Neuroscience
Les inhibiteurs en neurosciences sont des composés conçus pour moduler l'activité de protéines, d'enzymes ou de récepteurs spécifiques au sein du système nerveux. Ces inhibiteurs sont cruciaux pour étudier les mécanismes moléculaires sous-jacents au fonctionnement neuronal, à la transmission synaptique et aux maladies neurodégénératives. En ciblant les récepteurs des neurotransmetteurs, les canaux ioniques et les voies de signalisation, les inhibiteurs en neurosciences facilitent l'exploration du fonctionnement cérébral et le développement de stratégies thérapeutiques pour des troubles neurologiques tels que la maladie d'Alzheimer, de Parkinson et l'épilepsie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs en neurosciences de haute qualité pour soutenir vos recherches en neurobiologie, neuropharmacologie et sciences cognitives.
Sous-catégories appartenant à la catégorie "Neuroscience"
- récepteur 5-HT(940 produits)
- ACK(1 produits)
- AChR(574 produits)
- ATP Citrate Lyase(16 produits)
- Récepteur adrénergique(2.943 produits)
- BACE(36 produits)
- Bêta-amyloïde(204 produits)
- CaMK(68 produits)
- COX(561 produits)
- Récepteur de la dopamine(407 produits)
- Récepteur GABA(336 produits)
- Gamma-sécrétase(59 produits)
- GluR(255 produits)
- GlyT(24 produits)
- Récepteur de l'histamine(358 produits)
- LRRK2(33 produits)
- Récepteur de la mélatonine(24 produits)
- NMDAR(28 produits)
- Récepteur OX(40 produits)
- Récepteur opioïde(297 produits)
Affichez 12 plus de sous-catégories
5398 produits trouvés pour "Neuroscience"
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nAChR antagonist 1
CAS :<p>Compound B15, a potent α7 nAChR antagonist, IC50 = 3.3 μM, promising for research on schizophrenia, Alzheimer's, and inflammation.</p>Formule :C19H22N4O2Couleur et forme :SolidMasse moléculaire :338.4BACE1-IN-4
CAS :<p>BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.</p>Formule :C21H23F2N5O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.57HDAC6-IN-9
CAS :<p>HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.</p>Formule :C19H16N2O3Degré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :320.34BRD0418
CAS :<p>BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.</p>Formule :C29H32N2O5Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :488.57Elzasonan hydrochloride
CAS :<p>Elzasonan hydrochloride is a serotonin 1B and serotonin 1D receptor antagonist. It is utilized in the study of depression.</p>Formule :C22H24Cl3N3OSCouleur et forme :SolidMasse moléculaire :484.87hMAO-B-IN-10
<p>hMAO-B-IN-10 (compound 7) is an inhibitor of MAO-A/B with IC50 values of 424.1 nM and 177.9 nM, respectively. It has demonstrated neuroprotective effects in the MPTP-induced mouse model of Parkinson's Disease (PD).</p>Formule :C16H12N4O4Couleur et forme :SolidMasse moléculaire :324.29TP003
CAS :<p>TP003 is a novel non-selective GABAA receptor benzodiazepine site agonist with affinity for α1β2gam2, α2β3gam2, α3β3gam2, α5β2gam2, EC50 of 20.3, 10.6, 3.24, 5.</p>Formule :C23H16F3N3ODegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :407.39Tiprenolol hydrochloride
CAS :<p>Tiprenolol hydrochloride is a β-adrenoceptor (β-adrenoceptor) antagonist. This compound is effective in eliminating ventricular arrhythmias in dogs caused by intravenous administration of adrenaline, following inhalation of halothane.</p>Formule :C13H22ClNO2SCouleur et forme :SolidMasse moléculaire :291.84Poskine
