récepteur 5-HT
Les récepteurs 5-HT, également connus sous le nom de récepteurs de la sérotonine, sont un groupe de récepteurs couplés aux protéines G (GPCR) qui médiatisent les effets de la sérotonine, un neurotransmetteur impliqué dans la régulation de l'humeur, l'anxiété, le sommeil, l'appétit et d'autres processus physiologiques. Ces récepteurs sont divisés en plusieurs sous-types, chacun ayant des fonctions et des propriétés pharmacologiques distinctes. Les modulateurs des récepteurs 5-HT sont largement étudiés pour leurs rôles dans le traitement de la dépression, des troubles anxieux et d'autres affections neuropsychiatriques. Chez CymitQuimica, nous offrons une gamme de modulateurs des récepteurs 5-HT de haute qualité pour soutenir vos recherches en neuropharmacologie, troubles de l'humeur et signalisation GPCR.
1025 produits trouvés pour "récepteur 5-HT"
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Brilaroxazine
CAS :Brilaroxazine (RP5063): multimodal dopamine/5-HT modulator, partial agonist at D2/D3/D4, 5-HT1A/2A, and antagonist at 5-HT2B/7.Formule :C22H25Cl2N3O3Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :450.36Ref: TM-T14782
1mg100,00€5mg236,00€1mL*10mM (DMSO)268,00€10mg385,00€25mg663,00€50mg954,00€100mg1.305,00€200mg1.738,00€Bexicaserin
CAS :Bexicaserin (Compound 3), a 5-HT2C receptor agonist, has potential applications in research pertaining to obesity and psychiatric disorders [1].Formule :C15H19F2N3OCouleur et forme :SolidMasse moléculaire :295.3313,14-dihydro-15-keto Prostaglandin E2
CAS :13,14-dihydro-15-keto Prostaglandin E2 (13,14-dihydro-15-keto PGE2) serves as the predominant metabolite of PGE2 in plasma, created through a 15-keto PGE2 intermediate by the action of 15-oxo-PG Δ13 reductase. Unlike its precursor PGE2, this compound exhibits poor binding affinity towards EP2 and EP4 PGE2 receptors (Ki values of 12 and 57 µM, respectively) in CHO cells and fails to stimulate adenylate cyclase activity therein (EC50s >18 and >38 µM, respectively). Concentrations of 13,14-dihydro-15-keto PGE2 are notably higher in the plasma of pregnant women during their third trimester and at labor and delivery stages, whereas its levels are found to be reduced in the tumor tissues of patients with non-small cell lung cancer (NSCLC) compared to adjacent healthy tissue.Formule :C20H32O5Couleur et forme :SolidMasse moléculaire :352.5Amesergide
CAS :Amesergide is an orally active and selective serotonin (5-HT1/2) antagonist that inhibits weight gain in offspring of female CD rats, for depression research.Formule :C25H35N3ODegré de pureté :100% - 99.54%Couleur et forme :SolidMasse moléculaire :393.56PNU109291
CAS :PNU109291, a potent and selective agonist of the 5-HT1D receptor, effectively mitigates dural plasma extravasation induced by trigeminal ganglion stimulation.Formule :C24H31N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :409.52SB 258719
CAS :SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.Formule :C18H30N2O2SDegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :338.51Ref: TM-T12855
2mg34,00€5mg52,00€1mL*10mM (DMSO)58,00€10mg85,00€25mg155,00€50mg240,00€100mg355,00€200mg502,00€5-HT2A receptor agonist-3
CAS :5-HT2A receptor agonist-3 represents the highest selectivity for the human 5-HT2A receptor currently identified, exhibiting a K i of 2.5 nM.Formule :C21H26BrNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.34R-96544
CAS :R-96544 is an orally active antagonist of the 5-HT2A receptor that has demonstrated the ability to inhibit platelet aggregation in vitro [1].Formule :C22H30ClNO3Couleur et forme :SolidMasse moléculaire :391.935-HT3 antagonist 1
CAS :5-HT3 antagonist 1 is a potent and selective antagonist of 5-HT3 receptor.Formule :C22H27N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.48L-772,405
