récepteur 5-HT
Les récepteurs 5-HT, également connus sous le nom de récepteurs de la sérotonine, sont un groupe de récepteurs couplés aux protéines G (GPCR) qui médiatisent les effets de la sérotonine, un neurotransmetteur impliqué dans la régulation de l'humeur, l'anxiété, le sommeil, l'appétit et d'autres processus physiologiques. Ces récepteurs sont divisés en plusieurs sous-types, chacun ayant des fonctions et des propriétés pharmacologiques distinctes. Les modulateurs des récepteurs 5-HT sont largement étudiés pour leurs rôles dans le traitement de la dépression, des troubles anxieux et d'autres affections neuropsychiatriques. Chez CymitQuimica, nous offrons une gamme de modulateurs des récepteurs 5-HT de haute qualité pour soutenir vos recherches en neuropharmacologie, troubles de l'humeur et signalisation GPCR.
940 produits trouvés pour "récepteur 5-HT"
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PNU109291
CAS :<p>PNU109291, a potent and selective agonist of the 5-HT1D receptor, effectively mitigates dural plasma extravasation induced by trigeminal ganglion stimulation.</p>Formule :C24H31N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :409.52Facinicline hydrochloride
CAS :<p>Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM).</p>Formule :C15H19ClN4ODegré de pureté :98.70%Couleur et forme :SolidMasse moléculaire :306.79NAD 299 hydrochloride
CAS :<p>Selective, high affinity 5-HT1A receptor antagonist</p>Formule :C18H24ClFN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.85GR 125487 sulfamate
CAS :<p>GR 125487 sulfamate is a 5-HT4 receptor antagonist.</p>Formule :C19H29FN4O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :524.58Capeserod HCl
CAS :<p>Capeserod HCl, a 5-hydroxytriptamine 4 (5-HT4) receptor agonist, is used potentially for the treatment of Alzheimer's disease.</p>Formule :C23H26Cl2N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :493.38L-772,405
CAS :<p>L-772,405 is a highly selective agonists of h5-HT(1D) receptor.</p>Formule :C26H31FN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.56DU-125530
CAS :<p>DU-125530 is a 5-HT1A receptor antagonist.</p>Formule :C23H26ClN3O5SCouleur et forme :SolidMasse moléculaire :491.99YM348
CAS :<p>YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM).</p>Formule :C14H17N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :243.3Flesinoxan
CAS :<p>Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).</p>Formule :C22H26FN3O4Couleur et forme :SolidMasse moléculaire :415.46Osemozotan Free Base
CAS :<p>Osemozotan Free Base is a 5-HT(1A) receptor agonist.</p>Formule :C19H21NO5Couleur et forme :SolidMasse moléculaire :343.37NAS-181
CAS :<p>NAS-181 is a potent and selective rat 5-hydroxytryptamine 1B (r5-HT1B) antagonist (Ki: 47 nM).NAS-181 enhances the accumulation of 5-HTP in rat brain regions.</p>Formule :C20H30N2O7SCouleur et forme :SolidMasse moléculaire :442.53GYKI-46903 HCl
CAS :<p>GYKI-46903 is a noncompetitive 5-HT3 receptor antagonist.</p>Formule :C17H21ClFNO2Couleur et forme :SolidMasse moléculaire :325.812-Methyl-5-HT
CAS :<p>2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.</p>Formule :C11H14N2ODegré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :190.24GR 127935 hydrochloride
CAS :<p>5-HT1B/1D receptor antagonist</p>Formule :C29H32ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.05Abaperidone
CAS :<p>Abaperidone is an atypical antipsychotic, antagonizes 5-HT2A (IC50=6.2 nM) and D2 receptors (IC50=17 nM), reduces hsp70 mRNA in rat brains.</p>Formule :C25H25FN2O5Degré de pureté :98.22%Couleur et forme :SolidMasse moléculaire :452.475-HT2A receptor agonist-3
CAS :<p>5-HT2A receptor agonist-3 represents the highest selectivity for the human 5-HT2A receptor currently identified, exhibiting a K i of 2.5 nM.</p>Formule :C21H26BrNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.345-HT2C agonist-3
