Bêta-amyloïde
Les inhibiteurs de bêta-amyloïde sont des composés qui ciblent spécifiquement et inhibent la formation ou l'agrégation des peptides bêta-amyloïdes, impliqués de manière critique dans la pathogenèse de la maladie d'Alzheimer. L'accumulation de plaques bêta-amyloïdes dans le cerveau est l'un des principaux signes pathologiques de la maladie d'Alzheimer, contribuant à la dysfonction neuronale, à la perte synaptique et au déclin cognitif. En empêchant l'agrégation des bêta-amyloïdes, ces inhibiteurs font l'objet de recherches intensives comme agents thérapeutiques potentiels visant à ralentir ou même arrêter la progression de la maladie d'Alzheimer. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de bêta-amyloïde de haute qualité pour soutenir vos recherches sur les troubles neurodégénératifs, l'agrégation des protéines et le développement de thérapies pour la maladie d'Alzheimer.
228 produits trouvés pour "Bêta-amyloïde"
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LC kinetic stabilizer-2
CAS :LC Kinetic Stabilizer-2 is a powerful stabilizer for amyloidogenic immunoglobulin light chains (LC), demonstrating significant efficacy with an EC50 of 24 nM.Formule :C28H31N3O3Couleur et forme :SolidMasse moléculaire :457.56THK-523
CAS :THK-523 selectively binds to tau in Alzheimer's, potent in vitro/vivo. 18F-THK523 excels in tau imaging.Formule :C17H15FN2OCouleur et forme :SolidMasse moléculaire :282.31Neuroinflammatory-IN-2
CAS :Neuroinflammatory-IN-2: anti-neuroinflammatory, inhibits MAO-B (IC50: 10.30µM), 96.33% Aβ1-42 aggregation reduction, neuroprotective in PC-12 cells.Formule :C25H27FN2O3Couleur et forme :SolidMasse moléculaire :422.49KMS88009
CAS :KMS88009 is an amyloid-β aggregation inhibitor that acts by ameliorating neurodegenerative disorder.Formule :C19H19NO2Couleur et forme :SolidMasse moléculaire :293.36ELND006
CAS :ELND006, an oral Alzheimer's drug, has improved bioavailability as a nanosuspension, and food doesn't affect it.Formule :C20H14F5N3O2SCouleur et forme :SolidMasse moléculaire :455.4TC-E 5006
CAS :γ-secretase modulatorFormule :C29H29F4NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :499.54OAB-14
CAS :OAB-14, a Bexarotene derivative, enhances β-amyloid clearance and cognitive function in APP/PS1 mice, improving Alzheimer's symptoms.Formule :C32H46N4O2Couleur et forme :SolidMasse moléculaire :518.73YIAD-0205
CAS :YIAD-0205, an orally administered inhibitor of Aβ(1-42) aggregation, has exhibited in vivo efficacy in a 5XFAD transgenic mouse model that harbors five familialFormule :C26H16Br2ClN3Couleur et forme :SolidMasse moléculaire :565.69BTA-1
CAS :BTA-1 is an uncharged derivative of thioflavin-T that has high affinity for Aβ fibrils and shows very good brain entry and clearance [1].Formule :C14H12N2SCouleur et forme :SolidMasse moléculaire :240.32K 01-162
CAS :K 01-162 binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM.Formule :C15H14BrNCouleur et forme :SolidMasse moléculaire :288.18Chrysamine G
CAS :Chrysamine G, Congo red analog, blocks Aβ toxicity, probes Alzheimer's amyloid.Formule :C26H16N4Na2O6Couleur et forme :SolidMasse moléculaire :526.416Glutaminyl Cyclase Inhibitor 2
CAS :Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor (IC50: 1.23 μM).Formule :C19H20FN3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :309.38BuChE-IN-2
CAS :BuChE-IN-2 inhibits BuChE (IC50: 1.28 μM), NO (0.67 μM), Aβ, ROS, chelates Cu2+, penetrates BBB, used in Alzheimer's research.Formule :C28H20F4N6O3Couleur et forme :SolidMasse moléculaire :564.49TML-6
CAS :TML-6, an oral derivative of curcumin, may help in Alzheimer's research by targeting amyloid production and various molecular pathways.Formule :C30H37NO7Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :523.62Ref: TM-T37148
