Neuroscience
Les inhibiteurs en neurosciences sont des composés conçus pour moduler l'activité de protéines, d'enzymes ou de récepteurs spécifiques au sein du système nerveux. Ces inhibiteurs sont cruciaux pour étudier les mécanismes moléculaires sous-jacents au fonctionnement neuronal, à la transmission synaptique et aux maladies neurodégénératives. En ciblant les récepteurs des neurotransmetteurs, les canaux ioniques et les voies de signalisation, les inhibiteurs en neurosciences facilitent l'exploration du fonctionnement cérébral et le développement de stratégies thérapeutiques pour des troubles neurologiques tels que la maladie d'Alzheimer, de Parkinson et l'épilepsie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs en neurosciences de haute qualité pour soutenir vos recherches en neurobiologie, neuropharmacologie et sciences cognitives.
Sous-catégories appartenant à la catégorie "Neuroscience"
- récepteur 5-HT(939 produits)
- ACK(1 produits)
- AChR(574 produits)
- ATP Citrate Lyase(16 produits)
- Récepteur adrénergique(2.943 produits)
- BACE(36 produits)
- Bêta-amyloïde(204 produits)
- CaMK(68 produits)
- COX(561 produits)
- Récepteur de la dopamine(407 produits)
- Récepteur GABA(336 produits)
- Gamma-sécrétase(59 produits)
- GluR(255 produits)
- GlyT(24 produits)
- Récepteur de l'histamine(358 produits)
- LRRK2(33 produits)
- Récepteur de la mélatonine(24 produits)
- NMDAR(28 produits)
- Récepteur OX(40 produits)
- Récepteur opioïde(297 produits)
Affichez 12 plus de sous-catégories
5397 produits trouvés pour "Neuroscience"
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DL-Thyroxine
CAS :<p>DL-Thyroxine is a thyroid hormone that acts as a monoamine oxidase (monoamine oxidase) inhibitor.</p>Formule :C15H11I4NO4Couleur et forme :SolidMasse moléculaire :776.87Serotonin maleate
CAS :<p>Serotonin hydrogen maleate serves as a monoaminergic neurotransmitter and an endogenous 5-HT receptor agonist within the central nervous system (CNS). It also functions as an inhibitor of catechol O-methyltransferase (COMT), exhibiting a Ki value of 44 μM.</p>Formule :C14H16N2O5Couleur et forme :SolidMasse moléculaire :292.287AAZ-A 154 benzoate
CAS :<p>AAZ-A 154 benzoate is a selective, competitive, and non-hallucinogenic 5-HT2AR antagonist. This compound facilitates neuronal growth in rodents and produces lasting beneficial behavioral effects.</p>Formule :C21H26N2O3Couleur et forme :SolidMasse moléculaire :354.44CVN766
CAS :<p>CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and >10 μM for OX2R. CVN766 can be used to study schizophrenia [1].</p>Formule :C20H21F3N8OCouleur et forme :SolidMasse moléculaire :446.43Amyloid-β-IN-2
CAS :<p>Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.</p>Formule :C22H21F2N3O2Couleur et forme :SolidMasse moléculaire :397.42Glutaminyl Cyclase Inhibitor 3
CAS :<p>Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.</p>Formule :C24H32N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.61GABAA receptor agonist 2
<p>Compound 4c, a potent GABAA agonist with anti-depressive effects in mouse FST/TST, shows promise in depression research.</p>Formule :C22H36O5Couleur et forme :SolidMasse moléculaire :380.52(S)-YNT-3708
CAS :<p>(S)-YNT-3708 is the S-isomer of YNT-3708, demonstrating relatively low activity against OX1R and OX2R receptors, with EC50 values of 3595 nM and 1661 nM, respectively.</p>Formule :C35H36N4O6SCouleur et forme :SolidMasse moléculaire :640.749MAO-A inhibitor 3
CAS :<p>MAO-A inhibitor3 (Compound 360) is an MAO-A inhibitor with an IC50 greater than 100 μM. It is utilized in the investigation of neurological disorders.</p>Formule :C11H8O5Couleur et forme :SolidMasse moléculaire :220.178LB-102
CAS :<p>LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.</p>Formule :C18H29N3O4SCouleur et forme :SolidMasse moléculaire :383.51AChE-IN-25
