Neuroscience
Les inhibiteurs en neurosciences sont des composés conçus pour moduler l'activité de protéines, d'enzymes ou de récepteurs spécifiques au sein du système nerveux. Ces inhibiteurs sont cruciaux pour étudier les mécanismes moléculaires sous-jacents au fonctionnement neuronal, à la transmission synaptique et aux maladies neurodégénératives. En ciblant les récepteurs des neurotransmetteurs, les canaux ioniques et les voies de signalisation, les inhibiteurs en neurosciences facilitent l'exploration du fonctionnement cérébral et le développement de stratégies thérapeutiques pour des troubles neurologiques tels que la maladie d'Alzheimer, de Parkinson et l'épilepsie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs en neurosciences de haute qualité pour soutenir vos recherches en neurobiologie, neuropharmacologie et sciences cognitives.
Sous-catégories appartenant à la catégorie "Neuroscience"
- récepteur 5-HT(940 produits)
- ACK(1 produits)
- AChR(574 produits)
- ATP Citrate Lyase(16 produits)
- Récepteur adrénergique(2.942 produits)
- BACE(36 produits)
- Bêta-amyloïde(204 produits)
- CaMK(68 produits)
- COX(562 produits)
- Récepteur de la dopamine(407 produits)
- Récepteur GABA(336 produits)
- Gamma-sécrétase(59 produits)
- GluR(255 produits)
- GlyT(24 produits)
- Récepteur de l'histamine(358 produits)
- LRRK2(33 produits)
- Récepteur de la mélatonine(24 produits)
- NMDAR(28 produits)
- Récepteur OX(40 produits)
- Récepteur opioïde(296 produits)
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5400 produits trouvés pour "Neuroscience"
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Melatonin-Tamoxifen Conjugate
<p>Melatonin-Tamoxifen Conjugate (compound 16c) is an anticancer drug conjugate made of Melatonin and Tamoxifen, serving as an effective antagonist of ERα (IC50 = 863 nM). In cells expressing the hMT1 receptor, it binds to MLT receptors (Ki = 3.1 nM) and exhibits the ability to promote β-arrestin activation (EC50 = 914 nM) and ERK activation (EC50 = 98 nM). The IC50 values for Melatonin-Tamoxifen Conjugate in MCF-7, MDA-MB-231, and HT-1080 cell lines are 6.8 μM, 6.4 μM, and 1.7 μM, respectively.</p>Formule :C47H58N4O4Couleur et forme :SolidMasse moléculaire :742.99Proadrenomedullin (1-20), human
CAS :<p>Endogenous peptide; agonist of MRGPRX2 (EC50=251 nM); noncompetitive inhibitor of nicotinic receptors; reduces catecholamine secretion; antihypertensive.</p>Formule :C112H178N36O27Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2460.84(+)-Coclaurine hydrochloride
CAS :<p>(+)-Coclaurine hydrochloride, also known as (+)-(R)-Coclaurine, is a benzyltetrahydroisoquinoline alkaloid extracted from multiple plant species.</p>Formule :C17H20ClNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :321.8FGIN-1-43
CAS :<p>FGIN-1-43 is a potent and specific ligand for the mitochondrial DBI receptor.</p>Formule :C28H36Cl2N2ODegré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :487.5(Iso)-Atagabalin HCl
CAS :<p>(Iso)-Atagabalin HCl(isomer-Atagabalin HCl) is an alpha -2- delta ligand that can be used to treat non-restorative sleep.</p>Formule :C10H20ClNO2Degré de pureté :99.26% - >99.99%Couleur et forme :SoildMasse moléculaire :221.72JPC0323
<p>JPC0323 is a dual positive allosteric modulator of the 5-HT2C and 5-HT2A receptors, featuring on-target properties, acceptable plasma exposure, and adequate</p>Formule :C22H43NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :385.58[D-Trp7,9,10]-Substance P
