin is a potent inverse agonist of the serotonin receptor (5-HT2A).
Formule :C₂₄H₂₉F₂N₃O₂
Couleur et forme :Solid
Masse moléculaire :429.50
Ref: TM-T201055
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DSP-1053 benzenesulfonate
CAS :
- 1176326-78-5
DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.
Formule :C₃₂H₃₈BrNO₇S
Couleur et forme :Solid
Masse moléculaire :660.62
Ref: TM-T72220
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Zanapezil fumarate
CAS :
- 263248-42-6
Zanapezil is an acetylcholinesterase (AChE) inhibitor. Zanapezil increases choline acetyltransferase activity in cultured rat septal cholinergic neurons.
Formule :C₂₉H₃₆N₂O₅
Couleur et forme :Solid
Masse moléculaire :492.61
Ref: TM-T29203
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LY367385 hydrochloride
CAS :
- 2829282-00-8
LY367385 hydrochloride: selective mGluR1a antagonist, IC50 = 8.8 μM, neuroprotective, anticonvulsant, antiepileptic.
Formule :C₁₀H₁₂ClNO₄
Couleur et forme :Solid
Masse moléculaire :245.66
Ref: TM-T60355
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Dihydro-β-erythroidine
CAS :
- 23255-54-1
Dihydro-β-erythroidine, a competitive nicotinic receptor antagonist, effectively blocks the discriminative stimulus properties and inhibits the anxiolytic
Formule :C₁₆H₂₁NO₃
Couleur et forme :Solid
Masse moléculaire :275.34
Ref: TM-T72382
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Azotomycin
CAS :
- 7644-67-9
Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.
Formule :C₁₇H₂₃N₇O₈
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :453.41
Ref: TM-T26729
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HDAC6-IN-9
CAS :
- 2796282-58-9
HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.
Formule :C₁₉H₁₆N₂O₃
Degré de pureté :98.84%
Couleur et forme :Solid
Masse moléculaire :320.34
Ref: TM-T60856
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Gabaculine HCl
CAS :
- 59556-17-1
Gabaculine, an irreversible GABA-T inhibitor (Ki: 2.9 μM), impacts plastid development and affects DPOR/GluTR levels.
Formule :C₇H₁₀ClNO₂
Couleur et forme :Solid
Masse moléculaire :175.61
Ref: TM-T24080
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MAO-A inhibitor 3
CAS :
- 35924-44-8
MAO-A inhibitor3 (Compound 360) is an MAO-A inhibitor with an IC50 greater than 100 μM. It is utilized in the investigation of neurological disorders.
Formule :C₁₁H₈O₅
Couleur et forme :Solid
Masse moléculaire :220.178
Ref: TM-T205117
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Lu 26-046
CAS :
- 143756-51-8
Lu 26-046 is a muscarinic receptor agonist.
Formule :C₁₀H₁₂N₂OS
Couleur et forme :Solid
Masse moléculaire :208.28
Ref: TM-T70651
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hAChE-IN-10
CAS :
- 3058182-98-9
hAChE-IN-10 (Compound ET11) is an inhibitor of human acetylcholinesterase (AChE) with an IC50 of 6.34 nM. This compound is capable of scavenging free radicals and exhibits antioxidant activity. Additionally, hAChE-IN-10 demonstrates metal-chelating properties, inhibiting Cu2+-induced Aβ1-42 aggregation, reducing amyloid plaque formation, and offering neuroprotective effects. It also ameliorates cognitive impairment in mice induced by Scopolamine.
Formule :C₂₅H₂₄ClFN₆O₂
Couleur et forme :Solid
Masse moléculaire :494.948
Ref: TM-T204876
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SEP-363856 mesylate
CAS :
- 2375116-27-9
SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.
Formule :C₁₀H₁₇NO₄S₂
Couleur et forme :Solid
Masse moléculaire :279.38
Ref: TM-T201258
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AAZ-A 154
CAS :
- 2481740-94-5
AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.