1mg94,00€5mg222,00€1mL*10mM (DMSO)256,00€10mg356,00€25mg708,00€50mg1.063,00€100mg1.674,00€SV5
CAS :SV5: potent anti-Alzheimer's, protects SHSY-5Y from Aβ1-42 death, stable with optimal pharmacology in plasma, antioxidant, neuroprotective.Formule :C21H30N2O4S2Couleur et forme :SolidMasse moléculaire :438.6Antioxidant agent-2
CAS :Antioxidant agent-2 (3c), BBB-permeable, selectively chelates metals; shows neuroprotection, fights liver damage in Alzheimer's research.Formule :C23H26N2O7Couleur et forme :SolidMasse moléculaire :442.46BACE1/2-IN-1
CAS :BACE1/2-IN-1 inhibits BACE1/2 with IC50s of 0.01μM/0.0053μM, has better permeability and lower Pgp efflux but reduced metabolic stability.Formule :C21H31N5OSCouleur et forme :SolidMasse moléculaire :401.57JNJ-40418677
CAS :JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting the processing of Notch.Formule :C26H22F6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :480.44q-FTAA
CAS :q-FTAA targets Aβ1-42 fibrils (330-630 nM) and ADPBC (300-500 nM), useful in Alzheimer's disease research.Formule :C21H14O6S4Couleur et forme :SolidMasse moléculaire :490.59SEN-1269
CAS :SEN-1269 prevents amyloid-β aggregation, shields neurons, and improves memory by hindering Aβ(1-42)-induced issues.Formule :C18H18N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :322.36Glutaminyl Cyclase Inhibitor 5
Glutaminyl Cyclase Inhibitor 5 is a potent, selective inhibitor of human glutaminyl cyclase (hQC), demonstrating an inhibition concentration half-max (IC 50) ofFormule :C22H30N6OCouleur et forme :SolidMasse moléculaire :394.51AY1511
CAS :AY1511 is a low cytotoxic inhibitor of amyloid β (Aβ) aggregation [1].Formule :C17H14O6Couleur et forme :SolidMasse moléculaire :314.29γ-Secretase modulator 12
CAS :γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM.Formule :C25H23N3O2Couleur et forme :SolidMasse moléculaire :397.47CGP52411
CAS :CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM).Formule :C20H15N3O2Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :329.35Caprospinol
CAS :Caprospinol inhibits β-Amyloid (Aβ) protein neurotoxicity.Formule :C33H52O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :512.76RU-505
CAS :RU-505 is an interaction inhibitor of Aβ-fibrinogen that acts by rescuing altered thrombosis and cognitive decline in Alzheimer's disease mice.Formule :C28H32FN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.58AZ4800
CAS :AZD4800 is a gamma secretase modulators.Formule :C24H29N5O3Couleur et forme :SolidMasse moléculaire :435.52Astrophloxine
CAS :Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers.Astrophloxine can be used to detect aggregated Aβ in brain tissue andFormule :C27H33IN2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :512.47RS-0466
CAS :RS-0466 is an β-amyloid-induced cytotoxicity inhibitor.Formule :C17H17N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :323.35Aβ Fibrillization modulator 1
CAS :Aβ Fibrillization Modulator 1 stabilizes amyloid-beta (Aβ) monomers, preventing their aggregation into fibrils.Formule :C17H12N4O3SSeCouleur et forme :SolidMasse moléculaire :431.33BChE-IN-8
CAS :BChE-IN-8, compound 20, is a potent oral BChE inhibitor effective on eqBChE and hBChE, crosses blood-brain barrier, and may help in Alzheimer's research.Formule :C18H12BrN7O2Couleur et forme :SolidMasse moléculaire :438.24MK-3328
CAS :MK-3328, a potential Alzheimer's drug, binds β-Amyloid with strong affinity (IC50:10.5 nM) and may serve as a PET ligand to gauge plaque load.Formule :C14H9FN4ODegré de pureté :99.77% - >99.99%Couleur et forme :SolidMasse moléculaire :268.25Ref: TM-T16094
1mg315,00€5mg745,00€10mg1.018,00€25mg1.431,00€50mg1.783,00€100mg2.250,00€500mg4.410,00€Ezeprogind disulfate
CAS :Ezeprogind disulfate: neurotrophic inducer targeting neurodegeneration causes like Abeta, tau; for neurological disorder research.Formule :C25H48N6O8S2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :624.81Aβ-IN-1
