Neuroscience
Les inhibiteurs en neurosciences sont des composés conçus pour moduler l'activité de protéines, d'enzymes ou de récepteurs spécifiques au sein du système nerveux. Ces inhibiteurs sont cruciaux pour étudier les mécanismes moléculaires sous-jacents au fonctionnement neuronal, à la transmission synaptique et aux maladies neurodégénératives. En ciblant les récepteurs des neurotransmetteurs, les canaux ioniques et les voies de signalisation, les inhibiteurs en neurosciences facilitent l'exploration du fonctionnement cérébral et le développement de stratégies thérapeutiques pour des troubles neurologiques tels que la maladie d'Alzheimer, de Parkinson et l'épilepsie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs en neurosciences de haute qualité pour soutenir vos recherches en neurobiologie, neuropharmacologie et sciences cognitives.
Sous-catégories appartenant à la catégorie "Neuroscience"
- récepteur 5-HT(1.025 produits)
- ACK(1 produits)
- AChR(646 produits)
- ATP Citrate Lyase(17 produits)
- Récepteur adrénergique(3.022 produits)
- BACE(37 produits)
- Bêta-amyloïde(228 produits)
- CaMK(73 produits)
- COX(600 produits)
- Récepteur de la dopamine(445 produits)
- Récepteur GABA(373 produits)
- Gamma-sécrétase(61 produits)
- GluR(265 produits)
- GlyT(26 produits)
- Récepteur de l'histamine(385 produits)
- LRRK2(43 produits)
- Récepteur de la mélatonine(26 produits)
- NMDAR(10 produits)
- Récepteur OX(41 produits)
- Récepteur opioïde(327 produits)
Affichez 12 plus de sous-catégories
5584 produits trouvés pour "Neuroscience"
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CAS :Subtype-selective nicotinic agonistFormule :C13H15ClN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :234.72BChE-IN-5
BChE-IN-5: potent, selective BChE inhibitor (IC50: 2.8 nM), more effective on hBChE, potential in Alzheimer's research.Formule :C30H42N4OCouleur et forme :SolidMasse moléculaire :474.68AChE-IN-24
AChE-IN-24: Strong AChE blocker, crosses blood-brain barrier, IC50=0.053 μM, useful for AD research.Formule :C22H30N2O4S2Couleur et forme :SolidMasse moléculaire :450.61Revexepride
CAS :Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.Formule :C21H32ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.95BRD0418
CAS :BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.Formule :C29H32N2O5Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :488.57Beloxepin
CAS :Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.Formule :C19H21NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.38AChE-IN-11
AChE-IN-11 aids Alzheimer's research, has neuroprotection/antioxidant properties (ORAC=2.5), and acts on AChE, MAO-B, BACE1 with IC50 values of 7.9-9.9 μM.Formule :C18H28N2O4Couleur et forme :SolidMasse moléculaire :336.43β-CCM
CAS :β-CCM is a benzodiazepine receptor inverse agonist with anxiogenic and convulsant effects. It enhances emotional reactivity and reduces interference sensitivity in spatial working memory tasks. β-CCM is applicable in research related to anxiety disorders.Formule :C13H10N2O2Couleur et forme :SolidMasse moléculaire :226.231CGS-9895
CAS :CGS-9895 is a GABA antagonist that operates by interacting with the benzodiazepine binding site on GABA receptors containing the γ subunit (ag).Formule :C17H13N3O2Couleur et forme :SolidMasse moléculaire :291.304PDE4B/7A-IN-1
CAS :5-HT1A antagonist; Ki=8nM, Kb=0.04nM. PDE4B IC50=80.4μM; PDE7A IC50=151.3μM. Good biofilm penetration, stable, anticognitive, antidepressant.Formule :C25H35N3O3Couleur et forme :SolidMasse moléculaire :425.56LOXL2-IN-1 tosylate
LOX-IN-5 tosylate (compound 22) is a selective oral inhibitor of lysyl oxidase-like 2 (LOXL2) with an IC50 of less than 300 nM, and it exhibits anti-fibrotic properties.Formule :C28H33FN4O5S2Couleur et forme :SolidMasse moléculaire :588.7142002-G12
CAS :2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.Formule :C20H16N6Couleur et forme :SolidMasse moléculaire :340.381RTIOXA-43
CAS :RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.Formule :C37H37N5O5SDegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :663.79Ref: TM-T87345
1mg210,00€5mg516,00€1mL*10mM (DMSO)754,00€10mg833,00€25mg1.607,00€50mg2.582,00€100mg3.492,00€5-HT2A receptor agonist-7