Formule :C₁₄H₂₀N₂O
Couleur et forme :Solid
Masse moléculaire :232.32
Ref: TM-T200737
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(RS)-AMPA hydrochloride
CAS :
- 2922283-04-1
(RS)-AMPA ((±)-AMPA) hydrochloride is a glutamate analog and serves as an efficient selective agonist for the excitatory neurotransmitter L-glutamic acid (L-glutamic acid). It does not interfere with the binding sites of alginate or NMDA receptors.
Formule :C₇H₁₁ClN₂O₄
Couleur et forme :Solid
Masse moléculaire :222.63
Ref: TM-T200780
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RTIOXA-43
CAS :
- 2832067-72-6
RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.
Formule :C₃₇H₃₇N₅O₅S
Degré de pureté :99.17%
Couleur et forme :Solid
Masse moléculaire :663.79
Ref: TM-T87345
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LP 12 hydrochloride hydrate
LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.
Formule :C₃₂H₃₉N₃O·HCl·xH₂O
Couleur et forme :Solid
Ref: TM-T64269
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Rodatristat ethyl
CAS :
- 1673571-51-1
Rodatristat ethyl is an oral TPH1 inhibitor reducing 5-HT levels & lowering PAH at low doses.
Formule :C₂₉H₃₁ClF₃N₅O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :590.04
Ref: TM-T16779
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LB-102
CAS :
- 2227154-23-4
LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.
Formule :C₁₈H₂₉N₃O₄S
Couleur et forme :Solid
Masse moléculaire :383.51
Ref: TM-T200914
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Ro4368554
CAS :
- 478082-99-4
Ro4368554 is a selective 5-HT6 antagonist capable of crossing the blood-brain barrier. It can reverse memory deficits caused by scopolamine and tryptophan depletion. Ro4368554 is applicable for research related to memory impairments.
Formule :C₁₉H₂₁N₃O₂S
Couleur et forme :Solid
Masse moléculaire :355.454
Ref: TM-T204915
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Nafimidone hydrochloride
CAS :
- 70891-37-1
Nafimidone hydrochloride, an antiepileptic agent, inhibits acetylcholinesterase, protects neurons, and ameliorates cognitive decline. It is utilized in epilepsy research.
Formule :C₁₅H₁₃ClN₂O
Couleur et forme :Solid
Masse moléculaire :272.73
Ref: TM-T201733
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BACE1-IN-5
CAS :
- 2581114-83-0
BACE1-IN-5 inhibits BACE1 (IC50: 9.1 nM) & Aβ production (IC50: 0.82 nM), enhances hERG inhibition & P-gp efflux.
Formule :C₁₈H₁₆F₅N₅O₂S
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :461.41
Ref: TM-T10453
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DA-8031
CAS :
- 1148027-74-0
DA-8031 is a selective and orally active serotonin reuptake inhibitor. It is utilized in research related to premature ejaculation (PE).
Formule :C₂₁H₂₄N₂O₂
Couleur et forme :Solid
Masse moléculaire :336.43
Ref: TM-T201663
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Notch inhibitor 1
CAS :
- 1584647-27-7
Notch inhibitor 1 blocks Notch 1/3 (IC50: 7.8/8.5 nM) and aids cancer research.
Formule :C₂₆H₂₅F₇N₄O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :574.49
Ref: TM-T16341
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Sulamserod hydrochloride
CAS :
- 184159-40-8
Sulamserod hydrochloride is a 5-HT4 receptor antagonist. It is utilized in research related to gastrointestinal disorders.
Formule :C₁₉H₂₉Cl₂N₃O₅S
Couleur et forme :Solid
Masse moléculaire :482.42
Ref: TM-T201756
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S-8510 phosphate
CAS :
- 151466-23-8
S-8510 phosphate is an agonist of inverse Benzodiazepine (BDZ) receptor(Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively).
