Neuroscience
Les inhibiteurs en neurosciences sont des composés conçus pour moduler l'activité de protéines, d'enzymes ou de récepteurs spécifiques au sein du système nerveux. Ces inhibiteurs sont cruciaux pour étudier les mécanismes moléculaires sous-jacents au fonctionnement neuronal, à la transmission synaptique et aux maladies neurodégénératives. En ciblant les récepteurs des neurotransmetteurs, les canaux ioniques et les voies de signalisation, les inhibiteurs en neurosciences facilitent l'exploration du fonctionnement cérébral et le développement de stratégies thérapeutiques pour des troubles neurologiques tels que la maladie d'Alzheimer, de Parkinson et l'épilepsie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs en neurosciences de haute qualité pour soutenir vos recherches en neurobiologie, neuropharmacologie et sciences cognitives.
Sous-catégories appartenant à la catégorie "Neuroscience"
- récepteur 5-HT(1.025 produits)
- ACK(1 produits)
- AChR(645 produits)
- ATP Citrate Lyase(17 produits)
- Récepteur adrénergique(3.018 produits)
- BACE(37 produits)
- Bêta-amyloïde(228 produits)
- CaMK(73 produits)
- COX(600 produits)
- Récepteur de la dopamine(445 produits)
- Récepteur GABA(372 produits)
- Gamma-sécrétase(61 produits)
- GluR(265 produits)
- GlyT(26 produits)
- Récepteur de l'histamine(385 produits)
- LRRK2(43 produits)
- Récepteur de la mélatonine(26 produits)
- NMDAR(10 produits)
- Récepteur OX(41 produits)
- Récepteur opioïde(327 produits)
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5530 produits trouvés pour "Neuroscience"
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SB 243213 hydrochloride
CAS :SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).ItFormule :C22H20ClF3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.87Thiomuscimol hydrobromide
CAS :Thiomuscimol hydrobromide is an agonist of GABAA receptor.Formule :C4H6N2OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :130.17MAO-IN-4
CAS :MAO-IN-4 (Compound 2l), a monoamine oxidase (MAO) inhibitor, demonstrates IC50 values of 0.07 μM for MAO-A and 0.75 μM for MAO-B. This compound is utilized in studying depression and Parkinson's disease (PD) [1].Formule :C18H11Cl2N3OSCouleur et forme :SolidMasse moléculaire :388.27AChE/BuChE-IN-3
CAS :AChE/BuChE-IN-3 inhibits AChE (IC50: 0.65 μM), BuChE (IC50: 5.77 μM), crosses BBB, and hinders Aβ1-42 aggregation for Alzheimer's research.Formule :C30H30F3N3O6Couleur et forme :SolidMasse moléculaire :585.57Buntanetap L-Tartrate
CAS :Buntanetap (L-Tartrate) functions as an oral small molecule inhibitor targeting multiple neurotoxic proteins. It decreases the production of amyloid precursor protein (APP) by inhibiting the translation of its mRNA [1].Formule :C24H29N3O8Couleur et forme :SolidMasse moléculaire :487.50LY 215840
CAS :5-HT2/5-HT7 receptor antagonistFormule :C24H33N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.54Norneostigmine
CAS :Norneostigmine is a potent inhibitor of AChE capable of crossing the blood-brain barrier. When administered to mice, it achieves a 50% inhibition rate of brain AChE activity within 10 minutes, comparable to the effect of Tetrahydroaminoacridine (57% inhibition in 10 minutes). Norneostigmine is applicable in research on Alzheimer's disease and other memory-related disorders.Formule :C11H16N2O2Couleur et forme :SolidMasse moléculaire :208.26β-CCM
