Neuroscience

Les inhibiteurs en neurosciences sont des composés conçus pour moduler l'activité de protéines, d'enzymes ou de récepteurs spécifiques au sein du système nerveux. Ces inhibiteurs sont cruciaux pour étudier les mécanismes moléculaires sous-jacents au fonctionnement neuronal, à la transmission synaptique et aux maladies neurodégénératives. En ciblant les récepteurs des neurotransmetteurs, les canaux ioniques et les voies de signalisation, les inhibiteurs en neurosciences facilitent l'exploration du fonctionnement cérébral et le développement de stratégies thérapeutiques pour des troubles neurologiques tels que la maladie d'Alzheimer, de Parkinson et l'épilepsie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs en neurosciences de haute qualité pour soutenir vos recherches en neurobiologie, neuropharmacologie et sciences cognitives.

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5398 produits trouvés pour "Neuroscience"

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PF-06648671
CAS :
- 1587727-31-8
PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.
Formule :C₂₅H₂₃ClF₄N₄O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :538.92
Ref: TM-T24621
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Moxetomidate
CAS :
- 1567838-90-7
Moxetomidate is a GABAA receptor (GABAA receptor) agonist with hypnotic properties.
Formule :C₁₅H₁₈N₂O₃
Couleur et forme :Solid
Masse moléculaire :274.315
Ref: TM-T205308
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UB 165
CAS :
- 200432-86-6
Subtype-selective nicotinic agonist
Formule :C₁₃H₁₅ClN₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :234.72
Ref: TM-T23485
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Revexepride
CAS :
- 219984-49-3
Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.
Formule :C₂₁H₃₂ClN₃O₄
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :425.95
Ref: TM-T16737
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MAO-B-IN-6
MAO-B-IN-6 is a selective, potent, orally active MAO-B inhibitor (IC50: 0.019 μM). MAO-B-IN-6 is superior to Safinamide both in vitro and in vivo.
Couleur et forme :Solid
Ref: TM-T64271
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Rodatristat
CAS :
- 1673568-73-4
Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).
Formule :C₂₇H₂₇ClF₃N₅O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :561.98
Ref: TM-T16780
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5-HT2A/5-HT2C inverse agonist 1
CAS :
- 2718990-76-0
5-HT2A/5-HT2C inverse agonist 1 serves as a dual and potent inverse agonist for the 5-HT2A and 5-HT2C receptors, with hERG inhibition properties that mitigate cardiovascular risks. Demonstrating significant antipsychotic efficacy in the MK-801-induced mouse model, this compound holds potential for psychosis research.
Formule :C₂₄H₃₅N₅O₂
Couleur et forme :Solid
Masse moléculaire :425.57
Ref: TM-T200089
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MAO-B-IN-28
CAS :
- 3028096-72-9
MAO-B-IN-28 (compound 10e) is a potent hMAO-B inhibitor with an IC50 value of 1.9±0.5 nM, potentially serving as a candidate molecule for neurodegenerative disease research.
Formule :C₁₉H₁₀F₃NO₄S
Masse moléculaire :405.35
Ref: TM-T208337
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Pomaglumetad methionil
CAS :
- 956385-05-0
Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.
Formule :C₁₂H₂₀N₂O₈S₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :384.43
Ref: TM-T12520
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CaMKIIα-IN-1
CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.
Formule :C₁₄H₁₁ClO₄
Couleur et forme :Solid
Masse moléculaire :278.69
Ref: TM-T60515
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2,6-Dimethoxybenzylamine hydrochloride
CAS :
- 34967-23-2
2,6-Dimethoxybenzylamine hydrochloride (Compound 5) exhibits reversible inhibitory activity against copper amine oxidase (CAO) and inhibits benzylamine oxidase (BAO) and monoamine oxidase B (MAO B) with IC50 values of 120 μM and 190 μM, respectively.
Formule :C₉H₁₄ClNO₂
Couleur et forme :Solid
Masse moléculaire :203.666
Ref: TM-T204789
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LY2794193
CAS :
- 2173037-97-1
LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.