CAS :<p>Poskine is an anticholinergic and central nervous system depressant. It is utilized in research related to Parkinson's disease and motion sickness.</p>Formule :C20H25NO5Couleur et forme :SolidMasse moléculaire :359.42MAO-A inhibitor 1
CAS :<p>MAO-A Inhibitor 1 (compound VIII) acts as a MAO-A inhibitor and exhibits an IC50 value of 100 μM [1].</p>Formule :C14H12O4Couleur et forme :SolidMasse moléculaire :244.24SNRI-IN-1
CAS :<p>SNRI-IN-1 (Compound 7a) acts as a dual inhibitor of serotonin and noradrenaline monoamine reuptake, with a P-glycoprotein Efflux Ratio of 20 [1].</p>Formule :C16H20Cl2N2O2Couleur et forme :SolidMasse moléculaire :343.25ChEs/MAOs-IN-2
CAS :<p>ChEs/MAOs-IN-2 (compound a11) serves as an inhibitor for both cholinesterases and monoamine oxidases, exhibiting IC 50 values of 0.10 µM for MAO-A, 0.20 µM for MAO-B, 0.30 µM for AChE, and 0.40 µM for BChE. This compound shows promise for Alzheimer's disease research [1].</p>Formule :C15H12N2O3SCouleur et forme :SolidMasse moléculaire :300.33Amyloid-β-IN-2
CAS :<p>Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.</p>Formule :C22H21F2N3O2Couleur et forme :SolidMasse moléculaire :397.42CB2R/5-HT1AR agonist 1
CAS :<p>Compound 2o, also known as CB2R/5-HT1AR agonist 1, serves as a partial orally active agonist for the CB2 receptor (EC50 = 479.6 nM) and a full agonist for the 5-HT1A receptor (EC50 = 2.7 μM). This compound demonstrates both anti-anxiety and anti-depressive effects and has favorable pharmacokinetic properties [1].</p>Formule :C24H33NO3Couleur et forme :SolidMasse moléculaire :383.52Tebideutorexant
CAS :<p>Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.</p>Formule :C23H16D2F4N4O2Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :460.42Befiradol hydrochloride
CAS :<p>Befiradol HCl (NLX-112) is a selective 5-HT1A receptor agonist with anxiolytic effects and prevents ATXN3 aggregation.</p>Formule :C20H23Cl2F2N3ODegré de pureté :99.1%Couleur et forme :SolidMasse moléculaire :430.32PF470
CAS :<p>PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.</p>Formule :C18H16N6OCouleur et forme :SolidMasse moléculaire :332.36SZ1676
CAS :<p>SZ1676 is a derivative of SZ1677, which is an agent of neuromuscular blocking.</p>Formule :C37H59BrN2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :707.78P2X7 receptor antagonist-5
CAS :<p>P2X7 receptor antagonist-5 (compound 13a) is a potent, orally active, and long-lasting antagonist of the P2X7 receptor.</p>Formule :C21H17F3N6O3S2Couleur et forme :SolidMasse moléculaire :522.52Cyproflanilide
CAS :<p>Cyproflanilide is a GABAR antagonist that exhibits high activity against a variety of pests, including those from the Lepidoptera, Coleoptera, and Thysanoptera orders.</p>Formule :C28H17BrF12N2O2Couleur et forme :SolidMasse moléculaire :721.332002-G12
CAS :<p>2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.</p>Formule :C20H16N6Couleur et forme :SolidMasse moléculaire :340.381Serotonin maleate
CAS :<p>Serotonin hydrogen maleate serves as a monoaminergic neurotransmitter and an endogenous 5-HT receptor agonist within the central nervous system (CNS). It also functions as an inhibitor of catechol O-methyltransferase (COMT), exhibiting a Ki value of 44 μM.</p>Formule :C14H16N2O5Couleur et forme :SolidMasse moléculaire :292.287CaMKIIα-IN-1
<p>CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.</p>Formule :C14H11ClO4Couleur et forme :SolidMasse moléculaire :278.69BACE-1 inhibitor 2
