Neuroscience
Les inhibiteurs en neurosciences sont des composés conçus pour moduler l'activité de protéines, d'enzymes ou de récepteurs spécifiques au sein du système nerveux. Ces inhibiteurs sont cruciaux pour étudier les mécanismes moléculaires sous-jacents au fonctionnement neuronal, à la transmission synaptique et aux maladies neurodégénératives. En ciblant les récepteurs des neurotransmetteurs, les canaux ioniques et les voies de signalisation, les inhibiteurs en neurosciences facilitent l'exploration du fonctionnement cérébral et le développement de stratégies thérapeutiques pour des troubles neurologiques tels que la maladie d'Alzheimer, de Parkinson et l'épilepsie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs en neurosciences de haute qualité pour soutenir vos recherches en neurobiologie, neuropharmacologie et sciences cognitives.
Sous-catégories appartenant à la catégorie "Neuroscience"
- récepteur 5-HT(1.025 produits)
- ACK(1 produits)
- AChR(645 produits)
- ATP Citrate Lyase(17 produits)
- Récepteur adrénergique(3.018 produits)
- BACE(37 produits)
- Bêta-amyloïde(228 produits)
- CaMK(73 produits)
- COX(600 produits)
- Récepteur de la dopamine(445 produits)
- Récepteur GABA(372 produits)
- Gamma-sécrétase(61 produits)
- GluR(265 produits)
- GlyT(26 produits)
- Récepteur de l'histamine(385 produits)
- LRRK2(43 produits)
- Récepteur de la mélatonine(26 produits)
- NMDAR(10 produits)
- Récepteur OX(41 produits)
- Récepteur opioïde(327 produits)
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5530 produits trouvés pour "Neuroscience"
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(9R)-RO7185876
CAS :(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.Formule :C25H28F3N7Couleur et forme :SolidMasse moléculaire :483.532(+)-Cevimeline hydrochloride hemihydrate
(+)-Cevimeline HCl hemihydrate is a muscarinic agonist for dry mouth in Sjogren's with rapid absorption, differing metabolism in species.Formule :C10H19ClNO1·5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :244.78Norneostigmine
CAS :Norneostigmine is a potent inhibitor of AChE capable of crossing the blood-brain barrier. When administered to mice, it achieves a 50% inhibition rate of brain AChE activity within 10 minutes, comparable to the effect of Tetrahydroaminoacridine (57% inhibition in 10 minutes). Norneostigmine is applicable in research on Alzheimer's disease and other memory-related disorders.Formule :C11H16N2O2Couleur et forme :SolidMasse moléculaire :208.26BACE1-IN-2
CAS :BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).Formule :C19H15F4N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.35LY-2979165
CAS :LY-2979165 is a metabotropic glutamate receptor agonist prodrug.Formule :C13H17N5O5SCouleur et forme :SolidMasse moléculaire :355.37ChE/Aβ1-42-IN-1
ChE/Aβ1-42-IN-1 (compound 28) is a potent aggregation inhibitor of ChE and Aβ 1-42 with excellent BBB permeability.Formule :C19H24N2O3Couleur et forme :SolidMasse moléculaire :328.41LK-732
CAS :LK-732 is a thrombin inhibitor with antithrombotic activity. It exhibits dose-dependent inhibition in models of hypercoagulability, with an IC50 value of 1.3 mg/kg. LK-732 is used in cardiovascular and cerebrovascular research.Formule :C25H29N5O3SCouleur et forme :SolidMasse moléculaire :479.59(E)-CHBO4
CAS :(E)-CHBO4 is an MAO-B inhibitor with an IC50 value of 0.023 μM, making it a potential candidate for research into Parkinson's disease treatment.Formule :C15H10BrFOCouleur et forme :SolidMasse moléculaire :305.142HDAC6-IN-9
CAS :HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.Formule :C19H16N2O3Degré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :320.34MAO-B-IN-5
CAS :MAO-B-IN-5: potent, selective oral MAO-B inhibitor, IC50=0.204μM, potential for Parkinson's research.