Formule :C₁₆H₁₈N₂O₆
Degré de pureté :98.15%
Couleur et forme :Solid
Masse moléculaire :334.32
Ref: TM-T15807
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BMS-901715
CAS :
- 1699861-37-4
BMS-901715 is an effective and selective inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50: 3.3 nM).
Formule :C₂₂H₂₈N₁₀O
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :448.52
Ref: TM-T10571
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AChE-IN-10
AChE-IN-10 (24r) inhibits AChE (IC50=2.4 nM), reducing amyloid buildup, tau phosphorylation, and promotes neuron health.
Formule :C₂₃H₂₇F₂NO₄S
Couleur et forme :Solid
Masse moléculaire :451.53
Ref: TM-T62743
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5-HT6/5-HT2AR antagonist-1
Potent 5-HT6/5-HT2A receptors dual antagonist with K i of 11 nM & 39 nM.
Formule :C₂₁H₂₆N₆S
Couleur et forme :Solid
Masse moléculaire :394.54
Ref: TM-T61837
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5-IAI hydrochloride
CAS :
- 1782044-60-3
5-IAI hydrochloride is a psychoactive analog of para-iodoamphetamine. 5-IAI hydrochloride significantly reduces serotonin uptake sites and hippocampal serotonin levels in rats.
Formule :C₉H₁₁ClIN
Couleur et forme :Solid
Masse moléculaire :295.548
Ref: TM-T204949
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Amyloid-β-IN-2
CAS :
- 1603833-55-1
Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.
Formule :C₂₂H₂₁F₂N₃O₂
Couleur et forme :Solid
Masse moléculaire :397.42
Ref: TM-T207418
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GABA-IN-4
CAS :
- 61-38-1
GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.
Formule :C₁₇H₁₃ClN₂O₂
Couleur et forme :Solid
Masse moléculaire :312.75
Ref: TM-T205501
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K027
K027 is a potent organophosphate (OP) inhibitor of acetylcholinesterase (AChE) reactivation. k027 can be used to study Alzheimer's disease.
Formule :C₁₅H₁₈Br₂N₄O₂
Couleur et forme :Solid
Masse moléculaire :446.14
Ref: TM-T62634
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LRRK2-IN-2
CAS :
- 2641059-19-8
LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.
Formule :C₂₃H₂₃Cl₂F₃N₆O₂
Couleur et forme :Solid
Masse moléculaire :543.37
Ref: TM-T63824
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PF470
CAS :
- 1539296-45-1
PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.
Formule :C₁₈H₁₆N₆O
Couleur et forme :Solid
Masse moléculaire :332.36
Ref: TM-T200534
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LRRK2-IN-5
LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.
Formule :C₂₄H₂₆F₂N₄O₂S
Couleur et forme :Solid
Masse moléculaire :472.55
Ref: TM-T63057
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DA-8031
CAS :
- 1148027-74-0
DA-8031 is a selective and orally active serotonin reuptake inhibitor. It is utilized in research related to premature ejaculation (PE).
Formule :C₂₁H₂₄N₂O₂
Couleur et forme :Solid
Masse moléculaire :336.43
Ref: TM-T201663
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5-HT7R antagonist 3
CAS :
- 1887043-58-4
Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.
Formule :C₃₀H₃₃FN₄O₃
Couleur et forme :Solid
Masse moléculaire :516.61
Ref: TM-T201849
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MAO-B-IN-34
CAS :
- 86710-21-6
MAO-B-IN-34 (compound 3d) is an inhibitor of monoamine oxidase B.
Formule :C₁₅H₉Cl₂NO₃
Couleur et forme :Solid
Masse moléculaire :322.14
Ref: TM-T200499
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8 Hydroxy PIPAT oxalate
CAS :
- 1451210-48-2
8 Hydroxy PIPAT oxalate is a selective 5-HT1A receptor agonist that enhances the spontaneous release of histamine by promoting the degranulation of mast cells in guinea pig and human intestinal preparations. By activating the serotonin signaling pathway, this compound demonstrates potential in regulating gastrointestinal functions and offers insight into the management and suppression of functional gastrointestinal disorders such as irritable bowel syndrome. Its effects in increasing histamine release could play a crucial role in gastrointestinal regulation.
