Neuroscience
Les inhibiteurs en neurosciences sont des composés conçus pour moduler l'activité de protéines, d'enzymes ou de récepteurs spécifiques au sein du système nerveux. Ces inhibiteurs sont cruciaux pour étudier les mécanismes moléculaires sous-jacents au fonctionnement neuronal, à la transmission synaptique et aux maladies neurodégénératives. En ciblant les récepteurs des neurotransmetteurs, les canaux ioniques et les voies de signalisation, les inhibiteurs en neurosciences facilitent l'exploration du fonctionnement cérébral et le développement de stratégies thérapeutiques pour des troubles neurologiques tels que la maladie d'Alzheimer, de Parkinson et l'épilepsie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs en neurosciences de haute qualité pour soutenir vos recherches en neurobiologie, neuropharmacologie et sciences cognitives.
Sous-catégories appartenant à la catégorie "Neuroscience"
- récepteur 5-HT(940 produits)
- ACK(1 produits)
- AChR(574 produits)
- ATP Citrate Lyase(16 produits)
- Récepteur adrénergique(2.942 produits)
- BACE(36 produits)
- Bêta-amyloïde(204 produits)
- CaMK(68 produits)
- COX(562 produits)
- Récepteur de la dopamine(407 produits)
- Récepteur GABA(336 produits)
- Gamma-sécrétase(59 produits)
- GluR(255 produits)
- GlyT(24 produits)
- Récepteur de l'histamine(358 produits)
- LRRK2(33 produits)
- Récepteur de la mélatonine(24 produits)
- NMDAR(28 produits)
- Récepteur OX(40 produits)
- Récepteur opioïde(296 produits)
Affichez 12 plus de sous-catégories
5400 produits trouvés pour "Neuroscience"
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Cyproflanilide
CAS :<p>Cyproflanilide is a GABAR antagonist that exhibits high activity against a variety of pests, including those from the Lepidoptera, Coleoptera, and Thysanoptera orders.</p>Formule :C28H17BrF12N2O2Couleur et forme :SolidMasse moléculaire :721.33P2X7 receptor antagonist-5
CAS :<p>P2X7 receptor antagonist-5 (compound 13a) is a potent, orally active, and long-lasting antagonist of the P2X7 receptor.</p>Formule :C21H17F3N6O3S2Couleur et forme :SolidMasse moléculaire :522.52AChE/BACE1/GSK3β-IN-1
<p>AChE/BACE1/GSK3β-IN-1 is an orally active, blood-brain barrier-transparent, moderately bioavailable triple inhibitor of AChE/BACE1/GSK3β.</p>Formule :C26H27FN2O4Couleur et forme :SolidMasse moléculaire :450.5Pomaglumetad methionil
CAS :<p>Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.</p>Formule :C12H20N2O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :384.43AChE/BChE-IN-3 hydrochloride
<p>AChE/BChE-IN-3 (BMC-1) HCl is a dual inhibitor with IC50s: eqBChE 0.383 μM, elAChE 6.08 μM.</p>Formule :C15H25ClN2O3Couleur et forme :SolidMasse moléculaire :316.82DL-AP5 lithium
CAS :<p>DL-AP5 (2-APV) lithium is a competitive antagonist of the NMDA (N-Methyl-D-aspartate) receptor. It exhibits notable analgesic activity and specifically blocks channels in the rabbit retina.</p>Formule :C5H11LiNO5PCouleur et forme :SolidMasse moléculaire :203.06Elzasonan hydrochloride
CAS :<p>Elzasonan hydrochloride is a serotonin 1B and serotonin 1D receptor antagonist. It is utilized in the study of depression.</p>Formule :C22H24Cl3N3OSCouleur et forme :SolidMasse moléculaire :484.87hMAO-B-IN-10
<p>hMAO-B-IN-10 (compound 7) is an inhibitor of MAO-A/B with IC50 values of 424.1 nM and 177.9 nM, respectively. It has demonstrated neuroprotective effects in the MPTP-induced mouse model of Parkinson's Disease (PD).</p>Formule :C16H12N4O4Couleur et forme :SolidMasse moléculaire :324.29Flucopride
CAS :<p>Flucopride (Compound 4a) acts as an acetylcholinesterase inhibitor (AChE) with an IC50 value of 24 nM and serves as a partial agonist for the human 5-HT4 receptor (5-HT4R) with a Ki of 9.6 nM for (h)5-HT4R. It promotes non-amyloidogenic processing of APP in COS-7 cells transiently expressing (h)5-HT4R with an EC50 of 23.0 nM. Flucopride is also likely to exhibit significant gastrointestinal tract (GIT) penetration and blood-brain barrier (BBB) permeability, as determined in PAMPA experiments.</p>Formule :C22H33FN2O2Couleur et forme :SolidMasse moléculaire :376.51R-137696
