récepteur 5-HT
Les récepteurs 5-HT, également connus sous le nom de récepteurs de la sérotonine, sont un groupe de récepteurs couplés aux protéines G (GPCR) qui médiatisent les effets de la sérotonine, un neurotransmetteur impliqué dans la régulation de l'humeur, l'anxiété, le sommeil, l'appétit et d'autres processus physiologiques. Ces récepteurs sont divisés en plusieurs sous-types, chacun ayant des fonctions et des propriétés pharmacologiques distinctes. Les modulateurs des récepteurs 5-HT sont largement étudiés pour leurs rôles dans le traitement de la dépression, des troubles anxieux et d'autres affections neuropsychiatriques. Chez CymitQuimica, nous offrons une gamme de modulateurs des récepteurs 5-HT de haute qualité pour soutenir vos recherches en neuropharmacologie, troubles de l'humeur et signalisation GPCR.
940 produits trouvés pour "récepteur 5-HT"
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MM 77 dihydrochloride
CAS :<p>MM 77 dihydrochloride is an effecitve 5-HT1A receptor postsynaptic antagonist with anxiolytic-like activity.</p>Formule :C19H29Cl2N3O3Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :418.36SB-215505
CAS :<p>SB215505: potent 5-HT2B/2C blocker, enhances rat wakefulness/motor activity. (pKi: 5-HT2B - 8.3, 5-HT2C - 7.66, 5-HT2A - 6.77).</p>Formule :C19H16ClN3ODegré de pureté :98.33%Couleur et forme :SolidMasse moléculaire :337.85-HT2 antagonist 1
CAS :<p>5-HT2 antagonist 1 is a potent 5-HT2 receptor antagonist, has weak α1 adrenoceptor blocking activity.</p>Formule :C22H29FN4O2Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :400.49SB228357
CAS :<p>SB228357 is a potent and selective antagonist of the 5-HT receptor with pKis of 6.9, 8.0, and 9.0 for 5-HT2A, 5-HT2B, and 5-HT2C, respectively.</p>Formule :C22H17F4N3O2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :431.385HT6-ligand-1
CAS :<p>5HT6-ligand-1 is an orally active ligand of 5-HT6 receptor (Ki = 1.43 nM).</p>Formule :C20H22BrN3O2SDegré de pureté :99.24% - 99.93%Couleur et forme :SolidMasse moléculaire :448.38Itasetron
CAS :<p>Itasetron, a 5-HT3 antagonist, prevents memory loss in rats and has antiemetic effects in cancer treatments.</p>Formule :C16H20N4O2Degré de pureté :98.58% - 99.33%Couleur et forme :SolidMasse moléculaire :300.36RS 67333 hydrochloride
CAS :<p>RS 67333 hydrochloride is a selective 5-HT4R partial agonist (pKi=8.7) with neuroprotective properties for Alzheimer's research.</p>Formule :C19H30Cl2N2O2Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :389.36LY-2624803
CAS :<p>LY-2624803 is a 5-HT2A receptor antagonist and histamine receptor inverse agonist that can be used to improve slow wave sleep.</p>Formule :C22H25N3O3Degré de pureté :99.78% - 99.97%Couleur et forme :SolidMasse moléculaire :379.45GR 46611
CAS :<p>GR 46611 is a selective 5-HT1B and 5-HT1D receptor agonist and can be used in studies about the treatment of epilepsy.</p>Formule :C23H27N3O2Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :377.48(Z)-Thiothixene
CAS :<p>(Z)-Thiothixene (Thiothixene) is an antagonist of serotonergic receptor.</p>Formule :C23H29N3O2S2Degré de pureté :99.21%Couleur et forme :Yellow To Yellow With A Tan Cast PowderMasse moléculaire :443.63Teniloxazine
CAS :<p>Teniloxazine is an orally available antidepressant compound with anti-hypoxic properties.</p>Formule :C16H19NO2SDegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :289.39Lesopitron
CAS :<p>Lesopitron: anxiolytic, 5-HT1A agonist, treats rodent anxiety, counters benzodiazepine withdrawal, low toxicity, no alcohol/barbiturate interaction.</p>Formule :C15H21ClN6Degré de pureté :99.15% - 99.38%Couleur et forme :SolidMasse moléculaire :320.82Felcisetrag
CAS :<p>Felcisetrag (TD-8954), an oral 5-HT4 agonist with GI prokinetic effects, has a high affinity (pKi 9.4) for h5-HT4(c) receptors.</p>Formule :C25H37N5O3Degré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :455.59UNC9994