CAS :<p>BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1].</p>Formule :C21H21F4N5O3Couleur et forme :SolidMasse moléculaire :467.42Alixorexton
CAS :<p>Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.</p>Formule :C21H30N2O5SCouleur et forme :SolidMasse moléculaire :422.538Glutaminyl Cyclase Inhibitor 3
CAS :<p>Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.</p>Formule :C24H32N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.61(E)-CHBO4
CAS :<p>(E)-CHBO4 is an MAO-B inhibitor with an IC50 value of 0.023 μM, making it a potential candidate for research into Parkinson's disease treatment.</p>Formule :C15H10BrFOCouleur et forme :SolidMasse moléculaire :305.142YNT-3708
CAS :<p>YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.</p>Formule :C35H36N4O6SCouleur et forme :SolidMasse moléculaire :640.749SB 258741 hydrochloride
<p>SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].</p>Formule :C19H31ClN2O2SCouleur et forme :SolidMasse moléculaire :386.98γ-secretase modulator 6
CAS :<p>Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.</p>Formule :C25H26N6O2Couleur et forme :SolidMasse moléculaire :442.513MAO-B-IN-34
CAS :<p>MAO-B-IN-34 (compound 3d) is an inhibitor of monoamine oxidase B.</p>Formule :C15H9Cl2NO3Couleur et forme :SolidMasse moléculaire :322.14MAO-IN-4
CAS :<p>MAO-IN-4 (Compound 2l), a monoamine oxidase (MAO) inhibitor, demonstrates IC50 values of 0.07 μM for MAO-A and 0.75 μM for MAO-B. This compound is utilized in studying depression and Parkinson's disease (PD) [1].</p>Formule :C18H11Cl2N3OSCouleur et forme :SolidMasse moléculaire :388.27(-)-5-HT2C agonist-3
CAS :<p>Compound (−)-19, also known as (-)-5-HT2C agonist-3, is a selective 5-HT2C agonist exhibiting a preference for Gq signaling. It demonstrates efficiency with EC50 values for 5-HT2 receptor subtypes as follows: 5-HT2C at 103 nM, 5-HT2B at 570 nM, and 5-HT2A at 72 nM. This compound is utilized in research on antipsychotics.</p>Formule :C19H23ClFNO2Couleur et forme :SolidMasse moléculaire :351.84AChE-IN-83
CAS :<p>AChE-IN-83 (compound f1) is an AChE inhibitor that suppresses nematode growth and acetylcholinesterase activity in rice seeds while being safe for the seeds. It specifically targets Aphelenchoides besseyi, with an LC50 of 19.0 μg/mL over 48 hours. AChE-IN-83 impedes nematode populations and behaviors in rice seeds, damages the nematode cuticle, and induces reactive oxygen species, lipofuscin, and lipid generation within the nematodes.</p>Formule :C10H7ClN2O2SCouleur et forme :SolidMasse moléculaire :254.693Terguride
CAS :<p>Terguride: treats hyperprolactinemia, blocks 5-HT2A/B, activates dopamine receptors, studied for PAH.</p>Formule :C20H28N4OCouleur et forme :SolidMasse moléculaire :340.46YM 202074
CAS :<p>metabotropic glutamate receptor type 1 (mGlu1) antagonist</p>Formule :C56H72N8O16S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1177.34β-Secretase Inhibitor III
<p>β-Secretase Inhibitor III is a highly selective inhibitor of BACE1 with a Ki value of 0.13 nM.</p>Formule :C20H20F2N4O3SCouleur et forme :SolidMasse moléculaire :434.46LP 12 hydrochloride hydrate
<p>LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.</p>Formule :C32H39N3O·HCl·xH2OCouleur et forme :SolidAAK1-IN-2 TFA
<p>AAK1-IN-2 TFA (compound (S)-31) is a selective and potent AAK1 inhibitor (IC50: 5.8 nM) that can cross the blood-brain barrier.</p>Formule :C24H22F6N4O4Couleur et forme :SolidMasse moléculaire :544.455-HT7R antagonist 3