CAS :<p>R-137696 is an orally active 5-HT1A receptor agonist that facilitates the relaxation of the proximal stomach. It is utilized in research related to functional dyspepsia.</p>Formule :C17H23N3O2Couleur et forme :SolidMasse moléculaire :301.38Neral
CAS :<p>Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.</p>Formule :C10H16OCouleur et forme :SolidMasse moléculaire :152.23ROS151
<p>ROS151 is an AChE inhibitor with IC50 values of 14 nM (hAChE), 1.68 μM (eqBChE), and 8.17 μM (hFAAH). Additionally, it acts as a chelating agent for Fe3+ and Cu2+. ROS151 is utilized in research related to Alzheimer's disease.</p>Formule :C18H18FN3O6Couleur et forme :SolidMasse moléculaire :391.35TP003
CAS :<p>TP003 is a novel non-selective GABAA receptor benzodiazepine site agonist with affinity for α1β2gam2, α2β3gam2, α3β3gam2, α5β2gam2, EC50 of 20.3, 10.6, 3.24, 5.</p>Formule :C23H16F3N3ODegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :407.39SEP-363856 mesylate
CAS :<p>SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.</p>Formule :C10H17NO4S2Couleur et forme :SolidMasse moléculaire :279.38Desmethylflunitrazepam
CAS :<p>Desmethylflunitrazepam (Norflunitrazepam) is a benzodiazepine derivative and an active metabolite of Flunitrazepam.</p>Formule :C15H10FN3O3Couleur et forme :SolidMasse moléculaire :299.26Tiprenolol hydrochloride
CAS :<p>Tiprenolol hydrochloride is a β-adrenoceptor (β-adrenoceptor) antagonist. This compound is effective in eliminating ventricular arrhythmias in dogs caused by intravenous administration of adrenaline, following inhalation of halothane.</p>Formule :C13H22ClNO2SCouleur et forme :SolidMasse moléculaire :291.84(S)-Norfluoxetine
CAS :<p>(S)-Norfluoxetine, the S enantiomer of Norfluoxetine, functions as a selective serotonin reuptake inhibitor. It enhances allopregnanolone levels and reduces aggression in socially isolated mice.</p>Formule :C16H16F3NOCouleur et forme :SolidMasse moléculaire :295.3SB 243213 dihydrochloride
CAS :<p>SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for</p>Formule :C22H21Cl2F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.33Etoperidone
CAS :<p>Etoperidone is an antidepressant that acts as an orally active reuptake inhibitor for serotonin (serotonin) and noradrenaline (nor-adrenaline). It demonstrates specific binding affinities (Kd) for several receptors: 36 nM at the 5-HT2 receptor, 38 nM at the α1-adrenergic receptor (α1-adrenergic receptor), 85 nM at the 5-HT1A receptor, and 570 nM at the α2-adrenergic receptor (α2-adrenergic receptor).</p>Formule :C19H28ClN5OCouleur et forme :SolidMasse moléculaire :377.91Dihydro-β-erythroidine hydrobromide
CAS :<p>Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs).</p>Formule :C16H22BrNO3Degré de pureté :98%Couleur et forme :White SolidMasse moléculaire :356.26RTIOXA-43
CAS :<p>RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.</p>Formule :C37H37N5O5SDegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :663.79(9R)-RO7185876
CAS :<p>(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.</p>Formule :C25H28F3N7Couleur et forme :SolidMasse moléculaire :483.532BPN-15606 besylate
<p>BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).</p>Formule :C29H29FN6O4SCouleur et forme :SolidMasse moléculaire :576.64DSP-1053 benzenesulfonate
CAS :<p>DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.</p>Formule :C32H38BrNO7SCouleur et forme :SolidMasse moléculaire :660.62Nafimidone hydrochloride
CAS :<p>Nafimidone hydrochloride, an antiepileptic agent, inhibits acetylcholinesterase, protects neurons, and ameliorates cognitive decline. It is utilized in epilepsy research.</p>Formule :C15H13ClN2OCouleur et forme :SolidMasse moléculaire :272.73DA-8031