CAS :<p>UNC9994 is a β-arrestin-biased dopamine D₂ receptor agonist (β-arrestin EC50 = 50 nM; Emax = 97%) with robust in vivo antipsychotic drug-like activities.</p>Formule :C21H22Cl2N2OSCouleur et forme :SolidMasse moléculaire :421.385-HT2 agonist-1
CAS :<p>Compound 24, a 5-HT2 agonist-1, selectively activates 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC50 values of 10 nM, 8.3 nM, and 1.6 nM, respectively.</p>Formule :C19H23ClN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :346.85MIN-117
CAS :<p>MIN-117, a SSRI/5-HT receptor antagonist, is potentially used for the treatment of depression.</p>Formule :C25H26Cl3N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.854-Chloro-L-phenylalanine
CAS :<p>4-Chloro-L-phenalanine (L-PCPA) is an inhibitor of 5-HT biosynthesis and a non-specific antagonist of tryptophan hydroxylases (TPH1 and TPH2).</p>Formule :C9H10ClNO2Degré de pureté :99.76% - 99.96%Couleur et forme :SolidMasse moléculaire :199.63UNC9994 hydrochloride
CAS :<p>UNC9994 hydrochloride is a selective β-arrestin-biased D2R agonist, Ki of 79 nM, that stimulates β-arrestin and modulates cAMP.</p>Formule :C21H23Cl3N2OSCouleur et forme :SolidMasse moléculaire :457.845-HT2A&5-HT2C agonist-1
CAS :<p>5-HT2A&5-HT2C agonist-1 (Example 2) is a dual-acting agent targeting the 5-HT2A and 5-HT2C receptors with respective IC50 values of 196 nM and 0.9 nM.</p>Formule :C14H20N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :232.32(S)-Renzapride
<p>(S)-Renzapride (BRL 24924), 5-HT4 agonist (Ki 115 nM), 5HT2b/5HT3 antagonist, for C-IBS study.</p>Formule :C16H22ClN3O2Couleur et forme :SolidMasse moléculaire :323.82LY320954
CAS :<p>LY320954 is an antagonist of 5-HT2A receptor.</p>Formule :C21H26N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :382.46(S)-Bexicaserin
CAS :<p>(S)-Bexcaserin (compound 2) serves as a 5-HT2C receptor agonist, presenting research possibilities in obesity and psychiatric disorders [1].</p>Formule :C15H19F2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.33Befiradol
CAS :<p>Befiradol (NLX-112) is an agonist of 5-HT1A receptor.</p>Formule :C20H22ClF2N3OCouleur et forme :SolidMasse moléculaire :393.86Frovatriptan
CAS :<p>Frovatriptan, potent 5-HT 1B/D agonist, shows high cerebroselectivity and efficacy for migraine with aura.</p>Formule :C14H17N3OCouleur et forme :SolidMasse moléculaire :243.3LY108742
CAS :<p>LY108742 is an antagonist of 5-HT2.</p>Formule :C21H28N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.46Dothiepin
CAS :<p>Dothiepin (Dosulepin; Dothep), an antidepressant with sedative/anxiolytic properties, preferentially inhibits noradrenaline over serotonin uptake, enhancing</p>Formule :C19H21NSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.445-HT2C agonist-3 free base
CAS :<p>5-HT2C agonist-3 ((+)-19) free base, a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM), exhibits antipsychotic drug-like activity and inhibits Amphetamine-</p>Formule :C19H22FNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :315.38Brilaroxazine
CAS :<p>Brilaroxazine (RP5063): multimodal dopamine/5-HT modulator, partial agonist at D2/D3/D4, 5-HT1A/2A, and antagonist at 5-HT2B/7.</p>Formule :C22H25Cl2N3O3Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :450.36Robalzotan
CAS :<p>Robalzotan is a selective 5-HT1A receptor antagonist.</p>Formule :C18H23FN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :318.39Gentisein
CAS :<p>Gentisein (NSC-329491), a primary metabolite of Mangiferin, exhibits significant inhibition of serotonin uptake, demonstrating potency with an IC50 value of 4.7</p>Formule :C13H8O5Degré de pureté :96.89%Couleur et forme :SolidMasse moléculaire :244.2(±)-Fabesetron hydrochloride
CAS :<p>FK1052 hydrochloride is a potent 5-HT3 and 5-HT4 receptor dual antagonist.</p>Formule :C18H20ClN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :329.825-HT3-In-1
CAS :<p>5-HT3-In-1 (compound example 8) exhabits with 5-HT3 inhibition activity.</p>Formule :C16H21ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :352.82Velusetrag
