Neuroscience
Les inhibiteurs en neurosciences sont des composés conçus pour moduler l'activité de protéines, d'enzymes ou de récepteurs spécifiques au sein du système nerveux. Ces inhibiteurs sont cruciaux pour étudier les mécanismes moléculaires sous-jacents au fonctionnement neuronal, à la transmission synaptique et aux maladies neurodégénératives. En ciblant les récepteurs des neurotransmetteurs, les canaux ioniques et les voies de signalisation, les inhibiteurs en neurosciences facilitent l'exploration du fonctionnement cérébral et le développement de stratégies thérapeutiques pour des troubles neurologiques tels que la maladie d'Alzheimer, de Parkinson et l'épilepsie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs en neurosciences de haute qualité pour soutenir vos recherches en neurobiologie, neuropharmacologie et sciences cognitives.
Sous-catégories appartenant à la catégorie "Neuroscience"
- récepteur 5-HT(1.025 produits)
- ACK(1 produits)
- AChR(645 produits)
- ATP Citrate Lyase(17 produits)
- Récepteur adrénergique(3.018 produits)
- BACE(37 produits)
- Bêta-amyloïde(228 produits)
- CaMK(73 produits)
- COX(600 produits)
- Récepteur de la dopamine(445 produits)
- Récepteur GABA(372 produits)
- Gamma-sécrétase(61 produits)
- GluR(265 produits)
- GlyT(26 produits)
- Récepteur de l'histamine(385 produits)
- LRRK2(43 produits)
- Récepteur de la mélatonine(26 produits)
- NMDAR(10 produits)
- Récepteur OX(41 produits)
- Récepteur opioïde(327 produits)
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5548 produits trouvés pour "Neuroscience"
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Graphislactone A
CAS :Graphislactone A, an antioxidant from Cephalosporium and M. olivacea, scavenges radicals and reduces LDL peroxidation, inhibits AChE (IC50: 27μM).Formule :C16H14O6Couleur et forme :SolidMasse moléculaire :302.28BuChE-IN-13
BuChE-IN-13 (compound 3) is a BuChE inhibitor that exhibits anti-Alzheimers activity. It is utilized in the research of neurodegenerative diseases.
Couleur et forme :Odour Solid(Met(O)35)-Amyloid β-Protein (1-42)
(Met(O)35)-Amyloid β-Protein (1-42) represents the oxidized form of Methionine 35 in Aβ42, capable of producing an oligomer size distribution akin to that ofFormule :C203H311N55O61SCouleur et forme :SolidMasse moléculaire :4530.04mcK6A1
mcK6A1 serves as an inhibitor of amyloid-β (Aβ) aggregation, selectively binding to the 16KLVFFA21 fragment of Aβ42, leading to the formation of an extended β-sheet structure and preventing the formation of Aβ42 oligomers. This compound is valuable for research into Alzheimer's disease and other amyloid-related disorders.Formule :C71H99N17O16Couleur et forme :SolidMasse moléculaire :1446.65OM99-2
CAS :OM99-2, an 8-residue peptidomimetic, binds memapsin 2 with 9.58 nM Ki; promising for Alzheimer's research.Formule :C41H64N8O14Couleur et forme :SolidMasse moléculaire :893.005Biotin-β-Amyloid (1-42), human TFA
Biotin-β-Amyloid (1-42), human TFA, also known as Biotin-Amyloid β-Peptide (1-42) (human) TFA, is a biotin-labeled 42-amino acid peptide implicated in theFormule :C215H326F3N57O64S2Couleur et forme :SolidMasse moléculaire :4854.36AChE/Aβ-IN-6
