récepteur 5-HT
Les récepteurs 5-HT, également connus sous le nom de récepteurs de la sérotonine, sont un groupe de récepteurs couplés aux protéines G (GPCR) qui médiatisent les effets de la sérotonine, un neurotransmetteur impliqué dans la régulation de l'humeur, l'anxiété, le sommeil, l'appétit et d'autres processus physiologiques. Ces récepteurs sont divisés en plusieurs sous-types, chacun ayant des fonctions et des propriétés pharmacologiques distinctes. Les modulateurs des récepteurs 5-HT sont largement étudiés pour leurs rôles dans le traitement de la dépression, des troubles anxieux et d'autres affections neuropsychiatriques. Chez CymitQuimica, nous offrons une gamme de modulateurs des récepteurs 5-HT de haute qualité pour soutenir vos recherches en neuropharmacologie, troubles de l'humeur et signalisation GPCR.
993 produits trouvés pour "récepteur 5-HT"
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ASP-2205
CAS :<p>ASP-2205, a 5-HT2C receptor agonist (human 5-HT2C receptor, EC50=0.85 nM; rat 5-HT2C receptor, EC50=2.5 nM), enhances the urethral closure reflex mediated by the genital nerve, thereby preventing urinary incontinence.</p>Formule :C19H28N2OCouleur et forme :SolidMasse moléculaire :300.44Remlifanserin
CAS :Remlifanserin is a potent inverse agonist of the serotonin receptor (5-HT2A).Formule :C24H29F2N3O2Couleur et forme :SolidMasse moléculaire :429.50YM-31636 free base
CAS :<p>YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.</p>Formule :C14H11N3SCouleur et forme :SolidMasse moléculaire :253.32Tiprenolol hydrochloride
CAS :Tiprenolol hydrochloride is a β-adrenoceptor (β-adrenoceptor) antagonist. This compound is effective in eliminating ventricular arrhythmias in dogs caused by intravenous administration of adrenaline, following inhalation of halothane.Formule :C13H22ClNO2SCouleur et forme :SolidMasse moléculaire :291.845-HT6R/MAO-B modulator 1
5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.Formule :C33H38N4O3SCouleur et forme :SolidMasse moléculaire :570.74PDE4B/7A-IN-1
CAS :5-HT1A antagonist; Ki=8nM, Kb=0.04nM. PDE4B IC50=80.4μM; PDE7A IC50=151.3μM. Good biofilm penetration, stable, anticognitive, antidepressant.Formule :C25H35N3O3Couleur et forme :SolidMasse moléculaire :425.56AAZ-A 154 hydrochloride
CAS :<p>AAZ-A 154 hydrochloride is a selective, competitive, non-hallucinogenic antagonist of 5-HT2AR. It promotes neuronal growth in rodents and results in enduring beneficial behavioral effects.</p>Formule :C14H21ClN2OCouleur et forme :SolidMasse moléculaire :268.78SB 243213 dihydrochloride
CAS :SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 forFormule :C22H21Cl2F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.33LK-732
CAS :LK-732 is a thrombin inhibitor with antithrombotic activity. It exhibits dose-dependent inhibition in models of hypercoagulability, with an IC50 value of 1.3 mg/kg. LK-732 is used in cardiovascular and cerebrovascular research.Formule :C25H29N5O3SCouleur et forme :SolidMasse moléculaire :479.59Befiradol hydrochloride
CAS :<p>Befiradol HCl (NLX-112) is a selective 5-HT1A receptor agonist with anxiolytic effects and prevents ATXN3 aggregation.</p>Formule :C20H23Cl2F2N3ODegré de pureté :99.1%Couleur et forme :SolidMasse moléculaire :430.32(-)-5-HT2C agonist-3
CAS :<p>Compound (−)-19, also known as (-)-5-HT2C agonist-3, is a selective 5-HT2C agonist exhibiting a preference for Gq signaling. It demonstrates efficiency with EC50 values for 5-HT2 receptor subtypes as follows: 5-HT2C at 103 nM, 5-HT2B at 570 nM, and 5-HT2A at 72 nM. This compound is utilized in research on antipsychotics.</p>Formule :C19H23ClFNO2Couleur et forme :SolidMasse moléculaire :351.84(S)-Praziquantel
CAS :(S)-Praziquantel is the inactive isomer of R-praziquantel.Formule :C19H24N2O2Couleur et forme :SolidMasse moléculaire :312.406CB2R/5-HT1AR agonist 1
CAS :<p>Compound 2o, also known as CB2R/5-HT1AR agonist 1, serves as a partial orally active agonist for the CB2 receptor (EC50 = 479.6 nM) and a full agonist for the 5-HT1A receptor (EC50 = 2.7 μM). This compound demonstrates both anti-anxiety and anti-depressive effects and has favorable pharmacokinetic properties [1].</p>Formule :C24H33NO3Couleur et forme :SolidMasse moléculaire :383.52SEP-363856 mesylate
CAS :<p>SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.</p>Formule :C10H17NO4S2Couleur et forme :SolidMasse moléculaire :279.385-HT1A antagonist 1
<p>Compound 6f is a potent, selective 5-HT1A receptor blocker (Ki: 35 nM), useful in CNS disorder research.</p>Formule :C23H29ClN6O2Couleur et forme :SolidMasse moléculaire :456.97AChE-IN-5
AChE-IN-5: oral, crosses blood-brain barrier, targets AChE/5-HT1A/SERT, potent with 2.29 nM IC50.Formule :C38H45N5OCouleur et forme :SolidMasse moléculaire :587.8Mesulergine hydrochloride
CAS :5-HT2A and 2C receptor antagonistFormule :C18H27ClN4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.95Sulamserod hydrochloride
CAS :<p>Sulamserod hydrochloride is a 5-HT4 receptor antagonist. It is utilized in research related to gastrointestinal disorders.</p>Formule :C19H29Cl2N3O5SCouleur et forme :SolidMasse moléculaire :482.42Flucopride
CAS :Flucopride (Compound 4a) acts as an acetylcholinesterase inhibitor (AChE) with an IC50 value of 24 nM and serves as a partial agonist for the human 5-HT4 receptor (5-HT4R) with a Ki of 9.6 nM for (h)5-HT4R. It promotes non-amyloidogenic processing of APP in COS-7 cells transiently expressing (h)5-HT4R with an EC50 of 23.0 nM. Flucopride is also likely to exhibit significant gastrointestinal tract (GIT) penetration and blood-brain barrier (BBB) permeability, as determined in PAMPA experiments.Formule :C22H33FN2O2Couleur et forme :SolidMasse moléculaire :376.51R-137696
CAS :R-137696 is an orally active 5-HT1A receptor agonist that facilitates the relaxation of the proximal stomach. It is utilized in research related to functional dyspepsia.Formule :C17H23N3O2Couleur et forme :SolidMasse moléculaire :301.38