CAS :<p>Velusetrag(TD-5108), a potent 5-HT4 agonist, is in development for gastroparesis, constipation, and IBS.</p>Formule :C25H36N4O5SCouleur et forme :SolidMasse moléculaire :504.64GR-127935
CAS :<p>GR-127935 is a potent and selective 5-HT1B/1D receptor antagonist.</p>Formule :C29H31N5O3Couleur et forme :SolidMasse moléculaire :497.595-HT2 agonist-1 free base
CAS :<p>Compound 24 (5-HT2 agonist-1 free base) is a potent agonist for 5-HT2A, 5-HT2B, and 5-HT2C receptors, exhibiting IC50 values of 10 nM, 8.3 nM, and 1.6 nM,</p>Formule :C19H22N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :310.39Indeloxazine hydrochloride
CAS :<p>Indeloxazine HCl: Serotonin releaser, NE reuptake inhibitor, NMDA antagonist; antidepressant that boosts acetylcholine in rats.</p>Formule :C14H18ClNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.75Mesembrine
CAS :<p>Mesembrine is an alkaloid, a 5-HT transporter inhibitor (K i 1.4 nM), and inhibits PDE4B (IC50 7.8 μM).</p>Formule :C17H23NO3Couleur et forme :SolidMasse moléculaire :289.37CP-122288
CAS :<p>CP-122288: potent, selective 5-HT1B/D/F agonist; inhibits plasma protein extravasation, neurogenic inflammation.</p>Formule :C16H23N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :321.44SB 258719
CAS :<p>SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.</p>Formule :C18H30N2O2SDegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :338.51Cyanopindolol fumarate
CAS :<p>Cyanopindolol fumarate is a 5-HT receptor antagonist [1].</p>Formule :C16H21N3O2C4H4O4Couleur et forme :SolidMasse moléculaire :345.45-HT2A antagonist 1
CAS :<p>5-HT2A antagonist 1, from US5728835A & JP 1007727, may treat gastrointestinal and circulatory issues.</p>Formule :C26H28N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.53Nemonapride
CAS :<p>Nemonapride is a dopamine D2-like receptor antagonist.</p>Formule :C21H26ClN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.9LY-426965
CAS :<p>LY-426965 is a selective, potent, orally bioavailable 5-HT1A antagonist.</p>Formule :C28H38N2O2Couleur et forme :SolidMasse moléculaire :434.61Gepirone
CAS :<p>Gepirone is a 5-HT1A receptor agonist belonging to the buspirone family. Gepirone HCl possesses greater selectivity for the 5-HT1A receptor than SSRIs.</p>Formule :C19H29N5O2Degré de pureté :99.35% - 99.89%Couleur et forme :SolidMasse moléculaire :359.47LY 53857
CAS :<p>LY 53857 is a potent and selective antagonist of 5-HT2 serotonin receptor.</p>Formule :C27H36N2O7Couleur et forme :SolidMasse moléculaire :500.592NAS181
CAS :<p>rat 5-HT1B receptor antagonist</p>Formule :C21H34N2O10S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.63Wf-516
CAS :<p>Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant</p>Formule :C25H25Cl2N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :502.39FPPQ
CAS :<p>FPPQ blocks 5-HT3 and 5-HT6 receptors (Ki: 0.9 & 3 nM) and may improve psychosis and cognition.</p>Formule :C21H19FN4O2SCouleur et forme :SolidMasse moléculaire :410.46R-96544
CAS :<p>R-96544 is an orally active antagonist of the 5-HT2A receptor that has demonstrated the ability to inhibit platelet aggregation in vitro [1].</p>Formule :C22H30ClNO3Couleur et forme :SolidMasse moléculaire :391.935-HT3 antagonist 1
CAS :<p>5-HT3 antagonist 1 is a potent and selective antagonist of 5-HT3 receptor.</p>Formule :C22H27N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.48PNU109291
CAS :<p>PNU109291, a potent and selective agonist of the 5-HT1D receptor, effectively mitigates dural plasma extravasation induced by trigeminal ganglion stimulation.</p>Formule :C24H31N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :409.52Facinicline hydrochloride
CAS :<p>Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM).</p>Formule :C15H19ClN4ODegré de pureté :98.70%Couleur et forme :SolidMasse moléculaire :306.79NAD 299 hydrochloride
CAS :<p>Selective, high affinity 5-HT1A receptor antagonist</p>Formule :C18H24ClFN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.85GR 125487 sulfamate