CAS :β-CCM is a benzodiazepine receptor inverse agonist with anxiogenic and convulsant effects. It enhances emotional reactivity and reduces interference sensitivity in spatial working memory tasks. β-CCM is applicable in research related to anxiety disorders.Formule :C13H10N2O2Couleur et forme :SolidMasse moléculaire :226.231MAO-B-IN-42
CAS :MAO-B-IN-42 (Compound 4f) is a selective and reversible monoamine oxidase-B (MAO-B) inhibitor, with an IC50 value of 0.184 μM. By blocking the oxidative deamination of monoamines catalyzed by MAO-B, it helps maintain neurotransmitter levels. MAO-B-IN-42 shows potential for research into Parkinson's disease.Formule :C19H12FNO2Couleur et forme :SolidMasse moléculaire :305.302LRRK2-IN-12
CAS :LRRK2-IN-12 (compound 1) is a potent inhibitor of LRRK2 (G20195) with an IC 50 of 0.45 nM, LRRK2 WT with an IC 50 of 1.1 nM, and LRRK2 WT ADP-Glo with an IC 50 of 0.46 nM. This compound is utilized in research related to Alzheimer's Disease [1].Formule :C18H17ClN8O2Couleur et forme :SolidMasse moléculaire :412.83(S)-Praziquantel
CAS :(S)-Praziquantel is the inactive isomer of R-praziquantel.Formule :C19H24N2O2Couleur et forme :SolidMasse moléculaire :312.406HW161023
CAS :HW161023 (compound) is an orally active inhibitor of AP2 associated protein kinase 1 (AAK1), exhibiting IC50 values of 5.4 nM for AAK1 and 11.9 μM for hERG. HW161023 can suppress pain response in a rat model of chronic sciatic nerve compression injury.Formule :C20H24F2N4OCouleur et forme :SolidMasse moléculaire :374.428AChE-IN-10
AChE-IN-10 (24r) inhibits AChE (IC50=2.4 nM), reducing amyloid buildup, tau phosphorylation, and promotes neuron health.Formule :C23H27F2NO4SCouleur et forme :SolidMasse moléculaire :451.53R-96544 hydrochloride
CAS :5-HT2 receptor antagonistFormule :C22H29NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.47(S)-YNT-3708
CAS :(S)-YNT-3708 is the S-isomer of YNT-3708, demonstrating relatively low activity against OX1R and OX2R receptors, with EC50 values of 3595 nM and 1661 nM, respectively.Formule :C35H36N4O6SCouleur et forme :SolidMasse moléculaire :640.749PTCA
CAS :PTCA is a potent ligand for Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα), with a pKi value of 7.2.Formule :C10H5Cl2NO2SCouleur et forme :SolidMasse moléculaire :274.123CGS-9895
CAS :CGS-9895 is a GABA antagonist that operates by interacting with the benzodiazepine binding site on GABA receptors containing the γ subunit (ag).Formule :C17H13N3O2Couleur et forme :SolidMasse moléculaire :291.304UB 165
CAS :Subtype-selective nicotinic agonistFormule :C13H15ClN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :234.72BACE-1 inhibitor 2
CAS :BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1].Formule :C21H21F4N5O3Couleur et forme :SolidMasse moléculaire :467.42Amyloid-β-IN-3
CAS :Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.Formule :C22H21F2N3O2Couleur et forme :SolidMasse moléculaire :397.42FCOB02
CAS :FCOB02 is a monoamine oxidase B (MAO-B) ligand. It can be labeled as [18F]FCOB02, serving as a 4-methylcoumarin-like targeting probe. [18F]FCOB02 demonstrates high affinity for MAO-B, with an IC50 of 10.68 nM. It is utilized for specific imaging and quantitative analysis of MAO-B in vivo.Formule :C16H12FNO3Couleur et forme :SolidMasse moléculaire :285.27Revexepride
CAS :Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.Formule :C21H32ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.95AChE-IN-24
AChE-IN-24: Strong AChE blocker, crosses blood-brain barrier, IC50=0.053 μM, useful for AD research.Formule :C22H30N2O4S2Couleur et forme :SolidMasse moléculaire :450.61AChE-IN-83