Formule :C19H21FN2O2Degré de pureté :97.68%Couleur et forme :SolidMasse moléculaire :328.38SB 258741 hydrochloride
SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].Formule :C19H31ClN2O2SCouleur et forme :SolidMasse moléculaire :386.98Thiomuscimol hydrobromide
CAS :Thiomuscimol hydrobromide is an agonist of GABAA receptor.Formule :C4H6N2OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :130.17BGT1-IN-1
CAS :BGT1-IN-1 (compound 9) is an effective inhibitor of BGT1, demonstrating IC50 values of 13.9 µM for hBGT1 and 58.3 µM for GAT3. It exhibits no cytotoxic effects and possesses neuroprotective activity.Formule :C6H9NO2Couleur et forme :SolidMasse moléculaire :127.14Pomaglumetad methionil
CAS :Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.Formule :C12H20N2O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :384.43(-)-5-HT2C agonist-3
CAS :Compound (−)-19, also known as (-)-5-HT2C agonist-3, is a selective 5-HT2C agonist exhibiting a preference for Gq signaling. It demonstrates efficiency with EC50 values for 5-HT2 receptor subtypes as follows: 5-HT2C at 103 nM, 5-HT2B at 570 nM, and 5-HT2A at 72 nM. This compound is utilized in research on antipsychotics.Formule :C19H23ClFNO2Couleur et forme :SolidMasse moléculaire :351.84LRRK2-IN-12
CAS :LRRK2-IN-12 (compound 1) is a potent inhibitor of LRRK2 (G20195) with an IC 50 of 0.45 nM, LRRK2 WT with an IC 50 of 1.1 nM, and LRRK2 WT ADP-Glo with an IC 50 of 0.46 nM. This compound is utilized in research related to Alzheimer's Disease [1].Formule :C18H17ClN8O2Couleur et forme :SolidMasse moléculaire :412.83OX2R agonist 1
CAS :OX2R agonist 1 is an OX2R activator with an EC50 of less than 100 nM. It is utilized in research related to narcolepsy and cataplexy.Formule :C21H28F2N2O5SCouleur et forme :SolidMasse moléculaire :458.52PF-06648671
CAS :PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.Formule :C25H23ClF4N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.92MAO-B-IN-6
MAO-B-IN-6 is a selective, potent, orally active MAO-B inhibitor (IC50: 0.019 μM). MAO-B-IN-6 is superior to Safinamide both in vitro and in vivo.Couleur et forme :SolidNedemelteon
CAS :Nedemelteon is an agonist of the melatonin receptor (melatonin receptor).Formule :C15H18N2O2Couleur et forme :SolidMasse moléculaire :258.32LRRK2-IN-20
CAS :LRRK2-IN-20 (EX. 4.64) is a selective inhibitor of LRRK2 with a potency of pIC50 at 0.7921 nM. This compound is applicable in research studies focused on Parkinson's Disease (PD).Formule :C24H32ClN7OCouleur et forme :SolidMasse moléculaire :470.015-HT6/5-HT2AR antagonist-1
Potent 5-HT6/5-HT2A receptors dual antagonist with K i of 11 nM & 39 nM.Formule :C21H26N6SCouleur et forme :SolidMasse moléculaire :394.54MAO-A/SERT-IN-1
CAS :MAO-A/SERT-IN-1 acts as an inhibitor for both MAO-A and the serotonin transporter (SERT). It decreases the SERT-mediated reuptake of 5-HT and demonstrates neuroprotective properties in cellular inhibition models. Additionally, this compound has shown to alleviate depressive behaviors in both zebrafish and mice.Formule :C19H14N2O5Couleur et forme :SolidMasse moléculaire :350.32LRRK2-IN-4
CAS :LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.Formule :C25H29ClF2N6O2Couleur et forme :SolidMasse moléculaire :518.99Illudinine
CAS :Illudinine is a sesquiterpene alkaloid that acts as an inhibitor of monoamine oxidase B (MAO-B), with an IC50 value of 18.3 μM. It is applicable in research focused on neurological disorders.Formule :C16H17NO3Couleur et forme :SolidMasse moléculaire :271.31AChE-IN-5
AChE-IN-5: oral, crosses blood-brain barrier, targets AChE/5-HT1A/SERT, potent with 2.29 nM IC50.Formule :C38H45N5OCouleur et forme :SolidMasse moléculaire :587.8VU6005806
CAS :VU6005806 is a potent M4 PAM with EC50s: 94 nM (human), 28 nM (rat), 87 nM (dog), 68 nM (cyno); studied for neuropsychiatric disorders.Formule :C17H16F3N7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :439.41Cyproflanilide