CAS :<p>GR 125487 sulfamate is a 5-HT4 receptor antagonist.</p>Formule :C19H29FN4O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :524.58Capeserod HCl
CAS :<p>Capeserod HCl, a 5-hydroxytriptamine 4 (5-HT4) receptor agonist, is used potentially for the treatment of Alzheimer's disease.</p>Formule :C23H26Cl2N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :493.38L-772,405
CAS :<p>L-772,405 is a highly selective agonists of h5-HT(1D) receptor.</p>Formule :C26H31FN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.56DU-125530
CAS :<p>DU-125530 is a 5-HT1A receptor antagonist.</p>Formule :C23H26ClN3O5SCouleur et forme :SolidMasse moléculaire :491.99YM348
CAS :<p>YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM).</p>Formule :C14H17N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :243.3Flesinoxan
CAS :<p>Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).</p>Formule :C22H26FN3O4Couleur et forme :SolidMasse moléculaire :415.46Osemozotan Free Base
CAS :<p>Osemozotan Free Base is a 5-HT(1A) receptor agonist.</p>Formule :C19H21NO5Couleur et forme :SolidMasse moléculaire :343.37NAS-181
CAS :<p>NAS-181 is a potent and selective rat 5-hydroxytryptamine 1B (r5-HT1B) antagonist (Ki: 47 nM).NAS-181 enhances the accumulation of 5-HTP in rat brain regions.</p>Formule :C20H30N2O7SCouleur et forme :SolidMasse moléculaire :442.53GYKI-46903 HCl
CAS :<p>GYKI-46903 is a noncompetitive 5-HT3 receptor antagonist.</p>Formule :C17H21ClFNO2Couleur et forme :SolidMasse moléculaire :325.812-Methyl-5-HT
CAS :<p>2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.</p>Formule :C11H14N2ODegré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :190.24GR 127935 hydrochloride
CAS :<p>5-HT1B/1D receptor antagonist</p>Formule :C29H32ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.05Abaperidone
CAS :<p>Abaperidone is an atypical antipsychotic, antagonizes 5-HT2A (IC50=6.2 nM) and D2 receptors (IC50=17 nM), reduces hsp70 mRNA in rat brains.</p>Formule :C25H25FN2O5Degré de pureté :98.22%Couleur et forme :SolidMasse moléculaire :452.475-HT2A receptor agonist-3
CAS :<p>5-HT2A receptor agonist-3 represents the highest selectivity for the human 5-HT2A receptor currently identified, exhibiting a K i of 2.5 nM.</p>Formule :C21H26BrNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.345-HT2C agonist-3
CAS :<p>5-HT2C agonist-3 ((+)-19), a selective 5-HT2C agonist (EC 50: 24 nM, Ki: 78 nM), exhibits antipsychotic-like activity by blocking amphetamine-induced</p>Formule :C19H23ClFNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.84PZ-1190
CAS :<p>PZ-1190, a multitarget ligand for serotonin and dopamine receptors, exhibits potential antipsychotic activity in rodents [1].</p>Formule :C27H30N4O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.68WAY-607695
CAS :<p>WAY-607695 is a potential 5-HT1A receptor agonist.</p>Formule :C13H12FNO2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :233.24Didesmethyl cariprazine
CAS :<p>Didesmethyl cariprazine, Cariprazine's active metabolite, treats schizophrenia/bipolar with D3/D2 affinity; half-life 1-3 weeks.</p>Formule :C19H28Cl2N4ODegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :399.36SB 216641 hydrochloride
CAS :<p>SB 216641 hydrochloride (SB-216641A) is a 5-HT1B/D receptor antagonist with anxiolytic properties.</p>Formule :C28H31ClN4O4Degré de pureté :98.06% - 99.23%Couleur et forme :SolidMasse moléculaire :523.02Osemozotan HCl
CAS :<p>Osemozotan is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder.</p>Formule :C19H22ClNO5Degré de pureté :98.87% - 99.63%Couleur et forme :SolidMasse moléculaire :379.84Lumateperone
CAS :<p>Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).</p>Formule :C24H28FN3ODegré de pureté :99.68% - 99.91%Couleur et forme :SolidMasse moléculaire :393.5SB-616234-A
CAS :<p>SB-616234-A is a selective and orally bioavailable antagonist of 5-HT1B receptor, with anxiolytic and antidepressant activity.</p>Formule :C32H36ClN5O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :574.11Tiprenolol hydrochloride