CAS :<p>DA-8031 is a selective and orally active serotonin reuptake inhibitor. It is utilized in research related to premature ejaculation (PE).</p>Formule :C21H24N2O2Couleur et forme :SolidMasse moléculaire :336.43AZD 2066 hydrate
<p>AZD 2066 hydrate is a selective, orally active, and brain-penetrant antagonist of mGluR5. It exhibits antinociceptive effects [1].</p>Formule :C19H18ClN5O3Couleur et forme :SolidMasse moléculaire :386.33LY367385 hydrochloride
CAS :<p>LY367385 hydrochloride: selective mGluR1a antagonist, IC50 = 8.8 μM, neuroprotective, anticonvulsant, antiepileptic.</p>Formule :C10H12ClNO4Couleur et forme :SolidMasse moléculaire :245.66Rocavorexant
CAS :<p>Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.</p>Formule :C18H19F3N8OCouleur et forme :SolidMasse moléculaire :420.392(S)-Praziquantel
CAS :<p>(S)-Praziquantel is the inactive isomer of R-praziquantel.</p>Formule :C19H24N2O2Couleur et forme :SolidMasse moléculaire :312.406AChE/BChE/MAO-B-IN-5
CAS :<p>AChE/BChE/MAO-B-IN-5 is a multi-target inhibitor capable of crossing the blood-brain barrier, targeting cholinesterases (AChE and BChE) and monoamine oxidase MAO-B. It exhibits IC50 values of 0.24 µM for AChE, 6.29 µM for BChE, and 0.11 µM for MAO-B. AChE/BChE/MAO-B-IN-5 holds potential for research in neurodegenerative diseases such as Alzheimer's disease.</p>Formule :C22H14F3NO2Couleur et forme :SolidMasse moléculaire :381.347VU6005806
CAS :<p>VU6005806 is a potent M4 PAM with EC50s: 94 nM (human), 28 nM (rat), 87 nM (dog), 68 nM (cyno); studied for neuropsychiatric disorders.</p>Formule :C17H16F3N7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :439.415-HT7R antagonist 3
CAS :<p>Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.</p>Formule :C30H33FN4O3Couleur et forme :SolidMasse moléculaire :516.61LP 12 hydrochloride hydrate
<p>LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.</p>Formule :C32H39N3O·HCl·xH2OCouleur et forme :SolidBACE1-IN-2
CAS :<p>BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).</p>Formule :C19H15F4N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.35Sulamserod hydrochloride
CAS :<p>Sulamserod hydrochloride is a 5-HT4 receptor antagonist. It is utilized in research related to gastrointestinal disorders.</p>Formule :C19H29Cl2N3O5SCouleur et forme :SolidMasse moléculaire :482.42Aβ-IN-2
<p>Aβ-IN-2 is a peptide inhibitor of Aβ1-42.</p>Formule :C37H51NOCouleur et forme :SolidMasse moléculaire :525.81γ-Secretase modulator 11 hydrochloride
CAS :<p>γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM).</p>Formule :C28H23ClF2N4O2Couleur et forme :SolidMasse moléculaire :520.96CaMKIIα-IN-1
<p>CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.</p>Formule :C14H11ClO4Couleur et forme :SolidMasse moléculaire :278.69BMS-901715
CAS :<p>BMS-901715 is an effective and selective inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50: 3.3 nM).</p>Formule :C22H28N10ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.52UB 165
CAS :<p>Subtype-selective nicotinic agonist</p>Formule :C13H15ClN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :234.72Rodatristat
CAS :<p>Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).</p>Formule :C27H27ClF3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :561.98Monoamine Oxidase B inhibitor 1
<p>Potent, selective MAO-B inhibitor; reversible; oral; crosses BBB; IC50=0.02 nM; potential for Parkinson's research.</p>Formule :C18H15FO3Couleur et forme :SolidMasse moléculaire :298.31AChE-IN-10
<p>AChE-IN-10 (24r) inhibits AChE (IC50=2.4 nM), reducing amyloid buildup, tau phosphorylation, and promotes neuron health.</p>Formule :C23H27F2NO4SCouleur et forme :SolidMasse moléculaire :451.53MAO-B-IN-28
CAS :<p>MAO-B-IN-28 (compound 10e) is a potent hMAO-B inhibitor with an IC50 value of 1.9±0.5 nM, potentially serving as a candidate molecule for neurodegenerative disease research.</p>Formule :C19H10F3NO4SMasse moléculaire :405.35K027