CAS :AChE-IN-83 (compound f1) is an AChE inhibitor that suppresses nematode growth and acetylcholinesterase activity in rice seeds while being safe for the seeds. It specifically targets Aphelenchoides besseyi, with an LC50 of 19.0 μg/mL over 48 hours. AChE-IN-83 impedes nematode populations and behaviors in rice seeds, damages the nematode cuticle, and induces reactive oxygen species, lipofuscin, and lipid generation within the nematodes.Formule :C10H7ClN2O2SCouleur et forme :SolidMasse moléculaire :254.6935-HT2A receptor agonist-7
CAS :5-HT2A receptor agonist-7 (517) functions as a modulator of the 5-HT2A receptor, with an EC50 value of less than 100 nM.Formule :C12H11F2N3Couleur et forme :SolidMasse moléculaire :235.233GABAA receptor agonist 2
Compound 4c, a potent GABAA agonist with anti-depressive effects in mouse FST/TST, shows promise in depression research.Formule :C22H36O5Couleur et forme :SolidMasse moléculaire :380.52MAO-A/SERT-IN-1
CAS :MAO-A/SERT-IN-1 acts as an inhibitor for both MAO-A and the serotonin transporter (SERT). It decreases the SERT-mediated reuptake of 5-HT and demonstrates neuroprotective properties in cellular inhibition models. Additionally, this compound has shown to alleviate depressive behaviors in both zebrafish and mice.Formule :C19H14N2O5Couleur et forme :SolidMasse moléculaire :350.325-HT1A modulator 4
CAS :5-HT1A modulator 4 (Compound 1) is a ligand for the 5-HT receptor, with Ki values of 2.18 μM for 5-HT1A and 19.7 μM for 5-HT2A.Formule :C9H14N4Couleur et forme :SolidMasse moléculaire :178.234BPN-15606 besylate
BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).Formule :C29H29FN6O4SCouleur et forme :SolidMasse moléculaire :576.64CVN766
CAS :CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and >10 μM for OX2R. CVN766 can be used to study schizophrenia [1].Formule :C20H21F3N8OCouleur et forme :SolidMasse moléculaire :446.43MMB-4
CAS :MMB-4 is an oxime that can reactivate cholinesterases (cholinesterases) which have been inactivated due to exposure to organophosphates such as Sarin or Soman.Formule :C13H14Br2N4O2Couleur et forme :SolidMasse moléculaire :418.084Monoamine Oxidase B inhibitor 1
Potent, selective MAO-B inhibitor; reversible; oral; crosses BBB; IC50=0.02 nM; potential for Parkinson's research.Formule :C18H15FO3Couleur et forme :SolidMasse moléculaire :298.31MAO-B-IN-40
CAS :MAO-B-IN-40 (3a) is an inhibitor of MAOB, exhibiting an IC50 value of 0.493 μM against hMAOB, and demonstrates significant neuroprotective and antioxidant effects. MAO-B-IN-40 (3a) is applicable in Parkinson's disease research.Formule :C17H15N3O3Couleur et forme :SolidMasse moléculaire :309.319SEP-363856 mesylate
CAS :SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.Formule :C10H17NO4S2Couleur et forme :SolidMasse moléculaire :279.38CaMKIIα-IN-1
CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.Formule :C14H11ClO4Couleur et forme :SolidMasse moléculaire :278.69GABAA receptor agonist 1
Compound 3e, a potent GABAA agonist, targets GABA sites and has potential anti-depressive effects in mice.Formule :C20H30O3Couleur et forme :SolidMasse moléculaire :318.45MAO-B-IN-6
MAO-B-IN-6 is a selective, potent, orally active MAO-B inhibitor (IC50: 0.019 μM). MAO-B-IN-6 is superior to Safinamide both in vitro and in vivo.Couleur et forme :SolidBChE-IN-3
BChE-IN-3: Selective, pseudo-irreversible BChE inhibitor (IC50: 56.9 nM); borderline reversible AChE inhibitor.Formule :C26H41N3O2Couleur et forme :SolidMasse moléculaire :427.62YM-202074