Formule :C₁₂H₁₃N₄O₆P
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :340.23
Ref: TM-T12792
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MADAM
CAS :
- 411208-45-2
MADAM demonstrates high affinity and selectivity for 5-HTT, with a Ki value of 1.6 nM. It is utilized as a PET radiotracer for visualizing serotonin transporters.
Formule :C₁₆H₂₀N₂S
Couleur et forme :Solid
Masse moléculaire :272.408
Ref: TM-T204693
+ Info
MAO-B-IN-28
CAS :
- 3028096-72-9
MAO-B-IN-28 (compound 10e) is a potent hMAO-B inhibitor with an IC50 value of 1.9±0.5 nM, potentially serving as a candidate molecule for neurodegenerative disease research.
Formule :C₁₉H₁₀F₃NO₄S
Masse moléculaire :405.35
Ref: TM-T208337
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BChE-IN-38
CAS :
- 3054159-55-3
BChE-IN-38 (compound 13) is a potent BChE inhibitor, with Ki values of 62.05, 28.78, 14.09, and 1.15 nM for hCAI, hCAII, AChE, and BChE, respectively. BChE-IN-38 also demonstrates cytotoxic activity.
Formule :C₂₇H₂₀N₄
Couleur et forme :Solid
Masse moléculaire :400.474
Ref: TM-T204514
+ Info
GABA-IN-4
CAS :
- 61-38-1
GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.
Formule :C₁₇H₁₃ClN₂O₂
Couleur et forme :Solid
Masse moléculaire :312.75
Ref: TM-T205501
+ Info
Dihydro-β-erythroidine hydrobromide
CAS :
- 29734-68-7
Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs).
Formule :C₁₆H₂₂BrNO₃
Degré de pureté :98%
Couleur et forme :White Solid
Masse moléculaire :356.26
Ref: TM-T11041
+ Info
Pomaglumetad methionil
CAS :
- 956385-05-0
Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.
Formule :C₁₂H₂₀N₂O₈S₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :384.43
Ref: TM-T12520
+ Info
2,6-Dimethoxybenzylamine hydrochloride
CAS :
- 34967-23-2
2,6-Dimethoxybenzylamine hydrochloride (Compound 5) exhibits reversible inhibitory activity against copper amine oxidase (CAO) and inhibits benzylamine oxidase (BAO) and monoamine oxidase B (MAO B) with IC50 values of 120 μM and 190 μM, respectively.
Formule :C₉H₁₄ClNO₂
Couleur et forme :Solid
Masse moléculaire :203.666
Ref: TM-T204789
+ Info
F 14679
CAS :
- 208109-38-0
F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.
Formule :C₂₁H₂₅ClF₂N₄O
Degré de pureté :99.09%
Couleur et forme :Solid
Masse moléculaire :422.9
Ref: TM-T62269
+ Info
BACE-1 inhibitor 2
CAS :
- 2563970-92-1
BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1].
Formule :C₂₁H₂₁F₄N₅O₃
Couleur et forme :Solid
Masse moléculaire :467.42
Ref: TM-T62995
+ Info
FP0429
CAS :
- 870860-41-6
FP0429 is an agonist of mGlu4.
Formule :C₁₀H₁₂N₂O₇
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :272.21
Ref: TM-T27355
+ Info
BPN-15606 besylate
BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).
Formule :C₂₉H₂₉FN₆O₄S
Couleur et forme :Solid
Masse moléculaire :576.64
Ref: TM-T64081
+ Info
COX-2-IN-47
CAS :
- 2043670-02-4
COX-2-IN-47 (compound 6c) is a selective inhibitor of COX-2, exhibiting an IC50 of 0.03 μM. This compound also displays antiedema activity.
Formule :C₁₈H₁₈N₂O₄
Couleur et forme :Solid
Masse moléculaire :326.35
Ref: TM-T200034
+ Info
VA012
CAS :
- 885898-58-8
VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.