CAS :<p>Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.</p>Formule :C30H33FN4O3Couleur et forme :SolidMasse moléculaire :516.61Anti-Aβ agent 1A
<p>Anti-Aβ agent 1A is a potent anti-amyloid-β agent.</p>Formule :C35H49NO4Couleur et forme :SolidMasse moléculaire :547.77Dihydro-β-erythroidine hydrobromide
CAS :<p>Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs).</p>Formule :C16H22BrNO3Degré de pureté :98%Couleur et forme :White SolidMasse moléculaire :356.26FP0429
CAS :<p>FP0429 is an agonist of mGlu4.</p>Formule :C10H12N2O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :272.21(+)-Cevimeline hydrochloride hemihydrate
<p>(+)-Cevimeline HCl hemihydrate is a muscarinic agonist for dry mouth in Sjogren's with rapid absorption, differing metabolism in species.</p>Formule :C10H19ClNO1·5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :244.78SB 243213 hydrochloride
CAS :<p>SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It</p>Formule :C22H20ClF3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.87Beloxepin
CAS :<p>Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.</p>Formule :C19H21NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.38PF-06648671
CAS :<p>PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.</p>Formule :C25H23ClF4N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.92U92016A hydrochloride
CAS :<p>U92016A hydrochloride: potent, orally active 5-HT1A agonist, metabolically stable, high intrinsic activity, Ki=0.2 nM.</p>Formule :C19H26ClN3Couleur et forme :SolidMasse moléculaire :331.89MAO-B-IN-42
CAS :<p>MAO-B-IN-42 (Compound 4f) is a selective and reversible monoamine oxidase-B (MAO-B) inhibitor, with an IC50 value of 0.184 μM. By blocking the oxidative deamination of monoamines catalyzed by MAO-B, it helps maintain neurotransmitter levels. MAO-B-IN-42 shows potential for research into Parkinson's disease.</p>Formule :C19H12FNO2Couleur et forme :SolidMasse moléculaire :305.302MADAM
CAS :<p>MADAM demonstrates high affinity and selectivity for 5-HTT, with a Ki value of 1.6 nM. It is utilized as a PET radiotracer for visualizing serotonin transporters.</p>Formule :C16H20N2SCouleur et forme :SolidMasse moléculaire :272.408AChE/BChE/MAO-B-IN-5
CAS :<p>AChE/BChE/MAO-B-IN-5 is a multi-target inhibitor capable of crossing the blood-brain barrier, targeting cholinesterases (AChE and BChE) and monoamine oxidase MAO-B. It exhibits IC50 values of 0.24 µM for AChE, 6.29 µM for BChE, and 0.11 µM for MAO-B. AChE/BChE/MAO-B-IN-5 holds potential for research in neurodegenerative diseases such as Alzheimer's disease.</p>Formule :C22H14F3NO2Couleur et forme :SolidMasse moléculaire :381.347ZK 93426 hydrochloride
CAS :<p>benzodiazepine receptor antagonist,competitive</p>Formule :C18H21ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.82Amyloid-β-IN-3
CAS :<p>Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.</p>Formule :C22H21F2N3O2Couleur et forme :SolidMasse moléculaire :397.42Fletazepam
CAS :<p>Fletazepam, a benzodiazepine derivative, exhibits sedative, anti-anxiety, and muscle-relaxant properties. It is utilized in neurological research.</p>Formule :C17H13ClF4N2Couleur et forme :SolidMasse moléculaire :356.74LRRK2-IN-16
CAS :<p>LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.</p>Formule :C18H19N5OSCouleur et forme :SolidMasse moléculaire :353.441UB 165
CAS :<p>Subtype-selective nicotinic agonist</p>Formule :C13H15ClN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :234.72Pareptide monohydrochloride