CAS :L-772,405 is a highly selective agonists of h5-HT(1D) receptor.Formule :C26H31FN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.56SB 649915
CAS :SB 649915 is a serotonin reuptake inhibitor and 5-HT1A and 5-HT1B receptor antagonist.Formule :C26H29N3O3Couleur et forme :SolidMasse moléculaire :431.53Velusetrag
CAS :Velusetrag(TD-5108), a potent 5-HT4 agonist, is in development for gastroparesis, constipation, and IBS.Formule :C25H36N4O5SCouleur et forme :SolidMasse moléculaire :504.64(±)-Fabesetron hydrochloride
CAS :FK1052 hydrochloride is a potent 5-HT3 and 5-HT4 receptor dual antagonist.Formule :C18H20ClN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :329.82NAD 299 hydrochloride
CAS :Selective, high affinity 5-HT1A receptor antagonistFormule :C18H24ClFN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.85GR 125487 sulfamate
CAS :GR 125487 sulfamate is a 5-HT4 receptor antagonist.Formule :C19H29FN4O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :524.58Flesinoxan HCl
CAS :Flesinoxan HCl is the salt form of Flesinoxan, which is a selective 5-HT1A receptor agonist.Formule :C22H27ClFN3O4Couleur et forme :SolidMasse moléculaire :451.92NAS-181 free base
CAS :NAS-181 free base is a 5-HT(1B) receptor antagonist.Formule :C19H26N2O4Couleur et forme :SolidMasse moléculaire :346.42(S)-Renzapride
(S)-Renzapride (BRL 24924), 5-HT4 agonist (Ki 115 nM), 5HT2b/5HT3 antagonist, for C-IBS study.Formule :C16H22ClN3O2Couleur et forme :SolidMasse moléculaire :323.82UNC9994
CAS :UNC9994 is a β-arrestin-biased dopamine D₂ receptor agonist (β-arrestin EC50 = 50 nM; Emax = 97%) with robust in vivo antipsychotic drug-like activities.Formule :C21H22Cl2N2OSCouleur et forme :SolidMasse moléculaire :421.38Facinicline hydrochloride
CAS :Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM).Formule :C15H19ClN4ODegré de pureté :98.70%Couleur et forme :SolidMasse moléculaire :306.792-Methyl-5-HT
CAS :2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.Formule :C11H14N2ODegré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :190.24Ref: TM-T10075
5mg48,00€1mL*10mM (DMSO)50,00€10mg84,00€25mg177,00€50mg334,00€100mg500,00€500mg1.099,00€GR 127935 hydrochloride
CAS :5-HT1B/1D receptor antagonistFormule :C29H32ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.051-Carboxycyclohexaneacetic Acid
CAS :1-Carboxycyclohexaneacetic acid may be present as a potential impurity in commercial gabapentin, an antiepileptic drug. Furthermore, it serves as a precursor for synthesizing antagonists targeting the serotonin (5-HT) receptor subtype 5-HT2A.Formule :C9H14O4Couleur et forme :SolidMasse moléculaire :186.207Wf-516
CAS :Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressantFormule :C25H25Cl2N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :502.39MDL-74156
CAS :MDL-74156 is an active metabolite of dolasetron and a 5-hydroxy-tryptamine3 (5-HT3) antagonist.Formule :C19H22N2O3Couleur et forme :SolidMasse moléculaire :326.39Butriptyline
CAS :Butriptyline (Butriptylene), a tricyclic antidepressant, is effective when administered orally [1].Formule :C21H27NCouleur et forme :SolidMasse moléculaire :293.45Abaperidone
CAS :Abaperidone is an atypical antipsychotic, antagonizes 5-HT2A (IC50=6.2 nM) and D2 receptors (IC50=17 nM), reduces hsp70 mRNA in rat brains.Formule :C25H25FN2O5Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :452.47Indeloxazine hydrochloride
CAS :Indeloxazine HCl: Serotonin releaser, NE reuptake inhibitor, NMDA antagonist; antidepressant that boosts acetylcholine in rats.Formule :C14H18ClNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.75FK-1052
