Bêta-amyloïde
Les inhibiteurs de bêta-amyloïde sont des composés qui ciblent spécifiquement et inhibent la formation ou l'agrégation des peptides bêta-amyloïdes, impliqués de manière critique dans la pathogenèse de la maladie d'Alzheimer. L'accumulation de plaques bêta-amyloïdes dans le cerveau est l'un des principaux signes pathologiques de la maladie d'Alzheimer, contribuant à la dysfonction neuronale, à la perte synaptique et au déclin cognitif. En empêchant l'agrégation des bêta-amyloïdes, ces inhibiteurs font l'objet de recherches intensives comme agents thérapeutiques potentiels visant à ralentir ou même arrêter la progression de la maladie d'Alzheimer. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de bêta-amyloïde de haute qualité pour soutenir vos recherches sur les troubles neurodégénératifs, l'agrégation des protéines et le développement de thérapies pour la maladie d'Alzheimer.
227 produits trouvés pour "Bêta-amyloïde"
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TRV-1387
CAS :TRV-1387, a benzofurazan derivative, inhibits the aggregation of tau and amyloid-β [1].Formule :C23H25F3N4O2Couleur et forme :SolidMasse moléculaire :446.47γ-Secretase-IN-1
CAS :γ-Secretase-IN-1 is a γ-secretase inhibitor that displays partial antiproliferative activity against T-47D cells.Formule :C27H24F2N4O3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :490.5Ref: TM-T3521
1mg127,00€5mg406,00€10mg652,00€25mg1.293,00€50mg1.738,00€100mg2.357,00€1mL*10mM (DMSO)439,00€MDR-1339
CAS :MDR-1339 is a blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.Formule :C20H22O4Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :326.39MAO-B-IN-45
CAS :MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. It selectively inhibits MAO-B with an IC50 of 87.47 nM, demonstrating a selectivity over MAO-A by more than 229 times. In vitro, MAO-B-IN-45 exhibits significant anti-ferroptosis activity by modulating iron metabolism pathways and the GSH-GPX4 axis. Additionally, it improves cognitive and behavioral deficits in 3×Tg (APP/Tau/Ps1) Alzheimer's disease mice and significantly reduces levels of ferritin heavy chain 1 (FTH1), β-amyloid protein (APP), and Tau protein phosphorylation (p-Tau) in their brains.Formule :C17H14ClNO3Couleur et forme :SolidMasse moléculaire :315.75cSPM
cSPM (Cyclic spermine) is an Aβ42 inhibitor. cSPM inhibits the aggregation of three different peptides, Aβ42, tryptophan and insulin, and reduces cytotoxicity.Formule :C27H57N7Couleur et forme :SolidMasse moléculaire :479.79Buntanetap L-Tartrate
CAS :Buntanetap (L-Tartrate) functions as an oral small molecule inhibitor targeting multiple neurotoxic proteins. It decreases the production of amyloid precursor protein (APP) by inhibiting the translation of its mRNA [1].Formule :C24H29N3O8Couleur et forme :SolidMasse moléculaire :487.50Thiazolo[5,4-c]pyridin-4(5H)-one
CAS :Thiazolo[5,4-c]pyridin-4(5H)-one is a compound used for diagnostic imaging of TDP-43, in PET imaging of neurodegenerative diseases ALS、AD、FTD、LATE.Formule :C22H22FN5O2SDegré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :439.51γ-secretase modulator 5
Compound 22d is a GSM that crosses the blood-brain barrier, inhibits Aβ42 production (IC50: 60 nM), and may help study Alzheimer's.Couleur et forme :SolidAntioxidant agent-8
Antioxidant agent-8, an oral Aβ 1-42 inhibitor, reduces fibril aggregation & promotes disaggregation; it's neuroprotective & BBB permeable.Formule :C13H12O5Couleur et forme :SolidMasse moléculaire :248.23Amyloid-β-IN-2
CAS :Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.Formule :C22H21F2N3O2Couleur et forme :SolidMasse moléculaire :397.42Aβ42 agonist-1
CAS :Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.Formule :C15H11NO2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :237.25Aβ aggregation-IN-1
CAS :Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.Formule :C9H8BF3O2Couleur et forme :SolidMasse moléculaire :215.965Glutaminyl Cyclase Inhibitor 3
CAS :Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.Formule :C24H32N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.61(9R)-RO7185876
CAS :(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.Formule :C25H28F3N7Couleur et forme :SolidMasse moléculaire :483.532QP5020
CAS :QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.Formule :C20H19FN6Masse moléculaire :362.40Anti-Aβ agent 1A
Anti-Aβ agent 1A is a potent anti-amyloid-β agent.Formule :C35H49NO4Couleur et forme :SolidMasse moléculaire :547.77IXA62
CAS :IXA62 is an orally active, selective IRE1/XBP1s agonist (EC50= 0.31 μM) that can reduce Aβ secretion.Formule :C24H23N3O3Couleur et forme :SolidMasse moléculaire :401.458Amilo-5MER
CAS :Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.Formule :C23H40N6O9SCouleur et forme :SolidMasse moléculaire :576.664MAO-B-IN-10
MAO-B-IN-10: Potent, selective MAO-B inhibitor; crosses blood-brain barrier; IC50 5.3 μM; reduces Aβ aggregation 58.2%, disaggregates 43.3%.Formule :C23H26N2O4Couleur et forme :SolidMasse moléculaire :394.46BF-168
CAS :BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).Formule :C18H17FN2O2Couleur et forme :SolidMasse moléculaire :312.342002-G12
CAS :2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.Formule :C20H16N6Couleur et forme :SolidMasse moléculaire :340.381γ-secretase modulator 6
CAS :Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.
Formule :C25H26N6O2Couleur et forme :SolidMasse moléculaire :442.513Aβ-IN-2
Aβ-IN-2 is a peptide inhibitor of Aβ1-42.Formule :C37H51NOCouleur et forme :SolidMasse moléculaire :525.81Amyloid-β-IN-3
CAS :Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.Formule :C22H21F2N3O2Couleur et forme :SolidMasse moléculaire :397.42BMS 299897
CAS :BMS 299897, a sulfonamide γ-secretase inhibitor, inhibits Aβ production with an IC50 of 7 nM in HEK293 cells overexpressing APP.
Formule :C24H21ClF3NO4SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :511.94Xanthocillin X permethyl ether
CAS :Xanthocillin X permethyl ether, a natural product extracted from fungal sources, exhibits Aβ-42 lowering activity.Formule :C20H16N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :316.35BF 227
CAS :BF 227 is a candidate for an amyloid imaging probe for PET [Ki: 4.3 nM for Aβ1-42 fibrils].Formule :C16H16FN3O2SCouleur et forme :SolidMasse moléculaire :333.38
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