<p>AChE-IN-25: selective, potent AChE inhibitor, non-competitive, IC50 = 2.95 μM, for Alzheimer's research.</p>Formule :C20H15ClN4O4SCouleur et forme :SolidMasse moléculaire :442.88Nafimidone hydrochloride
CAS :<p>Nafimidone hydrochloride, an antiepileptic agent, inhibits acetylcholinesterase, protects neurons, and ameliorates cognitive decline. It is utilized in epilepsy research.</p>Formule :C15H13ClN2OCouleur et forme :SolidMasse moléculaire :272.73DA-8031
CAS :<p>DA-8031 is a selective and orally active serotonin reuptake inhibitor. It is utilized in research related to premature ejaculation (PE).</p>Formule :C21H24N2O2Couleur et forme :SolidMasse moléculaire :336.43Dual AChE-MAO B-IN-1
<p>Dual AChE-MAO B-IN-1: orally active CNS-permeable, safe, stable neuroprotective agent; AChE IC50=550 nM, MAO-B IC50=8.2 nM.</p>Formule :C23H25F2NO4Couleur et forme :SolidMasse moléculaire :417.45Sulamserod hydrochloride
CAS :<p>Sulamserod hydrochloride is a 5-HT4 receptor antagonist. It is utilized in research related to gastrointestinal disorders.</p>Formule :C19H29Cl2N3O5SCouleur et forme :SolidMasse moléculaire :482.42PXS-5153A monohydrochloride
CAS :<p>PXS-5153A is an oral, fast-acting LOXL2/3 inhibitor with IC50 <40 nM for LOXL2 and 63 nM for LOXL3, potentially treating fibrosis.</p>Formule :C20H25Cl2FN4O2SDegré de pureté :98%Couleur et forme :Odour SolidMasse moléculaire :475.41BChE-IN-5
<p>BChE-IN-5: potent, selective BChE inhibitor (IC50: 2.8 nM), more effective on hBChE, potential in Alzheimer's research.</p>Formule :C30H42N4OCouleur et forme :SolidMasse moléculaire :474.68SB 243213 dihydrochloride
CAS :<p>SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for</p>Formule :C22H21Cl2F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.33Antioxidant agent-8
<p>Antioxidant agent-8, an oral Aβ 1-42 inhibitor, reduces fibril aggregation & promotes disaggregation; it's neuroprotective & BBB permeable.</p>Formule :C13H12O5Couleur et forme :SolidMasse moléculaire :248.235-HT1A modulator 4
CAS :<p>5-HT1A modulator 4 (Compound 1) is a ligand for the 5-HT receptor, with Ki values of 2.18 μM for 5-HT1A and 19.7 μM for 5-HT2A.</p>Formule :C9H14N4Couleur et forme :SolidMasse moléculaire :178.234MMB-4
CAS :<p>MMB-4 is an oxime that can reactivate cholinesterases (cholinesterases) which have been inactivated due to exposure to organophosphates such as Sarin or Soman.</p>Formule :C13H14Br2N4O2Couleur et forme :SolidMasse moléculaire :418.084CPPG
CAS :<p>CPPG: potent group II/III mGlu receptor antagonist, 20x more selective for group III (IC50: 2.2 nM) than II (46.2 nM) in rat cortex.</p>Formule :C11H14NO5PCouleur et forme :SolidMasse moléculaire :271.21SGE-516
CAS :<p>SGE516: neuroactive steroid, enhances GABAA, lowers neuronal activity, protects from seizures.</p>Formule :C23H35N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :385.54eeAChE-IN-1
<p>eeAChE-IN-1 is a strong inhibitor of eeAChE (IC50: 23 nM).</p>Formule :C27H30N6O5SCouleur et forme :SolidMasse moléculaire :550.63Gabaculine HCl
CAS :<p>Gabaculine, an irreversible GABA-T inhibitor (Ki: 2.9 μM), impacts plastid development and affects DPOR/GluTR levels.</p>Formule :C7H10ClNO2Couleur et forme :SolidMasse moléculaire :175.61LRRK2-IN-4
CAS :<p>LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.</p>Formule :C25H29ClF2N6O2Couleur et forme :SolidMasse moléculaire :518.99HDAC6-IN-9
CAS :<p>HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.</p>Formule :C19H16N2O3Degré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :320.34R-96544 hydrochloride
CAS :<p>5-HT2 receptor antagonist</p>Formule :C22H29NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.47PTCA
CAS :<p>PTCA is a potent ligand for Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα), with a pKi value of 7.2.</p>Formule :C10H5Cl2NO2SCouleur et forme :SolidMasse moléculaire :274.123Pomaglumetad methionil
