Bêta-amyloïde
Les inhibiteurs de bêta-amyloïde sont des composés qui ciblent spécifiquement et inhibent la formation ou l'agrégation des peptides bêta-amyloïdes, impliqués de manière critique dans la pathogenèse de la maladie d'Alzheimer. L'accumulation de plaques bêta-amyloïdes dans le cerveau est l'un des principaux signes pathologiques de la maladie d'Alzheimer, contribuant à la dysfonction neuronale, à la perte synaptique et au déclin cognitif. En empêchant l'agrégation des bêta-amyloïdes, ces inhibiteurs font l'objet de recherches intensives comme agents thérapeutiques potentiels visant à ralentir ou même arrêter la progression de la maladie d'Alzheimer. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de bêta-amyloïde de haute qualité pour soutenir vos recherches sur les troubles neurodégénératifs, l'agrégation des protéines et le développement de thérapies pour la maladie d'Alzheimer.
205 produits trouvés pour "Bêta-amyloïde"
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BChE-IN-8
CAS :<p>BChE-IN-8, compound 20, is a potent oral BChE inhibitor effective on eqBChE and hBChE, crosses blood-brain barrier, and may help in Alzheimer's research.</p>Formule :C18H12BrN7O2Couleur et forme :SolidMasse moléculaire :438.24BACE1/2-IN-1
CAS :<p>BACE1/2-IN-1 inhibits BACE1/2 with IC50s of 0.01μM/0.0053μM, has better permeability and lower Pgp efflux but reduced metabolic stability.</p>Formule :C21H31N5OSCouleur et forme :SolidMasse moléculaire :401.57Antioxidant agent-2
CAS :<p>Antioxidant agent-2 (3c), BBB-permeable, selectively chelates metals; shows neuroprotection, fights liver damage in Alzheimer's research.</p>Formule :C23H26N2O7Couleur et forme :SolidMasse moléculaire :442.46SV5
CAS :<p>SV5: potent anti-Alzheimer's, protects SHSY-5Y from Aβ1-42 death, stable with optimal pharmacology in plasma, antioxidant, neuroprotective.</p>Formule :C21H30N2O4S2Couleur et forme :SolidMasse moléculaire :438.6γ-Secretase modulator 12
CAS :<p>γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM.</p>Formule :C25H23N3O2Couleur et forme :SolidMasse moléculaire :397.47AY1511
CAS :<p>AY1511 is a low cytotoxic inhibitor of amyloid β (Aβ) aggregation [1].</p>Formule :C17H14O6Couleur et forme :SolidMasse moléculaire :314.29TML-6
CAS :<p>TML-6, an oral derivative of curcumin, may help in Alzheimer's research by targeting amyloid production and various molecular pathways.</p>Formule :C30H37NO7Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :523.62BuChE-IN-2
CAS :<p>BuChE-IN-2 inhibits BuChE (IC50: 1.28 μM), NO (0.67 μM), Aβ, ROS, chelates Cu2+, penetrates BBB, used in Alzheimer's research.</p>Formule :C28H20F4N6O3Couleur et forme :SolidMasse moléculaire :564.49Glutaminyl Cyclase Inhibitor 5
<p>Glutaminyl Cyclase Inhibitor 5 is a potent, selective inhibitor of human glutaminyl cyclase (hQC), demonstrating an inhibition concentration half-max (IC 50) of</p>Formule :C22H30N6OCouleur et forme :SolidMasse moléculaire :394.51Aleplasinin
CAS :<p>Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic</p>Formule :C28H27NO3Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :425.52Buntanetap
CAS :<p>Buntanetap ((+)-Phenserine) is an inhibitor of TINAPs used in the study of neurological disorders, endocrine and metabolic disorders, and cardiovascular disease</p>Formule :C20H23N3O2Degré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :337.42Glutaminyl Cyclase Inhibitor 1
CAS :<p>Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor (IC50: 0.5 μM) that can be used to study neurological disorders.</p>Formule :C21H24FN3O2Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :369.43Aβ-IN-1
