Neuroscience
Les inhibiteurs en neurosciences sont des composés conçus pour moduler l'activité de protéines, d'enzymes ou de récepteurs spécifiques au sein du système nerveux. Ces inhibiteurs sont cruciaux pour étudier les mécanismes moléculaires sous-jacents au fonctionnement neuronal, à la transmission synaptique et aux maladies neurodégénératives. En ciblant les récepteurs des neurotransmetteurs, les canaux ioniques et les voies de signalisation, les inhibiteurs en neurosciences facilitent l'exploration du fonctionnement cérébral et le développement de stratégies thérapeutiques pour des troubles neurologiques tels que la maladie d'Alzheimer, de Parkinson et l'épilepsie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs en neurosciences de haute qualité pour soutenir vos recherches en neurobiologie, neuropharmacologie et sciences cognitives.
Sous-catégories appartenant à la catégorie "Neuroscience"
- récepteur 5-HT(940 produits)
- ACK(1 produits)
- AChR(574 produits)
- ATP Citrate Lyase(16 produits)
- Récepteur adrénergique(2.939 produits)
- BACE(36 produits)
- Bêta-amyloïde(204 produits)
- CaMK(68 produits)
- COX(562 produits)
- Récepteur de la dopamine(407 produits)
- Récepteur GABA(336 produits)
- Gamma-sécrétase(59 produits)
- GluR(255 produits)
- GlyT(24 produits)
- Récepteur de l'histamine(358 produits)
- LRRK2(33 produits)
- Récepteur de la mélatonine(24 produits)
- NMDAR(28 produits)
- Récepteur OX(40 produits)
- Récepteur opioïde(296 produits)
Affichez 12 plus de sous-catégories
5400 produits trouvés pour "Neuroscience"
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Aβ42-IN-1
CAS :<p>Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).</p>Formule :C29H27ClN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :499Amyloid-β-IN-3
CAS :<p>Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.</p>Formule :C22H21F2N3O2Couleur et forme :SolidMasse moléculaire :397.42BGT1-IN-1
CAS :<p>BGT1-IN-1 (compound 9) is an effective inhibitor of BGT1, demonstrating IC50 values of 13.9 µM for hBGT1 and 58.3 µM for GAT3. It exhibits no cytotoxic effects and possesses neuroprotective activity.</p>Formule :C6H9NO2Couleur et forme :SolidMasse moléculaire :127.14AChE/Aβ-IN-5
CAS :<p>Compound AV-2, also known as AChE/Aβ-IN-5, is a bifunctional inhibitor that acts on AChE and auto-induced Aβ (Amyloid-β) aggregation. This compound has demonstrated significant efficacy in mitigating cognitive impairment in mice induced by scopolamine and Aβ [1].</p>Formule :C25H24N4Couleur et forme :SolidMasse moléculaire :380.48CPPG
CAS :<p>CPPG: potent group II/III mGlu receptor antagonist, 20x more selective for group III (IC50: 2.2 nM) than II (46.2 nM) in rat cortex.</p>Formule :C11H14NO5PCouleur et forme :SolidMasse moléculaire :271.215-IAI hydrochloride
CAS :<p>5-IAI hydrochloride is a psychoactive analog of para-iodoamphetamine. 5-IAI hydrochloride significantly reduces serotonin uptake sites and hippocampal serotonin levels in rats.</p>Formule :C9H11ClINCouleur et forme :SolidMasse moléculaire :295.548AChE-IN-63
CAS :<p>AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 μM. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 μM and 1.342 μM, respectively. AChE-IN-63 is effective in inhibiting Aβ aggregation and preventing the formation and deposition of Aβ1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimer's disease [1].</p>Formule :C18H19N5OCouleur et forme :SolidMasse moléculaire :321.38Tebideutorexant
CAS :<p>Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.</p>Formule :C23H16D2F4N4O2Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :460.42nAChR antagonist 1
CAS :<p>Compound B15, a potent α7 nAChR antagonist, IC50 = 3.3 μM, promising for research on schizophrenia, Alzheimer's, and inflammation.</p>Formule :C19H22N4O2Couleur et forme :SolidMasse moléculaire :338.4Nedemelteon
CAS :<p>Nedemelteon is an agonist of the melatonin receptor (melatonin receptor).</p>Formule :C15H18N2O2Couleur et forme :SolidMasse moléculaire :258.32CEase-IN-1
<p>CEase-IN-1 (A1H3), potent CEase inhibitor, IC50 0.36μM, for hypercholesterolemia study.</p>Formule :C13H15F3N2O2Couleur et forme :SolidMasse moléculaire :288.27MAO-B-IN-34
CAS :<p>MAO-B-IN-34 (compound 3d) is an inhibitor of monoamine oxidase B.</p>Formule :C15H9Cl2NO3Couleur et forme :SolidMasse moléculaire :322.14Aβ-IN-2