CAS :Cyproflanilide is a GABAR antagonist that exhibits high activity against a variety of pests, including those from the Lepidoptera, Coleoptera, and Thysanoptera orders.Formule :C28H17BrF12N2O2Couleur et forme :SolidMasse moléculaire :721.33AChE-IN-25
AChE-IN-25: selective, potent AChE inhibitor, non-competitive, IC50 = 2.95 μM, for Alzheimer's research.Formule :C20H15ClN4O4SCouleur et forme :SolidMasse moléculaire :442.88VA012
CAS :VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.Formule :C21H19N3Couleur et forme :SolidMasse moléculaire :313.40AChE-IN-63
CAS :AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 μM. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 μM and 1.342 μM, respectively. AChE-IN-63 is effective in inhibiting Aβ aggregation and preventing the formation and deposition of Aβ1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimer's disease [1].Formule :C18H19N5OCouleur et forme :SolidMasse moléculaire :321.38AChE/Aβ-IN-5
CAS :Compound AV-2, also known as AChE/Aβ-IN-5, is a bifunctional inhibitor that acts on AChE and auto-induced Aβ (Amyloid-β) aggregation. This compound has demonstrated significant efficacy in mitigating cognitive impairment in mice induced by scopolamine and Aβ [1].Formule :C25H24N4Couleur et forme :SolidMasse moléculaire :380.48BChE-IN-5
BChE-IN-5: potent, selective BChE inhibitor (IC50: 2.8 nM), more effective on hBChE, potential in Alzheimer's research.Formule :C30H42N4OCouleur et forme :SolidMasse moléculaire :474.68nAChR antagonist 1
CAS :Compound B15, a potent α7 nAChR antagonist, IC50 = 3.3 μM, promising for research on schizophrenia, Alzheimer's, and inflammation.Formule :C19H22N4O2Couleur et forme :SolidMasse moléculaire :338.4DAPM
CAS :DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.Formule :C20H20F2N2O4Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :390.38AChE/BuChE-IN-3
CAS :AChE/BuChE-IN-3 inhibits AChE (IC50: 0.65 μM), BuChE (IC50: 5.77 μM), crosses BBB, and hinders Aβ1-42 aggregation for Alzheimer's research.Formule :C30H30F3N3O6Couleur et forme :SolidMasse moléculaire :585.57Dihydro-β-erythroidine hydrobromide
CAS :Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs).Formule :C16H22BrNO3Degré de pureté :98%Couleur et forme :White SolidMasse moléculaire :356.26BMS-986163
CAS :BMS-986163, GluN2B negative allosteric modulator prodrug, converts to BMS-986169 (Ki=4 nM), antidepressant-like activity.Formule :C23H28FN2O5PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.45BACE-1 inhibitor 2
CAS :BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1].Formule :C21H21F4N5O3Couleur et forme :SolidMasse moléculaire :467.42BRD0418
CAS :BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.Formule :C29H32N2O5Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :488.57BMS-901715
CAS :BMS-901715 is an effective and selective inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50: 3.3 nM).Formule :C22H28N10ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.52RO-1-5237
CAS :RO-1-5237, a cholinergic compound and a metabolic product of Pyridostigmine Bromide, is utilized in research for myasthenia gravis.Formule :C6H8BrNOCouleur et forme :SolidMasse moléculaire :190.04VU6016235
CAS :VU6016235 is a structurally unique, orally available, and highly selective tricyclic M4 muscarinic acetylcholine receptor positive allosteric modulator.Formule :C21H22N4OSCouleur et forme :SolidMasse moléculaire :378.49Aβ aggregation-IN-1
CAS :Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.Formule :C9H8BF3O2Couleur et forme :SolidMasse moléculaire :215.965Gabaculine HCl
CAS :Gabaculine, an irreversible GABA-T inhibitor (Ki: 2.9 μM), impacts plastid development and affects DPOR/GluTR levels.Formule :C7H10ClNO2Couleur et forme :SolidMasse moléculaire :175.61Amyloid-β-IN-3
