COX
Les inhibiteurs de la cyclooxygénase (COX) sont des composés qui bloquent l'activité des enzymes COX, impliquées dans la production de prostaglandines, des médiateurs clés de l'inflammation et de la douleur. En neurosciences, les inhibiteurs de la COX sont étudiés pour leur potentiel à réduire la neuroinflammation, qui est impliquée dans diverses maladies neurodégénératives telles que la maladie d'Alzheimer, la maladie de Parkinson et la sclérose en plaques. En inhibant la COX, ces composés peuvent aider à atténuer les processus inflammatoires dans le cerveau et à protéger contre les lésions neuronales. Chez CymitQuimica, nous fournissons une gamme d'inhibiteurs de la COX pour soutenir vos recherches sur la neuroinflammation, la gestion de la douleur et les maladies neurodégénératives.
562 produits trouvés pour "COX"
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Safrole oxide
CAS :<p>Safrole oxide inhibits neuronal growth, induces apoptosis, elevates COX-2, IL-8, ROS, promoting endothelial-to-neuron-like cell transdifferentiation.</p>Formule :C10H10O3Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :178.18(-)-Ibuprofenamide
CAS :<p>(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.</p>Formule :C13H19NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :205.3Piroxicam cinnamate
CAS :<p>Cinnoxicam is a COX inhibitor used for bone/joint inflammation, rheumatic issues, and varicocele-related oligospermia.</p>Formule :C24H19N3O5SCouleur et forme :SolidMasse moléculaire :461.49GW-406381
CAS :<p>GW-406381 is a highly selective COX-2 inhibitor peripherally and centrally, reducing spontaneous ectopic discharges following chronic compressive injury.</p>Formule :C21H19N3O3SDegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :393.46COX-2/5-LOX-IN-2
CAS :<p>COX-2/5-LOX-IN-2, a benzothiophen derivative, inhibits COX-1, COX-2, 5-LOX with IC50s of 5.40, 0.01, 1.78 μM. More effective than Celecoxib, Indomethacin.</p>Formule :C18H13N3O4S2Couleur et forme :SolidMasse moléculaire :399.44COX-2-IN-19
CAS :<p>COX-2-IN-19, a potent COX-2 inhibitor, IC50 of 1.76 μM, has strong anti-inflammatory effects in vivo.</p>Formule :C18H18N4O2SCouleur et forme :SolidMasse moléculaire :354.43Timegadine
CAS :<p>Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM</p>Formule :C20H23N5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.5ADU-S100
CAS :<p>ADU-S100 (MIW815) is a STING agonist that significantly induces the production of IFN-β,TNF-α,IL-6,and MCP-1,induces TBK1 and IRF3 phosphorylation,antitumour.</p>Formule :C20H24N10O10P2S2Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :690.54COX-2/5-LOX-IN-1
CAS :<p>COX-2/5-LOX-IN-1, a benzothiophen-2-yl pyrazole, inhibits COX-2 & 5-LOX with IC50: COX-1 (12.13μM), COX-2 (0.4μM), 5-LOX (4.96μM). Better than Celecoxib.</p>Formule :C14H10ClN3O4S2Couleur et forme :SolidMasse moléculaire :383.83Heterophdoid A
CAS :<p>Heterophdoid A is an anti-inflammatory agent that inhibits NO production in BV-2 cells (IC50: 5.93 μM).</p>Formule :C26H42O10Couleur et forme :SolidMasse moléculaire :514.61Naproxcinod
CAS :<p>Naproxcinod is a derivative of naproxen, analgesic and anti-inflammatory, a COX-inhibitory nitric oxide donor (CINOD), osteoarthritis and inflammatory.</p>Formule :C18H21NO6Couleur et forme :SolidMasse moléculaire :347.36Nitroflurbiprofen
CAS :<p>Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive</p>Formule :C19H20FNO5Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :361.36COX-2-IN-28
CAS :<p>COX-2-IN-28 is a potent and selective COX-2 inhibitor capable of acting on COX-2 (IC50: 0.054 μM), 15-LOX (IC50: 2.14 μM) and COX-1 (IC50: 13.21 μM).</p>Formule :C30H27N7S3Couleur et forme :SolidMasse moléculaire :581.78COX-2-IN-11
CAS :<p>COX-2-IN-11 (compound 7b2) is a potent and selective COX-2 inhibitor. COX-2-IN-11 has the potential in inflammation disease research[1].</p>Formule :C12H12OS3Couleur et forme :SolidMasse moléculaire :268.42Naproxen etemesil