<p>Aβ-IN-2 is a peptide inhibitor of Aβ1-42.</p>Formule :C37H51NOCouleur et forme :SolidMasse moléculaire :525.81Fletazepam
CAS :<p>Fletazepam, a benzodiazepine derivative, exhibits sedative, anti-anxiety, and muscle-relaxant properties. It is utilized in neurological research.</p>Formule :C17H13ClF4N2Couleur et forme :SolidMasse moléculaire :356.74Beloxepin
CAS :<p>Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.</p>Formule :C19H21NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.38AChE-IN-22
<p>AChE-IN-22 (10q) selectively inhibits AChE (IC50: 0.88 μM), less on BuChE (IC50: 10 μM), targets CAS and PAS, useful in Alzheimer's research.</p>Formule :C21H20N4O5SCouleur et forme :SolidMasse moléculaire :440.47Pareptide monohydrochloride
CAS :<p>Pareptide monohydrochloride is a metabolically stable analog of melatonin inhibitor (MIF).</p>Formule :C14H27ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :334.84PF470
CAS :<p>PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.</p>Formule :C18H16N6OCouleur et forme :SolidMasse moléculaire :332.365-HT1A antagonist 1
<p>Compound 6f is a potent, selective 5-HT1A receptor blocker (Ki: 35 nM), useful in CNS disorder research.</p>Formule :C23H29ClN6O2Couleur et forme :SolidMasse moléculaire :456.97Nafimidone hydrochloride
CAS :<p>Nafimidone hydrochloride, an antiepileptic agent, inhibits acetylcholinesterase, protects neurons, and ameliorates cognitive decline. It is utilized in epilepsy research.</p>Formule :C15H13ClN2OCouleur et forme :SolidMasse moléculaire :272.73Azotomycin
CAS :<p>Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.</p>Formule :C17H23N7O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :453.41Metoquizine
CAS :<p>Metoquizine is an anticholinergic compound. It is a muscarinic acetylcholine receptor antagonist that has been used to treat ulcers.</p>Formule :C22H27N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.48VU6007496
CAS :<p>VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).</p>Formule :C25H27N5O2Couleur et forme :SolidMasse moléculaire :429.51EF1502 free base
CAS :<p>EF1502 is a potent and selective GABA transporter inhibitor.</p>Formule :C22H26N2O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.58AChE/BChE-IN-19
CAS :<p>AChE/BChE-IN-19 (compound 12) is a nicotinic hydrazine derivative that acts as an inhibitor of AChE (IC50=21.45 nM) and BChE (IC50=18.42 nM), and it is applicable in Alzheimer's disease research.</p>Formule :C26H22N4O3Masse moléculaire :438.48HDAC6-IN-9
CAS :<p>HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.</p>Formule :C19H16N2O3Degré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :320.34Rodatristat ethyl
CAS :<p>Rodatristat ethyl is an oral TPH1 inhibitor reducing 5-HT levels & lowering PAH at low doses.</p>Formule :C29H31ClF3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :590.04Serotonin maleate
CAS :<p>Serotonin hydrogen maleate serves as a monoaminergic neurotransmitter and an endogenous 5-HT receptor agonist within the central nervous system (CNS). It also functions as an inhibitor of catechol O-methyltransferase (COMT), exhibiting a Ki value of 44 μM.</p>Formule :C14H16N2O5Couleur et forme :SolidMasse moléculaire :292.287SB 243213 hydrochloride
CAS :<p>SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It</p>Formule :C22H20ClF3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.87LRRK2-IN-16
CAS :<p>LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.</p>Formule :C18H19N5OSCouleur et forme :SolidMasse moléculaire :353.441Sulamserod hydrochloride
CAS :<p>Sulamserod hydrochloride is a 5-HT4 receptor antagonist. It is utilized in research related to gastrointestinal disorders.</p>Formule :C19H29Cl2N3O5SCouleur et forme :SolidMasse moléculaire :482.42Glutaminyl Cyclase Inhibitor 3
CAS :<p>Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.</p>Formule :C24H32N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.61(E)-CHBO4
CAS :<p>(E)-CHBO4 is an MAO-B inhibitor with an IC50 value of 0.023 μM, making it a potential candidate for research into Parkinson's disease treatment.</p>Formule :C15H10BrFOCouleur et forme :SolidMasse moléculaire :305.142SEP-363856 mesylate
CAS :<p>SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.</p>Formule :C10H17NO4S2Couleur et forme :SolidMasse moléculaire :279.38AChE-IN-83