Formule :C₁₈H₂₄INO₅
Couleur et forme :Solid
Masse moléculaire :461.29
Ref: TM-T201052
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Poskine
CAS :
- 585-14-8
Poskine is an anticholinergic and central nervous system depressant. It is utilized in research related to Parkinson's disease and motion sickness.
Formule :C₂₀H₂₅NO₅
Couleur et forme :Solid
Masse moléculaire :359.42
Ref: TM-T201100
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MAO-B-IN-10
MAO-B-IN-10: Potent, selective MAO-B inhibitor; crosses blood-brain barrier; IC50 5.3 μM; reduces Aβ aggregation 58.2%, disaggregates 43.3%.
Formule :C₂₃H₂₆N₂O₄
Couleur et forme :Solid
Masse moléculaire :394.46
Ref: TM-T61830
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BChE-IN-5
BChE-IN-5: potent, selective BChE inhibitor (IC50: 2.8 nM), more effective on hBChE, potential in Alzheimer's research.
Formule :C₃₀H₄₂N₄O
Couleur et forme :Solid
Masse moléculaire :474.68
Ref: TM-T63091
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RO-1-5237
CAS :
- 31034-86-3
RO-1-5237, a cholinergic compound and a metabolic product of Pyridostigmine Bromide, is utilized in research for myasthenia gravis.
Formule :C₆H₈BrNO
Couleur et forme :Solid
Masse moléculaire :190.04
Ref: TM-T200816
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Sulamserod hydrochloride
CAS :
- 184159-40-8
Sulamserod hydrochloride is a 5-HT4 receptor antagonist. It is utilized in research related to gastrointestinal disorders.
Formule :C₁₉H₂₉Cl₂N₃O₅S
Couleur et forme :Solid
Masse moléculaire :482.42
Ref: TM-T201756
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BRD0418
CAS :
- 1565827-99-7
BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.
Formule :C₂₉H₃₂N₂O₅
Degré de pureté :99.57%
Couleur et forme :Solid
Masse moléculaire :488.57
Ref: TM-T30577
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(9R)-RO7185876
CAS :
- 2226077-86-5
(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.
Formule :C₂₅H₂₈F₃N₇
Couleur et forme :Solid
Masse moléculaire :483.532
Ref: TM-T204358
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BPN-15606 besylate
BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).
Formule :C₂₉H₂₉FN₆O₄S
Couleur et forme :Solid
Masse moléculaire :576.64
Ref: TM-T64081
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BACE1-IN-2
CAS :
- 1352416-78-4
BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
Formule :C₁₉H₁₅F₄N₅O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :421.35
Ref: TM-T10451
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LB-102
CAS :
- 2227154-23-4
LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.
Formule :C₁₈H₂₉N₃O₄S
Couleur et forme :Solid
Masse moléculaire :383.51
Ref: TM-T200914
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PF-06751979
CAS :
- 1818339-66-0
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
Formule :C₁₈H₁₉F₂N₅O₃S₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :455.5
Ref: TM-T12429
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LY3020371 hydrochloride
CAS :
- 1377615-44-5
LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.
Formule :C₁₅H₁₆ClF₂NO₅S
Couleur et forme :Solid
Masse moléculaire :395.81
Ref: TM-T11911
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SB 243213 hydrochloride
CAS :
- 200940-23-4
SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It
Formule :C₂₂H₂₀ClF₃N₄O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :464.87
Ref: TM-T12859
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Remlifanserin
CAS :
- 2289704-13-6
Remlifanserin is a potent inverse agonist of the serotonin receptor (5-HT2A).
Formule :C₂₄H₂₉F₂N₃O₂
Couleur et forme :Solid
Masse moléculaire :429.50
Ref: TM-T201055
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AAZ-A 154 hydrobromide
CAS :
- 2930845-96-6
AAZ-A 154 hydrobromide is a selective, competitive, non-hallucinogenic 5-HT2AR antagonist. It promotes neuronal growth in rodents and yields enduring beneficial behavioral effects.