CAS :<p>Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.</p>Formule :C12H20N2O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :384.43AM-6494
CAS :<p>AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).</p>Formule :C22H21F2N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.5FP0429
CAS :<p>FP0429 is an agonist of mGlu4.</p>Formule :C10H12N2O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :272.21(S)-Norfluoxetine
CAS :<p>(S)-Norfluoxetine, the S enantiomer of Norfluoxetine, functions as a selective serotonin reuptake inhibitor. It enhances allopregnanolone levels and reduces aggression in socially isolated mice.</p>Formule :C16H16F3NOCouleur et forme :SolidMasse moléculaire :295.3Tiprenolol hydrochloride
CAS :<p>Tiprenolol hydrochloride is a β-adrenoceptor (β-adrenoceptor) antagonist. This compound is effective in eliminating ventricular arrhythmias in dogs caused by intravenous administration of adrenaline, following inhalation of halothane.</p>Formule :C13H22ClNO2SCouleur et forme :SolidMasse moléculaire :291.84Desmethylflunitrazepam
CAS :<p>Desmethylflunitrazepam (Norflunitrazepam) is a benzodiazepine derivative and an active metabolite of Flunitrazepam.</p>Formule :C15H10FN3O3Couleur et forme :SolidMasse moléculaire :299.26Lu 26-046
CAS :<p>Lu 26-046 is a muscarinic receptor agonist.</p>Formule :C10H12N2OSCouleur et forme :SolidMasse moléculaire :208.28BACE1-IN-2
CAS :<p>BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).</p>Formule :C19H15F4N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.35AChE/BChE-IN-24
CAS :<p>AChE/BChE-IN-24 (compound 5k) functions as a neuroprotective agent by inhibiting acetylcholinesterase. It targets both AChE and BChE, demonstrating IC50 values of 16.38 μM and 10.44 μM, respectively.</p>Formule :C20H21N3Couleur et forme :SolidMasse moléculaire :303.4CL-13
<p>CL-13 is an inhibitor of butyrylcholinesterase (BChE), exhibiting an IC50 of 1.15 μM and a selectivity index (SI) of 9.2 for acetylcholinesterase. It demonstrates antioxidative activity in SH-SY5Y cells with a DPPHEC50 of 47.01 μM and has the capacity to chelate metals involved in Aβ aggregation and/or oxidative stress, showing no neurotoxicity at concentrations up to 50 μM. CL-13 can also reverse scopolamine-induced cognitive impairments without affecting motor abilities in mice.</p>Formule :C29H32N4OSCouleur et forme :SolidMasse moléculaire :484.66ROS151
<p>ROS151 is an AChE inhibitor with IC50 values of 14 nM (hAChE), 1.68 μM (eqBChE), and 8.17 μM (hFAAH). Additionally, it acts as a chelating agent for Fe3+ and Cu2+. ROS151 is utilized in research related to Alzheimer's disease.</p>Formule :C18H18FN3O6Couleur et forme :SolidMasse moléculaire :391.35Neral
CAS :<p>Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.</p>Formule :C10H16OCouleur et forme :SolidMasse moléculaire :152.23R-137696
CAS :<p>R-137696 is an orally active 5-HT1A receptor agonist that facilitates the relaxation of the proximal stomach. It is utilized in research related to functional dyspepsia.</p>Formule :C17H23N3O2Couleur et forme :SolidMasse moléculaire :301.38Flucopride
CAS :<p>Flucopride (Compound 4a) acts as an acetylcholinesterase inhibitor (AChE) with an IC50 value of 24 nM and serves as a partial agonist for the human 5-HT4 receptor (5-HT4R) with a Ki of 9.6 nM for (h)5-HT4R. It promotes non-amyloidogenic processing of APP in COS-7 cells transiently expressing (h)5-HT4R with an EC50 of 23.0 nM. Flucopride is also likely to exhibit significant gastrointestinal tract (GIT) penetration and blood-brain barrier (BBB) permeability, as determined in PAMPA experiments.</p>Formule :C22H33FN2O2Couleur et forme :SolidMasse moléculaire :376.51Tipindole
CAS :<p>Tipindole is a serotonin antagonist utilized in research related to depression.</p>Formule :C16H20N2O2SCouleur et forme :SolidMasse moléculaire :304.41AChE-IN-11