CAS :FK-1052 is a serotonin 3 & 4 dual receptor antagonist.Formule :C18H19N3OCouleur et forme :SolidMasse moléculaire :293.365-HT2C agonist-3
CAS :5-HT2C agonist-3 ((+)-19), a selective 5-HT2C agonist (EC 50: 24 nM, Ki: 78 nM), exhibits antipsychotic-like activity by blocking amphetamine-inducedFormule :C19H23ClFNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.845-HT2 agonist-1 free base
CAS :Compound 24 (5-HT2 agonist-1 free base) is a potent agonist for 5-HT2A, 5-HT2B, and 5-HT2C receptors, exhibiting IC50 values of 10 nM, 8.3 nM, and 1.6 nM,Formule :C19H22N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :310.394-Chloro-L-phenylalanine
CAS :4-Chloro-L-phenalanine (L-PCPA) is an inhibitor of 5-HT biosynthesis and a non-specific antagonist of tryptophan hydroxylases (TPH1 and TPH2).Formule :C9H10ClNO2Degré de pureté :99.76% - 99.96%Couleur et forme :SolidMasse moléculaire :199.63LY320954
CAS :LY320954 is an antagonist of 5-HT2A receptor.Formule :C21H26N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :382.46YM348
CAS :YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM).Formule :C14H17N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :243.3GR-127935
CAS :GR-127935 is a potent and selective 5-HT1B/1D receptor antagonist.Formule :C29H31N5O3Couleur et forme :SolidMasse moléculaire :497.59Frovatriptan
CAS :Frovatriptan, potent 5-HT 1B/D agonist, shows high cerebroselectivity and efficacy for migraine with aura.Formule :C14H17N3ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :243.3Robalzotan
CAS :Robalzotan is a selective 5-HT1A receptor antagonist.Formule :C18H23FN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :318.39NAS181
CAS :rat 5-HT1B receptor antagonistFormule :C21H34N2O10S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.63Osemozotan Free Base
CAS :Osemozotan Free Base is a 5-HT(1A) receptor agonist.Formule :C19H21NO5Couleur et forme :SolidMasse moléculaire :343.375-HT2 agonist-1
CAS :Compound 24, a 5-HT2 agonist-1, selectively activates 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC50 values of 10 nM, 8.3 nM, and 1.6 nM, respectively.Formule :C19H23ClN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :346.85CP-122288
CAS :CP-122288: potent, selective 5-HT1B/D/F agonist; inhibits plasma protein extravasation, neurogenic inflammation.Formule :C16H23N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :321.44MIN-117
CAS :MIN-117, a SSRI/5-HT receptor antagonist, is potentially used for the treatment of depression.Formule :C25H26Cl3N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.855-HT2A&5-HT2C agonist-1
CAS :5-HT2A&5-HT2C agonist-1 (Example 2) is a dual-acting agent targeting the 5-HT2A and 5-HT2C receptors with respective IC50 values of 196 nM and 0.9 nM.Formule :C14H20N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :232.32Nemonapride
CAS :Nemonapride is a dopamine D2-like receptor antagonist.Formule :C21H26ClN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.95-HT3-In-1
CAS :5-HT3-In-1 (compound example 8) exhabits with 5-HT3 inhibition activity.Formule :C16H21ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :352.82(S)-Bexicaserin
CAS :(S)-Bexcaserin (compound 2) serves as a 5-HT2C receptor agonist, presenting research possibilities in obesity and psychiatric disorders [1].Formule :C15H19F2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.33SB 216641 hydrochloride
CAS :SB 216641 hydrochloride (SB-216641A) is a 5-HT1B/D receptor antagonist with anxiolytic properties.Formule :C28H31ClN4O4Degré de pureté :98.06% - 99.23%Couleur et forme :SolidMasse moléculaire :523.02WAY-607695
CAS :WAY-607695 is a potential 5-HT1A receptor agonist.Formule :C13H12FNO2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :233.24Didesmethyl cariprazine