<p>K027 is a potent organophosphate (OP) inhibitor of acetylcholinesterase (AChE) reactivation. k027 can be used to study Alzheimer's disease.</p>Formule :C15H18Br2N4O2Couleur et forme :SolidMasse moléculaire :446.14LRRK2-IN-2
CAS :<p>LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.</p>Formule :C23H23Cl2F3N6O2Couleur et forme :SolidMasse moléculaire :543.37Aβ42-IN-1
CAS :<p>Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).</p>Formule :C29H27ClN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :499MAO-A inhibitor 1
CAS :<p>MAO-A Inhibitor 1 (compound VIII) acts as a MAO-A inhibitor and exhibits an IC50 value of 100 μM [1].</p>Formule :C14H12O4Couleur et forme :SolidMasse moléculaire :244.24Alixorexton
CAS :<p>Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.</p>Formule :C21H30N2O5SCouleur et forme :SolidMasse moléculaire :422.538Dual AChE-MAO B-IN-1
<p>Dual AChE-MAO B-IN-1: orally active CNS-permeable, safe, stable neuroprotective agent; AChE IC50=550 nM, MAO-B IC50=8.2 nM.</p>Formule :C23H25F2NO4Couleur et forme :SolidMasse moléculaire :417.45MAO-B-IN-6
<p>MAO-B-IN-6 is a selective, potent, orally active MAO-B inhibitor (IC50: 0.019 μM). MAO-B-IN-6 is superior to Safinamide both in vitro and in vivo.</p>Couleur et forme :SolidAM9405
<p>AM9405: peripheral CB1/5-HT3 agonist, suppresses gut motility, relieves GI disorder symptoms in mice.</p>Formule :C24H33BrN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.44YM 202074
CAS :<p>metabotropic glutamate receptor type 1 (mGlu1) antagonist</p>Formule :C56H72N8O16S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1177.34P2X4 antagonist-1
CAS :<p>P2X4 antagonist-1 is a potent P2X4 receptor antagonist used in the study of neurological, cardiovascular, and immune system diseases.</p>Formule :C20H15Cl3N2O4SDegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :485.77AChE/BChE-IN-19
CAS :<p>AChE/BChE-IN-19 (compound 12) is a nicotinic hydrazine derivative that acts as an inhibitor of AChE (IC50=21.45 nM) and BChE (IC50=18.42 nM), and it is applicable in Alzheimer's disease research.</p>Formule :C26H22N4O3Masse moléculaire :438.48QP5020
CAS :<p>QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.</p>Formule :C20H19FN6Masse moléculaire :362.40VU6016235
CAS :<p>VU6016235 is a structurally unique, orally available, and highly selective tricyclic M4 muscarinic acetylcholine receptor positive allosteric modulator.</p>Formule :C21H22N4OSCouleur et forme :SolidMasse moléculaire :378.49SNRI-IN-1
CAS :<p>SNRI-IN-1 (Compound 7a) acts as a dual inhibitor of serotonin and noradrenaline monoamine reuptake, with a P-glycoprotein Efflux Ratio of 20 [1].</p>Formule :C16H20Cl2N2O2Couleur et forme :SolidMasse moléculaire :343.25PF470
CAS :<p>PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.</p>Formule :C18H16N6OCouleur et forme :SolidMasse moléculaire :332.36F 14679
CAS :<p>F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.</p>Formule :C21H25ClF2N4ODegré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :422.9YM-31636 free base
CAS :<p>YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.</p>Formule :C14H11N3SCouleur et forme :SolidMasse moléculaire :253.32ASP-2205
CAS :<p>ASP-2205, a 5-HT2C receptor agonist (human 5-HT2C receptor, EC50=0.85 nM; rat 5-HT2C receptor, EC50=2.5 nM), enhances the urethral closure reflex mediated by the genital nerve, thereby preventing urinary incontinence.</p>Formule :C19H28N2OCouleur et forme :SolidMasse moléculaire :300.44AGH-107
CAS :<p>AGH-107 is a highly selective 5-HT7 receptor agonist that can cross the blood-brain barrier, featuring a Ki value of 6 nM and an EC50 value of 19 nM. Demonstrating high selectivity for central nervous system targets, AGH-107 also exhibits high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures.</p>Formule :C13H12IN3Couleur et forme :SolidMasse moléculaire :337.16AChE-IN-79