<p>AChE-IN-11 aids Alzheimer's research, has neuroprotection/antioxidant properties (ORAC=2.5), and acts on AChE, MAO-B, BACE1 with IC50 values of 7.9-9.9 μM.</p>Formule :C18H28N2O4Couleur et forme :SolidMasse moléculaire :336.43YM-31636 free base
CAS :<p>YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.</p>Formule :C14H11N3SCouleur et forme :SolidMasse moléculaire :253.32F 14679
CAS :<p>F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.</p>Formule :C21H25ClF2N4ODegré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :422.9hAChE-IN-10
CAS :<p>hAChE-IN-10 (Compound ET11) is an inhibitor of human acetylcholinesterase (AChE) with an IC50 of 6.34 nM. This compound is capable of scavenging free radicals and exhibits antioxidant activity. Additionally, hAChE-IN-10 demonstrates metal-chelating properties, inhibiting Cu2+-induced Aβ1-42 aggregation, reducing amyloid plaque formation, and offering neuroprotective effects. It also ameliorates cognitive impairment in mice induced by Scopolamine.</p>Formule :C25H24ClFN6O2Couleur et forme :SolidMasse moléculaire :494.948S-8510 phosphate
CAS :<p>S-8510 phosphate is an agonist of inverse Benzodiazepine (BDZ) receptor(Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively).</p>Formule :C12H13N4O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :340.23BF-168
CAS :<p>BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).</p>Formule :C18H17FN2O2Couleur et forme :SolidMasse moléculaire :312.345-IAI hydrochloride
CAS :<p>5-IAI hydrochloride is a psychoactive analog of para-iodoamphetamine. 5-IAI hydrochloride significantly reduces serotonin uptake sites and hippocampal serotonin levels in rats.</p>Formule :C9H11ClINCouleur et forme :SolidMasse moléculaire :295.548Aβ42-IN-1
CAS :<p>Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).</p>Formule :C29H27ClN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :499LY 541850
CAS :<p>LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human</p>Formule :C9H13NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :199.2Anti-Aβ agent 1A
<p>Anti-Aβ agent 1A is a potent anti-amyloid-β agent.</p>Formule :C35H49NO4Couleur et forme :SolidMasse moléculaire :547.77MADAM
CAS :<p>MADAM demonstrates high affinity and selectivity for 5-HTT, with a Ki value of 1.6 nM. It is utilized as a PET radiotracer for visualizing serotonin transporters.</p>Formule :C16H20N2SCouleur et forme :SolidMasse moléculaire :272.408D3/5-HT receptor modulator-1
CAS :<p>D3/5-HT receptor modulator-1 (compound 5i) is a selective antagonist of the dopamine D3 and 5-HT2A receptors, and a partial agonist at the 5-HT1A receptor. It exhibits Ki values of 4.5 nM, 11.9 nM, and 15.3 nM for the dopamine D3, 5-HT2A, and 5-HT1A receptors respectively. The compound shows lower affinity for the dopamine D2 receptor, 5-HT2C receptor, and hERG channel. D3/5-HT receptor modulator-1 possesses atypical antipsychotic properties.</p>Formule :C24H29N3O2Couleur et forme :SolidMasse moléculaire :391.506(9R)-RO7185876
CAS :<p>(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.</p>Formule :C25H28F3N7Couleur et forme :SolidMasse moléculaire :483.53225B-NBOH hydrochloride
CAS :<p>25B-NBOH hydrochloride is a phenethylamine that exhibits high affinity for serotonin (5-HT) receptors 5-HT2A and 5-HT2C, with pKi values of 8.3 and 9.4, respectively.</p>Formule :C17H21BrClNO3Couleur et forme :SolidMasse moléculaire :402.711Moxetomidate
CAS :<p>Moxetomidate is a GABAA receptor (GABAA receptor) agonist with hypnotic properties.</p>Formule :C15H18N2O3Couleur et forme :SolidMasse moléculaire :274.315DSP-1053 benzenesulfonate
CAS :<p>DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.</p>Formule :C32H38BrNO7SCouleur et forme :SolidMasse moléculaire :660.62Alixorexton
CAS :<p>Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.</p>Formule :C21H30N2O5SCouleur et forme :SolidMasse moléculaire :422.538LRRK2-IN-2