CAS :<p>5-HT2C agonist-3 ((+)-19), a selective 5-HT2C agonist (EC 50: 24 nM, Ki: 78 nM), exhibits antipsychotic-like activity by blocking amphetamine-induced</p>Formule :C19H23ClFNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.84PZ-1190
CAS :<p>PZ-1190, a multitarget ligand for serotonin and dopamine receptors, exhibits potential antipsychotic activity in rodents [1].</p>Formule :C27H30N4O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.68WAY-607695
CAS :<p>WAY-607695 is a potential 5-HT1A receptor agonist.</p>Formule :C13H12FNO2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :233.24Didesmethyl cariprazine
CAS :<p>Didesmethyl cariprazine, Cariprazine's active metabolite, treats schizophrenia/bipolar with D3/D2 affinity; half-life 1-3 weeks.</p>Formule :C19H28Cl2N4ODegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :399.36SB 216641 hydrochloride
CAS :<p>SB 216641 hydrochloride (SB-216641A) is a 5-HT1B/D receptor antagonist with anxiolytic properties.</p>Formule :C28H31ClN4O4Degré de pureté :98.06% - 99.23%Couleur et forme :SolidMasse moléculaire :523.02Osemozotan HCl
CAS :<p>Osemozotan is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder.</p>Formule :C19H22ClNO5Degré de pureté :98.87% - 99.63%Couleur et forme :SolidMasse moléculaire :379.84Lumateperone
CAS :<p>Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).</p>Formule :C24H28FN3ODegré de pureté :99.68% - 99.91%Couleur et forme :SolidMasse moléculaire :393.5SB-616234-A
CAS :<p>SB-616234-A is a selective and orally bioavailable antagonist of 5-HT1B receptor, with anxiolytic and antidepressant activity.</p>Formule :C32H36ClN5O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :574.11Tiprenolol hydrochloride
CAS :<p>Tiprenolol hydrochloride is a β-adrenoceptor (β-adrenoceptor) antagonist. This compound is effective in eliminating ventricular arrhythmias in dogs caused by intravenous administration of adrenaline, following inhalation of halothane.</p>Formule :C13H22ClNO2SCouleur et forme :SolidMasse moléculaire :291.84ASP-2205
CAS :<p>ASP-2205, a 5-HT2C receptor agonist (human 5-HT2C receptor, EC50=0.85 nM; rat 5-HT2C receptor, EC50=2.5 nM), enhances the urethral closure reflex mediated by the genital nerve, thereby preventing urinary incontinence.</p>Formule :C19H28N2OCouleur et forme :SolidMasse moléculaire :300.44Etoperidone
CAS :<p>Etoperidone is an antidepressant that acts as an orally active reuptake inhibitor for serotonin (serotonin) and noradrenaline (nor-adrenaline). It demonstrates specific binding affinities (Kd) for several receptors: 36 nM at the 5-HT2 receptor, 38 nM at the α1-adrenergic receptor (α1-adrenergic receptor), 85 nM at the 5-HT1A receptor, and 570 nM at the α2-adrenergic receptor (α2-adrenergic receptor).</p>Formule :C19H28ClN5OCouleur et forme :SolidMasse moléculaire :377.91Tipindole
CAS :<p>Tipindole is a serotonin antagonist utilized in research related to depression.</p>Formule :C16H20N2O2SCouleur et forme :SolidMasse moléculaire :304.41Elzasonan hydrochloride
CAS :<p>Elzasonan hydrochloride is a serotonin 1B and serotonin 1D receptor antagonist. It is utilized in the study of depression.</p>Formule :C22H24Cl3N3OSCouleur et forme :SolidMasse moléculaire :484.87AGH-107
CAS :<p>AGH-107 is a highly selective 5-HT7 receptor agonist that can cross the blood-brain barrier, featuring a Ki value of 6 nM and an EC50 value of 19 nM. Demonstrating high selectivity for central nervous system targets, AGH-107 also exhibits high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures.</p>Formule :C13H12IN3Couleur et forme :SolidMasse moléculaire :337.16R-137696
CAS :<p>R-137696 is an orally active 5-HT1A receptor agonist that facilitates the relaxation of the proximal stomach. It is utilized in research related to functional dyspepsia.</p>Formule :C17H23N3O2Couleur et forme :SolidMasse moléculaire :301.38SEP-363856 mesylate