CAS :Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.Formule :C22H21F2N3O2Couleur et forme :SolidMasse moléculaire :397.42Lu 26-046
CAS :Lu 26-046 is a muscarinic receptor agonist.Formule :C10H12N2OSCouleur et forme :SolidMasse moléculaire :208.28AAZ-A 154
CAS :AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.Formule :C14H20N2OCouleur et forme :SolidMasse moléculaire :232.32MAO-B-IN-40
CAS :MAO-B-IN-40 (3a) is an inhibitor of MAOB, exhibiting an IC50 value of 0.493 μM against hMAOB, and demonstrates significant neuroprotective and antioxidant effects. MAO-B-IN-40 (3a) is applicable in Parkinson's disease research.Formule :C17H15N3O3Couleur et forme :SolidMasse moléculaire :309.319MAO-IN-4
CAS :MAO-IN-4 (Compound 2l), a monoamine oxidase (MAO) inhibitor, demonstrates IC50 values of 0.07 μM for MAO-A and 0.75 μM for MAO-B. This compound is utilized in studying depression and Parkinson's disease (PD) [1].Formule :C18H11Cl2N3OSCouleur et forme :SolidMasse moléculaire :388.27γ-Secretase modulator 11 hydrochloride
CAS :γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM).Formule :C28H23ClF2N4O2Couleur et forme :SolidMasse moléculaire :520.96CaMKIIα-IN-1
CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.Formule :C14H11ClO4Couleur et forme :SolidMasse moléculaire :278.69Mesulergine hydrochloride
CAS :5-HT2A and 2C receptor antagonistFormule :C18H27ClN4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.95LY3020371 hydrochloride
CAS :LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.Formule :C15H16ClF2NO5SCouleur et forme :SolidMasse moléculaire :395.81LY367385 hydrochloride
CAS :LY367385 hydrochloride: selective mGluR1a antagonist, IC50 = 8.8 μM, neuroprotective, anticonvulsant, antiepileptic.Formule :C10H12ClNO4Couleur et forme :SolidMasse moléculaire :245.66LRRK2-IN-6
LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).Formule :C23H24F2N4O2SCouleur et forme :SolidMasse moléculaire :458.52PF470
CAS :PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.Formule :C18H16N6OCouleur et forme :SolidMasse moléculaire :332.36MMB-4
CAS :MMB-4 is an oxime that can reactivate cholinesterases (cholinesterases) which have been inactivated due to exposure to organophosphates such as Sarin or Soman.Formule :C13H14Br2N4O2Couleur et forme :SolidMasse moléculaire :418.084Aβ-IN-2
Aβ-IN-2 is a peptide inhibitor of Aβ1-42.Formule :C37H51NOCouleur et forme :SolidMasse moléculaire :525.81Tiprenolol hydrochloride
CAS :Tiprenolol hydrochloride is a β-adrenoceptor (β-adrenoceptor) antagonist. This compound is effective in eliminating ventricular arrhythmias in dogs caused by intravenous administration of adrenaline, following inhalation of halothane.Formule :C13H22ClNO2SCouleur et forme :SolidMasse moléculaire :291.84CEase-IN-1
CEase-IN-1 (A1H3), potent CEase inhibitor, IC50 0.36μM, for hypercholesterolemia study.Formule :C13H15F3N2O2Couleur et forme :SolidMasse moléculaire :288.27Etoperidone
CAS :Etoperidone is an antidepressant that acts as an orally active reuptake inhibitor for serotonin (serotonin) and noradrenaline (nor-adrenaline). It demonstrates specific binding affinities (Kd) for several receptors: 36 nM at the 5-HT2 receptor, 38 nM at the α1-adrenergic receptor (α1-adrenergic receptor), 85 nM at the 5-HT1A receptor, and 570 nM at the α2-adrenergic receptor (α2-adrenergic receptor).Formule :C19H28ClN5OCouleur et forme :SolidMasse moléculaire :377.91AM-6494
CAS :AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).Formule :C22H21F2N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.5γ-secretase modulator 5
Compound 22d is a GSM that crosses the blood-brain barrier, inhibits Aβ42 production (IC50: 60 nM), and may help study Alzheimer's.Couleur et forme :Solid5-HT6R/MAO-B modulator 1
5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.Formule :C33H38N4O3SCouleur et forme :SolidMasse moléculaire :570.74CPPG