CAS :Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM).Formule :C35H49NDegré de pureté :99.1%Couleur et forme :SoildMasse moléculaire :483.77Glutaminyl Cyclase Inhibitor 1
CAS :Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor (IC50: 0.5 μM) that can be used to study neurological disorders.Formule :C21H24FN3O2Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :369.43Aleplasinin
CAS :Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolyticFormule :C28H27NO3Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :425.52Ref: TM-T29856
1mg54,00€5mg114,00€1mL*10mM (DMSO)126,00€10mg178,00€25mg409,00€50mg620,00€100mg982,00€200mg1.314,00€PPI-1019
CAS :PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD).Formule :C36H54N6O5Degré de pureté :95.16% - 98.16%Couleur et forme :SolidMasse moléculaire :650.85BI-1408
CAS :BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).Formule :C22H23FN6Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :390.46amyloid P-IN-1
CAS :amyloid P-IN-1 can be used in studies about diseases with depletion of serum amyloid P components such as Alzheimer's disease, amyloidosis, osteoarthritis, andFormule :C30H44N2O14Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :656.68MAO-B-IN-9
CAS :MAO-B-IN-9 is a monoamine oxidase B MAO-B inhibitor (IC50: 0.18 μM) that crosses the blood-brain barrier with potency, selectivity and time-dependence.Formule :C18H24N2O2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :300.4Ref: TM-T60671
2mg39,00€5mg58,00€1mL*10mM (DMSO)66,00€10mg93,00€25mg167,00€50mg260,00€100mg378,00€200mg552,00€Fenlean
CAS :"Fenlean (FLZ) in phase I trial at Chinese Academy's Institute of Pharmacy for Parkinson's treatment."Formule :C26H27NO6Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :449.5Ref: TM-T31773
1mg73,00€2mg98,00€5mg165,00€10mg295,00€25mg532,00€50mg800,00€100mg954,00€200mg1.288,00€BMS 433796
CAS :BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.Formule :C21H20F2N4O4Degré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :430.4NNC 26-9100
CAS :Somatostatin sst4 receptor agonistFormule :C22H25BrCl2N6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.35Aβ/tau aggregation-IN-3
CAS :Aβ/tau aggregation-IN-3 is a potent inhibitor of amyloid protein aggregation, exhibiting an IC50 value of 0.85 µM in an Aβ-Thioflavin T (Aβ-ThT) functionalFormule :C23H22N4O3Couleur et forme :SolidMasse moléculaire :402.45QM-FN-SO3
CAS :QM-FN-SO3 is a blood-brain barrier (BBB)-penetrable, near-infrared (NIR) probe with aggregation-induced emission (AIE) activity, specifically designed for the detection of Aβ plaques. It exhibits ultra-high signal-to-noise (S/N) ratio, binding affinity, and high-performance NIR emission, making it suitable for in vivo detection of Aβ plaques [1].Formule :C29H25N4NaO3S2Couleur et forme :SolidMasse moléculaire :564.65RAGE/SERT-IN-1
CAS :RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM andFormule :C38H41ClN4OSCouleur et forme :SolidMasse moléculaire :637.28Anti-amyloid agent-1
CAS :Anti-amyloid agent-1 is a potent compound that inhibits amyloid aggregation, offering a promising approach for research into the treatment of amyloidosis [1].Formule :C21H17F3N2O3Couleur et forme :SolidMasse moléculaire :402.37QR-0217
CAS :QR-0217 is a potent inhibitor of both Aβ1-40 and α-synuclein aggregation, exhibiting an IC50 of 7.5 µM for Aβ1-40.Formule :C19H13NO3Couleur et forme :SolidMasse moléculaire :303.31ELND007
CAS :ELND007 is a Gamma secretase inhibitor.Formule :C19H14F4N4O2SCouleur et forme :SolidMasse moléculaire :438.4PQM130
CAS :PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity.Formule :C23H27NO4Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :381.46