<p>AChE-IN-79 (compound 3i) is an acetylcholinesterase inhibitor with an IC50 of 2.7 µM, suitable for studies related to Alzheimer's disease.</p>Formule :C29H27NO6SCouleur et forme :SolidMasse moléculaire :517.59ChEs/MAOs-IN-2
CAS :<p>ChEs/MAOs-IN-2 (compound a11) serves as an inhibitor for both cholinesterases and monoamine oxidases, exhibiting IC 50 values of 0.10 µM for MAO-A, 0.20 µM for MAO-B, 0.30 µM for AChE, and 0.40 µM for BChE. This compound shows promise for Alzheimer's disease research [1].</p>Formule :C15H12N2O3SCouleur et forme :SolidMasse moléculaire :300.33BACE1-IN-4
CAS :<p>BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.</p>Formule :C21H23F2N5O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.57γ-secretase modulator 6
CAS :<p>Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.</p>Formule :C25H26N6O2Couleur et forme :SolidMasse moléculaire :442.513Remlifanserin
CAS :<p>Remlifanserin is a potent inverse agonist of the serotonin receptor (5-HT2A).</p>Formule :C24H29F2N3O2Couleur et forme :SolidMasse moléculaire :429.50CB2R/5-HT1AR agonist 1
CAS :<p>Compound 2o, also known as CB2R/5-HT1AR agonist 1, serves as a partial orally active agonist for the CB2 receptor (EC50 = 479.6 nM) and a full agonist for the 5-HT1A receptor (EC50 = 2.7 μM). This compound demonstrates both anti-anxiety and anti-depressive effects and has favorable pharmacokinetic properties [1].</p>Formule :C24H33NO3Couleur et forme :SolidMasse moléculaire :383.52EF1502 free base
CAS :<p>EF1502 is a potent and selective GABA transporter inhibitor.</p>Formule :C22H26N2O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.58Monoamine Oxidase B inhibitor 2
<p>MAO-B inhibitor 2: potent, reversible, oral, selective (IC50=1.33 nM), BBB-penetrant, with anti-oxidant and anti-inflammatory effects for Parkinson's study.</p>Formule :C19H19FO3Couleur et forme :SolidMasse moléculaire :314.35BACE-1 inhibitor 2
CAS :<p>BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1].</p>Formule :C21H21F4N5O3Couleur et forme :SolidMasse moléculaire :467.42CVN636
CAS :<p>CVN636, a potent and selective allosteric agonist for the mGluR7 receptor, exhibits oral activity and CNS permeability [1], with an EC50 of 7 nM for human</p>Formule :C19H20FNO4SCouleur et forme :SolidMasse moléculaire :377.43LB-102
CAS :<p>LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.</p>Formule :C18H29N3O4SCouleur et forme :SolidMasse moléculaire :383.51Tebideutorexant
CAS :<p>Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.</p>Formule :C23H16D2F4N4O2Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :460.42PXS-4787 hydrochloride
CAS :<p>PXS-4787 hydrochloride is a specific and potent pan-lysyl oxidase inhibitor that effectively eliminates the activity of lysyl oxidase. It exhibits varying IC50 values against different forms of the enzyme, including 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4). In addition, PXS-4787 hydrochloride reduces the deposition and cross-linking of collagen I secreted by human fibroblasts.</p>Formule :C10H13ClFNO2SCouleur et forme :SolidMasse moléculaire :265.73Amyloid-β-IN-3
CAS :<p>Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.</p>Formule :C22H21F2N3O2Couleur et forme :SolidMasse moléculaire :397.42Amyloid-β-IN-2
CAS :<p>Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.</p>Formule :C22H21F2N3O2Couleur et forme :SolidMasse moléculaire :397.42LRRK2-IN-16
CAS :<p>LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.</p>Formule :C18H19N5OSCouleur et forme :SolidMasse moléculaire :353.441LRRK2-IN-6
<p>LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).</p>Formule :C23H24F2N4O2SCouleur et forme :SolidMasse moléculaire :458.52CL-13