Formule :C₂₁H₁₉N₃
Couleur et forme :Solid
Masse moléculaire :313.40
Ref: TM-T200241
+ Info
MAO-A/SERT-IN-1
CAS :
- 3001361-38-9
MAO-A/SERT-IN-1 acts as an inhibitor for both MAO-A and the serotonin transporter (SERT). It decreases the SERT-mediated reuptake of 5-HT and demonstrates neuroprotective properties in cellular inhibition models. Additionally, this compound has shown to alleviate depressive behaviors in both zebrafish and mice.
Formule :C₁₉H₁₄N₂O₅
Couleur et forme :Solid
Masse moléculaire :350.32
Ref: TM-T200256
+ Info
(+)-Cevimeline hydrochloride hemihydrate
(+)-Cevimeline HCl hemihydrate is a muscarinic agonist for dry mouth in Sjogren's with rapid absorption, differing metabolism in species.
Formule :C₁₀H₁₉ClNO₁·5S
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :244.78
Ref: TM-T13460
+ Info
5-HT2A/5-HT2C inverse agonist 1
CAS :
- 2718990-76-0
5-HT2A/5-HT2C inverse agonist 1 serves as a dual and potent inverse agonist for the 5-HT2A and 5-HT2C receptors, with hERG inhibition properties that mitigate cardiovascular risks. Demonstrating significant antipsychotic efficacy in the MK-801-induced mouse model, this compound holds potential for psychosis research.
Formule :C₂₄H₃₅N₅O₂
Couleur et forme :Solid
Masse moléculaire :425.57
Ref: TM-T200089
+ Info
YM-31636 free base
CAS :
- 159081-22-8
YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.
Formule :C₁₄H₁₁N₃S
Couleur et forme :Solid
Masse moléculaire :253.32
Ref: TM-T201587
+ Info
ASP-2205
CAS :
- 1334440-09-3
ASP-2205, a 5-HT2C receptor agonist (human 5-HT2C receptor, EC50=0.85 nM; rat 5-HT2C receptor, EC50=2.5 nM), enhances the urethral closure reflex mediated by the genital nerve, thereby preventing urinary incontinence.
Formule :C₁₉H₂₈N₂O
Couleur et forme :Solid
Masse moléculaire :300.44
Ref: TM-T201450
+ Info
Elzasonan hydrochloride
CAS :
- 220322-05-4
Elzasonan hydrochloride is a serotonin 1B and serotonin 1D receptor antagonist. It is utilized in the study of depression.
Formule :C₂₂H₂₄Cl₃N₃OS
Couleur et forme :Solid
Masse moléculaire :484.87
Ref: TM-T201763
+ Info
PF-06648671
CAS :
- 1587727-31-8
PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.
Formule :C₂₅H₂₃ClF₄N₄O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :538.92
Ref: TM-T24621
+ Info
hMAO-B-IN-10
hMAO-B-IN-10 (compound 7) is an inhibitor of MAO-A/B with IC50 values of 424.1 nM and 177.9 nM, respectively. It has demonstrated neuroprotective effects in the MPTP-induced mouse model of Parkinson's Disease (PD).
Formule :C₁₆H₁₂N₄O₄
Couleur et forme :Solid
Masse moléculaire :324.29
Ref: TM-T201531
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AGH-107
CAS :
- 2172907-10-5
AGH-107 is a highly selective 5-HT7 receptor agonist that can cross the blood-brain barrier, featuring a Ki value of 6 nM and an EC50 value of 19 nM. Demonstrating high selectivity for central nervous system targets, AGH-107 also exhibits high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures.
Formule :C₁₃H₁₂IN₃
Couleur et forme :Solid
Masse moléculaire :337.16
Ref: TM-T201735
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Carlina oxide
CAS :
- 502-22-7
Carlina oxide is both an AChE inhibitor and an antioxidant, effective in eliminating mosquito larvae (LC50=1.39 μg/mL). Furthermore, Carlina oxide exhibits cytotoxicity in vertebrate cells, human dermis, and HCT116 and MDA-MB231 cell lines.
