Neuroscience

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat PKBg. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PKBg. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat PKBg, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat PKBg in the samples is then determined by comparing the OD of the samples to the standard curve.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse NCAN. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse NCAN. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse NCAN, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse NCAN in the samples is then determined by comparing the OD of the samples to the standard curve.

DISC-0974 is a humanized antibody targeting RGMC/HFE2, which can be used to study urogenital system diseases.

Compound 40 is a selective M1/M4 muscarinic antagonist with an IC50 of 19 nM for M1 receptors and 42 nM for M4 receptors [1].

Fentonium bromide is a biochemical.

CVN417 is an orally active antagonist of nAChR containing the α6 subunit, modulating phasic dopaminergic neurotransmission in an impulse-dependent fashion.

Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated form of LRRK2[G2019S], exhibiting a Km value of 10 μM.

E3 Ligase Ligand 41 (Compound SI-13) serves as a ligand for the E3 ubiquitin ligase DCAF16. It is designed to connect with SLF through a linker, enabling the formation of KB03-SLF.

Org 13011 has CNS activity and induces conditioned taste aversion by mediating 5-HT 1A receptors.

GABAA receptor modulator-4 (Compound 4) acts as a negative allosteric modulator of the GABAA receptor. It inhibits the peak and steady-state currents mediated by the α1β3γ2 GABAA receptors, with an IC50 of 10 μM for both.

Compound 8 (5-HT6R antagonist 1), a 5-HT6R antagonist (K i : 5 nM), not only demonstrates inhibition of platelet aggregation and excellent metabolic stability

N-Methylcyclohexaneethaneamine is a useful organic compound for research related to life sciences.

Melatonin-Tamoxifen Conjugate (compound 16c) is an anticancer drug conjugate made of Melatonin and Tamoxifen, serving as an effective antagonist of ERα (IC50 = 863 nM). In cells expressing the hMT1 receptor, it binds to MLT receptors (Ki = 3.1 nM) and exhibits the ability to promote β-arrestin activation (EC50 = 914 nM) and ERK activation (EC50 = 98 nM). The IC50 values for Melatonin-Tamoxifen Conjugate in MCF-7, MDA-MB-231, and HT-1080 cell lines are 6.8 μM, 6.4 μM, and 1.7 μM, respectively.

MAO-B-IN-36 (Compound A6) is an effective MAO-B inhibitor with an IC50 of 13 nM.

Substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.

GM-60186, a potent inhibitor of the 5-HT receptor 2B (HTR2B) with an IC50 of 257 nM, effectively suppresses the proliferation and migration of colorectal cancer cells.

M4 mAChR agonist-1 (4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-) is an effective agonist of M4 mAChR (EC50 >10 μM).

Flupyradifurone (flupyradifurone) is a systemic insecticide and nicotinic acetylcholine receptor (nAChR) agonist interfer nervous system of insects.

SIB 1553A is an agonist of nAChRs, a cognitive enhancer that can be used to study diseases associated with neurodegeneration.

Pep63, a neuroprotective peptide (VFQVRARTVA), enhances synaptic plasticity and memory. It competitively binds with Aβ1-42 oligomers, thereby inhibiting the formation of Aβ fibrils. Pep63 is employed in research focused on Alzheimer's disease (AD).

BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.

Rilmazolam is a triazolobenzodiazepine compound and serves as the active metabolite of Rilmazafone.

7-Methyl DMT (7-TMT) acts as a 5-HT2 receptor agonist. Structurally, it is a tryptamine derivative and serves as an analytical reference for the psychoactive substance DOM. It is also applicable in research related to neurological disorders.

4-Hydroxy MPT (4-OH-MPT) is a serotonin-active compound that acts as an agonist for 5-HT2A and 5-HT2B receptors, with EC50 values of 3.82 nM and 3.4 nM, respectively.

5-HT2A receptor agonist-6 (compound 47) is a selective agonist of the 5-HT2A receptor with a pEC50 value of 6.58.

(D-Asp1)-Amyloid β-Protein (1-42), a peptide fragment of amyloid β-protein (Aβ), serves as the primary constituent of vascular and parenchymal amyloid deposits

3-Chloroamphetamine hydrochloride is a derivative of amphetamine that acts as a central nervous system stimulant by releasing serotonin and dopamine.

Pyrazolam is a psychoactive benzodiazepine compound serving as a central nervous system depressant. [Pyrazolam] can lead to psychomotor impairment.

2,6-DMA hydrochloride is a phenethylamine and acts as an agonist of the serotonin 5-HT2 receptor, with a pA2 value of 5.09.

Lysyl Hydroxylase 2-IN-2 (compound 13) is a potent inhibitor of Lysyl Hydroxylase 2 (LH2), exhibiting an IC50 of approximately 500 nM.

AChE/BuChE-IN-4 is a multi-target AChE/BuChE inhibitor with IC50 values of 2.08 and 7.41 μM for AChE and BuChE, respectively.

Nemifitide diTFA is a synthetic pentapeptide with antidepressant properties, resembling MIF, that crosses the blood-brain barrier.

Brexpiprazole S-oxide is the main metabolite of Brexpiprazole, a human 5-HT1A and dopamine receptor partial agonist (Ki: 0.12, 0.3 nM).

Arotinolol HCl is a non-selective α/β-blocker, anti-hypertensive, anti-obesity, and improves aortic stiffness.

AChE-IN-41 (Compound 2), a Galantamine-Memantine hybrid, possesses cholinesterase inhibitory capabilities.

Deoxynojirimycin tetrabenzyl ether aids in making 1-dNM, a strong α-glucosidase I & II blocker.

MmTx2 toxin, extracted from the venom of the coral snake, serves as a modulator of the GABA A receptor, increasing its responsiveness to agonists.

β-Amyloid (1-38), derived from mice and rats, is a chemical compound comprising 38 amino acids, specifically residues 1-38 of the Aβ peptide.

ZZL-7 is a rapid antidepressant targeting nNOS & SERT in DRN, crosses blood-brain barrier, with MDD research potential.

OXA(17-33) TFA: Potent OX1 agonist, ~23x more selective for OX1 (EC50=8.29nM) than OX2 (187nM).

CPN-351 (compound 9a) is a pentapeptide that acts as a selective antagonist for human NMUR1, with a pA2 value of 7.35. It exhibits ten times greater antagonistic activity toward human NMUR1 compared to NMUR2. CPN-351 is applicable in inflammation research.

PSAM agonist targeting PSAML141F-GlyR and related ion channels in mice; ideal concentration ≤5 mg/kg; plasmids at Addgene.

COX-2-IN-33 (compound 5f) is a selective COX-2 inhibitor with an IC50 value of 45.5 nM and exhibits potential as an anti-inflammatory agent.

Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used for edema and chronic renal insufficiency.

Pirimiphos-ethyl is used as an organophosphorus pesticide.