BACE1-IN-15 (compound 4j) serves as an effective inhibitor of BACE1 (β-secretase), efficiently mitigating the copper-induced toxicity of Aβ, with an EC50 value of 0.68 μM.Couleur et forme :Odour SolidAAK1-IN-9
AAK1-IN-9 (Compound 3) is an inhibitor of AAK1 (adaptor associated kinase 1) with an IC50 value of 10.92 nM, and it is applicable in the study of neurodegenerative diseases.Couleur et forme :Odour Solid(Met(O2)35)-Amyloid β-Protein (1-42)
(Met(O2)35)-Amyloid β-Protein (1-42) is a peptide [1] .Formule :C203H311N55O62SCouleur et forme :SolidMasse moléculaire :4546.04SAHM1 TFA
SAHM1 TFA inhibits the Notch pathway, stabilizes alpha helices, and blocks Notch complex formation.Formule :C96H163N36F3O25SCouleur et forme :SolidMasse moléculaire :2310.6(D-Asp1)-Amyloid β-Protein (1-42)
CAS :(D-Asp1)-Amyloid β-Protein (1-42), a peptide fragment of amyloid β-protein (Aβ), serves as the primary constituent of vascular and parenchymal amyloid depositsFormule :C203H311N55O60SCouleur et forme :SolidMasse moléculaire :4514.04CALP2 TFA
CALP2 TFA, a CaM antagonist with 7.9 µM Kd, blocks CaM-dependent enzymes, boosts Ca2+ levels, and activates macrophages.Formule :C70H105F3N14O15SCouleur et forme :SolidMasse moléculaire :1471.72RN341
RN341 is a LRRK2-specific type II kinase inhibitor (IC50 of 296 nM). It prevents the phosphorylation of LRRK2 by stabilizing an open conformation, thereby avoiding S935 dephosphorylation. Additionally, RN341 rescues LRRK2-mediated kinesin motility blockage by preventing microtubule binding. This compound effectively inhibits both wild-type and G2019S LRRK2 at the cellular level, offering a novel avenue for Parkinson's disease research.Couleur et forme :Odour Solidmeta-Fluoxetine (hydrochloride)
CAS :meta-Fluoxetine (hydrochloride) can be used in related research in the field of life sciences. Its product number is T37474 and CAS number is 79088-29-2.Formule :C17H19ClF3NOCouleur et forme :SolidMasse moléculaire :345.79PSEM 308 hydrochloride
PSAM agonist targeting PSAML141F-GlyR and related ion channels in mice; ideal concentration ≤5 mg/kg; plasmids at Addgene.Couleur et forme :SolidGABAA receptor modulator-3
GABAA receptor modulator-3 (compound 3b) is a positive allosteric modulator (PAM). It inhibits the peak current and steady-state current of α1β3γ2 GABAAR with IC50 values of 671 μM and 64 μM, respectively.Formule :C18H22O2Couleur et forme :SolidMasse moléculaire :270.37β-Amyloid (25-35) acetate
β-Amyloid (25-35) acetate is the Aβ(25-35) fragment of amyloid beta peptide, neurotoxicity, construct Alzheimer's disease cell and animal models.Degré de pureté :98.26%KRP-199 sodium
KRP-199 sodium sodium is highly potent and selective for AMPA-R in vitro and exhibits good neuroprotection in vivo.Formule :C22H12F3N5Na2O7Degré de pureté :97.27%Couleur et forme :SoildMasse moléculaire :561.33mGluR3 modulator-1
CAS :1-ethyl-3-morpholin-4-yl tetrahydroisoquinoline: mGluR3 modulator, potential for Parkinson's.Formule :C16H21N3ODegré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :271.36AChE/MAO-B-IN-7
AChE/MAO-B-IN-7 (VAV-8) is a compound that acts as a dual inhibitor of acetylcholinesterase (AChE) and MAO-B, with the ability to cross the blood-brain barrier. It also inhibits the aggregation of Aβ42, making it a valuable compound for Alzheimer's disease (AD) research.
