COX
Les inhibiteurs de la cyclooxygénase (COX) sont des composés qui bloquent l'activité des enzymes COX, impliquées dans la production de prostaglandines, des médiateurs clés de l'inflammation et de la douleur. En neurosciences, les inhibiteurs de la COX sont étudiés pour leur potentiel à réduire la neuroinflammation, qui est impliquée dans diverses maladies neurodégénératives telles que la maladie d'Alzheimer, la maladie de Parkinson et la sclérose en plaques. En inhibant la COX, ces composés peuvent aider à atténuer les processus inflammatoires dans le cerveau et à protéger contre les lésions neuronales. Chez CymitQuimica, nous fournissons une gamme d'inhibiteurs de la COX pour soutenir vos recherches sur la neuroinflammation, la gestion de la douleur et les maladies neurodégénératives.
561 produits trouvés pour "COX"
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COX-2-IN-34
CAS :<p>COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.</p>Formule :C13H11NO4Degré de pureté :98.08%Couleur et forme :SoildMasse moléculaire :245.23COX-1-IN-2
<p>COX-1-IN-2 (compound 5h) serves as a potent anti-inflammatory and analgesic agent. This compound demonstrates a significant inhibitory effect on COX-1, with an IC 50 value of 38.76 nM.</p>Formule :C29H22FN3OSCouleur et forme :SolidMasse moléculaire :479.572-(Phosphonooxy)benzoic acid
CAS :<p>2-(Phosphonooxy)benzoic acid (Fosfosal), used as the anti-inflammatory agent, has the anti-bacterial effect.</p>Formule :C7H7O6PDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :218.1Guaiacol-d3
CAS :<p>Guaiacol-d3 is a deuterated form of Guaiacol, which is a phenolic compound known for its ability to inhibit COX-2 expression and NF-κB activation in response to LPS stimulation, exhibiting anti-inflammatory properties.</p>Formule :C7H8O2Couleur et forme :SolidMasse moléculaire :127.16Vedaprofen
CAS :<p>Vedaprofen (PM 150) is a COX-1 inhibitor with anti-inflammatory effects, blocking E. coli clamp at IC50 222 μM, Ki 131 μM.</p>Formule :C19H22O2Degré de pureté :99.24% - 99.70%Couleur et forme :SolidMasse moléculaire :282.38COX-2/15-LOX-IN-2
<p>COX-2/15-LOX-IN-2 is a potent inhibitor of both COX-2 and 15-LOX, demonstrating IC50 values of 0.065 μM for COX-2 and 1.86 μM for 15-LOX.</p>Formule :C27H26N6OS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.66COX-2-IN-49
<p>COX-2-IN-49 (compound 6c) is a potent inhibitor of cyclooxygenase-2 (COX-2), displaying an IC50 value of 2.671 µM. This compound exhibits anti-proliferative properties and holds potential for use in cancer research.</p>Couleur et forme :Odour SolidEtofenamate
CAS :<p>Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.</p>Formule :C18H18F3NO4Degré de pureté :98% - 99.97%Couleur et forme :SolidMasse moléculaire :369.334-Methylamino antipyrine hydrochloride
CAS :<p>4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole.</p>Formule :C12H16ClN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :253.735-LOX/sEH-IN-1
<p>Compound 8o (5-LOX/sEH-IN-1) is a dual inhibitor with cardioprotective properties, targeting both 5-LOX and sEH with IC50 values of 3.05 μM and 2.20 nM respectively. It also inhibits the activity of COX-2 (IC50=10.50 μM). Possessing analgesic and anti-inflammatory properties, 5-LOX/sEH-IN-1 reduces ulcerogenicity, making it a potential candidate for developing anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects.</p>Couleur et forme :Odour SolidBMP-4
CAS :<p>BMP-4, a heparin-binding peptide, exhibits anti-inflammatory and anti-chondrogenic properties. In murine chondrocytes and macrophages, it effectively mitigates inflammation and alleviates symptoms of various arthritides by dose-dependently suppressing the expression of inflammatory proteins such as iNOS, COX2, IFN, and IL6 through modulation of the iNOS-IFN-IL6 signaling pathway.</p>Formule :C52H93N25O13SCouleur et forme :SolidMasse moléculaire :1308.52SARS-CoV-2 Mpro-IN-41
<p>SARS-CoV-2 Mpro-IN-41 (Compound 7e) is an orally active inhibitor targeting COX-2 and SARS-CoV-2 Mpro, with respective IC50 values of 9.66 μM and 13.24 μM. It also demonstrates inhibitory activity against COX-1 (IC50: 46.11 μM). This compound significantly suppresses the expression of inflammation-related cytokines such as TNF-α, IL-6, and IL-1β, exhibiting anti-inflammatory properties. By selectively inhibiting COX-2 and SARS-CoV-2 Mpro, SARS-CoV-2 Mpro-IN-41 exerts both anti-inflammatory and antiviral effects, making it a potential candidate for research in inflammation and COVID-19 treatment.</p>Formule :C27H23ClN4O3SCouleur et forme :SolidMasse moléculaire :518.11794COX-1/2-IN-5
<p>COX-1/2-IN-5 (compound 2a) functions as a dual inhibitor of COX1/2, demonstrating inhibitory concentrations (IC50) of 2.650 μM and 0.958 μM, respectively, and</p>Formule :C21H22N2O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.472-O-Sinapoyl makisterone A
<p>Compound 2, formally known as 2-O-Sinapoyl makisterone A, is a sinapinic acid-ecdysterone hybrid that acts as a selective inhibitor of COX-2, effectively</p>Formule :C39H56O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :700.86Lobuprofen
CAS :<p>Lobuprofen is a small molecule COX inhibitor that is used to treat neurological disorders.</p>Formule :C25H33ClN2O2Degré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :428.99Anti-inflammatory agent 50
<p>Anti-inflammatory agent 50 (compound a1), a derivative of Fusidic acid, exerts its effects through inhibition of inflammatory mediators including NO, IL-6, and</p>Formule :C40H55N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.88Hamaline
CAS :<p>Hamaline (9-(4-chlorobenzyl)-6-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole) is a substrate-selective cyclooxygenase-2 (COX-2) inhibitor.</p>Formule :C20H19ClN2ODegré de pureté :99.88%Couleur et forme :SoildMasse moléculaire :338.83COX-2-IN-52
<p>COX-2-IN-52 (Compound 5l) is an orally active and selective COX-2 inhibitor with an IC50 of 54 nM. It can suppress the release of NO in cells, exhibiting anti-inflammatory properties. COX-2-IN-52 offers high gastrointestinal safety and is suitable for research on oral anti-inflammatory drugs.</p>Formule :C16H13IN4O4S2Couleur et forme :SolidMasse moléculaire :516.333Axinelline A
CAS :<p>Axinelline A: COX inhibitor, IC50 of 2.22 μM (COX-2) & 8.89 μM (COX-1), anti-inflammatory.</p>Formule :C12H15NO6Couleur et forme :SolidMasse moléculaire :269.25Chloranthalactone B
CAS :<p>Chloranthalactone B, a sesquiterpenoid from Sarcandra glabra, inhibits inflammation via AP-1 & p38 MAPK.</p>Formule :C15H16O3Couleur et forme :SolidMasse moléculaire :244.29