CAS :<p>Pareptide monohydrochloride is a metabolically stable analog of melatonin inhibitor (MIF).</p>Formule :C14H27ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :334.84AChE/Aβ-IN-5
CAS :<p>Compound AV-2, also known as AChE/Aβ-IN-5, is a bifunctional inhibitor that acts on AChE and auto-induced Aβ (Amyloid-β) aggregation. This compound has demonstrated significant efficacy in mitigating cognitive impairment in mice induced by scopolamine and Aβ [1].</p>Formule :C25H24N4Couleur et forme :SolidMasse moléculaire :380.48BChE-IN-38
CAS :<p>BChE-IN-38 (compound 13) is a potent BChE inhibitor, with Ki values of 62.05, 28.78, 14.09, and 1.15 nM for hCAI, hCAII, AChE, and BChE, respectively. BChE-IN-38 also demonstrates cytotoxic activity.</p>Formule :C27H20N4Couleur et forme :SolidMasse moléculaire :400.4742,6-Dimethoxybenzylamine hydrochloride
CAS :<p>2,6-Dimethoxybenzylamine hydrochloride (Compound 5) exhibits reversible inhibitory activity against copper amine oxidase (CAO) and inhibits benzylamine oxidase (BAO) and monoamine oxidase B (MAO B) with IC50 values of 120 μM and 190 μM, respectively.</p>Formule :C9H14ClNO2Couleur et forme :SolidMasse moléculaire :203.666Metoquizine
CAS :<p>Metoquizine is an anticholinergic compound. It is a muscarinic acetylcholine receptor antagonist that has been used to treat ulcers.</p>Formule :C22H27N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.48AZD 2066 hydrate
<p>AZD 2066 hydrate is a selective, orally active, and brain-penetrant antagonist of mGluR5. It exhibits antinociceptive effects [1].</p>Formule :C19H18ClN5O3Couleur et forme :SolidMasse moléculaire :386.33AChE-IN-63
CAS :<p>AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 μM. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 μM and 1.342 μM, respectively. AChE-IN-63 is effective in inhibiting Aβ aggregation and preventing the formation and deposition of Aβ1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimer's disease [1].</p>Formule :C18H19N5OCouleur et forme :SolidMasse moléculaire :321.38YM-31636 free base
CAS :<p>YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.</p>Formule :C14H11N3SCouleur et forme :SolidMasse moléculaire :253.32Azotomycin
CAS :<p>Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.</p>Formule :C17H23N7O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :453.41HW161023
CAS :<p>HW161023 (compound) is an orally active inhibitor of AP2 associated protein kinase 1 (AAK1), exhibiting IC50 values of 5.4 nM for AAK1 and 11.9 μM for hERG. HW161023 can suppress pain response in a rat model of chronic sciatic nerve compression injury.</p>Formule :C20H24F2N4OCouleur et forme :SolidMasse moléculaire :374.428(RS)-AMPA hydrochloride
CAS :<p>(RS)-AMPA ((±)-AMPA) hydrochloride is a glutamate analog and serves as an efficient selective agonist for the excitatory neurotransmitter L-glutamic acid (L-glutamic acid). It does not interfere with the binding sites of alginate or NMDA receptors.</p>Formule :C7H11ClN2O4Couleur et forme :SolidMasse moléculaire :222.63CVN766
CAS :<p>CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and >10 μM for OX2R. CVN766 can be used to study schizophrenia [1].</p>Formule :C20H21F3N8OCouleur et forme :SolidMasse moléculaire :446.43AChE/BACE1/GSK3β-IN-1
<p>AChE/BACE1/GSK3β-IN-1 is an orally active, blood-brain barrier-transparent, moderately bioavailable triple inhibitor of AChE/BACE1/GSK3β.</p>Formule :C26H27FN2O4Couleur et forme :SolidMasse moléculaire :450.5R-96544 hydrochloride