<p>CL-13 is an inhibitor of butyrylcholinesterase (BChE), exhibiting an IC50 of 1.15 μM and a selectivity index (SI) of 9.2 for acetylcholinesterase. It demonstrates antioxidative activity in SH-SY5Y cells with a DPPHEC50 of 47.01 μM and has the capacity to chelate metals involved in Aβ aggregation and/or oxidative stress, showing no neurotoxicity at concentrations up to 50 μM. CL-13 can also reverse scopolamine-induced cognitive impairments without affecting motor abilities in mice.</p>Formule :C29H32N4OSCouleur et forme :SolidMasse moléculaire :484.66Tipindole
CAS :<p>Tipindole is a serotonin antagonist utilized in research related to depression.</p>Formule :C16H20N2O2SCouleur et forme :SolidMasse moléculaire :304.41CaMKK2-IN-1
CAS :<p>CaMKK2-IN-1 is a selective and potent inhibitor of CaMKK2, exhibiting an IC50 of 7 nM.</p>Formule :C22H22N2O3Masse moléculaire :362.42Poskine
CAS :<p>Poskine is an anticholinergic and central nervous system depressant. It is utilized in research related to Parkinson's disease and motion sickness.</p>Formule :C20H25NO5Couleur et forme :SolidMasse moléculaire :359.42(+)-Sparteine sulfate pentahydrate
<p>(+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons.</p>Formule :C15H38N2O9SCouleur et forme :SolidMasse moléculaire :422.54Fletazepam
CAS :<p>Fletazepam, a benzodiazepine derivative, exhibits sedative, anti-anxiety, and muscle-relaxant properties. It is utilized in neurological research.</p>Formule :C17H13ClF4N2Couleur et forme :SolidMasse moléculaire :356.74hAChE/Aβ1-42-IN-1
CAS :<p>Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines and</p>Formule :C20H24N6OCouleur et forme :SolidMasse moléculaire :364.44VU6007496
CAS :<p>VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).</p>Formule :C25H27N5O2Couleur et forme :SolidMasse moléculaire :429.51LY593093
CAS :<p>LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor.</p>Formule :C32H30FN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :507.6SB 258741 hydrochloride
<p>SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].</p>Formule :C19H31ClN2O2SCouleur et forme :SolidMasse moléculaire :386.98AChE-IN-47
CAS :<p>AChE-IN-47 (compound g17) is an acetylcholinesterase (AChE) inhibitor with an IC50 of 0.24 μM. It prevents the self-aggregation of β-amyloid peptides and exhibits neuroprotective properties by effectively reducing the accumulation of intracellular reactive oxygen species (ROS).</p>Formule :C20H17F3N4O4SMasse moléculaire :466.431,9-Dideoxyforskolin
CAS :<p>The compound is an inactive analog of forskolin(an adenylyl cyclase activator).</p>Formule :C22H34O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.55-HT6/5-HT2AR antagonist-1
<p>Potent 5-HT6/5-HT2A receptors dual antagonist with K i of 11 nM & 39 nM.</p>Formule :C21H26N6SCouleur et forme :SolidMasse moléculaire :394.542002-G12
CAS :<p>2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.</p>Formule :C20H16N6Couleur et forme :SolidMasse moléculaire :340.381AM-6494
CAS :<p>AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).</p>Formule :C22H21F2N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.5Tuclazepam
CAS :<p>Tuclazepam (KC 1956) is a derivative of the benzodiazepine class of drugs, exhibiting anti-anxiety and sedative properties.</p>Formule :C17H16Cl2N2OCouleur et forme :SolidMasse moléculaire :335.23AChE/BChE-IN-24
CAS :<p>AChE/BChE-IN-24 (compound 5k) functions as a neuroprotective agent by inhibiting acetylcholinesterase. It targets both AChE and BChE, demonstrating IC50 values of 16.38 μM and 10.44 μM, respectively.</p>Formule :C20H21N3Couleur et forme :SolidMasse moléculaire :303.4Aβ42 agonist-1
CAS :<p>Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.</p>Formule :C15H11NO2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :237.25AChE-IN-26
CAS :<p>AChE-IN-26 (compound 4a) is an AChE (acetylcholinesterase) inhibitor (IC50: 0.42 μM).</p>Formule :C21H21BrN2O3Degré de pureté :99.24% - 99.85%Couleur et forme :SoildMasse moléculaire :429.31