CAS :Didesmethyl cariprazine, Cariprazine's active metabolite, treats schizophrenia/bipolar with D3/D2 affinity; half-life 1-3 weeks.Formule :C19H28Cl2N4ODegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :399.36Osemozotan HCl
CAS :Osemozotan is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder.Formule :C19H22ClNO5Degré de pureté :98.87% - 99.63%Couleur et forme :SolidMasse moléculaire :379.84SB-616234-A
CAS :SB-616234-A is a selective and orally bioavailable antagonist of 5-HT1B receptor, with anxiolytic and antidepressant activity.Formule :C32H36ClN5O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :574.11Lumateperone
CAS :Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).Formule :C24H28FN3ODegré de pureté :99.68% - 99.91%Couleur et forme :SolidMasse moléculaire :393.5Tiprenolol hydrochloride
CAS :Tiprenolol hydrochloride is a β-adrenoceptor (β-adrenoceptor) antagonist. This compound is effective in eliminating ventricular arrhythmias in dogs caused by intravenous administration of adrenaline, following inhalation of halothane.Formule :C13H22ClNO2SCouleur et forme :SolidMasse moléculaire :291.84AM9405
AM9405: peripheral CB1/5-HT3 agonist, suppresses gut motility, relieves GI disorder symptoms in mice.Formule :C24H33BrN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.44SB 224289
CAS :SB 224289: selective 5-HT1B antagonist, pKi 8.2, 60x selectivity, effective orally.Formule :C32H32N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :520.62F 14679
CAS :F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.Formule :C21H25ClF2N4ODegré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :422.95-HT6R/MAO-B modulator 1
5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.Formule :C33H38N4O3SCouleur et forme :SolidMasse moléculaire :570.74SB 243213 hydrochloride
CAS :SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).ItFormule :C22H20ClF3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.87Beloxepin
CAS :Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.Formule :C19H21NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.38(-)-5-HT2C agonist-3
CAS :Compound (−)-19, also known as (-)-5-HT2C agonist-3, is a selective 5-HT2C agonist exhibiting a preference for Gq signaling. It demonstrates efficiency with EC50 values for 5-HT2 receptor subtypes as follows: 5-HT2C at 103 nM, 5-HT2B at 570 nM, and 5-HT2A at 72 nM. This compound is utilized in research on antipsychotics.Formule :C19H23ClFNO2Couleur et forme :SolidMasse moléculaire :351.84AAZ-A 154 hydrochloride
CAS :AAZ-A 154 hydrochloride is a selective, competitive, non-hallucinogenic antagonist of 5-HT2AR. It promotes neuronal growth in rodents and results in enduring beneficial behavioral effects.Formule :C14H21ClN2OCouleur et forme :SolidMasse moléculaire :268.785-HT1A modulator 4
CAS :5-HT1A modulator 4 (Compound 1) is a ligand for the 5-HT receptor, with Ki values of 2.18 μM for 5-HT1A and 19.7 μM for 5-HT2A.Formule :C9H14N4Couleur et forme :SolidMasse moléculaire :178.234THRX-194556
CAS :THRX-194556 is an agonist of the 5-HT4 receptor. It is applicable in the study of gastrointestinal functional disorders and Alzheimer's disease.Formule :C28H41N5O5SCouleur et forme :SolidMasse moléculaire :559.7215-HT7R antagonist 3
CAS :Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.Formule :C30H33FN4O3Couleur et forme :SolidMasse moléculaire :516.61AChE-IN-5
AChE-IN-5: oral, crosses blood-brain barrier, targets AChE/5-HT1A/SERT, potent with 2.29 nM IC50.Formule :C38H45N5OCouleur et forme :SolidMasse moléculaire :587.85-HT1A antagonist 1
Compound 6f is a potent, selective 5-HT1A receptor blocker (Ki: 35 nM), useful in CNS disorder research.Formule :C23H29ClN6O2Couleur et forme :SolidMasse moléculaire :456.97Mesulergine hydrochloride