CAS :<p>5-HT2 receptor antagonist</p>Formule :C22H29NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.47AAZ-A 154
CAS :<p>AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.</p>Formule :C14H20N2OCouleur et forme :SolidMasse moléculaire :232.32LOXL2-IN-1 tosylate
<p>LOX-IN-5 tosylate (compound 22) is a selective oral inhibitor of lysyl oxidase-like 2 (LOXL2) with an IC50 of less than 300 nM, and it exhibits anti-fibrotic properties.</p>Formule :C28H33FN4O5S2Couleur et forme :SolidMasse moléculaire :588.714P2X4 antagonist-1
CAS :<p>P2X4 antagonist-1 is a potent P2X4 receptor antagonist used in the study of neurological, cardiovascular, and immune system diseases.</p>Formule :C20H15Cl3N2O4SDegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :485.77Dual AChE-MAO B-IN-1
<p>Dual AChE-MAO B-IN-1: orally active CNS-permeable, safe, stable neuroprotective agent; AChE IC50=550 nM, MAO-B IC50=8.2 nM.</p>Formule :C23H25F2NO4Couleur et forme :SolidMasse moléculaire :417.45VU6005806
CAS :<p>VU6005806 is a potent M4 PAM with EC50s: 94 nM (human), 28 nM (rat), 87 nM (dog), 68 nM (cyno); studied for neuropsychiatric disorders.</p>Formule :C17H16F3N7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :439.41BACE1-IN-8
<p>BACE1-IN-8 is a potent inhibitor of BACE1 (β-site APP lyase 1) (IC50: 3.9 μM).</p>Formule :C29H45N5O7Couleur et forme :SolidMasse moléculaire :575.78 Hydroxy PIPAT oxalate
CAS :<p>8 Hydroxy PIPAT oxalate is a selective 5-HT1A receptor agonist that enhances the spontaneous release of histamine by promoting the degranulation of mast cells in guinea pig and human intestinal preparations. By activating the serotonin signaling pathway, this compound demonstrates potential in regulating gastrointestinal functions and offers insight into the management and suppression of functional gastrointestinal disorders such as irritable bowel syndrome. Its effects in increasing histamine release could play a crucial role in gastrointestinal regulation.</p>Formule :C18H24INO5Couleur et forme :SolidMasse moléculaire :461.29S-8510 phosphate
CAS :<p>S-8510 phosphate is an agonist of inverse Benzodiazepine (BDZ) receptor(Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively).</p>Formule :C12H13N4O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :340.23PTCA
CAS :<p>PTCA is a potent ligand for Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα), with a pKi value of 7.2.</p>Formule :C10H5Cl2NO2SCouleur et forme :SolidMasse moléculaire :274.123Lu 26-046
CAS :<p>Lu 26-046 is a muscarinic receptor agonist.</p>Formule :C10H12N2OSCouleur et forme :SolidMasse moléculaire :208.28Moxetomidate
CAS :<p>Moxetomidate is a GABAA receptor (GABAA receptor) agonist with hypnotic properties.</p>Formule :C15H18N2O3Couleur et forme :SolidMasse moléculaire :274.315DA-8031
CAS :<p>DA-8031 is a selective and orally active serotonin reuptake inhibitor. It is utilized in research related to premature ejaculation (PE).</p>Formule :C21H24N2O2Couleur et forme :SolidMasse moléculaire :336.43AChE-IN-11
<p>AChE-IN-11 aids Alzheimer's research, has neuroprotection/antioxidant properties (ORAC=2.5), and acts on AChE, MAO-B, BACE1 with IC50 values of 7.9-9.9 μM.</p>Formule :C18H28N2O4Couleur et forme :SolidMasse moléculaire :336.43RO-1-5237
CAS :<p>RO-1-5237, a cholinergic compound and a metabolic product of Pyridostigmine Bromide, is utilized in research for myasthenia gravis.</p>Formule :C6H8BrNOCouleur et forme :SolidMasse moléculaire :190.04AAZ-A 154 hydrobromide