Formule :C₁₄H₂₁BrN₂O
Couleur et forme :Solid
Masse moléculaire :313.23
Ref: TM-T200446
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AChE-IN-84
CAS :
- 3779-42-8
AChE-IN-84 (compound 21) is an inhibitor of AChE.
Formule :C₆H₁₅Br₂N
Couleur et forme :Solid
Masse moléculaire :260.998
Ref: TM-T205413
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CVN766
CAS :
- 1803557-42-7
CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and >10 μM for OX2R. CVN766 can be used to study schizophrenia [1].
Formule :C₂₀H₂₁F₃N₈O
Couleur et forme :Solid
Masse moléculaire :446.43
Ref: TM-T86110
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γ-secretase modulator 6
CAS :
- 1255700-88-9
Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.
Formule :C₂₅H₂₆N₆O₂
Couleur et forme :Solid
Masse moléculaire :442.513
Ref: TM-T206107
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Serotonin maleate
CAS :
- 18525-25-2
Serotonin hydrogen maleate serves as a monoaminergic neurotransmitter and an endogenous 5-HT receptor agonist within the central nervous system (CNS). It also functions as an inhibitor of catechol O-methyltransferase (COMT), exhibiting a Ki value of 44 μM.
Formule :C₁₄H₁₆N₂O₅
Couleur et forme :Solid
Masse moléculaire :292.287
Ref: TM-T204388
+ Info
CPPG
CAS :
- 183364-82-1
CPPG: potent group II/III mGlu receptor antagonist, 20x more selective for group III (IC50: 2.2 nM) than II (46.2 nM) in rat cortex.
Formule :C₁₁H₁₄NO₅P
Couleur et forme :Solid
Masse moléculaire :271.21
Ref: TM-T10880
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2002-G12
CAS :
- 313666-93-2
2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.
Formule :C₂₀H₁₆N₆
Couleur et forme :Solid
Masse moléculaire :340.381
Ref: TM-T204830
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Rodatristat ethyl
CAS :
- 1673571-51-1
Rodatristat ethyl is an oral TPH1 inhibitor reducing 5-HT levels & lowering PAH at low doses.
Formule :C₂₉H₃₁ClF₃N₅O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :590.04
Ref: TM-T16779
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F 14679
CAS :
- 208109-38-0
F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.
Formule :C₂₁H₂₅ClF₂N₄O
Degré de pureté :99.09%
Couleur et forme :Solid
Masse moléculaire :422.9
Ref: TM-T62269
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YM-31636 free base
CAS :
- 159081-22-8
YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.
Formule :C₁₄H₁₁N₃S
Couleur et forme :Solid
Masse moléculaire :253.32
Ref: TM-T201587
+ Info
Elzasonan hydrochloride
CAS :
- 220322-05-4
Elzasonan hydrochloride is a serotonin 1B and serotonin 1D receptor antagonist. It is utilized in the study of depression.
Formule :C₂₂H₂₄Cl₃N₃OS
Couleur et forme :Solid
Masse moléculaire :484.87
Ref: TM-T201763
+ Info
hMAO-B-IN-10
hMAO-B-IN-10 (compound 7) is an inhibitor of MAO-A/B with IC50 values of 424.1 nM and 177.9 nM, respectively. It has demonstrated neuroprotective effects in the MPTP-induced mouse model of Parkinson's Disease (PD).
Formule :C₁₆H₁₂N₄O₄
Couleur et forme :Solid
Masse moléculaire :324.29
Ref: TM-T201531
+ Info
CL-13
CL-13 is an inhibitor of butyrylcholinesterase (BChE), exhibiting an IC50 of 1.15 μM and a selectivity index (SI) of 9.2 for acetylcholinesterase. It demonstrates antioxidative activity in SH-SY5Y cells with a DPPHEC50 of 47.01 μM and has the capacity to chelate metals involved in Aβ aggregation and/or oxidative stress, showing no neurotoxicity at concentrations up to 50 μM. CL-13 can also reverse scopolamine-induced cognitive impairments without affecting motor abilities in mice.