CAS :<p>Tiprenolol hydrochloride is a β-adrenoceptor (β-adrenoceptor) antagonist. This compound is effective in eliminating ventricular arrhythmias in dogs caused by intravenous administration of adrenaline, following inhalation of halothane.</p>Formule :C13H22ClNO2SCouleur et forme :SolidMasse moléculaire :291.84ASP-2205
CAS :<p>ASP-2205, a 5-HT2C receptor agonist (human 5-HT2C receptor, EC50=0.85 nM; rat 5-HT2C receptor, EC50=2.5 nM), enhances the urethral closure reflex mediated by the genital nerve, thereby preventing urinary incontinence.</p>Formule :C19H28N2OCouleur et forme :SolidMasse moléculaire :300.44Etoperidone
CAS :<p>Etoperidone is an antidepressant that acts as an orally active reuptake inhibitor for serotonin (serotonin) and noradrenaline (nor-adrenaline). It demonstrates specific binding affinities (Kd) for several receptors: 36 nM at the 5-HT2 receptor, 38 nM at the α1-adrenergic receptor (α1-adrenergic receptor), 85 nM at the 5-HT1A receptor, and 570 nM at the α2-adrenergic receptor (α2-adrenergic receptor).</p>Formule :C19H28ClN5OCouleur et forme :SolidMasse moléculaire :377.91Tipindole
CAS :<p>Tipindole is a serotonin antagonist utilized in research related to depression.</p>Formule :C16H20N2O2SCouleur et forme :SolidMasse moléculaire :304.41Elzasonan hydrochloride
CAS :<p>Elzasonan hydrochloride is a serotonin 1B and serotonin 1D receptor antagonist. It is utilized in the study of depression.</p>Formule :C22H24Cl3N3OSCouleur et forme :SolidMasse moléculaire :484.87AGH-107
CAS :<p>AGH-107 is a highly selective 5-HT7 receptor agonist that can cross the blood-brain barrier, featuring a Ki value of 6 nM and an EC50 value of 19 nM. Demonstrating high selectivity for central nervous system targets, AGH-107 also exhibits high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures.</p>Formule :C13H12IN3Couleur et forme :SolidMasse moléculaire :337.16R-137696
CAS :<p>R-137696 is an orally active 5-HT1A receptor agonist that facilitates the relaxation of the proximal stomach. It is utilized in research related to functional dyspepsia.</p>Formule :C17H23N3O2Couleur et forme :SolidMasse moléculaire :301.38SEP-363856 mesylate
CAS :<p>SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.</p>Formule :C10H17NO4S2Couleur et forme :SolidMasse moléculaire :279.38Flucopride
CAS :<p>Flucopride (Compound 4a) acts as an acetylcholinesterase inhibitor (AChE) with an IC50 value of 24 nM and serves as a partial agonist for the human 5-HT4 receptor (5-HT4R) with a Ki of 9.6 nM for (h)5-HT4R. It promotes non-amyloidogenic processing of APP in COS-7 cells transiently expressing (h)5-HT4R with an EC50 of 23.0 nM. Flucopride is also likely to exhibit significant gastrointestinal tract (GIT) penetration and blood-brain barrier (BBB) permeability, as determined in PAMPA experiments.</p>Formule :C22H33FN2O2Couleur et forme :SolidMasse moléculaire :376.51Sulamserod hydrochloride
CAS :<p>Sulamserod hydrochloride is a 5-HT4 receptor antagonist. It is utilized in research related to gastrointestinal disorders.</p>Formule :C19H29Cl2N3O5SCouleur et forme :SolidMasse moléculaire :482.42Rodatristat ethyl
CAS :<p>Rodatristat ethyl is an oral TPH1 inhibitor reducing 5-HT levels & lowering PAH at low doses.</p>Formule :C29H31ClF3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :590.04SB 258741 hydrochloride
<p>SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].</p>Formule :C19H31ClN2O2SCouleur et forme :SolidMasse moléculaire :386.98DSP-1053 benzenesulfonate
CAS :<p>DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.</p>Formule :C32H38BrNO7SCouleur et forme :SolidMasse moléculaire :660.62AM9405
<p>AM9405: peripheral CB1/5-HT3 agonist, suppresses gut motility, relieves GI disorder symptoms in mice.</p>Formule :C24H33BrN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.44SB 224289
CAS :<p>SB 224289: selective 5-HT1B antagonist, pKi 8.2, 60x selectivity, effective orally.</p>Formule :C32H32N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :520.625-HT6R/MAO-B modulator 1