Formule :C₁₃H₁₀O
Couleur et forme :Solid
Masse moléculaire :182.22
Ref: TM-T88796
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AAZ-A 154 mesylate
CAS :
- 2930846-03-8
AAZ-A 154 mesylate mesylate is a selective, competitive, and non-hallucinogenic antagonist of 5-HT2AR. It enhances neuronal growth in rodents and produces enduring beneficial behavioral effects.
Formule :C₁₅H₂₄N₂O₄S
Couleur et forme :Solid
Masse moléculaire :328.43
Ref: TM-T200486
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TP003
CAS :
- 628690-75-5
TP003 is a novel non-selective GABAA receptor benzodiazepine site agonist with affinity for α1β2gam2, α2β3gam2, α3β3gam2, α5β2gam2, EC50 of 20.3, 10.6, 3.24, 5.
Formule :C₂₃H₁₆F₃N₃O
Degré de pureté :99.17%
Couleur et forme :Solid
Masse moléculaire :407.39
Ref: TM-T23466
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AAZ-A 154 hydrochloride
CAS :
- 2930845-89-7
AAZ-A 154 hydrochloride is a selective, competitive, non-hallucinogenic antagonist of 5-HT2AR. It promotes neuronal growth in rodents and results in enduring beneficial behavioral effects.
Formule :C₁₄H₂₁ClN₂O
Couleur et forme :Solid
Masse moléculaire :268.78
Ref: TM-T200509
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nAChR antagonist 1
CAS :
- 2987393-37-1
Compound B15, a potent α7 nAChR antagonist, IC50 = 3.3 μM, promising for research on schizophrenia, Alzheimer's, and inflammation.
Formule :C₁₉H₂₂N₄O₂
Couleur et forme :Solid
Masse moléculaire :338.4
Ref: TM-T61064
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AAZ-A 154 benzoate
CAS :
- 2930845-92-2
AAZ-A 154 benzoate is a selective, competitive, and non-hallucinogenic 5-HT2AR antagonist. This compound facilitates neuronal growth in rodents and produces lasting beneficial behavioral effects.
Formule :C₂₁H₂₆N₂O₃
Couleur et forme :Solid
Masse moléculaire :354.44
Ref: TM-T200491
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Tiprenolol hydrochloride
CAS :
- 13379-87-8
Tiprenolol hydrochloride is a β-adrenoceptor (β-adrenoceptor) antagonist. This compound is effective in eliminating ventricular arrhythmias in dogs caused by intravenous administration of adrenaline, following inhalation of halothane.
Formule :C₁₃H₂₂ClNO₂S
Couleur et forme :Solid
Masse moléculaire :291.84
Ref: TM-T201760
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(S)-Norfluoxetine
CAS :
- 126924-38-7
(S)-Norfluoxetine, the S enantiomer of Norfluoxetine, functions as a selective serotonin reuptake inhibitor. It enhances allopregnanolone levels and reduces aggression in socially isolated mice.
Formule :C₁₆H₁₆F₃NO
Couleur et forme :Solid
Masse moléculaire :295.3
Ref: TM-T201552
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AM-6494
CAS :
- 1874232-80-0
AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
Formule :C₂₂H₂₁F₂N₅O₃S
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :473.5
Ref: TM-T10292
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AAZ-A 154 hydrobromide
CAS :
- 2930845-96-6
AAZ-A 154 hydrobromide is a selective, competitive, non-hallucinogenic 5-HT2AR antagonist. It promotes neuronal growth in rodents and yields enduring beneficial behavioral effects.
Formule :C₁₄H₂₁BrN₂O
Couleur et forme :Solid
Masse moléculaire :313.23
Ref: TM-T200446
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Amyloid-β-IN-2
CAS :
- 1603833-55-1
Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.