CAS :YM-202074: Selective mGlu1 antagonist, binds allosteric site (Ki=4.8 nM), inhibits mGlu1 (IC50=8.6 nM).Formule :C22H30N4O2SCouleur et forme :SolidMasse moléculaire :414.56LY-2979165
CAS :LY-2979165 is a metabotropic glutamate receptor agonist prodrug.Formule :C13H17N5O5SCouleur et forme :SolidMasse moléculaire :355.37LRRK2-IN-20
CAS :LRRK2-IN-20 (EX. 4.64) is a selective inhibitor of LRRK2 with a potency of pIC50 at 0.7921 nM. This compound is applicable in research studies focused on Parkinson's Disease (PD).Formule :C24H32ClN7OCouleur et forme :SolidMasse moléculaire :470.01γ-secretase modulator 5
Compound 22d is a GSM that crosses the blood-brain barrier, inhibits Aβ42 production (IC50: 60 nM), and may help study Alzheimer's.Couleur et forme :SolidAprindine
CAS :Aprindine, an arrhythmia inhibitor, stabilizes the cell membranes of heart muscle cells to prevent abnormal electrical impulses and irregular heartbeats. In hematological toxicity studies, aprindine demonstrated potential inhibitory effects on the replicative capacity of mouse and human blood cells at specific concentrations [1].Formule :C22H30N2Masse moléculaire :322.49VA012
CAS :VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.Formule :C21H19N3Couleur et forme :SolidMasse moléculaire :313.4025C-NBF hydrochloride
CAS :25C-NBF hydrochloride is an agonist of 5-HT receptors, specifically activating 5-HT2A and 5-HT2C receptors, with an EC50 of approximately 0.3 μM.Formule :C17H20Cl2FNO2Masse moléculaire :360.251(R)-(-)-Pirlindole mesylate
CAS :(R)-(–)-Pirlindole acts as a monoamine oxidase A (MAO-A) inhibitor with an IC50 value of 0.43 µM, exhibiting selectivity for MAO-A compared to MAO-B. When administered at 50 mg/kg, it reduces immobility time in the forced swim test in mice and, at 25 mg/kg, inhibits reserpine-induced palpebral ptosis in mice.Formule :C16H22N2O3SCouleur et forme :SolidMasse moléculaire :322.42p-F-HHSiD hydrochloride
CAS :p-F-HHSiD (p-Fluorohexahydrosiladifenidol) hydrochloride is a selective M3mAChR antagonist. It is capable of inhibiting acetylcholine-mediated vasodilation in human umbilical vein endothelial cells (HUVEC).Formule :C20H33ClFNOSiMasse moléculaire :386.019Glutaminyl Cyclase Inhibitor 3
CAS :Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.Formule :C24H32N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.61NY0116
CAS :NY0116 is an agonist of the neuromedin U receptor 2 (NMUR2), exhibiting EC50 values of 27.76 μM for hNMUR1 and 13.61 μM for hNMUR2. In NMUR2 stably expressing HEK293 cells, NY0116 reduces cAMP levels while enhancing calcium signaling [1].Formule :C22H23N3OCouleur et forme :SolidMasse moléculaire :345.44Jimscaline
CAS :Jimscaline (compound R-(-)2) is a 5-HT2A agonist and a mescaline analogue, used in neuroscience research.Formule :C13H19NO3Couleur et forme :SolidMasse moléculaire :237.295RTIOXA-43
CAS :RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.Formule :C37H37N5O5SDegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :663.79Ref: TM-T87345
1mg210,00€5mg516,00€10mg833,00€25mg1.607,00€50mg2.582,00€100mg3.492,00€1mL*10mM (DMSO)754,00€5-HT2A receptor agonist-8
CAS :5-HT2A receptor agonist-8 (compound 8) is a potent 5-HT2A receptor agonist with an EC50 of 0.6784 nM. It is suitable for research related to depression and bipolar disorder.Formule :C22H27N3OCouleur et forme :SolidMasse moléculaire :349.47Carlina oxide