CAS :<p>AChE-IN-83 (compound f1) is an AChE inhibitor that suppresses nematode growth and acetylcholinesterase activity in rice seeds while being safe for the seeds. It specifically targets Aphelenchoides besseyi, with an LC50 of 19.0 μg/mL over 48 hours. AChE-IN-83 impedes nematode populations and behaviors in rice seeds, damages the nematode cuticle, and induces reactive oxygen species, lipofuscin, and lipid generation within the nematodes.</p>Formule :C10H7ClN2O2SCouleur et forme :SolidMasse moléculaire :254.693MMB-4
CAS :<p>MMB-4 is an oxime that can reactivate cholinesterases (cholinesterases) which have been inactivated due to exposure to organophosphates such as Sarin or Soman.</p>Formule :C13H14Br2N4O2Couleur et forme :SolidMasse moléculaire :418.084LY2794193
CAS :<p>LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.</p>Formule :C16H18N2O6Degré de pureté :98.15%Couleur et forme :SolidMasse moléculaire :334.32P2X4 antagonist-1
CAS :<p>P2X4 antagonist-1 is a potent P2X4 receptor antagonist used in the study of neurological, cardiovascular, and immune system diseases.</p>Formule :C20H15Cl3N2O4SDegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :485.77RTIOXA-43
CAS :<p>RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.</p>Formule :C37H37N5O5SDegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :663.79MAO-B-IN-40
CAS :<p>MAO-B-IN-40 (3a) is an inhibitor of MAOB, exhibiting an IC50 value of 0.493 μM against hMAOB, and demonstrates significant neuroprotective and antioxidant effects. MAO-B-IN-40 (3a) is applicable in Parkinson's disease research.</p>Formule :C17H15N3O3Couleur et forme :SolidMasse moléculaire :309.319Mesulergine hydrochloride
CAS :<p>5-HT2A and 2C receptor antagonist</p>Formule :C18H27ClN4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.95LRRK2-IN-4
CAS :<p>LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.</p>Formule :C25H29ClF2N6O2Couleur et forme :SolidMasse moléculaire :518.99Gabaculine HCl
CAS :<p>Gabaculine, an irreversible GABA-T inhibitor (Ki: 2.9 μM), impacts plastid development and affects DPOR/GluTR levels.</p>Formule :C7H10ClNO2Couleur et forme :SolidMasse moléculaire :175.61THRX-194556
CAS :<p>THRX-194556 is an agonist of the 5-HT4 receptor. It is applicable in the study of gastrointestinal functional disorders and Alzheimer's disease.</p>Formule :C28H41N5O5SCouleur et forme :SolidMasse moléculaire :559.721DA-8031
CAS :<p>DA-8031 is a selective and orally active serotonin reuptake inhibitor. It is utilized in research related to premature ejaculation (PE).</p>Formule :C21H24N2O2Couleur et forme :SolidMasse moléculaire :336.43SZ1676
CAS :<p>SZ1676 is a derivative of SZ1677, which is an agent of neuromuscular blocking.</p>Formule :C37H59BrN2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :707.78YM 202074
CAS :<p>metabotropic glutamate receptor type 1 (mGlu1) antagonist</p>Formule :C56H72N8O16S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1177.34FCOB02
CAS :<p>FCOB02 is a monoamine oxidase B (MAO-B) ligand. It can be labeled as [18F]FCOB02, serving as a 4-methylcoumarin-like targeting probe. [18F]FCOB02 demonstrates high affinity for MAO-B, with an IC50 of 10.68 nM. It is utilized for specific imaging and quantitative analysis of MAO-B in vivo.</p>Formule :C16H12FNO3Couleur et forme :SolidMasse moléculaire :285.278 Hydroxy PIPAT oxalate
CAS :<p>8 Hydroxy PIPAT oxalate is a selective 5-HT1A receptor agonist that enhances the spontaneous release of histamine by promoting the degranulation of mast cells in guinea pig and human intestinal preparations. By activating the serotonin signaling pathway, this compound demonstrates potential in regulating gastrointestinal functions and offers insight into the management and suppression of functional gastrointestinal disorders such as irritable bowel syndrome. Its effects in increasing histamine release could play a crucial role in gastrointestinal regulation.</p>Formule :C18H24INO5Couleur et forme :SolidMasse moléculaire :461.29Iclepertin
CAS :<p>Iclepertin (BI-425809) is a GlyT1 inhibitor.Iclepertin is used for the treatment of Alzheimer;s disease and other CNS disorders.</p>Formule :C20H18F6N2O5SDegré de pureté :98.89% - 98.93%Couleur et forme :SolidMasse moléculaire :512.42