Formule :C₂₂H₂₁F₂N₃O₂
Couleur et forme :Solid
Masse moléculaire :397.42
Ref: TM-T207418
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Beloxepin
CAS :
- 135928-30-2
Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.
Formule :C₁₉H₂₁NO₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :295.38
Ref: TM-T26765
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(9R)-RO7185876
CAS :
- 2226077-86-5
(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.
Formule :C₂₅H₂₈F₃N₇
Couleur et forme :Solid
Masse moléculaire :483.532
Ref: TM-T204358
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Buntanetap L-Tartrate
CAS :
- 865795-23-9
Buntanetap (L-Tartrate) functions as an oral small molecule inhibitor targeting multiple neurotoxic proteins. It decreases the production of amyloid precursor protein (APP) by inhibiting the translation of its mRNA [1].
Formule :C₂₄H₂₉N₃O₈
Couleur et forme :Solid
Masse moléculaire :487.50
Ref: TM-T85929
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CVN766
CAS :
- 1803557-42-7
CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and >10 μM for OX2R. CVN766 can be used to study schizophrenia [1].
Formule :C₂₀H₂₁F₃N₈O
Couleur et forme :Solid
Masse moléculaire :446.43
Ref: TM-T86110
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γ-secretase modulator 6
CAS :
- 1255700-88-9
Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.
Formule :C₂₅H₂₆N₆O₂
Couleur et forme :Solid
Masse moléculaire :442.513
Ref: TM-T206107
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MAO-IN-4
CAS :
- 3023217-85-5
MAO-IN-4 (Compound 2l), a monoamine oxidase (MAO) inhibitor, demonstrates IC50 values of 0.07 μM for MAO-A and 0.75 μM for MAO-B. This compound is utilized in studying depression and Parkinson's disease (PD) [1].
Formule :C₁₈H₁₁Cl₂N₃OS
Couleur et forme :Solid
Masse moléculaire :388.27
Ref: TM-T86859
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Amyloid-β-IN-3
CAS :
- 1603833-56-2
Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.
Formule :C₂₂H₂₁F₂N₃O₂
Couleur et forme :Solid
Masse moléculaire :397.42
Ref: TM-T207233
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AChE-IN-84
CAS :
- 3779-42-8
AChE-IN-84 (compound 21) is an inhibitor of AChE.
Formule :C₆H₁₅Br₂N
Couleur et forme :Solid
Masse moléculaire :260.998
Ref: TM-T205413
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Pareptide monohydrochloride
CAS :
- 63236-23-7
Pareptide monohydrochloride is a metabolically stable analog of melatonin inhibitor (MIF).
Formule :C₁₄H₂₇ClN₄O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :334.84
Ref: TM-T13707
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CPPG
CAS :
- 183364-82-1
CPPG: potent group II/III mGlu receptor antagonist, 20x more selective for group III (IC50: 2.2 nM) than II (46.2 nM) in rat cortex.
Formule :C₁₁H₁₄NO₅P
Couleur et forme :Solid
Masse moléculaire :271.21
Ref: TM-T10880
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AChE/Aβ-IN-5
CAS :
- 181114-32-9
Compound AV-2, also known as AChE/Aβ-IN-5, is a bifunctional inhibitor that acts on AChE and auto-induced Aβ (Amyloid-β) aggregation. This compound has demonstrated significant efficacy in mitigating cognitive impairment in mice induced by scopolamine and Aβ [1].
Formule :C₂₅H₂₄N₄
Couleur et forme :Solid
Masse moléculaire :380.48
Ref: TM-T85551
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AChE-IN-63
CAS :
- 876685-78-8
AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 μM. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 μM and 1.342 μM, respectively. AChE-IN-63 is effective in inhibiting Aβ aggregation and preventing the formation and deposition of Aβ1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimer's disease [1].