CAS :Carlina oxide is both an AChE inhibitor and an antioxidant, effective in eliminating mosquito larvae (LC50=1.39 μg/mL). Furthermore, Carlina oxide exhibits cytotoxicity in vertebrate cells, human dermis, and HCT116 and MDA-MB231 cell lines.Formule :C13H10OCouleur et forme :SolidMasse moléculaire :182.22LP 12 hydrochloride hydrate
LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.Formule :C32H39N3O·HCl·xH2OCouleur et forme :SolidU92016A hydrochloride
CAS :U92016A hydrochloride: potent, orally active 5-HT1A agonist, metabolically stable, high intrinsic activity, Ki=0.2 nM.Formule :C19H26ClN3Couleur et forme :SolidMasse moléculaire :331.895-HT6R/MAO-B modulator 1
5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.Formule :C33H38N4O3SCouleur et forme :SolidMasse moléculaire :570.74CTW0404
CAS :CTW0404 is an effective positive allosteric modulator (PAM) of the 5-HT receptor, with promising implications for research into neuropsychiatric disorders.Formule :C21H33N3O2Masse moléculaire :359.51Rocavorexant
CAS :Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.Formule :C18H19F3N8OCouleur et forme :SolidMasse moléculaire :420.392hAChE/Aβ1-42-IN-1
CAS :Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines andFormule :C20H24N6OCouleur et forme :SolidMasse moléculaire :364.44Thiazolo[5,4-c]pyridin-4(5H)-one
CAS :Thiazolo[5,4-c]pyridin-4(5H)-one is a compound used for diagnostic imaging of TDP-43, in PET imaging of neurodegenerative diseases ALS、AD、FTD、LATE.Formule :C22H22FN5O2SDegré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :439.51LOXL2-IN-1 tosylate
LOX-IN-5 tosylate (compound 22) is a selective oral inhibitor of lysyl oxidase-like 2 (LOXL2) with an IC50 of less than 300 nM, and it exhibits anti-fibrotic properties.Formule :C28H33FN4O5S2Couleur et forme :SolidMasse moléculaire :588.714AM9405
AM9405: peripheral CB1/5-HT3 agonist, suppresses gut motility, relieves GI disorder symptoms in mice.Formule :C24H33BrN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.44MAO-A inhibitor 3
CAS :MAO-A inhibitor3 (Compound 360) is an MAO-A inhibitor with an IC50 greater than 100 μM. It is utilized in the investigation of neurological disorders.Formule :C11H8O5Couleur et forme :SolidMasse moléculaire :220.178nAChR antagonist 1
CAS :Compound B15, a potent α7 nAChR antagonist, IC50 = 3.3 μM, promising for research on schizophrenia, Alzheimer's, and inflammation.Formule :C19H22N4O2Couleur et forme :SolidMasse moléculaire :338.4Refisolone
CAS :Refisolone is an antagonist of the GABAA receptor.Formule :C18H24O3Couleur et forme :SolidMasse moléculaire :288.381AChE-IN-63
CAS :AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 μM. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 μM and 1.342 μM, respectively. AChE-IN-63 is effective in inhibiting Aβ aggregation and preventing the formation and deposition of Aβ1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimer's disease [1].Formule :C18H19N5OCouleur et forme :SolidMasse moléculaire :321.38DL-Thyroxine
CAS :DL-Thyroxine is a thyroid hormone that acts as a monoamine oxidase (monoamine oxidase) inhibitor.Formule :C15H11I4NO4Couleur et forme :SolidMasse moléculaire :776.87hAChE-IN-10
CAS :hAChE-IN-10 (Compound ET11) is an inhibitor of human acetylcholinesterase (AChE) with an IC50 of 6.34 nM. This compound is capable of scavenging free radicals and exhibits antioxidant activity. Additionally, hAChE-IN-10 demonstrates metal-chelating properties, inhibiting Cu2+-induced Aβ1-42 aggregation, reducing amyloid plaque formation, and offering neuroprotective effects. It also ameliorates cognitive impairment in mice induced by Scopolamine.Formule :C25H24ClFN6O2Couleur et forme :SolidMasse moléculaire :494.948Ro4368554