CAS :<p>Substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.</p>Formule :C79H105N21O13SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1588.89isomer-Cilansetron
CAS :<p>isomer-Cilansetron is an isomer of Cilansetron.</p>Formule :C20H21N3ODegré de pureté :99.92% - 99.96%Couleur et forme :SoildMasse moléculaire :319.4Litoxetine HCl
<p>Litoxetine HCl, an SSRI and 5-HT antagonist, treats urinary incontinence and relaxes rat oesophageal muscles without antimuscarinic effects.</p>Formule :C16H20ClNODegré de pureté :99.56% - 99.75%Couleur et forme :SoildMasse moléculaire :277.79TMPH
CAS :<p>TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.</p>Formule :C16H31NO2Degré de pureté :99.78%Couleur et forme :SoildMasse moléculaire :269.42AChE/BuChE-IN-4
CAS :<p>AChE/BuChE-IN-4 is a multi-target AChE/BuChE inhibitor with IC50 values of 2.08 and 7.41 μM for AChE and BuChE, respectively.</p>Formule :C17H23N5Degré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :297.4Rilmazolam
CAS :<p>Rilmazolam is a triazolobenzodiazepine compound and serves as the active metabolite of Rilmazafone.</p>Formule :C19H15Cl2N5OCouleur et forme :SolidMasse moléculaire :400.26GM-60186
<p>GM-60186, a potent inhibitor of the 5-HT receptor 2B (HTR2B) with an IC50 of 257 nM, effectively suppresses the proliferation and migration of colorectal cancer cells.</p>Formule :C30H33FN2O4Couleur et forme :SolidMasse moléculaire :504.59Tranylcypromine
CAS :<p>Tranylcypromine (SKF 385), a potent monoamine oxidase (MAO) inhibitor [1], is used in medicinal applications.</p>Formule :C9H11NDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :133.19LY3020371
CAS :<p>LY3020371: potent, selective mGlu 2/3 receptor antagonist with Ki of 5.26 nM (hmGluR2) and 2.50 nM (hmGluR3); key in depression studies.</p>Formule :C15H15F2NO5SCouleur et forme :SolidMasse moléculaire :359.34(-)-Eseroline fumarate
CAS :<p>(-)-Eseroline fumarate, a Physostigmine metabolite and AChE inhibitor, triggers cancer cell LDH release and neuronal cell death.</p>Formule :C17H22N2O5Couleur et forme :SolidMasse moléculaire :334.37COX-2-IN-35
<p>COX-2-IN-35 (compound 7) is a selective inhibitor of COX-2, demonstrating anti-inflammatory activity, with an inhibitory concentration (IC 50) of 4.37 nM [1].</p>Formule :C22H19NO2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :393.52N-Desmethyl Pimavanserin
CAS :<p>N-Desmethyl Pimavanserin (AC-279) is the active metabolite of Pimavanserin and is used in the treatment of insomnia and other sleep disorders.</p>Formule :C24H32FN3O2Degré de pureté :98.02%Couleur et forme :SolidMasse moléculaire :413.53Suntinorexton
CAS :<p>Suntinorexton (TAK 861) is an orexin type 2 receptor (OX2R) agonist used in the study of neurologic disorders.</p>Formule :C23H28F2N2O4SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :466.54Xenopus orexin B
CAS :<p>Xenopus orexin B, a neuropeptide identified as an endogenous ligand for an orphan G-protein-coupled receptor, acts as a potent agonist of OX2R [1].</p>Formule :C130H219N45O40S2Couleur et forme :SolidMasse moléculaire :3116.54Aβ-IN-8
<p>Aβ-IN-8, also known as compound 7e, is a potent inhibitor of Aβ aggregation [1].</p>Formule :C22H16F3N3O3SCouleur et forme :SolidMasse moléculaire :459.44Femoxetine
CAS :<p>Femoxetine: antidepressant, enhances morphine, inhibits MAO-A/B, boosts mice's exercise capacity.</p>Formule :C20H25NO2Degré de pureté :99.1% - 99.35%Couleur et forme :SolidMasse moléculaire :311.42AL 34662