CAS :5-HT2A receptor agonist-7 (517) functions as a modulator of the 5-HT2A receptor, with an EC50 value of less than 100 nM.Formule :C12H11F2N3Couleur et forme :SolidMasse moléculaire :235.233SEP-363856 mesylate
CAS :SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.Formule :C10H17NO4S2Couleur et forme :SolidMasse moléculaire :279.38Nafimidone hydrochloride
CAS :Nafimidone hydrochloride, an antiepileptic agent, inhibits acetylcholinesterase, protects neurons, and ameliorates cognitive decline. It is utilized in epilepsy research.Formule :C15H13ClN2OCouleur et forme :SolidMasse moléculaire :272.73MAO-B-IN-42
CAS :MAO-B-IN-42 (Compound 4f) is a selective and reversible monoamine oxidase-B (MAO-B) inhibitor, with an IC50 value of 0.184 μM. By blocking the oxidative deamination of monoamines catalyzed by MAO-B, it helps maintain neurotransmitter levels. MAO-B-IN-42 shows potential for research into Parkinson's disease.Formule :C19H12FNO2Couleur et forme :SolidMasse moléculaire :305.302hAChE/Aβ1-42-IN-1
CAS :Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines andFormule :C20H24N6OCouleur et forme :SolidMasse moléculaire :364.44YM-202074
CAS :YM-202074: Selective mGlu1 antagonist, binds allosteric site (Ki=4.8 nM), inhibits mGlu1 (IC50=8.6 nM).Formule :C22H30N4O2SCouleur et forme :SolidMasse moléculaire :414.56DA-8031
CAS :DA-8031 is a selective and orally active serotonin reuptake inhibitor. It is utilized in research related to premature ejaculation (PE).Formule :C21H24N2O2Couleur et forme :SolidMasse moléculaire :336.43Rodatristat ethyl
CAS :Rodatristat ethyl is an oral TPH1 inhibitor reducing 5-HT levels & lowering PAH at low doses.Formule :C29H31ClF3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :590.04BACE1-IN-5
CAS :BACE1-IN-5 inhibits BACE1 (IC50: 9.1 nM) & Aβ production (IC50: 0.82 nM), enhances hERG inhibition & P-gp efflux.Formule :C18H16F5N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.41OX2R agonist 1
CAS :OX2R agonist 1 is an OX2R activator with an EC50 of less than 100 nM. It is utilized in research related to narcolepsy and cataplexy.Formule :C21H28F2N2O5SCouleur et forme :SolidMasse moléculaire :458.52(+)-Sparteine sulfate pentahydrate
(+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons.Formule :C15H38N2O9SCouleur et forme :SolidMasse moléculaire :422.54F 14679
CAS :F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.Formule :C21H25ClF2N4ODegré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :422.9YM-31636 free base
CAS :YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.Formule :C14H11N3SCouleur et forme :SolidMasse moléculaire :253.32LY367385 hydrochloride
CAS :LY367385 hydrochloride: selective mGluR1a antagonist, IC50 = 8.8 μM, neuroprotective, anticonvulsant, antiepileptic.Formule :C10H12ClNO4Couleur et forme :SolidMasse moléculaire :245.66DSP-1053 benzenesulfonate
CAS :DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.Formule :C32H38BrNO7SCouleur et forme :SolidMasse moléculaire :660.62Tipindole
CAS :Tipindole is a serotonin antagonist utilized in research related to depression.Formule :C16H20N2O2SCouleur et forme :SolidMasse moléculaire :304.41BPN-15606 besylate
BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).Formule :C29H29FN6O4SCouleur et forme :SolidMasse moléculaire :576.64Elzasonan hydrochloride
CAS :Elzasonan hydrochloride is a serotonin 1B and serotonin 1D receptor antagonist. It is utilized in the study of depression.Formule :C22H24Cl3N3OSCouleur et forme :SolidMasse moléculaire :484.87hMAO-B-IN-10
hMAO-B-IN-10 (compound 7) is an inhibitor of MAO-A/B with IC50 values of 424.1 nM and 177.9 nM, respectively. It has demonstrated neuroprotective effects in the MPTP-induced mouse model of Parkinson's Disease (PD).Formule :C16H12N4O4Couleur et forme :SolidMasse moléculaire :324.29nAChR antagonist 1
CAS :Compound B15, a potent α7 nAChR antagonist, IC50 = 3.3 μM, promising for research on schizophrenia, Alzheimer's, and inflammation.Formule :C19H22N4O2Couleur et forme :SolidMasse moléculaire :338.4GABAA receptor agonist 1