Formule :C₂₉H₃₂N₄OS
Couleur et forme :Solid
Masse moléculaire :484.66
Ref: TM-T201512
+ Info
AChE/BChE-IN-24
CAS :
- 3053509-06-8
AChE/BChE-IN-24 (compound 5k) functions as a neuroprotective agent by inhibiting acetylcholinesterase. It targets both AChE and BChE, demonstrating IC50 values of 16.38 μM and 10.44 μM, respectively.
Formule :C₂₀H₂₁N₃
Couleur et forme :Solid
Masse moléculaire :303.4
Ref: TM-T201846
+ Info
AChE-IN-79
AChE-IN-79 (compound 3i) is an acetylcholinesterase inhibitor with an IC50 of 2.7 µM, suitable for studies related to Alzheimer's disease.
Formule :C₂₉H₂₇NO₆S
Couleur et forme :Solid
Masse moléculaire :517.59
Ref: TM-T201516
+ Info
Nedemelteon
CAS :
- 1000334-38-2
Nedemelteon is an agonist of the melatonin receptor (melatonin receptor).
Formule :C₁₅H₁₈N₂O₂
Couleur et forme :Solid
Masse moléculaire :258.32
Ref: TM-T201036
+ Info
BGT1-IN-1
CAS :
- 406947-32-8
BGT1-IN-1 (compound 9) is an effective inhibitor of BGT1, demonstrating IC50 values of 13.9 µM for hBGT1 and 58.3 µM for GAT3. It exhibits no cytotoxic effects and possesses neuroprotective activity.
Formule :C₆H₉NO₂
Couleur et forme :Solid
Masse moléculaire :127.14
Ref: TM-T200935
+ Info
LRRK2-IN-16
CAS :
- 852375-30-5
LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.
Formule :C₁₈H₁₉N₅OS
Couleur et forme :Solid
Masse moléculaire :353.441
Ref: TM-T204380
+ Info
VU6016235
CAS :
- 2344787-70-6
VU6016235 is a structurally unique, orally available, and highly selective tricyclic M4 muscarinic acetylcholine receptor positive allosteric modulator.
Formule :C₂₁H₂₂N₄OS
Couleur et forme :Solid
Masse moléculaire :378.49
Ref: TM-T201326
+ Info
VU6007496
CAS :
- 2127101-85-1
VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).
Formule :C₂₅H₂₇N₅O₂
Couleur et forme :Solid
Masse moléculaire :429.51
Ref: TM-T200762
+ Info
Metoquizine
CAS :
- 7125-67-9
Metoquizine is an anticholinergic compound. It is a muscarinic acetylcholine receptor antagonist that has been used to treat ulcers.
Formule :C₂₂H₂₇N₅O
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :377.48
Ref: TM-T25805
+ Info
SZ1676
CAS :
- 159325-23-2
SZ1676 is a derivative of SZ1677, which is an agent of neuromuscular blocking.
Formule :C₃₇H₅₉BrN₂O₆
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :707.78
Ref: TM-T13908
+ Info
CaMKK2-IN-1
CAS :
- 3032691-65-6
CaMKK2-IN-1 is a selective and potent inhibitor of CaMKK2, exhibiting an IC50 of 7 nM.
Formule :C₂₂H₂₂N₂O₃
Masse moléculaire :362.42
Ref: TM-T208827
+ Info
QP5020
CAS :
- 3027434-06-3
QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.
Formule :C₂₀H₁₉FN₆
Masse moléculaire :362.40
Ref: TM-T208804
+ Info
SNRI-IN-1
CAS :
- 887766-95-2
SNRI-IN-1 (Compound 7a) acts as a dual inhibitor of serotonin and noradrenaline monoamine reuptake, with a P-glycoprotein Efflux Ratio of 20 [1].