CAS :5-HT2A and 2C receptor antagonistFormule :C18H27ClN4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.955-HT6/5-HT2AR antagonist-1
Potent 5-HT6/5-HT2A receptors dual antagonist with K i of 11 nM & 39 nM.Formule :C21H26N6SCouleur et forme :SolidMasse moléculaire :394.54Rodatristat
CAS :Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).Formule :C27H27ClF3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :561.98D3/5-HT receptor modulator-1
CAS :D3/5-HT receptor modulator-1 (compound 5i) is a selective antagonist of the dopamine D3 and 5-HT2A receptors, and a partial agonist at the 5-HT1A receptor. It exhibits Ki values of 4.5 nM, 11.9 nM, and 15.3 nM for the dopamine D3, 5-HT2A, and 5-HT1A receptors respectively. The compound shows lower affinity for the dopamine D2 receptor, 5-HT2C receptor, and hERG channel. D3/5-HT receptor modulator-1 possesses atypical antipsychotic properties.Formule :C24H29N3O2Couleur et forme :SolidMasse moléculaire :391.50625B-NBOH hydrochloride
CAS :25B-NBOH hydrochloride is a phenethylamine that exhibits high affinity for serotonin (5-HT) receptors 5-HT2A and 5-HT2C, with pKi values of 8.3 and 9.4, respectively.Formule :C17H21BrClNO3Couleur et forme :SolidMasse moléculaire :402.711SB 243213 dihydrochloride
CAS :SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 forFormule :C22H21Cl2F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.335-IAI hydrochloride
CAS :5-IAI hydrochloride is a psychoactive analog of para-iodoamphetamine. 5-IAI hydrochloride significantly reduces serotonin uptake sites and hippocampal serotonin levels in rats.Formule :C9H11ClINCouleur et forme :SolidMasse moléculaire :295.548Ro4368554
CAS :Ro4368554 is a selective 5-HT6 antagonist capable of crossing the blood-brain barrier. It can reverse memory deficits caused by scopolamine and tryptophan depletion. Ro4368554 is applicable for research related to memory impairments.Formule :C19H21N3O2SCouleur et forme :SolidMasse moléculaire :355.454LB-102
CAS :LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.Formule :C18H29N3O4SCouleur et forme :SolidMasse moléculaire :383.51Revexepride
CAS :Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.Formule :C21H32ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.95LP 12 hydrochloride hydrate
LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.Formule :C32H39N3O·HCl·xH2OCouleur et forme :SolidBefiradol hydrochloride
CAS :Befiradol HCl (NLX-112) is a selective 5-HT1A receptor agonist with anxiolytic effects and prevents ATXN3 aggregation.Formule :C20H23Cl2F2N3ODegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :430.32(S)-Praziquantel
CAS :(S)-Praziquantel is the inactive isomer of R-praziquantel.Formule :C19H24N2O2Couleur et forme :SolidMasse moléculaire :312.406CB2R/5-HT1AR agonist 1
CAS :Compound 2o, also known as CB2R/5-HT1AR agonist 1, serves as a partial orally active agonist for the CB2 receptor (EC50 = 479.6 nM) and a full agonist for the 5-HT1A receptor (EC50 = 2.7 μM). This compound demonstrates both anti-anxiety and anti-depressive effects and has favorable pharmacokinetic properties [1].Formule :C24H33NO3Couleur et forme :SolidMasse moléculaire :383.52VA012
CAS :VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.Formule :C21H19N3Couleur et forme :SolidMasse moléculaire :313.405-HT2A/5-HT2C inverse agonist 1
CAS :5-HT2A/5-HT2C inverse agonist 1 serves as a dual and potent inverse agonist for the 5-HT2A and 5-HT2C receptors, with hERG inhibition properties that mitigate cardiovascular risks. Demonstrating significant antipsychotic efficacy in the MK-801-induced mouse model, this compound holds potential for psychosis research.Formule :C24H35N5O2Couleur et forme :SolidMasse moléculaire :425.57Remlifanserin