<p>5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.</p>Formule :C33H38N4O3SCouleur et forme :SolidMasse moléculaire :570.74SB 243213 hydrochloride
CAS :<p>SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It</p>Formule :C22H20ClF3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.875-HT1A modulator 4
CAS :<p>5-HT1A modulator 4 (Compound 1) is a ligand for the 5-HT receptor, with Ki values of 2.18 μM for 5-HT1A and 19.7 μM for 5-HT2A.</p>Formule :C9H14N4Couleur et forme :SolidMasse moléculaire :178.2345-HT6/5-HT2AR antagonist-1
<p>Potent 5-HT6/5-HT2A receptors dual antagonist with K i of 11 nM & 39 nM.</p>Formule :C21H26N6SCouleur et forme :SolidMasse moléculaire :394.54THRX-194556
CAS :<p>THRX-194556 is an agonist of the 5-HT4 receptor. It is applicable in the study of gastrointestinal functional disorders and Alzheimer's disease.</p>Formule :C28H41N5O5SCouleur et forme :SolidMasse moléculaire :559.7215-HT7R antagonist 3
CAS :<p>Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.</p>Formule :C30H33FN4O3Couleur et forme :SolidMasse moléculaire :516.615-HT1A antagonist 1
<p>Compound 6f is a potent, selective 5-HT1A receptor blocker (Ki: 35 nM), useful in CNS disorder research.</p>Formule :C23H29ClN6O2Couleur et forme :SolidMasse moléculaire :456.97AChE-IN-5
<p>AChE-IN-5: oral, crosses blood-brain barrier, targets AChE/5-HT1A/SERT, potent with 2.29 nM IC50.</p>Formule :C38H45N5OCouleur et forme :SolidMasse moléculaire :587.8Mesulergine hydrochloride
CAS :<p>5-HT2A and 2C receptor antagonist</p>Formule :C18H27ClN4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.95Terguride
CAS :<p>Terguride: treats hyperprolactinemia, blocks 5-HT2A/B, activates dopamine receptors, studied for PAH.</p>Formule :C20H28N4OCouleur et forme :SolidMasse moléculaire :340.46U92016A hydrochloride
CAS :<p>U92016A hydrochloride: potent, orally active 5-HT1A agonist, metabolically stable, high intrinsic activity, Ki=0.2 nM.</p>Formule :C19H26ClN3Couleur et forme :SolidMasse moléculaire :331.89D3/5-HT receptor modulator-1
CAS :<p>D3/5-HT receptor modulator-1 (compound 5i) is a selective antagonist of the dopamine D3 and 5-HT2A receptors, and a partial agonist at the 5-HT1A receptor. It exhibits Ki values of 4.5 nM, 11.9 nM, and 15.3 nM for the dopamine D3, 5-HT2A, and 5-HT1A receptors respectively. The compound shows lower affinity for the dopamine D2 receptor, 5-HT2C receptor, and hERG channel. D3/5-HT receptor modulator-1 possesses atypical antipsychotic properties.</p>Formule :C24H29N3O2Couleur et forme :SolidMasse moléculaire :391.50625B-NBOH hydrochloride
CAS :<p>25B-NBOH hydrochloride is a phenethylamine that exhibits high affinity for serotonin (5-HT) receptors 5-HT2A and 5-HT2C, with pKi values of 8.3 and 9.4, respectively.</p>Formule :C17H21BrClNO3Couleur et forme :SolidMasse moléculaire :402.7115-IAI hydrochloride
CAS :<p>5-IAI hydrochloride is a psychoactive analog of para-iodoamphetamine. 5-IAI hydrochloride significantly reduces serotonin uptake sites and hippocampal serotonin levels in rats.</p>Formule :C9H11ClINCouleur et forme :SolidMasse moléculaire :295.548Ro4368554
CAS :<p>Ro4368554 is a selective 5-HT6 antagonist capable of crossing the blood-brain barrier. It can reverse memory deficits caused by scopolamine and tryptophan depletion. Ro4368554 is applicable for research related to memory impairments.</p>Formule :C19H21N3O2SCouleur et forme :SolidMasse moléculaire :355.454AAZ-A 154 hydrobromide
CAS :<p>AAZ-A 154 hydrobromide is a selective, competitive, non-hallucinogenic 5-HT2AR antagonist. It promotes neuronal growth in rodents and yields enduring beneficial behavioral effects.</p>Formule :C14H21BrN2OCouleur et forme :SolidMasse moléculaire :313.23LB-102
CAS :<p>LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.</p>Formule :C18H29N3O4SCouleur et forme :SolidMasse moléculaire :383.51Revexepride