Formule :C₁₆H₂₀Cl₂N₂O₂
Couleur et forme :Solid
Masse moléculaire :343.25
Ref: TM-T87412
+ Info
ChEs/MAOs-IN-2
CAS :
- 693268-77-8
ChEs/MAOs-IN-2 (compound a11) serves as an inhibitor for both cholinesterases and monoamine oxidases, exhibiting IC 50 values of 0.10 µM for MAO-A, 0.20 µM for MAO-B, 0.30 µM for AChE, and 0.40 µM for BChE. This compound shows promise for Alzheimer's disease research [1].
Formule :C₁₅H₁₂N₂O₃S
Couleur et forme :Solid
Masse moléculaire :300.33
Ref: TM-T86047
+ Info
AChE/Aβ-IN-5
CAS :
- 181114-32-9
Compound AV-2, also known as AChE/Aβ-IN-5, is a bifunctional inhibitor that acts on AChE and auto-induced Aβ (Amyloid-β) aggregation. This compound has demonstrated significant efficacy in mitigating cognitive impairment in mice induced by scopolamine and Aβ [1].
Formule :C₂₅H₂₄N₄
Couleur et forme :Solid
Masse moléculaire :380.48
Ref: TM-T85551
+ Info
AChE-IN-63
CAS :
- 876685-78-8
AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 μM. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 μM and 1.342 μM, respectively. AChE-IN-63 is effective in inhibiting Aβ aggregation and preventing the formation and deposition of Aβ1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimer's disease [1].
Formule :C₁₈H₁₉N₅O
Couleur et forme :Solid
Masse moléculaire :321.38
Ref: TM-T85555
+ Info
Monoamine Oxidase B inhibitor 2
MAO-B inhibitor 2: potent, reversible, oral, selective (IC50=1.33 nM), BBB-penetrant, with anti-oxidant and anti-inflammatory effects for Parkinson's study.
Formule :C₁₉H₁₉FO₃
Couleur et forme :Solid
Masse moléculaire :314.35
Ref: TM-T60806
+ Info
K203
K203 is a potent tabun-inhibited AChE reactivator and is an important antidote to organophosphorus poisoning.
Formule :C₁₆H₁₈Br₂N₄O₂
Couleur et forme :Solid
Masse moléculaire :458.15
Ref: TM-T62857
+ Info
AChE-IN-24
AChE-IN-24: Strong AChE blocker, crosses blood-brain barrier, IC50=0.053 μM, useful for AD research.
Formule :C₂₂H₃₀N₂O₄S₂
Couleur et forme :Solid
Masse moléculaire :450.61
Ref: TM-T62728
+ Info
LRRK2-IN-3
CAS :
- 2641054-60-4
LRRK2-IN-3: potent, selective oral LRRK2 blocker, BBB-penetrant, IC50 of 0.6 nM in hPBMCs, for Parkinson's research.
Formule :C₂₅H₂₉ClF₂N₆O₂
Couleur et forme :Solid
Masse moléculaire :518.99
Ref: TM-T63620
+ Info
AChE-IN-25
AChE-IN-25: selective, potent AChE inhibitor, non-competitive, IC50 = 2.95 μM, for Alzheimer's research.
Formule :C₂₀H₁₅ClN₄O₄S
Couleur et forme :Solid
Masse moléculaire :442.88
Ref: TM-T62590
+ Info
β-Secretase Inhibitor III
β-Secretase Inhibitor III is a highly selective inhibitor of BACE1 with a Ki value of 0.13 nM.
Formule :C₂₀H₂₀F₂N₄O₃S
Couleur et forme :Solid
Masse moléculaire :434.46
Ref: TM-T62455
+ Info
TDI-11861
CAS :
- 2857049-72-8
TDI-11861 is a second-gen sAC (ADCY10) inhibitor with an IC50 of 5.5 nM and slow dissociation.
Formule :C₂₂H₂₅ClF₂N₆O₃
Couleur et forme :Solid
Masse moléculaire :494.92
Ref: TM-T73297
+ Info
γ-secretase modulator 5
Compound 22d is a GSM that crosses the blood-brain barrier, inhibits Aβ42 production (IC50: 60 nM), and may help study Alzheimer's.