CAS :<p>LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.</p>Formule :C23H23Cl2F3N6O2Couleur et forme :SolidMasse moléculaire :543.37K027
<p>K027 is a potent organophosphate (OP) inhibitor of acetylcholinesterase (AChE) reactivation. k027 can be used to study Alzheimer's disease.</p>Formule :C15H18Br2N4O2Couleur et forme :SolidMasse moléculaire :446.145-HT6/5-HT2AR antagonist-1
<p>Potent 5-HT6/5-HT2A receptors dual antagonist with K i of 11 nM & 39 nM.</p>Formule :C21H26N6SCouleur et forme :SolidMasse moléculaire :394.54AChE-IN-10
<p>AChE-IN-10 (24r) inhibits AChE (IC50=2.4 nM), reducing amyloid buildup, tau phosphorylation, and promotes neuron health.</p>Formule :C23H27F2NO4SCouleur et forme :SolidMasse moléculaire :451.53BMS-901715
CAS :<p>BMS-901715 is an effective and selective inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50: 3.3 nM).</p>Formule :C22H28N10ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.52CaMKIIα-IN-1
<p>CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.</p>Formule :C14H11ClO4Couleur et forme :SolidMasse moléculaire :278.69Rodatristat
CAS :<p>Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).</p>Formule :C27H27ClF3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :561.98Monoamine Oxidase B inhibitor 1
<p>Potent, selective MAO-B inhibitor; reversible; oral; crosses BBB; IC50=0.02 nM; potential for Parkinson's research.</p>Formule :C18H15FO3Couleur et forme :SolidMasse moléculaire :298.31Aβ42 agonist-1
CAS :<p>Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.</p>Formule :C15H11NO2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :237.25VA012
CAS :<p>VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.</p>Formule :C21H19N3Couleur et forme :SolidMasse moléculaire :313.40SEP-363856 mesylate
CAS :<p>SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.</p>Formule :C10H17NO4S2Couleur et forme :SolidMasse moléculaire :279.38YNT-3708
CAS :<p>YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.</p>Formule :C35H36N4O6SCouleur et forme :SolidMasse moléculaire :640.749COX-2-IN-47
CAS :<p>COX-2-IN-47 (compound 6c) is a selective inhibitor of COX-2, exhibiting an IC50 of 0.03 μM. This compound also displays antiedema activity.</p>Formule :C18H18N2O4Couleur et forme :SolidMasse moléculaire :326.35MAO-B-IN-6
<p>MAO-B-IN-6 is a selective, potent, orally active MAO-B inhibitor (IC50: 0.019 μM). MAO-B-IN-6 is superior to Safinamide both in vitro and in vivo.</p>Couleur et forme :SolidRTIOXA-43
CAS :<p>RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.</p>Formule :C37H37N5O5SDegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :663.79BACE1-IN-8
<p>BACE1-IN-8 is a potent inhibitor of BACE1 (β-site APP lyase 1) (IC50: 3.9 μM).</p>Formule :C29H45N5O7Couleur et forme :SolidMasse moléculaire :575.7β-Secretase Inhibitor III
<p>β-Secretase Inhibitor III is a highly selective inhibitor of BACE1 with a Ki value of 0.13 nM.</p>Formule :C20H20F2N4O3SCouleur et forme :SolidMasse moléculaire :434.46Terguride
CAS :<p>Terguride: treats hyperprolactinemia, blocks 5-HT2A/B, activates dopamine receptors, studied for PAH.</p>Formule :C20H28N4OCouleur et forme :SolidMasse moléculaire :340.46ChEs/MAOs-IN-2
CAS :<p>ChEs/MAOs-IN-2 (compound a11) serves as an inhibitor for both cholinesterases and monoamine oxidases, exhibiting IC 50 values of 0.10 µM for MAO-A, 0.20 µM for MAO-B, 0.30 µM for AChE, and 0.40 µM for BChE. This compound shows promise for Alzheimer's disease research [1].</p>Formule :C15H12N2O3SCouleur et forme :SolidMasse moléculaire :300.33SNRI-IN-1
CAS :<p>SNRI-IN-1 (Compound 7a) acts as a dual inhibitor of serotonin and noradrenaline monoamine reuptake, with a P-glycoprotein Efflux Ratio of 20 [1].</p>Formule :C16H20Cl2N2O2Couleur et forme :SolidMasse moléculaire :343.25AAK1-IN-2 TFA