Formule :C22H21N3O3Couleur et forme :SolidMasse moléculaire :375.42G923-0271
CAS :G923-0271 is a TDP-43 inhibitor that improves disease phenotypes in TDP-43 nematode models and reduces the overexpression of human TDP-43, ALS FTD.Formule :C28H23FN4OCouleur et forme :SolidMasse moléculaire :450.51Imipramine N-oxide
CAS :Imipramine N-oxide is a tricyclic antidepressant (TCA) and imipramine analogue used to treat depression.Formule :C19H24N2ODegré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :296.41Ref: TM-T74205
1mg72,00€5mg157,00€10mg241,00€25mg409,00€50mg565,00€100mg794,00€1mL*10mM (DMSO)167,00€Lisuride maleate
CAS :Lisuride maleate is a non-selective dopamine agonist and G-protein-biased 5-HT2A receptor agonist capable of blocking prolactin release.Formule :C24H30N4O5Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :454.52Ref: TM-T8775
1mg204,00€5mg627,00€10mg898,00€25mg1.346,00€50mg1.745,00€100mg2.382,00€1mL*10mM (DMSO)627,00€SB236057
CAS :SB236057: potent selective inverse agonist at 5-HT autoreceptors; increases brain 5-HT; teratogen causing musculoskeletal defects in rodents.Formule :C33H34N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.65Imidafenacin Metabolite M4
CAS :Imidafenacin M4 is a CYP3A4-formed metabolite of the muscarinic antagonist imidafenacin.Formule :C18H19N3O3Couleur et forme :SolidMasse moléculaire :325.368N-desmethyl Zolmitriptan
CAS :DZT, an active metabolite of zolmitriptan, agonizes 5-HT1B/D receptors; contracts human cerebral arteries (EC50=100nM).Formule :C15H19N3O2Couleur et forme :SolidMasse moléculaire :273.33SCH-900229
CAS :SCH-900229, a potent presenilin 1 selective γ-secretase inhibitor, used to treat Alzheimer’s Disease.Formule :C21H21ClF2O6S2Couleur et forme :SolidMasse moléculaire :506.97C2-8
CAS :C2-8 inhibits polyQ aggregation, IC50=25 μM (HDQ51), 0.05 μM (PC12 cells), reduces neurodegeneration in Huntington's models.Formule :C19H14Br2N2O3SCouleur et forme :SolidMasse moléculaire :510.2Iloperidone metabolite P95
CAS :Iloperidone metabolite P95, a non-brain penetrating compound, binds 5-HT2A, α1-, α2B-, α2C-receptors with Ki of 7.08-83.18 nM.Formule :C23H25FN2O5Couleur et forme :SolidMasse moléculaire :428.465-HT5AR/5-HT6R ligand-1
5-HT5AR/5-HT6R ligand-1 (Compound PP10) is a ligand for serotonin receptors, exhibiting high affinity for the 5-HT5A and 5-HT6 receptors with Ki values of 59 nM and 96 nM, respectively. It possesses some antiproliferative activity against tumor cells and can be utilized in cancer research.Formule :C25H30N4O2SCouleur et forme :SolidMasse moléculaire :450.6Sandaracopimaric acid
CAS :Sandaracopimaric acid, an anti-inflammatory diterpene, relaxes pulmonary arteries with an EC50 of 43.93 μM.Formule :C20H30O2Couleur et forme :SolidMasse moléculaire :302.45LY-426965 hydrochloride
CAS :LY-426965 hydrochloride is a bioactive chemical.Formule :C28H39ClN2O2Couleur et forme :SolidMasse moléculaire :471.07Polyglutamine binding peptide 1
CAS :Polyglutamine binding peptide 1 (QBP1) is a peptide inhibitor of polyglutamine (polyQ). It effectively inhibits polyQ protein aggregation in vitro and prevents polyQ-induced cell death in cell cultures.Formule :C72H90N16O16Couleur et forme :SolidMasse moléculaire :1435.58CDD0102 HCl
CAS :CDD0102 HCl is a selective and potent M1 muscarinic receptor agonist for the treatment of Alzheimer's disease.Formule :C8H13ClN4ODegré de pureté :99.7%Couleur et forme :SoildMasse moléculaire :216.67Xenopus orexin B
CAS :Xenopus orexin B, a neuropeptide identified as an endogenous ligand for an orphan G-protein-coupled receptor, acts as a potent agonist of OX2R [1].Formule :C130H219N45O40S2Couleur et forme :SolidMasse moléculaire :3116.54AChE/BChE-IN-20