CAS :<p>AL 34662 is a selective and potent 5-HT2A receptor agonist with IC50s of 0.77 nM and 1.5 nM for rat and human 5-HT2 receptors, respectively.AL 34662 is also a</p>Formule :C10H13N3ODegré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :191.23BMS-906024
CAS :<p>BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.</p>Formule :C26H26F6N4O3Degré de pureté :99.88% - >99.99%Couleur et forme :SolidMasse moléculaire :556.5hAChE-IN-4
<p>Compd 5d (hAChE-IN-4) is a potent hAChE inhibitor that readily crosses the blood-brain barrier, exhibiting an IC50 of 0.25 μM, and is utilized in the study of</p>Formule :C30H23Cl3N2O3Couleur et forme :SolidMasse moléculaire :565.87Polyglutamine binding peptide 1
CAS :<p>Polyglutamine binding peptide 1 (QBP1) is a peptide inhibitor of polyglutamine (polyQ). It effectively inhibits polyQ protein aggregation in vitro and prevents polyQ-induced cell death in cell cultures.</p>Formule :C72H90N16O16Couleur et forme :SolidMasse moléculaire :1435.587-Methyl DMT
CAS :<p>7-Methyl DMT (7-TMT) acts as a 5-HT2 receptor agonist. Structurally, it is a tryptamine derivative and serves as an analytical reference for the psychoactive substance DOM. It is also applicable in research related to neurological disorders.</p>Formule :C13H18N2Couleur et forme :SolidMasse moléculaire :202.33-Hydroxy desalkylflurazepam
CAS :<p>3-Hydroxy desalkylflurazepam is a benzodiazepine compound with potential sedative and anxiolytic effects.</p>Formule :C15H10ClFN2O2Couleur et forme :SolidMasse moléculaire :304.7BSB
CAS :<p>BSB is a Congo red-derived fluorescent probe, an amyloid protein imaging agent, interacting with amyloid fibrils formed by Aβ (1-40) peptides in rodents.</p>Formule :C24H17BrO6Degré de pureté :95.53%Couleur et forme :SolidMasse moléculaire :481.29AChE-IN-70
<p>AChE-IN-70 (compound 4) is an acetylcholinesterase inhibitor. It exhibits larvicidal activity against mosquito larvae (Culex pipiens L.), making it useful for mosquito control research.</p>Couleur et forme :Odour Solid5-MeO-MET
CAS :<p>5-MeO-MET (5-Methoxy-N-methyl-N-ethyltryptamine) is a compound belonging to the 5-methoxytryptamine class. It acts as an agonist for 5-HT1A and 5-HT2A receptors. In mice, 5-MeO-MET inhibits locomotion and has sedative effects.</p>Formule :C14H20N2OCouleur et forme :SolidMasse moléculaire :232.32pCPA methyl ester hydrochloride
CAS :<p>pCPA methyl ester HCl inhibits tryptophan hydroxylase, 5-HT synthesis, crosses blood-brain barrier, lowers central 5-HT.</p>Formule :C10H13Cl2NO2Degré de pureté :99.73% - 99.88%Couleur et forme :SolidMasse moléculaire :250.125-HT5AR/5-HT6R ligand-1
<p>5-HT5AR/5-HT6R ligand-1 (Compound PP10) is a ligand for serotonin receptors, exhibiting high affinity for the 5-HT5A and 5-HT6 receptors with Ki values of 59 nM and 96 nM, respectively. It possesses some antiproliferative activity against tumor cells and can be utilized in cancer research.</p>Formule :C25H30N4O2SCouleur et forme :SolidMasse moléculaire :450.6YS-370
CAS :<p>YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.</p>Formule :C37H35BrN4O3Degré de pureté :98.055%Couleur et forme :SolidMasse moléculaire :663.6Methyllycaconitine citrate
CAS :<p>Methyllycaconitine citrate (MLA) is an α7 neuronal nicotinic acetylcholine receptor (α7nAChR) antagonist that crosses the blood-brain barrier.</p>Formule :C43H58N2O17Degré de pureté :98.03% - 98.91%Couleur et forme :SolidMasse moléculaire :874.92Vortioxetine D8
CAS :<p>Vortioxetine D8 is a deuterium-labeled antidepressant inhibiting 5-HT1A/B, 5-HT3A, 5-HT7 receptors & SERT (Ki: 15-1.6 nM).</p>Formule :C18H22N2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.5AChE-IN-46