CAS :<p>Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM).</p>Formule :C35H49NDegré de pureté :99.1%Couleur et forme :SoildMasse moléculaire :483.77amyloid P-IN-1
CAS :<p>amyloid P-IN-1 can be used in studies about diseases with depletion of serum amyloid P components such as Alzheimer's disease, amyloidosis, osteoarthritis, and</p>Formule :C30H44N2O14Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :656.68Fenlean
CAS :<p>"Fenlean (FLZ) in phase I trial at Chinese Academy's Institute of Pharmacy for Parkinson's treatment."</p>Formule :C26H27NO6Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :449.5Ezeprogind disulfate
CAS :<p>Ezeprogind disulfate: neurotrophic inducer targeting neurodegeneration causes like Abeta, tau; for neurological disorder research.</p>Formule :C25H48N6O8S2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :624.81DSS30
CAS :<p>DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid secretion to help prevent Alzheimer's.</p>Formule :C16H14ClNO3S2Degré de pureté :99.19% - 99.4%Couleur et forme :SolidMasse moléculaire :367.87MAO-B-IN-9
CAS :<p>MAO-B-IN-9 is a monoamine oxidase B MAO-B inhibitor (IC50: 0.18 μM) that crosses the blood-brain barrier with potency, selectivity and time-dependence.</p>Formule :C18H24N2O2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :300.4BI-1408
CAS :<p>BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).</p>Formule :C22H23FN6Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :390.46MK-3328
CAS :<p>MK-3328, a potential Alzheimer's drug, binds β-Amyloid with strong affinity (IC50:10.5 nM) and may serve as a PET ligand to gauge plaque load.</p>Formule :C14H9FN4ODegré de pureté :99.70% - >99.99%Couleur et forme :SolidMasse moléculaire :268.25PPI-1019
CAS :<p>PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD).</p>Formule :C36H54N6O5Degré de pureté :95.16% - 98.16%Couleur et forme :SolidMasse moléculaire :650.85QM-FN-SO3
CAS :<p>QM-FN-SO3 is a blood-brain barrier (BBB)-penetrable, near-infrared (NIR) probe with aggregation-induced emission (AIE) activity, specifically designed for the detection of Aβ plaques. It exhibits ultra-high signal-to-noise (S/N) ratio, binding affinity, and high-performance NIR emission, making it suitable for in vivo detection of Aβ plaques [1].</p>Formule :C29H25N4NaO3S2Couleur et forme :SolidMasse moléculaire :564.65Anti-amyloid agent-1
CAS :<p>Anti-amyloid agent-1 is a potent compound that inhibits amyloid aggregation, offering a promising approach for research into the treatment of amyloidosis [1].</p>Formule :C21H17F3N2O3Couleur et forme :SolidMasse moléculaire :402.37PQM130
CAS :<p>PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity.</p>Formule :C23H27NO4Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :381.46ELND007
CAS :<p>ELND007 is a Gamma secretase inhibitor.</p>Formule :C19H14F4N4O2SCouleur et forme :SolidMasse moléculaire :438.4Aβ/tau aggregation-IN-3
CAS :<p>Aβ/tau aggregation-IN-3 is a potent inhibitor of amyloid protein aggregation, exhibiting an IC50 value of 0.85 µM in an Aβ-Thioflavin T (Aβ-ThT) functional</p>Formule :C23H22N4O3Couleur et forme :SolidMasse moléculaire :402.45TRV-1387
CAS :<p>TRV-1387, a benzofurazan derivative, inhibits the aggregation of tau and amyloid-β [1].</p>Formule :C23H25F3N4O2Couleur et forme :SolidMasse moléculaire :446.47BMS 433796
CAS :<p>BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.</p>Formule :C21H20F2N4O4Degré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :430.4RAGE/SERT-IN-1
CAS :<p>RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM and</p>Formule :C38H41ClN4OSCouleur et forme :SolidMasse moléculaire :637.28QR-0217