AChE/BChE-IN-20 (compound 3m) serves as an inhibitor for both acetylcholinesterase (AChE, IC50=34.81 µM) and butyrylcholinesterase (BChE, IC50=20.66 µM). The affinity for the critical enzyme pockets and the favorable interaction profiles were established through molecular docking and kinetics simulation, making it relevant for the study of Alzheimer's disease.Couleur et forme :Odour SolidAL 34662
CAS :AL 34662 is a selective and potent 5-HT2A receptor agonist with IC50s of 0.77 nM and 1.5 nM for rat and human 5-HT2 receptors, respectively.AL 34662 is also aFormule :C10H13N3ODegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :191.23Amyloid-Forming peptide GNNQQNY
CAS :Amyloid-Forming peptide GNNQQNY, a biologically active heptapeptide derived from the N-terminal prion-determining domain of yeast Sup35, is instrumental inFormule :C33H48N12O14Couleur et forme :SolidMasse moléculaire :836.81C175-0062
CAS :C175-0062, a monoamine oxidase B (MAO-B) inhibitor, is applicable in research focused on neurodegenerative disorders such as Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS) [1].Formule :C21H18N2O5Couleur et forme :SolidMasse moléculaire :378.38Suntinorexton
CAS :Suntinorexton (TAK 861) is an orexin type 2 receptor (OX2R) agonist used in the study of neurologic disorders.Formule :C23H28F2N2O4SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :466.54Ref: TM-T39807
1mg171,00€5mg418,00€10mg666,00€25mg1.017,00€50mg1.372,00€100mg1.793,00€200mg2.405,00€1mL*10mM (DMSO)428,00€AChE-IN-70
AChE-IN-70 (compound 4) is an acetylcholinesterase inhibitor. It exhibits larvicidal activity against mosquito larvae (Culex pipiens L.), making it useful for mosquito control research.Couleur et forme :Odour SolidTMPH
CAS :TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.Formule :C16H31NO2Degré de pureté :99.78%Couleur et forme :SoildMasse moléculaire :269.42Ref: TM-T60080
2mg35,00€5mg55,00€10mg84,00€25mg133,00€50mg205,00€100mg301,00€200mg425,00€1mL*10mM (DMSO)54,00€[D-Trp7,9,10]-Substance P
CAS :Substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.Formule :C79H105N21O13SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1588.89Pomaglumetad methionil anhydrous
CAS :LY2140023, potential schizophrenia treatment, is an oral prodrug of LY404039, a selective mGlu2/3 agonist.Formule :C12H18N2O7S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.41Antidepressant agent 5
CAS :Antidepressant agent 5 is a 7-substituted tetrahydroisoquinoline derivative with antidepressant activity.Antidepressant agent 5 acts similarly to magnoflorine
Formule :C20H25NO3Degré de pureté :99.34%Couleur et forme :SoildMasse moléculaire :327.42Proadrenomedullin (1-20), human
CAS :Endogenous peptide; agonist of MRGPRX2 (EC50=251 nM); noncompetitive inhibitor of nicotinic receptors; reduces catecholamine secretion; antihypertensive.Formule :C112H178N36O27Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2460.84Mirtazapine N-oxide
CAS :Mirtazapine N-oxide, a mirtazapine metabolite, is produced by CYP1A2 and CYP3A4 in human liver.Formule :C17H19N3OCouleur et forme :SolidMasse moléculaire :281.3595-methoxy-α-Ethyltryptamine
CAS :5-Methoxy-alpha-ethyltryptamine is a psychoactive substance that can cause various effects. It belongs to the tryptamine chemical class and can be used for various psychoactive and stimulant effects.
Formule :C13H18N2ODegré de pureté :98.25%Couleur et forme :SolidMasse moléculaire :218.29Desmethyl Mirtazapine (hydrochloride)
CAS :Desmethyl mirtazapine is a metabolite of the antidepressant mirtazapine.1It is formed from mirtazapine by the cytochrome P450 (CYP) isoform CYP3A4.Formule :C16H18ClN3Couleur et forme :SolidMasse moléculaire :287.79Oxotremorine
CAS :Oxotremorine acts as an agonist of mAChR, specifically activating the M1 and M3 acetylcholine receptors. In drug discrimination experiments with macaques, it exhibits effects similar to nicotine.Formule :C12H18N2OCouleur et forme :SolidMasse moléculaire :206.28
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