<p>AChE-IN-46 (compound 4), a β-cyclocostunolide, functions as an acetylcholinesterase (AChE) inhibitor [1].</p>Formule :C15H22O2Couleur et forme :SolidMasse moléculaire :234.33Tiquizium
CAS :<p>Tiquizium has effective Antimuscarinic effect, and causes significant bronchodilation in patients with chronic obstructive pulmonary disease.</p>Formule :C19H24NS2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :330.5325N-NBOMe hydrochloride
CAS :<p>25N-NBOMe hydrochloride is a derivative of 2C-N and acts as an agonist for the 5-HT2A and 5-HT2C receptors, with Ki values of 0.144 nM and 1.06 nM, respectively. It has minimal effect on the release of preloaded neurotransmitters from recombinant dopamine, serotonin, and norepinephrine transporters.</p>Formule :C18H23ClN2O5Couleur et forme :SolidMasse moléculaire :382.844-Bromo-2,5-DMMA
CAS :<p>4-Bromo-2,5-DMMA (Compound 2) demonstrates affinity for the 5-HT2 binding site and has an ED50 of 0.82 mg/kg in rat discrimination experiments.</p>Formule :C12H18BrNO2Couleur et forme :SolidMasse moléculaire :288.18Mesoridazine Besylate
CAS :<p>Mesoridazine Besylate (Serentil), a piperidine antipsychotic and phenothiazine, treats schizophrenia; it's a thioridazine metabolite.</p>Formule :C27H32N2O4S3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :544.75ZZL-7
CAS :<p>ZZL-7 is a rapid antidepressant targeting nNOS & SERT in DRN, crosses blood-brain barrier, with MDD research potential.</p>Formule :C11H20N2O4Degré de pureté :99.79%Couleur et forme :SoildMasse moléculaire :244.29Riluzole-13C,15N2
CAS :<p>Riluzole-13C,15N2 (PK 26124-13C,15N2) is a 13C and 15N labeled form of Riluzole, a glutamate antagonist with anticonvulsant activity, inhibiting GABA uptake.</p>Formule :CC7H5F3OS15N2Couleur et forme :SolidMasse moléculaire :237.185-HT6R antagonist 1
<p>Compound 8 (5-HT6R antagonist 1), a 5-HT6R antagonist (K i : 5 nM), not only demonstrates inhibition of platelet aggregation and excellent metabolic stability</p>Formule :C17H22F2N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.39Amyloid β-Protein (3-42)
CAS :<p>Amyloid β-Protein (3-42), the precursor of Pyr peptide, serves as the foundation of the amyloid template block in Alzheimer's disease when modified to</p>Couleur et forme :SolidLY836
<p>LY836 is an orally active, neuroprotective compound that effectively inhibits the PSD95-nNOS association in cortical neurons.</p>Degré de pureté :98%Couleur et forme :Odour Solid(S)-3,4-DCPG HCl
<p>(S)-3,4-DCPG HCl is a selective mGluR8a agonist, impacting AV12-664 cells with an EC50 of 31 nM.</p>Formule :C10H10ClNO6Degré de pureté :99.53% - 99.9%Couleur et forme :SoildMasse moléculaire :275.64R-(+)-Cotinine
CAS :<p>R-(+)-Cotinine, an inactive nicotine metabolite, boosts Ach-induced current in human α7 nAChRs.</p>Formule :C10H12N2OCouleur et forme :SolidMasse moléculaire :176.22SB 699551
CAS :<p>SB 699551 is a selective 5-HT5A antagonist (Ki=6.31 nM) that enhances 5-HT neuronal function. It inhibits SERT (Ki=25.12 nM),inhibit breast cancer.</p>Formule :C34H45N3ODegré de pureté :99.83%Masse moléculaire :511.74(Met(O)35)-Amyloid β-Protein (1-42)
<p>(Met(O)35)-Amyloid β-Protein (1-42) represents the oxidized form of Methionine 35 in Aβ42, capable of producing an oligomer size distribution akin to that of</p>Formule :C203H311N55O61SCouleur et forme :SolidMasse moléculaire :4530.04
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