CAS :<p>Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.</p>Formule :C21H32ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.95Rodatristat
CAS :<p>Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).</p>Formule :C27H27ClF3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :561.98LP 12 hydrochloride hydrate
<p>LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.</p>Formule :C32H39N3O·HCl·xH2OCouleur et forme :SolidLY 215840
CAS :<p>5-HT2/5-HT7 receptor antagonist</p>Formule :C24H33N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.54(S)-Praziquantel
CAS :<p>(S)-Praziquantel is the inactive isomer of R-praziquantel.</p>Formule :C19H24N2O2Couleur et forme :SolidMasse moléculaire :312.406VA012
CAS :<p>VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.</p>Formule :C21H19N3Couleur et forme :SolidMasse moléculaire :313.40Remlifanserin
CAS :<p>Remlifanserin is a potent inverse agonist of the serotonin receptor (5-HT2A).</p>Formule :C24H29F2N3O2Couleur et forme :SolidMasse moléculaire :429.505-HT2A/5-HT2C inverse agonist 1
CAS :<p>5-HT2A/5-HT2C inverse agonist 1 serves as a dual and potent inverse agonist for the 5-HT2A and 5-HT2C receptors, with hERG inhibition properties that mitigate cardiovascular risks. Demonstrating significant antipsychotic efficacy in the MK-801-induced mouse model, this compound holds potential for psychosis research.</p>Formule :C24H35N5O2Couleur et forme :SolidMasse moléculaire :425.57Befiradol hydrochloride
CAS :<p>Befiradol HCl (NLX-112) is a selective 5-HT1A receptor agonist with anxiolytic effects and prevents ATXN3 aggregation.</p>Formule :C20H23Cl2F2N3ODegré de pureté :99.1%Couleur et forme :SolidMasse moléculaire :430.32Serotonin maleate
CAS :<p>Serotonin hydrogen maleate serves as a monoaminergic neurotransmitter and an endogenous 5-HT receptor agonist within the central nervous system (CNS). It also functions as an inhibitor of catechol O-methyltransferase (COMT), exhibiting a Ki value of 44 μM.</p>Formule :C14H16N2O5Couleur et forme :SolidMasse moléculaire :292.287CB2R/5-HT1AR agonist 1
CAS :<p>Compound 2o, also known as CB2R/5-HT1AR agonist 1, serves as a partial orally active agonist for the CB2 receptor (EC50 = 479.6 nM) and a full agonist for the 5-HT1A receptor (EC50 = 2.7 μM). This compound demonstrates both anti-anxiety and anti-depressive effects and has favorable pharmacokinetic properties [1].</p>Formule :C24H33NO3Couleur et forme :SolidMasse moléculaire :383.52SB 243213 dihydrochloride
CAS :<p>SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for</p>Formule :C22H21Cl2F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.33AAZ-A 154
CAS :<p>AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.</p>Formule :C14H20N2OCouleur et forme :SolidMasse moléculaire :232.32R-96544 hydrochloride
CAS :<p>5-HT2 receptor antagonist</p>Formule :C22H29NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.47AAZ-A 154 benzoate
CAS :<p>AAZ-A 154 benzoate is a selective, competitive, and non-hallucinogenic 5-HT2AR antagonist. This compound facilitates neuronal growth in rodents and produces lasting beneficial behavioral effects.</p>Formule :C21H26N2O3Couleur et forme :SolidMasse moléculaire :354.44F 14679
CAS :<p>F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.</p>Formule :C21H25ClF2N4ODegré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :422.9AAZ-A 154 mesylate
CAS :<p>AAZ-A 154 mesylate mesylate is a selective, competitive, and non-hallucinogenic antagonist of 5-HT2AR. It enhances neuronal growth in rodents and produces enduring beneficial behavioral effects.</p>Formule :C15H24N2O4SCouleur et forme :SolidMasse moléculaire :328.438 Hydroxy PIPAT oxalate
CAS :<p>8 Hydroxy PIPAT oxalate is a selective 5-HT1A receptor agonist that enhances the spontaneous release of histamine by promoting the degranulation of mast cells in guinea pig and human intestinal preparations. By activating the serotonin signaling pathway, this compound demonstrates potential in regulating gastrointestinal functions and offers insight into the management and suppression of functional gastrointestinal disorders such as irritable bowel syndrome. Its effects in increasing histamine release could play a crucial role in gastrointestinal regulation.</p>Formule :C18H24INO5Couleur et forme :SolidMasse moléculaire :461.29Beloxepin