CAS :<p>SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.</p>Formule :C10H17NO4S2Couleur et forme :SolidMasse moléculaire :279.38Flucopride
CAS :<p>Flucopride (Compound 4a) acts as an acetylcholinesterase inhibitor (AChE) with an IC50 value of 24 nM and serves as a partial agonist for the human 5-HT4 receptor (5-HT4R) with a Ki of 9.6 nM for (h)5-HT4R. It promotes non-amyloidogenic processing of APP in COS-7 cells transiently expressing (h)5-HT4R with an EC50 of 23.0 nM. Flucopride is also likely to exhibit significant gastrointestinal tract (GIT) penetration and blood-brain barrier (BBB) permeability, as determined in PAMPA experiments.</p>Formule :C22H33FN2O2Couleur et forme :SolidMasse moléculaire :376.51Sulamserod hydrochloride
CAS :<p>Sulamserod hydrochloride is a 5-HT4 receptor antagonist. It is utilized in research related to gastrointestinal disorders.</p>Formule :C19H29Cl2N3O5SCouleur et forme :SolidMasse moléculaire :482.42Rodatristat ethyl
CAS :<p>Rodatristat ethyl is an oral TPH1 inhibitor reducing 5-HT levels & lowering PAH at low doses.</p>Formule :C29H31ClF3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :590.04SB 258741 hydrochloride
<p>SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].</p>Formule :C19H31ClN2O2SCouleur et forme :SolidMasse moléculaire :386.98DSP-1053 benzenesulfonate
CAS :<p>DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.</p>Formule :C32H38BrNO7SCouleur et forme :SolidMasse moléculaire :660.62AM9405
<p>AM9405: peripheral CB1/5-HT3 agonist, suppresses gut motility, relieves GI disorder symptoms in mice.</p>Formule :C24H33BrN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.44SB 224289
CAS :<p>SB 224289: selective 5-HT1B antagonist, pKi 8.2, 60x selectivity, effective orally.</p>Formule :C32H32N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :520.625-HT6R/MAO-B modulator 1
<p>5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.</p>Formule :C33H38N4O3SCouleur et forme :SolidMasse moléculaire :570.74SB 243213 hydrochloride
CAS :<p>SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It</p>Formule :C22H20ClF3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.875-HT1A modulator 4
CAS :<p>5-HT1A modulator 4 (Compound 1) is a ligand for the 5-HT receptor, with Ki values of 2.18 μM for 5-HT1A and 19.7 μM for 5-HT2A.</p>Formule :C9H14N4Couleur et forme :SolidMasse moléculaire :178.2345-HT6/5-HT2AR antagonist-1
<p>Potent 5-HT6/5-HT2A receptors dual antagonist with K i of 11 nM & 39 nM.</p>Formule :C21H26N6SCouleur et forme :SolidMasse moléculaire :394.54THRX-194556
CAS :<p>THRX-194556 is an agonist of the 5-HT4 receptor. It is applicable in the study of gastrointestinal functional disorders and Alzheimer's disease.</p>Formule :C28H41N5O5SCouleur et forme :SolidMasse moléculaire :559.7215-HT7R antagonist 3
CAS :<p>Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.</p>Formule :C30H33FN4O3Couleur et forme :SolidMasse moléculaire :516.615-HT1A antagonist 1
<p>Compound 6f is a potent, selective 5-HT1A receptor blocker (Ki: 35 nM), useful in CNS disorder research.</p>Formule :C23H29ClN6O2Couleur et forme :SolidMasse moléculaire :456.97AChE-IN-5
<p>AChE-IN-5: oral, crosses blood-brain barrier, targets AChE/5-HT1A/SERT, potent with 2.29 nM IC50.</p>Formule :C38H45N5OCouleur et forme :SolidMasse moléculaire :587.8Mesulergine hydrochloride
CAS :<p>5-HT2A and 2C receptor antagonist</p>Formule :C18H27ClN4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.95Terguride
CAS :<p>Terguride: treats hyperprolactinemia, blocks 5-HT2A/B, activates dopamine receptors, studied for PAH.</p>Formule :C20H28N4OCouleur et forme :SolidMasse moléculaire :340.46U92016A hydrochloride
CAS :<p>U92016A hydrochloride: potent, orally active 5-HT1A agonist, metabolically stable, high intrinsic activity, Ki=0.2 nM.</p>Formule :C19H26ClN3Couleur et forme :SolidMasse moléculaire :331.89