CAS :CPPG: potent group II/III mGlu receptor antagonist, 20x more selective for group III (IC50: 2.2 nM) than II (46.2 nM) in rat cortex.Formule :C11H14NO5PCouleur et forme :SolidMasse moléculaire :271.21BChE-IN-2
BChE-IN-2, a pyrimidine/pyridine derivative, potently inhibits BChE (Ki 0.099 μM) and shows promise in AD research.Formule :C22H31N5Couleur et forme :SolidMasse moléculaire :365.52SB 224289
CAS :SB 224289: selective 5-HT1B antagonist, pKi 8.2, 60x selectivity, effective orally.Formule :C32H32N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :520.62GABAA receptor agonist 2
Compound 4c, a potent GABAA agonist with anti-depressive effects in mouse FST/TST, shows promise in depression research.Formule :C22H36O5Couleur et forme :SolidMasse moléculaire :380.52Zanapezil fumarate
CAS :Zanapezil is an acetylcholinesterase (AChE) inhibitor. Zanapezil increases choline acetyltransferase activity in cultured rat septal cholinergic neurons.Formule :C29H36N2O5Couleur et forme :SolidMasse moléculaire :492.612,6-Dimethoxybenzylamine hydrochloride
CAS :2,6-Dimethoxybenzylamine hydrochloride (Compound 5) exhibits reversible inhibitory activity against copper amine oxidase (CAO) and inhibits benzylamine oxidase (BAO) and monoamine oxidase B (MAO B) with IC50 values of 120 μM and 190 μM, respectively.Formule :C9H14ClNO2Couleur et forme :SolidMasse moléculaire :203.666BChE-IN-3
BChE-IN-3: Selective, pseudo-irreversible BChE inhibitor (IC50: 56.9 nM); borderline reversible AChE inhibitor.Formule :C26H41N3O2Couleur et forme :SolidMasse moléculaire :427.62AChE/BChE-IN-19
CAS :AChE/BChE-IN-19 (compound 12) is a nicotinic hydrazine derivative that acts as an inhibitor of AChE (IC50=21.45 nM) and BChE (IC50=18.42 nM), and it is applicable in Alzheimer's disease research.Formule :C26H22N4O3Masse moléculaire :438.48Dihydro-β-erythroidine
CAS :Dihydro-β-erythroidine, a competitive nicotinic receptor antagonist, effectively blocks the discriminative stimulus properties and inhibits the anxiolyticFormule :C16H21NO3Couleur et forme :SolidMasse moléculaire :275.34MAO-B-IN-28
CAS :MAO-B-IN-28 (compound 10e) is a potent hMAO-B inhibitor with an IC50 value of 1.9±0.5 nM, potentially serving as a candidate molecule for neurodegenerative disease research.Formule :C19H10F3NO4SMasse moléculaire :405.35SEP-363856 mesylate
CAS :SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.Formule :C10H17NO4S2Couleur et forme :SolidMasse moléculaire :279.38FCOB02
CAS :FCOB02 is a monoamine oxidase B (MAO-B) ligand. It can be labeled as [18F]FCOB02, serving as a 4-methylcoumarin-like targeting probe. [18F]FCOB02 demonstrates high affinity for MAO-B, with an IC50 of 10.68 nM. It is utilized for specific imaging and quantitative analysis of MAO-B in vivo.Formule :C16H12FNO3Couleur et forme :SolidMasse moléculaire :285.27RTIOXA-43
CAS :RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.Formule :C37H37N5O5SDegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :663.79Ref: TM-T87345
1mg210,00€5mg516,00€10mg833,00€25mg1.607,00€50mg2.582,00€100mg3.492,00€1mL*10mM (DMSO)754,00€Rocavorexant
CAS :Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.Formule :C18H19F3N8OCouleur et forme :SolidMasse moléculaire :420.392FP0429
CAS :FP0429 is an agonist of mGlu4.Formule :C10H12N2O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :272.21QP5020
CAS :QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.Formule :C20H19FN6Masse moléculaire :362.40DSP-1053 benzenesulfonate
CAS :DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.Formule :C32H38BrNO7SCouleur et forme :SolidMasse moléculaire :660.62LOXL2-IN-1 tosylate
LOX-IN-5 tosylate (compound 22) is a selective oral inhibitor of lysyl oxidase-like 2 (LOXL2) with an IC50 of less than 300 nM, and it exhibits anti-fibrotic properties.Formule :C28H33FN4O5S2Couleur et forme :SolidMasse moléculaire :588.714MAO-A inhibitor 3