<p>AAK1-IN-2 TFA (compound (S)-31) is a selective and potent AAK1 inhibitor (IC50: 5.8 nM) that can cross the blood-brain barrier.</p>Formule :C24H22F6N4O4Couleur et forme :SolidMasse moléculaire :544.45LY2794193
CAS :<p>LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.</p>Formule :C16H18N2O6Degré de pureté :98.15%Couleur et forme :SolidMasse moléculaire :334.32BChE-IN-2
<p>BChE-IN-2, a pyrimidine/pyridine derivative, potently inhibits BChE (Ki 0.099 μM) and shows promise in AD research.</p>Formule :C22H31N5Couleur et forme :SolidMasse moléculaire :365.52Aβ-IN-2
<p>Aβ-IN-2 is a peptide inhibitor of Aβ1-42.</p>Formule :C37H51NOCouleur et forme :SolidMasse moléculaire :525.818 Hydroxy PIPAT oxalate
CAS :<p>8 Hydroxy PIPAT oxalate is a selective 5-HT1A receptor agonist that enhances the spontaneous release of histamine by promoting the degranulation of mast cells in guinea pig and human intestinal preparations. By activating the serotonin signaling pathway, this compound demonstrates potential in regulating gastrointestinal functions and offers insight into the management and suppression of functional gastrointestinal disorders such as irritable bowel syndrome. Its effects in increasing histamine release could play a crucial role in gastrointestinal regulation.</p>Formule :C18H24INO5Couleur et forme :SolidMasse moléculaire :461.29MAO-B-IN-34
CAS :<p>MAO-B-IN-34 (compound 3d) is an inhibitor of monoamine oxidase B.</p>Formule :C15H9Cl2NO3Couleur et forme :SolidMasse moléculaire :322.14QP5020
CAS :<p>QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.</p>Formule :C20H19FN6Masse moléculaire :362.40MAO-B-IN-28
CAS :<p>MAO-B-IN-28 (compound 10e) is a potent hMAO-B inhibitor with an IC50 value of 1.9±0.5 nM, potentially serving as a candidate molecule for neurodegenerative disease research.</p>Formule :C19H10F3NO4SMasse moléculaire :405.35PF470
CAS :<p>PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.</p>Formule :C18H16N6OCouleur et forme :SolidMasse moléculaire :332.36Azotomycin
CAS :<p>Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.</p>Formule :C17H23N7O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :453.41VU6007496
CAS :<p>VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).</p>Formule :C25H27N5O2Couleur et forme :SolidMasse moléculaire :429.51LY593093
CAS :<p>LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor.</p>Formule :C32H30FN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :507.6EF1502 free base
CAS :<p>EF1502 is a potent and selective GABA transporter inhibitor.</p>Formule :C22H26N2O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.58Pareptide monohydrochloride
CAS :<p>Pareptide monohydrochloride is a metabolically stable analog of melatonin inhibitor (MIF).</p>Formule :C14H27ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :334.84Beloxepin
CAS :<p>Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.</p>Formule :C19H21NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.38AAZ-A 154 hydrobromide
CAS :<p>AAZ-A 154 hydrobromide is a selective, competitive, non-hallucinogenic 5-HT2AR antagonist. It promotes neuronal growth in rodents and yields enduring beneficial behavioral effects.</p>Formule :C14H21BrN2OCouleur et forme :SolidMasse moléculaire :313.23BMS 299897
CAS :<p>BMS 299897, a sulfonamide γ-secretase inhibitor, inhibits Aβ production with an IC50 of 7 nM in HEK293 cells overexpressing APP.</p>Formule :C24H21ClF3NO4SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :511.94LY2979165
CAS :<p>LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.</p>Formule :C13H22N6O6SDegré de pureté :98.41%Couleur et forme :SolidMasse moléculaire :390.42BDZ-g
CAS :<p>BDZ-g: potent, selective AMPA receptor antagonist; useful for researching neurological disorders.</p>Formule :C21H21N5O2SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :407.49