CAS :Remlifanserin is a potent inverse agonist of the serotonin receptor (5-HT2A).Formule :C24H29F2N3O2Couleur et forme :SolidMasse moléculaire :429.50Avitriptan
CAS :Avitriptan is a 5-HT1B/1D receptor agonist with pKi values of 7.44 for 5-HT1Brat, 7.68 for 5-HT1Bhuman, and 8.36 for 5-HT1Dhuman. It can induce contraction in isolated coronary arteries and is used for the treatment of migraines.Formule :C22H30N6O3SMasse moléculaire :458.577DSP-1053 benzenesulfonate
CAS :DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.Formule :C32H38BrNO7SCouleur et forme :SolidMasse moléculaire :660.62SB 258741 hydrochloride
SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].Formule :C19H31ClN2O2SCouleur et forme :SolidMasse moléculaire :386.98SEP-363856 mesylate
CAS :SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.Formule :C10H17NO4S2Couleur et forme :SolidMasse moléculaire :279.385-HT2A receptor agonist-7
CAS :5-HT2A receptor agonist-7 (517) functions as a modulator of the 5-HT2A receptor, with an EC50 value of less than 100 nM.Formule :C12H11F2N3Couleur et forme :SolidMasse moléculaire :235.23325C-NBF hydrochloride
CAS :25C-NBF hydrochloride is an agonist of 5-HT receptors, specifically activating 5-HT2A and 5-HT2C receptors, with an EC50 of approximately 0.3 μM.Formule :C17H20Cl2FNO2Masse moléculaire :360.251Jimscaline
CAS :Jimscaline (compound R-(-)2) is a 5-HT2A agonist and a mescaline analogue, used in neuroscience research.Formule :C13H19NO3Couleur et forme :SolidMasse moléculaire :237.295AAZ-A 154 hydrobromide
CAS :AAZ-A 154 hydrobromide is a selective, competitive, non-hallucinogenic 5-HT2AR antagonist. It promotes neuronal growth in rodents and yields enduring beneficial behavioral effects.Formule :C14H21BrN2OCouleur et forme :SolidMasse moléculaire :313.23CTW0404
CAS :CTW0404 is an effective positive allosteric modulator (PAM) of the 5-HT receptor, with promising implications for research into neuropsychiatric disorders.Formule :C21H33N3O2Masse moléculaire :359.515-HT2A receptor agonist-8
CAS :5-HT2A receptor agonist-8 (compound 8) is a potent 5-HT2A receptor agonist with an EC50 of 0.6784 nM. It is suitable for research related to depression and bipolar disorder.Formule :C22H27N3OCouleur et forme :SolidMasse moléculaire :349.47Sulamserod hydrochloride
CAS :Sulamserod hydrochloride is a 5-HT4 receptor antagonist. It is utilized in research related to gastrointestinal disorders.Formule :C19H29Cl2N3O5SCouleur et forme :SolidMasse moléculaire :482.42AAZ-A 154
CAS :AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.Formule :C14H20N2OCouleur et forme :SolidMasse moléculaire :232.32Serotonin maleate
CAS :Serotonin hydrogen maleate serves as a monoaminergic neurotransmitter and an endogenous 5-HT receptor agonist within the central nervous system (CNS). It also functions as an inhibitor of catechol O-methyltransferase (COMT), exhibiting a Ki value of 44 μM.Formule :C14H16N2O5Couleur et forme :SolidMasse moléculaire :292.287Terguride
CAS :Terguride: treats hyperprolactinemia, blocks 5-HT2A/B, activates dopamine receptors, studied for PAH.Formule :C20H28N4OCouleur et forme :SolidMasse moléculaire :340.46U92016A hydrochloride
CAS :U92016A hydrochloride: potent, orally active 5-HT1A agonist, metabolically stable, high intrinsic activity, Ki=0.2 nM.Formule :C19H26ClN3Couleur et forme :SolidMasse moléculaire :331.89R-96544 hydrochloride
CAS :5-HT2 receptor antagonistFormule :C22H29NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.47PDE4B/7A-IN-1
CAS :5-HT1A antagonist; Ki=8nM, Kb=0.04nM. PDE4B IC50=80.4μM; PDE7A IC50=151.3μM. Good biofilm penetration, stable, anticognitive, antidepressant.Formule :C25H35N3O3Couleur et forme :SolidMasse moléculaire :425.56