CAS :<p>Naproxen, a COX-1/2 inhibitor, has IC50s of 8.72/5.15 μM. Its prodrug, naproxen etemesil, is lipophilic and converts to active form upon absorption.</p>Formule :C17H20O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.4Apyramide
CAS :<p>Apyramide, an NSAID and prodrug of indomethacin, inhibits COX1/COX2 and permeates the blood-brain barrier.</p>Formule :C27H23ClN2O5Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :490.93ABT-963
CAS :<p>ABT-963: COX-2 inhibitor for osteoarthritis/pain with high selectivity, potency, and gastric safety.</p>Formule :C22H22F2N2O5SDegré de pureté :98% - 99.85%Couleur et forme :SolidMasse moléculaire :464.48ER-34122
CAS :<p>ER-34122, a novel orally available dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity.</p>Formule :C27H26ClN3O5Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :507.96Eltenac
CAS :<p>Eltenac, a cyclooxygenase (COX) inhibitor, is used potentially for the treatment of pain.</p>Formule :C12H9Cl2NO2SDegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :302.18Sudoxicam
CAS :<p>Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) is a reversible antagonist of COX with anti-inflammatory, anti-edema</p>Formule :C13H11N3O4S2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :337.37LM-1685
CAS :<p>LM-1685是一种有效且具有选择性的人单核细胞和全血中COX-2抑制剂，IC50分别为0.65 µM 和IC50 = 4.3 μM，是治疗炎症的潜在化合物。</p>Formule :C18H16ClNO4SDegré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :377.84SC-75416
CAS :<p>SC-75416, a cyclooxygenase-2 (COX-2) inhibitor, is used potentially for the treatment of postoperative inflammation.</p>Formule :C15H14ClF3O3Degré de pureté :98.67% - 98.67%Couleur et forme :SolidMasse moléculaire :334.72BN-82451 2HCl
CAS :<p>BN-82451, a cyclooxygenase inhibitor, is used potentially for the treatment of Huntington’s disease.</p>Formule :C18H28Cl2N2OSDegré de pureté :99.84% - >99.99%Couleur et forme :SolidMasse moléculaire :391.4Indazole-Cl
CAS :<p>Indazole-Cl is a selective ERß agonist and a selective estrogen receptor modifier (SERM).</p>Formule :C13H9ClN2O2Degré de pureté :99.02% - 99.86%Couleur et forme :SolidMasse moléculaire :260.68Biofor 389
CAS :<p>Biofor 389 (BF389) has anti-inflammatory activity and can be used to study arthritis.</p>Formule :C20H29NO3Degré de pureté :98.84% - 99.97%Couleur et forme :SolidMasse moléculaire :331.45L 651896
CAS :<p>L 651896 is an inhibitor of 5-lipoxygenase.</p>Formule :C18H18O3Degré de pureté :96.06% - 99.85%Couleur et forme :SolidMasse moléculaire :282.33Prostaglandin E2 Ethanolamide
CAS :<p>Prostaglandin E2 Ethanolamide (PGE 2 -EA), an analog of PGE2, is enzymatically synthesized through COX-2 oxygenation of endocannabinoids. It has the potential to modulate the production of the proinflammatory cytokine TNF-α in human blood and monocytic cells [1] [2].</p>Formule :C22H37NO5Couleur et forme :SolidMasse moléculaire :395.54Benoxaprofen
CAS :<p>Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.</p>Formule :C16H12ClNO3Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :301.72BW 755C
CAS :<p>BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.</p>Formule :C10H10F3N3Degré de pureté :96.52%Couleur et forme :SolidMasse moléculaire :229.2Antioxidant agent-15
CAS :<p>Antioxidant agent-15 (Compound 4) demonstrates potent antioxidant inhibition activity, exhibiting an IC50 value of 15.44 nM.</p>Formule :C19H14O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :274.31Thioflosulide
CAS :<p>Thioflosulide (L-745337) is a selective and potent COX2 inhibitor (IC50: 2.3 nM) with anti-inflammatory activity for the study of gastric ulcers.</p>Formule :C16H13F2NO3S2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :369.41Thromboxane B3