CAS :Ro4368554 is a selective 5-HT6 antagonist capable of crossing the blood-brain barrier. It can reverse memory deficits caused by scopolamine and tryptophan depletion. Ro4368554 is applicable for research related to memory impairments.Formule :C19H21N3O2SCouleur et forme :SolidMasse moléculaire :355.454LK-732
CAS :LK-732 is a thrombin inhibitor with antithrombotic activity. It exhibits dose-dependent inhibition in models of hypercoagulability, with an IC50 value of 1.3 mg/kg. LK-732 is used in cardiovascular and cerebrovascular research.Formule :C25H29N5O3SCouleur et forme :SolidMasse moléculaire :479.59GABA-IN-4
CAS :GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.Formule :C17H13ClN2O2Couleur et forme :SolidMasse moléculaire :312.75LRRK2-IN-16
CAS :LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.Formule :C18H19N5OSCouleur et forme :SolidMasse moléculaire :353.441BF-168
CAS :BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).Formule :C18H17FN2O2Couleur et forme :SolidMasse moléculaire :312.342002-G12
CAS :2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.Formule :C20H16N6Couleur et forme :SolidMasse moléculaire :340.381Serotonin maleate
CAS :Serotonin hydrogen maleate serves as a monoaminergic neurotransmitter and an endogenous 5-HT receptor agonist within the central nervous system (CNS). It also functions as an inhibitor of catechol O-methyltransferase (COMT), exhibiting a Ki value of 44 μM.Formule :C14H16N2O5Couleur et forme :SolidMasse moléculaire :292.2875-IAI hydrochloride
CAS :5-IAI hydrochloride is a psychoactive analog of para-iodoamphetamine. 5-IAI hydrochloride significantly reduces serotonin uptake sites and hippocampal serotonin levels in rats.Formule :C9H11ClINCouleur et forme :SolidMasse moléculaire :295.548Nafimidone hydrochloride
CAS :Nafimidone hydrochloride, an antiepileptic agent, inhibits acetylcholinesterase, protects neurons, and ameliorates cognitive decline. It is utilized in epilepsy research.Formule :C15H13ClN2OCouleur et forme :SolidMasse moléculaire :272.73AAK1-IN-2 TFA
AAK1-IN-2 TFA (compound (S)-31) is a selective and potent AAK1 inhibitor (IC50: 5.8 nM) that can cross the blood-brain barrier.Formule :C24H22F6N4O4Couleur et forme :SolidMasse moléculaire :544.45Aβ42-IN-1
CAS :Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).Formule :C29H27ClN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :499SRI-31255
CAS :SRI-31255 is an orally active LRRK2 inhibitor, with IC50 values of 520 nM for human wild-type (WT) and 427 nM for the G2019S mutant. It inhibits kinase activity by binding to the ATP-binding pocket of LRRK2, providing neuroprotective effects. SRI-31255 serves as a lead compound for developing LRRK2-targeted therapies for Parkinson’s disease research.Formule :C15H14N4Couleur et forme :SolidMasse moléculaire :250.30Terguride
CAS :Terguride: treats hyperprolactinemia, blocks 5-HT2A/B, activates dopamine receptors, studied for PAH.Formule :C20H28N4OCouleur et forme :SolidMasse moléculaire :340.46DA-8031
CAS :DA-8031 is a selective and orally active serotonin reuptake inhibitor. It is utilized in research related to premature ejaculation (PE).Formule :C21H24N2O2Couleur et forme :SolidMasse moléculaire :336.43LRRK2-IN-5
LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.Formule :C24H26F2N4O2SCouleur et forme :SolidMasse moléculaire :472.55Befiradol hydrochloride
CAS :Befiradol HCl (NLX-112) is a selective 5-HT1A receptor agonist with anxiolytic effects and prevents ATXN3 aggregation.Formule :C20H23Cl2F2N3ODegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :430.32OX2R agonist 1
CAS :OX2R agonist 1 is an OX2R activator with an EC50 of less than 100 nM. It is utilized in research related to narcolepsy and cataplexy.Formule :C21H28F2N2O5SCouleur et forme :SolidMasse moléculaire :458.52(-)-5-HT2C agonist-3
CAS :Compound (−)-19, also known as (-)-5-HT2C agonist-3, is a selective 5-HT2C agonist exhibiting a preference for Gq signaling. It demonstrates efficiency with EC50 values for 5-HT2 receptor subtypes as follows: 5-HT2C at 103 nM, 5-HT2B at 570 nM, and 5-HT2A at 72 nM. This compound is utilized in research on antipsychotics.Formule :C19H23ClFNO2Couleur et forme :SolidMasse moléculaire :351.84SB 224289
CAS :SB 224289: selective 5-HT1B antagonist, pKi 8.2, 60x selectivity, effective orally.Formule :C32H32N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :520.62DAPM
CAS :DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.Formule :C20H20F2N2O4Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :390.38LRRK2-IN-6
LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).Formule :C23H24F2N4O2SCouleur et forme :SolidMasse moléculaire :458.52(+)-Sparteine sulfate pentahydrate
(+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons.Formule :C15H38N2O9SCouleur et forme :SolidMasse moléculaire :422.54BRD0418
CAS :BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.Formule :C29H32N2O5Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :488.57(E)-CHBO4
CAS :(E)-CHBO4 is an MAO-B inhibitor with an IC50 value of 0.023 μM, making it a potential candidate for research into Parkinson's disease treatment.Formule :C15H10BrFOCouleur et forme :SolidMasse moléculaire :305.142K027
K027 is a potent organophosphate (OP) inhibitor of acetylcholinesterase (AChE) reactivation. k027 can be used to study Alzheimer's disease.Formule :C15H18Br2N4O2Couleur et forme :SolidMasse moléculaire :446.14PDE4B/7A-IN-1
CAS :5-HT1A antagonist; Ki=8nM, Kb=0.04nM. PDE4B IC50=80.4μM; PDE7A IC50=151.3μM. Good biofilm penetration, stable, anticognitive, antidepressant.Formule :C25H35N3O3Couleur et forme :SolidMasse moléculaire :425.56LRRK2-IN-2
CAS :LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.Formule :C23H23Cl2F3N6O2Couleur et forme :SolidMasse moléculaire :543.37SB 258741 hydrochloride
SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].Formule :C19H31ClN2O2SCouleur et forme :SolidMasse moléculaire :386.98ChE/Aβ1-42-IN-1
ChE/Aβ1-42-IN-1 (compound 28) is a potent aggregation inhibitor of ChE and Aβ 1-42 with excellent BBB permeability.Formule :C19H24N2O3Couleur et forme :SolidMasse moléculaire :328.41K203
K203 is a potent tabun-inhibited AChE reactivator and is an important antidote to organophosphorus poisoning.Formule :C16H18Br2N4O2Couleur et forme :SolidMasse moléculaire :458.15YM-31636 free base
CAS :YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.Formule :C14H11N3SCouleur et forme :SolidMasse moléculaire :253.32Elzasonan hydrochloride
CAS :Elzasonan hydrochloride is a serotonin 1B and serotonin 1D receptor antagonist. It is utilized in the study of depression.Formule :C22H24Cl3N3OSCouleur et forme :SolidMasse moléculaire :484.87
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