Couleur et forme :Solid
Ref: TM-T64258
+ Info
BACE-1 inhibitor 2
CAS :
- 2563970-92-1
BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1].
Formule :C₂₁H₂₁F₄N₅O₃
Couleur et forme :Solid
Masse moléculaire :467.42
Ref: TM-T62995
+ Info
YNT-3708
CAS :
- 2923137-99-7
YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.
Formule :C₃₅H₃₆N₄O₆S
Couleur et forme :Solid
Masse moléculaire :640.749
Ref: TM-T206764
+ Info
hAChE/Aβ1-42-IN-1
CAS :
- 2761149-17-9
Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines and
Formule :C₂₀H₂₄N₆O
Couleur et forme :Solid
Masse moléculaire :364.44
Ref: TM-T61388
+ Info
Terguride
CAS :
- 37686-84-3
Terguride: treats hyperprolactinemia, blocks 5-HT2A/B, activates dopamine receptors, studied for PAH.
Formule :C₂₀H₂₈N₄O
Couleur et forme :Solid
Masse moléculaire :340.46
Ref: TM-T71847
+ Info
AAK1-IN-2 TFA
AAK1-IN-2 TFA (compound (S)-31) is a selective and potent AAK1 inhibitor (IC50: 5.8 nM) that can cross the blood-brain barrier.
Formule :C₂₄H₂₂F₆N₄O₄
Couleur et forme :Solid
Masse moléculaire :544.45
Ref: TM-T63833
+ Info
ChE/Aβ1-42-IN-1
ChE/Aβ1-42-IN-1 (compound 28) is a potent aggregation inhibitor of ChE and Aβ 1-42 with excellent BBB permeability.
Formule :C₁₉H₂₄N₂O₃
Couleur et forme :Solid
Masse moléculaire :328.41
Ref: TM-T60940
+ Info
DSP-1053 benzenesulfonate
CAS :
- 1176326-78-5
DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.
Formule :C₃₂H₃₈BrNO₇S
Couleur et forme :Solid
Masse moléculaire :660.62
Ref: TM-T72220
+ Info
VU6005806
CAS :
- 2180914-37-6
VU6005806 is a potent M4 PAM with EC50s: 94 nM (human), 28 nM (rat), 87 nM (dog), 68 nM (cyno); studied for neuropsychiatric disorders.
Formule :C₁₇H₁₆F₃N₇O₂S
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :439.41
Ref: TM-T13322
+ Info
MAO-B-IN-42
CAS :
- 2568016-10-2
MAO-B-IN-42 (Compound 4f) is a selective and reversible monoamine oxidase-B (MAO-B) inhibitor, with an IC50 value of 0.184 μM. By blocking the oxidative deamination of monoamines catalyzed by MAO-B, it helps maintain neurotransmitter levels. MAO-B-IN-42 shows potential for research into Parkinson's disease.
Formule :C₁₉H₁₂FNO₂
Couleur et forme :Solid
Masse moléculaire :305.302
Ref: TM-T206712
+ Info
AChE/BChE-IN-3 hydrochloride
AChE/BChE-IN-3 (BMC-1) HCl is a dual inhibitor with IC50s: eqBChE 0.383 μM, elAChE 6.08 μM.
Formule :C₁₅H₂₅ClN₂O₃
Couleur et forme :Solid
Masse moléculaire :316.82
Ref: TM-T60831
+ Info
Notch inhibitor 1
CAS :
- 1584647-27-7
Notch inhibitor 1 blocks Notch 1/3 (IC50: 7.8/8.5 nM) and aids cancer research.
Formule :C₂₆H₂₅F₇N₄O₃
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :574.49
Ref: TM-T16341
+ Info
Dual AChE-MAO B-IN-1
Dual AChE-MAO B-IN-1: orally active CNS-permeable, safe, stable neuroprotective agent; AChE IC50=550 nM, MAO-B IC50=8.2 nM.