CAS :<p>Thromboxane B3 (TXB3), the stable hydrolysis product of TXA3, is synthesized from eicosapentaenoic acid (EPA) through the action of COX and thromboxane synthase enzymes. This compound is biosynthesized in several tissues, including seminal vesicles, lungs, polymorphonuclear leukocytes (PMNL), and ocular tissues.</p>Formule :C20H32O6Couleur et forme :SolidMasse moléculaire :368.5Amtolmetin guacil
CAS :<p>Amtolmetin guacil (ST-679) 抑制前列腺素合成和环氧合酶。 Amtolmetin guacil 具有与托美汀类似的 NSAID 特性，具有额外的镇痛、解热和胃保护特性。</p>Formule :C24H24N2O5Degré de pureté :99.85%Couleur et forme :White Needle-Shaped CrystalMasse moléculaire :420.46(-)-Bornyl ferulate
CAS :<p>(-)-Bornyl ferulate is a dual inhibitor of 5-lipoxygenase and cyclooxygenase (COX), exhibiting half-maximal inhibitory concentrations (IC50s) of 10.4 μM for 5-</p>Formule :C20H26O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :330.42Cimicoxib
CAS :<p>Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity.</p>Formule :C16H13ClFN3O3SDegré de pureté :98.22%Couleur et forme :SolidMasse moléculaire :381.81COX-2-IN-10
<p>COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.</p>Formule :C31H32FN5O2SCouleur et forme :SolidMasse moléculaire :557.68COX-2-IN-12
<p>COX-2-IN-12: Potent, selective COX-2 inhibitor, IC50=19.98μM, safe anti-inflammatory with low acute toxicity.</p>Formule :C17H19NO3Couleur et forme :SolidMasse moléculaire :285.34COX-2-IN-13
<p>COX-2-IN-13 is a potent, selective COX-2 inhibitor with 0.98 μM IC50; shows strong anti-inflammatory properties and low acute toxicity.</p>Formule :C19H18N2O5SCouleur et forme :SolidMasse moléculaire :386.42COX-2-IN-8
<p>COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib.</p>Formule :C19H19N3O4S2Couleur et forme :SolidMasse moléculaire :417.5Anti-inflammatory agent 9
<p>Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.</p>Formule :C18H15N5O2SCouleur et forme :SolidMasse moléculaire :365.41Soquelitinib
CAS :<p>Soquelitinib (CPI-818) is a selective ITK inhibitor， inhibits tumor growth,T-cell, up-regulatCXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells.</p>Formule :C25H30N4O4S2Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :514.66NLRP3-IN-69
CAS :<p>NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.</p>Formule :C25H24O7Couleur et forme :SolidMasse moléculaire :436.454Anti-inflammatory agent 10
<p>Tilomisole-derived benzimidazole-thiazole, orally active, favors COX-2 inhibition over COX-1.</p>Formule :C17H13BrN4O3S2Couleur et forme :SolidMasse moléculaire :465.34STAT1/3-IN-1
CAS :<p>STAT1/3-IN-1 (Compound 6k) is an inhibitor of STAT1/3 phosphorylation. It prevents the phosphorylation and nuclear translocation of STAT1/3. Additionally, STAT1/3-IN-1 inhibits the inflammatory enzymes iNOS and COX-2. This compound exhibits anti-inflammatory properties by reducing pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, without significant cytotoxicity.</p>Formule :C28H25ClN6O5Couleur et forme :SolidMasse moléculaire :560.988XO/COX/LOX-IN-1
<p>XO/COX/LOX-IN-1 targets XO/COX/LOX, used in research of inflammation, cancer, and metabolic disorders.</p>Formule :C24H20N4O2SCouleur et forme :SolidMasse moléculaire :428.51COX-2-IN-6
CAS :<p>COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.</p>Formule :C20H27NO6SDegré de pureté :99.29% - 99.69%Couleur et forme :SoildMasse moléculaire :409.5COX-1/2-IN-2
<p>COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.</p>Formule :C15H10ClIN2OCouleur et forme :SolidMasse moléculaire :396.61COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Formule :C22H23FN2O6S2Couleur et forme :SolidMasse moléculaire :494.56(R)-Ketoprofen
CAS :<p>(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.</p>Formule :C16H14O3Couleur et forme :SolidMasse moléculaire :254.28Ambuic acid
CAS :<p>Ambuic acid: cyclohexanone with antifungal, quorum-inhibiting, antibacterial properties, blocks cyclic peptides; reduces MRSA abscesses in mice.</p>Formule :C19H26O6Couleur et forme :SolidMasse moléculaire :350.41