Formule :C₁₈H₁₉N₅O
Couleur et forme :Solid
Masse moléculaire :321.38
Ref: TM-T85555
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LY2794193
CAS :
- 2173037-97-1
LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.
Formule :C₁₆H₁₈N₂O₆
Degré de pureté :98.15%
Couleur et forme :Solid
Masse moléculaire :334.32
Ref: TM-T15807
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Tebideutorexant
CAS :
- 1637681-55-0
Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.
Formule :C₂₃H₁₆D₂F₄N₄O₂
Degré de pureté :98.89%
Couleur et forme :Solid
Masse moléculaire :460.42
Ref: TM-T70332
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BF-168
CAS :
- 634911-47-0
BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).
Formule :C₁₈H₁₇FN₂O₂
Couleur et forme :Solid
Masse moléculaire :312.34
Ref: TM-T10529
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AChE-IN-8
AChE-IN-8 (Compound 19), potent acetylcholinesterase blocker; IC50 = 1.95 μM; potential Alzheimer's treatment.
Formule :C₂₀H₂₂N₄O₂S
Couleur et forme :Solid
Masse moléculaire :382.48
Ref: TM-T61648
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LRRK2-IN-5
LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.
Formule :C₂₄H₂₆F₂N₄O₂S
Couleur et forme :Solid
Masse moléculaire :472.55
Ref: TM-T63057
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Metoquizine
CAS :
- 7125-67-9
Metoquizine is an anticholinergic compound. It is a muscarinic acetylcholine receptor antagonist that has been used to treat ulcers.
Formule :C₂₂H₂₇N₅O
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :377.48
Ref: TM-T25805
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Monoamine Oxidase B inhibitor 2
MAO-B inhibitor 2: potent, reversible, oral, selective (IC50=1.33 nM), BBB-penetrant, with anti-oxidant and anti-inflammatory effects for Parkinson's study.
Formule :C₁₉H₁₉FO₃
Couleur et forme :Solid
Masse moléculaire :314.35
Ref: TM-T60806
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Moxetomidate
CAS :
- 1567838-90-7
Moxetomidate is a GABAA receptor (GABAA receptor) agonist with hypnotic properties.
Formule :C₁₅H₁₈N₂O₃
Couleur et forme :Solid
Masse moléculaire :274.315
Ref: TM-T205308
+ Info
BChE-IN-2
BChE-IN-2, a pyrimidine/pyridine derivative, potently inhibits BChE (Ki 0.099 μM) and shows promise in AD research.
Formule :C₂₂H₃₁N₅
Couleur et forme :Solid
Masse moléculaire :365.52
Ref: TM-T61408
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MAO-B-IN-34
CAS :
- 86710-21-6
MAO-B-IN-34 (compound 3d) is an inhibitor of monoamine oxidase B.
Formule :C₁₅H₉Cl₂NO₃
Couleur et forme :Solid
Masse moléculaire :322.14
Ref: TM-T200499
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Terguride
CAS :
- 37686-84-3
Terguride: treats hyperprolactinemia, blocks 5-HT2A/B, activates dopamine receptors, studied for PAH.
Formule :C₂₀H₂₈N₄O
Couleur et forme :Solid
Masse moléculaire :340.46
Ref: TM-T71847
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AChE-IN-83
CAS :
- 2828439-12-7
AChE-IN-83 (compound f1) is an AChE inhibitor that suppresses nematode growth and acetylcholinesterase activity in rice seeds while being safe for the seeds. It specifically targets Aphelenchoides besseyi, with an LC50 of 19.0 μg/mL over 48 hours. AChE-IN-83 impedes nematode populations and behaviors in rice seeds, damages the nematode cuticle, and induces reactive oxygen species, lipofuscin, and lipid generation within the nematodes.
Formule :C₁₀H₇ClN₂O₂S
Couleur et forme :Solid
Masse moléculaire :254.693
Ref: TM-T205656