CAS :<p>QR-0217 is a potent inhibitor of both Aβ1-40 and α-synuclein aggregation, exhibiting an IC50 of 7.5 µM for Aβ1-40.</p>Formule :C19H13NO3Couleur et forme :SolidMasse moléculaire :303.31NNC 26-9100
CAS :<p>Somatostatin sst4 receptor agonist</p>Formule :C22H25BrCl2N6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.35γ-Secretase-IN-1
CAS :<p>γ-Secretase-IN-1 is a γ-secretase inhibitor that displays partial antiproliferative activity against T-47D cells.</p>Formule :C27H24F2N4O3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :490.5MDR-1339
CAS :<p>MDR-1339 is a blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.</p>Formule :C20H22O4Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :326.39Glutaminyl Cyclase Inhibitor 3
CAS :<p>Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.</p>Formule :C24H32N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.61Antioxidant agent-8
<p>Antioxidant agent-8, an oral Aβ 1-42 inhibitor, reduces fibril aggregation & promotes disaggregation; it's neuroprotective & BBB permeable.</p>Formule :C13H12O5Couleur et forme :SolidMasse moléculaire :248.23Amilo-5MER
CAS :<p>Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.</p>Formule :C23H40N6O9SCouleur et forme :SolidMasse moléculaire :576.664Amyloid-β-IN-2
CAS :<p>Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.</p>Formule :C22H21F2N3O2Couleur et forme :SolidMasse moléculaire :397.42Anti-Aβ agent 1A
<p>Anti-Aβ agent 1A is a potent anti-amyloid-β agent.</p>Formule :C35H49NO4Couleur et forme :SolidMasse moléculaire :547.77MAO-B-IN-10
<p>MAO-B-IN-10: Potent, selective MAO-B inhibitor; crosses blood-brain barrier; IC50 5.3 μM; reduces Aβ aggregation 58.2%, disaggregates 43.3%.</p>Formule :C23H26N2O4Couleur et forme :SolidMasse moléculaire :394.46Aβ42 agonist-1
CAS :<p>Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.</p>Formule :C15H11NO2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :237.25Aβ aggregation-IN-1
CAS :<p>Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.</p>Formule :C9H8BF3O2Couleur et forme :SolidMasse moléculaire :215.965Buntanetap L-Tartrate
CAS :<p>Buntanetap (L-Tartrate) functions as an oral small molecule inhibitor targeting multiple neurotoxic proteins. It decreases the production of amyloid precursor protein (APP) by inhibiting the translation of its mRNA [1].</p>Formule :C24H29N3O8Couleur et forme :SolidMasse moléculaire :487.50cSPM
<p>cSPM (Cyclic spermine) is an Aβ42 inhibitor. cSPM inhibits the aggregation of three different peptides, Aβ42, tryptophan and insulin, and reduces cytotoxicity.</p>Formule :C27H57N7Couleur et forme :SolidMasse moléculaire :479.79QP5020
CAS :<p>QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.</p>Formule :C20H19FN6Masse moléculaire :362.40BF-168
CAS :<p>BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).</p>Formule :C18H17FN2O2Couleur et forme :SolidMasse moléculaire :312.342002-G12
CAS :<p>2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.</p>Formule :C20H16N6Couleur et forme :SolidMasse moléculaire :340.381(9R)-RO7185876
CAS :<p>(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.</p>Formule :C25H28F3N7Couleur et forme :SolidMasse moléculaire :483.532IXA62
CAS :<p>IXA62 is an orally active, selective IRE1/XBP1s agonist (EC50= 0.31 μM) that can reduce Aβ secretion.</p>Formule :C24H23N3O3Couleur et forme :SolidMasse moléculaire :401.458Amyloid-β-IN-3
CAS :<p>Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.</p>Formule :C22H21F2N3O2Couleur et forme :SolidMasse moléculaire :397.42γ-secretase modulator 6
CAS :<p>Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.</p>Formule :C25H26N6O2Couleur et forme :SolidMasse moléculaire :442.513