CAS :MAO-A inhibitor3 (Compound 360) is an MAO-A inhibitor with an IC50 greater than 100 μM. It is utilized in the investigation of neurological disorders.Formule :C11H8O5Couleur et forme :SolidMasse moléculaire :220.178hAChE-IN-10
CAS :hAChE-IN-10 (Compound ET11) is an inhibitor of human acetylcholinesterase (AChE) with an IC50 of 6.34 nM. This compound is capable of scavenging free radicals and exhibits antioxidant activity. Additionally, hAChE-IN-10 demonstrates metal-chelating properties, inhibiting Cu2+-induced Aβ1-42 aggregation, reducing amyloid plaque formation, and offering neuroprotective effects. It also ameliorates cognitive impairment in mice induced by Scopolamine.Formule :C25H24ClFN6O2Couleur et forme :SolidMasse moléculaire :494.948Ro4368554
CAS :Ro4368554 is a selective 5-HT6 antagonist capable of crossing the blood-brain barrier. It can reverse memory deficits caused by scopolamine and tryptophan depletion. Ro4368554 is applicable for research related to memory impairments.Formule :C19H21N3O2SCouleur et forme :SolidMasse moléculaire :355.454GABA-IN-4
CAS :GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.Formule :C17H13ClN2O2Couleur et forme :SolidMasse moléculaire :312.75BF-168
CAS :BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).Formule :C18H17FN2O2Couleur et forme :SolidMasse moléculaire :312.345-IAI hydrochloride
CAS :5-IAI hydrochloride is a psychoactive analog of para-iodoamphetamine. 5-IAI hydrochloride significantly reduces serotonin uptake sites and hippocampal serotonin levels in rats.Formule :C9H11ClINCouleur et forme :SolidMasse moléculaire :295.548hAChE/Aβ1-42-IN-1
CAS :Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines andFormule :C20H24N6OCouleur et forme :SolidMasse moléculaire :364.44Aβ42-IN-1
CAS :Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).Formule :C29H27ClN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4995-HT2A/5-HT2C inverse agonist 1
CAS :5-HT2A/5-HT2C inverse agonist 1 serves as a dual and potent inverse agonist for the 5-HT2A and 5-HT2C receptors, with hERG inhibition properties that mitigate cardiovascular risks. Demonstrating significant antipsychotic efficacy in the MK-801-induced mouse model, this compound holds potential for psychosis research.Formule :C24H35N5O2Couleur et forme :SolidMasse moléculaire :425.575-HT1A antagonist 1
Compound 6f is a potent, selective 5-HT1A receptor blocker (Ki: 35 nM), useful in CNS disorder research.Formule :C23H29ClN6O2Couleur et forme :SolidMasse moléculaire :456.97(R)-Norfluoxetine
CAS :(R)-Norfluoxetine is the (R)-enantiomer of Norfluoxetine. It functions as a potent serotonin reuptake inhibitor, with a Ki value of 13 nM. This compound is utilized in the research of depression.Formule :C16H16F3NOCouleur et forme :SolidMasse moléculaire :295.299Nafimidone hydrochloride
CAS :Nafimidone hydrochloride, an antiepileptic agent, inhibits acetylcholinesterase, protects neurons, and ameliorates cognitive decline. It is utilized in epilepsy research.Formule :C15H13ClN2OCouleur et forme :SolidMasse moléculaire :272.73Anti-Aβ agent 1A
Anti-Aβ agent 1A is a potent anti-amyloid-β agent.Formule :C35H49NO4Couleur et forme :SolidMasse moléculaire :547.77THRX-194556
CAS :THRX-194556 is an agonist of the 5-HT4 receptor. It is applicable in the study of gastrointestinal functional disorders and Alzheimer's disease.Formule :C28H41N5O5SCouleur et forme :SolidMasse moléculaire :559.721AChE-IN-24
AChE-IN-24: Strong AChE blocker, crosses blood-brain barrier, IC50=0.053 μM, useful for AD research.Formule :C22H30N2O4S2Couleur et forme :SolidMasse moléculaire :450.61BPN-15606 besylate
BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).Formule :C29H29FN6O4SCouleur et forme :SolidMasse moléculaire :576.64AChE-IN-22
AChE-IN-22 (10q) selectively inhibits AChE (IC50: 0.88 μM), less on BuChE (IC50: 10 μM), targets CAS and PAS, useful in Alzheimer's research.Formule :C21H20N4O5SCouleur et forme :SolidMasse moléculaire :440.47