CAS :<p>AAZ-A 154 hydrobromide is a selective, competitive, non-hallucinogenic 5-HT2AR antagonist. It promotes neuronal growth in rodents and yields enduring beneficial behavioral effects.</p>Formule :C14H21BrN2OCouleur et forme :SolidMasse moléculaire :313.23VA012
CAS :<p>VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.</p>Formule :C21H19N3Couleur et forme :SolidMasse moléculaire :313.40COX-2-IN-47
CAS :<p>COX-2-IN-47 (compound 6c) is a selective inhibitor of COX-2, exhibiting an IC50 of 0.03 μM. This compound also displays antiedema activity.</p>Formule :C18H18N2O4Couleur et forme :SolidMasse moléculaire :326.35LY2794193
CAS :<p>LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.</p>Formule :C16H18N2O6Degré de pureté :98.15%Couleur et forme :SolidMasse moléculaire :334.32BACE1-IN-5
CAS :<p>BACE1-IN-5 inhibits BACE1 (IC50: 9.1 nM) & Aβ production (IC50: 0.82 nM), enhances hERG inhibition & P-gp efflux.</p>Formule :C18H16F5N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.41AAZ-A 154 benzoate
CAS :<p>AAZ-A 154 benzoate is a selective, competitive, and non-hallucinogenic 5-HT2AR antagonist. This compound facilitates neuronal growth in rodents and produces lasting beneficial behavioral effects.</p>Formule :C21H26N2O3Couleur et forme :SolidMasse moléculaire :354.44Carlina oxide
CAS :<p>Carlina oxide is both an AChE inhibitor and an antioxidant, effective in eliminating mosquito larvae (LC50=1.39 μg/mL). Furthermore, Carlina oxide exhibits cytotoxicity in vertebrate cells, human dermis, and HCT116 and MDA-MB231 cell lines.</p>Formule :C13H10OCouleur et forme :SolidMasse moléculaire :182.22AAZ-A 154 hydrochloride
CAS :<p>AAZ-A 154 hydrochloride is a selective, competitive, non-hallucinogenic antagonist of 5-HT2AR. It promotes neuronal growth in rodents and results in enduring beneficial behavioral effects.</p>Formule :C14H21ClN2OCouleur et forme :SolidMasse moléculaire :268.78RTIOXA-43
CAS :<p>RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.</p>Formule :C37H37N5O5SDegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :663.79SEP-363856 mesylate
CAS :<p>SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.</p>Formule :C10H17NO4S2Couleur et forme :SolidMasse moléculaire :279.38SB 224289
CAS :<p>SB 224289: selective 5-HT1B antagonist, pKi 8.2, 60x selectivity, effective orally.</p>Formule :C32H32N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :520.62AChE/BChE-IN-1
<p>AChE/BChE-IN-1: dual AChE/BChE inhibitor, IC50 of 1.06 nM/7.3 nM, crosses blood-brain barrier, with antioxidant properties for Alzheimer's research.</p>Formule :C32H35ClN6O3Couleur et forme :SolidMasse moléculaire :587.11DSP-1053 benzenesulfonate
CAS :<p>DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.</p>Formule :C32H38BrNO7SCouleur et forme :SolidMasse moléculaire :660.62hAChE/Aβ1-42-IN-1
CAS :<p>Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines and</p>Formule :C20H24N6OCouleur et forme :SolidMasse moléculaire :364.44Sulamserod hydrochloride
CAS :<p>Sulamserod hydrochloride is a 5-HT4 receptor antagonist. It is utilized in research related to gastrointestinal disorders.</p>Formule :C19H29Cl2N3O5SCouleur et forme :SolidMasse moléculaire :482.4225B-NBOH hydrochloride
CAS :<p>25B-NBOH hydrochloride is a phenethylamine that exhibits high affinity for serotonin (5-HT) receptors 5-HT2A and 5-HT2C, with pKi values of 8.3 and 9.4, respectively.</p>Formule :C17H21BrClNO3Couleur et forme :SolidMasse moléculaire :402.711