CAS :<p>Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.</p>Formule :C19H21NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.38(-)-5-HT2C agonist-3
CAS :<p>Compound (−)-19, also known as (-)-5-HT2C agonist-3, is a selective 5-HT2C agonist exhibiting a preference for Gq signaling. It demonstrates efficiency with EC50 values for 5-HT2 receptor subtypes as follows: 5-HT2C at 103 nM, 5-HT2B at 570 nM, and 5-HT2A at 72 nM. This compound is utilized in research on antipsychotics.</p>Formule :C19H23ClFNO2Couleur et forme :SolidMasse moléculaire :351.84AAZ-A 154 hydrochloride
CAS :<p>AAZ-A 154 hydrochloride is a selective, competitive, non-hallucinogenic antagonist of 5-HT2AR. It promotes neuronal growth in rodents and results in enduring beneficial behavioral effects.</p>Formule :C14H21ClN2OCouleur et forme :SolidMasse moléculaire :268.78YM-31636 free base
CAS :<p>YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.</p>Formule :C14H11N3SCouleur et forme :SolidMasse moléculaire :253.32SB-224289 hydrochloride
CAS :<p>SB-224289 hydrochloride (SB-224289A) is a selective antagonist of 5-HT1B receptor, with anxiolytic effect.</p>Formule :C32H33ClN4O3Degré de pureté :97.82% - 98.99%Couleur et forme :SolidMasse moléculaire :557.08Pumosetrag Hydrochloride
CAS :<p>Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.</p>Formule :C15H18ClN3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :339.84SB-399885 hydrochloride
CAS :<p>SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.</p>Formule :C18H22Cl3N3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :482.817-Desmethyl-agomelatine
CAS :<p>7-Desmethyl-agomelatine, a metabolite of Agomelatine, exhibits lower activity than Agomelatine, which functions as a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.</p>Formule :C14H15NO2Couleur et forme :SolidMasse moléculaire :229.27Arotinolol
CAS :<p>Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand [125I-ICYP] to [5HT1B-serotonergic] receptor sites. It is an antihypertensive agent.</p>Formule :C15H21N3O2S3Couleur et forme :White SolidMasse moléculaire :371.54BRL 15572
CAS :<p>BRL 15572 is a useful organic compound for research related to life sciences. The catalog number is T64501 and the CAS number is 734517-40-9.</p>Formule :C25H27ClN2OCouleur et forme :SolidMasse moléculaire :406.95Sarizotan
CAS :<p>Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors, with IC50 values of 6.5 nM for rat 5-HT 1A, 0.1 nM for human 5-HT 1A, 15.1 nM for rat D 2, 17 nM for human D 2, 6.8 nM for human D 3, and 2.4 nM for human D 4.2.</p>Formule :C22H21FN2OCouleur et forme :SolidMasse moléculaire :348.421Desmethyl cariprazine
CAS :<p>Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (Ki: 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).</p>Formule :C20H30Cl2N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :413.38(Rac)-Rotigotine hydrochloride
CAS :<p>(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.</p>Formule :C19H26ClNOSCouleur et forme :SolidMasse moléculaire :351.93NLX-204 hydrochloride(2170405-10-2 free base)
<p>NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).</p>Formule :C20H23Cl2F2N3O2Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :446.322-Methyl-5-HT hydrochloride
CAS :<p>2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.</p>Formule :C11H15ClN2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :226.7Flumexadol
CAS :<p>Flumexadol is a selective 5-HT2C receptor agonist with an affinity (Ki) of 25 nM for the (+)-enantiomer and exhibits 40-fold selectivity over the 5-HT2A receptor. It is an orally active, non-narcotic analgesic.</p>Formule :C11H12F3NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :231.21