Compound 3e, a potent GABAA agonist, targets GABA sites and has potential anti-depressive effects in mice.Formule :C20H30O3Couleur et forme :SolidMasse moléculaire :318.45BChE-IN-2
BChE-IN-2, a pyrimidine/pyridine derivative, potently inhibits BChE (Ki 0.099 μM) and shows promise in AD research.Formule :C22H31N5Couleur et forme :SolidMasse moléculaire :365.52CVN636
CAS :CVN636, a potent and selective allosteric agonist for the mGluR7 receptor, exhibits oral activity and CNS permeability [1], with an EC50 of 7 nM for humanFormule :C19H20FNO4SCouleur et forme :SolidMasse moléculaire :377.43AGH-107
CAS :AGH-107 is a highly selective 5-HT7 receptor agonist that can cross the blood-brain barrier, featuring a Ki value of 6 nM and an EC50 value of 19 nM. Demonstrating high selectivity for central nervous system targets, AGH-107 also exhibits high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures.Formule :C13H12IN3Couleur et forme :SolidMasse moléculaire :337.16AChE-IN-83
CAS :AChE-IN-83 (compound f1) is an AChE inhibitor that suppresses nematode growth and acetylcholinesterase activity in rice seeds while being safe for the seeds. It specifically targets Aphelenchoides besseyi, with an LC50 of 19.0 μg/mL over 48 hours. AChE-IN-83 impedes nematode populations and behaviors in rice seeds, damages the nematode cuticle, and induces reactive oxygen species, lipofuscin, and lipid generation within the nematodes.Formule :C10H7ClN2O2SCouleur et forme :SolidMasse moléculaire :254.693CL-13
CL-13 is an inhibitor of butyrylcholinesterase (BChE), exhibiting an IC50 of 1.15 μM and a selectivity index (SI) of 9.2 for acetylcholinesterase. It demonstrates antioxidative activity in SH-SY5Y cells with a DPPHEC50 of 47.01 μM and has the capacity to chelate metals involved in Aβ aggregation and/or oxidative stress, showing no neurotoxicity at concentrations up to 50 μM. CL-13 can also reverse scopolamine-induced cognitive impairments without affecting motor abilities in mice.Formule :C29H32N4OSCouleur et forme :SolidMasse moléculaire :484.66ZK 93426 hydrochloride
CAS :benzodiazepine receptor antagonist,competitiveFormule :C18H21ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.82PF-06751979
CAS :PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).Formule :C18H19F2N5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :455.5AChE-IN-25
AChE-IN-25: selective, potent AChE inhibitor, non-competitive, IC50 = 2.95 μM, for Alzheimer's research.Formule :C20H15ClN4O4SCouleur et forme :SolidMasse moléculaire :442.885-HT1A modulator 4
CAS :5-HT1A modulator 4 (Compound 1) is a ligand for the 5-HT receptor, with Ki values of 2.18 μM for 5-HT1A and 19.7 μM for 5-HT2A.Formule :C9H14N4Couleur et forme :SolidMasse moléculaire :178.234Fletazepam
CAS :Fletazepam, a benzodiazepine derivative, exhibits sedative, anti-anxiety, and muscle-relaxant properties. It is utilized in neurological research.Formule :C17H13ClF4N2Couleur et forme :SolidMasse moléculaire :356.74DL-Thyroxine
CAS :DL-Thyroxine is a thyroid hormone that acts as a monoamine oxidase (monoamine oxidase) inhibitor.Formule :C15H11I4NO4Couleur et forme :SolidMasse moléculaire :776.87(9R)-RO7185876
CAS :(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.Formule :C25H28F3N7Couleur et forme :SolidMasse moléculaire :483.532Tiprenolol hydrochloride
CAS :Tiprenolol hydrochloride is a β-adrenoceptor (β-adrenoceptor) antagonist. This compound is effective in eliminating ventricular arrhythmias in dogs caused by intravenous administration of adrenaline, following inhalation of halothane.Formule :C13H22ClNO2SCouleur et forme :SolidMasse moléculaire :291.84AChE-IN-84
CAS :AChE-IN-84 (compound 21) is an inhibitor of AChE.Formule :C6H15Br2NCouleur et forme :SolidMasse moléculaire :260.998AM-6494
CAS :AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).Formule :C22H21F2N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.5FCOB02
CAS :FCOB02 is a monoamine oxidase B (MAO-B) ligand. It can be labeled as [18F]FCOB02, serving as a 4-methylcoumarin-like targeting probe. [18F]FCOB02 demonstrates high affinity for MAO-B, with an IC50 of 10.68 nM. It is utilized for specific imaging and quantitative analysis of MAO-B in vivo.Formule :C16H12FNO3Couleur et forme :SolidMasse moléculaire :285.27