Formule :C₂₃H₂₅F₂NO₄
Couleur et forme :Solid
Masse moléculaire :417.45
Ref: TM-T62172
+ Info
Ro4368554
CAS :
- 478082-99-4
Ro4368554 is a selective 5-HT6 antagonist capable of crossing the blood-brain barrier. It can reverse memory deficits caused by scopolamine and tryptophan depletion. Ro4368554 is applicable for research related to memory impairments.
Formule :C₁₉H₂₁N₃O₂S
Couleur et forme :Solid
Masse moléculaire :355.454
Ref: TM-T204915
+ Info
Aβ42-IN-1
CAS :
- 2582757-69-3
Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).
Formule :C₂₉H₂₇ClN₄O₂
Degré de pureté :98%
Couleur et forme :Solid
Masse moléculaire :499
Ref: TM-T10211
+ Info
Anti-Aβ agent 1A
Anti-Aβ agent 1A is a potent anti-amyloid-β agent.
Formule :C₃₅H₄₉NO₄
Couleur et forme :Solid
Masse moléculaire :547.77
Ref: TM-T63873
+ Info
MAO-B-IN-5
CAS :
- 849909-77-9
MAO-B-IN-5: potent, selective oral MAO-B inhibitor, IC50=0.204μM, potential for Parkinson's research.
Formule :C₁₉H₂₁FN₂O₂
Degré de pureté :97.68%
Couleur et forme :Solid
Masse moléculaire :328.38
Ref: TM-T9759
+ Info
Dihydro-β-erythroidine hydrobromide
CAS :
- 29734-68-7
Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs).
Formule :C₁₆H₂₂BrNO₃
Degré de pureté :98%
Couleur et forme :White Solid
Masse moléculaire :356.26
Ref: TM-T11041
+ Info
LP 12 hydrochloride hydrate
LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.
Formule :C₃₂H₃₉N₃O·HCl·xH₂O
Couleur et forme :Solid
Ref: TM-T64269
+ Info
VA012
CAS :
- 885898-58-8
VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.
Formule :C₂₁H₁₉N₃
Couleur et forme :Solid
Masse moléculaire :313.40
Ref: TM-T200241
+ Info
AChE-IN-22
AChE-IN-22 (10q) selectively inhibits AChE (IC50: 0.88 μM), less on BuChE (IC50: 10 μM), targets CAS and PAS, useful in Alzheimer's research.
Formule :C₂₁H₂₀N₄O₅S
Couleur et forme :Solid
Masse moléculaire :440.47
Ref: TM-T62541
+ Info
(RS)-AMPA hydrochloride
CAS :
- 2922283-04-1
(RS)-AMPA ((±)-AMPA) hydrochloride is a glutamate analog and serves as an efficient selective agonist for the excitatory neurotransmitter L-glutamic acid (L-glutamic acid). It does not interfere with the binding sites of alginate or NMDA receptors.
Formule :C₇H₁₁ClN₂O₄
Couleur et forme :Solid
Masse moléculaire :222.63
Ref: TM-T200780
+ Info
Umibecestat
CAS :
- 1387560-01-1
Umibecestat inhibits human and mouse BACE-1 (IC50: 11 nM & 10 nM), potentially for Alzheimer's research.
Formule :C₁₉H₁₅ClF₇N₅O₂
Degré de pureté :99.88%
Couleur et forme :Solid
Masse moléculaire :513.8
Ref: TM-T13253
+ Info
AChE/BChE-IN-10
CAS :
- 2924824-48-4
AChE/BChE-IN-10 inhibits AChE/BChE (IC50: 0.176/0.47 μM), crosses the blood-brain barrier, and prevents Aβ-aggregation.
Formule :C₂₆H₃₀N₂O₂
Degré de pureté :99.55% - 99.88%
Couleur et forme :Soild
Masse moléculaire :402.53
Ref: TM-T61969
+ Info
BDZ-g
CAS :
- 732278-52-3
BDZ-g: potent, selective AMPA receptor antagonist; useful for researching neurological disorders.
Formule :C₂₁H₂₁N₅O₂S
Degré de pureté :99.97%
Couleur et forme :Solid
Masse moléculaire :407.49
Ref: TM-T62042