COX
Les inhibiteurs de la cyclooxygénase (COX) sont des composés qui bloquent l'activité des enzymes COX, impliquées dans la production de prostaglandines, des médiateurs clés de l'inflammation et de la douleur. En neurosciences, les inhibiteurs de la COX sont étudiés pour leur potentiel à réduire la neuroinflammation, qui est impliquée dans diverses maladies neurodégénératives telles que la maladie d'Alzheimer, la maladie de Parkinson et la sclérose en plaques. En inhibant la COX, ces composés peuvent aider à atténuer les processus inflammatoires dans le cerveau et à protéger contre les lésions neuronales. Chez CymitQuimica, nous fournissons une gamme d'inhibiteurs de la COX pour soutenir vos recherches sur la neuroinflammation, la gestion de la douleur et les maladies neurodégénératives.
562 produits trouvés pour "COX"
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Suprofen
CAS :Formule :C14H12O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :260.3083Indobufen
CAS :<p>Indobufen (Ibustrin) is an inhibitor of platelet aggregation and is a reversible platelet cyclooxygenase (Cox) activity inhibitor.</p>Formule :C18H17NO3Degré de pureté :99.27% - 99.44%Couleur et forme :SolidMasse moléculaire :295.33Imatinib mesylate
CAS :Formule :C30H35N7O4SDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :589.7084Salicylic acid
CAS :<p>Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.</p>Formule :C7H6O3Degré de pureté :98.04% - 98.83%Couleur et forme :White Solid PowderMasse moléculaire :138.12Lornoxicam
CAS :<p>Lornoxicam (Chlortenoxicam) (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory, and</p>Formule :C13H10ClN3O4S2Degré de pureté :98.74% - 99.28%Couleur et forme :Crystalline SolidMasse moléculaire :371.82(R)-Naproxen
CAS :<p>(R)-Naproxen: anti-inflammatory with antipyretic and analgesic effects; treats gout, dysmenorrhea, rheumatoid arthritis.</p>Formule :C14H14O3Degré de pureté :99.62% - 99.94%Couleur et forme :SolidMasse moléculaire :230.26Nepafenac
CAS :<p>Nepafenac (AHR 9434) is an NSAID that acts as a cyclooxygenase inhibitor.</p>Formule :C15H14N2O2Degré de pureté :98.94% - 99.43%Couleur et forme :SolidMasse moléculaire :254.28Fenbufen
CAS :<p>Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis.</p>Formule :C16H14O3Degré de pureté :98.35% - 98.46%Couleur et forme :White SolidMasse moléculaire :254.28(Iso)-Samixogrel
CAS :<p>(Iso)-Samixogrel shows activity against Carbonic anhydrase and Cyclooxygenase 2.</p>Formule :C25H25ClN2O4SDegré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :484.99Timegadine hydrochloride
CAS :<p>Timegadine hydrochloride (SR1368 hydrochloride) is the hydrochloride salt form of Timegadine. It is an orally active inhibitor of COX and lipo-oxygenase, effectively suppressing COX in rabbit platelets and rat brain with IC50 values of 5 nM and 20 μM, respectively, and inhibiting lipo-oxygenase in horse and rabbit platelets with an IC50 of 100 μM. Timegadine hydrochloride also exhibits anti-arthritis activity.</p>Formule :C20H24ClN5SCouleur et forme :SolidMasse moléculaire :401.9615-LOX-IN-2
<p>15-LOX-IN-2 (Compound 2a) is an orally active inhibitor of COX-2/15-LOX and a partial agonist of PPARγ. It exhibits anti-inflammatory activity by inhibiting levels of 20-HETE, IL-1β, and TNF-α in LPS-treated RAW 264.7 cells. Additionally, it significantly enhances glucose uptake without the presence of insulin and is applicable in metabolic disease research.</p>Couleur et forme :Odour SolidAntiviral agent 61
<p>Antiviralagent 61 (compound Z40) serves as an effective antiviral agent with activity against Tomato Spotted Wilt Virus (TSWV), exhibiting an EC50 value of 252 µg/mL. It increases the RNA expression of Ndufb9, COX6B, 7.1.2.2, E, COX5B, Ndufs4, and SDHB, while reducing the expression of Ndufb7, Ndufa5, and G.</p>Formule :C22H23N5O4SCouleur et forme :SolidMasse moléculaire :453.51Feladilimab
CAS :<p>Feladilimab (GSK3359609) is an IgG4 monoclonal antibody that is an ICOS agonist.</p>Degré de pureté :SDS-PAGE:95% SEC-HPLC:98%Couleur et forme :LiquidMasse moléculaire :145.24 kDa4-ACETAMIDOANTIPYRINE
CAS :<p>4-ACETAMIDOANTIPYRINE, with CAS No. 83-15-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-ACETAMIDOANTIPYRINE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formule :C13H15N3O2Couleur et forme :SolidMasse moléculaire :245.28Lonazolac Calcium
CAS :<p>Lonazolac Calcium, a nonsteroidal anti-inflammatory drug (NSAID), is used to treat inflammation and pain.</p>Formule :C34H24CaCl2N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :663.56Amfenac sodium
CAS :<p>Amfenac is a nonsteroidal anti-inflammatory drug. Amfenac also has acetic acid moiety.</p>Formule :C15H12NNaO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :277.26COX-2/NLRP3-IN-1
<p>COX-2/NLRP3-IN-1 (Compound 6k) is an inhibitor that targets COX-2 and NLRP3, exhibiting an IC50 value of 1.53 μM for COX-2. This compound exerts anti-inflammatory effects by inhibiting the NF-κB/NLRP3 signaling pathway.</p>Formule :C24H19Cl2N5OSMasse moléculaire :495.06874Tebufelone
CAS :<p>Tebufelone is a potent NSAID, inhibits CO, has anti-inflammatory and analgesic properties, and blocks lipoxygenase products (IC50 ~20-22 microM).</p>Formule :C20H28O2Degré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :300.44M-5011
CAS :<p>M-5011: NSAID and immunomodulator for pain and inflammation; ED50 0.63mg/kg; reduces bone loss in arthritis; low ulcer risk.</p>Formule :C14H14O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :246.32Anti-inflammatory agent 78
<p>Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. It effectively inhibits PGE2, PGE1, COX-2, and COX-1. Additionally, Anti-inflammatory agent 78 suppresses the release of NO in LPS-stimulated RAW 264.7 cell lines.</p>Formule :C19H14ClNO4Masse moléculaire :355.06114Flunixin
CAS :<p>Flunixin is a nonsteroidal anti-inflammatory drug (NSAID), antipyretic, and analgesic used in pigs, horses, and cattle.</p>Formule :C14H11F3N2O2Couleur et forme :SolidMasse moléculaire :296.24Pemedolac
CAS :<p>Pemedolac (Dexpemedolac) is a small molecule COX inhibitor used to treat neurological disorders, skin and musculoskeletal disorders.</p>Formule :C22H23NO3Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :349.42Etofenamate
CAS :<p>Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.</p>Formule :C18H18F3NO4Degré de pureté :98% - 99.97%Couleur et forme :SolidMasse moléculaire :369.33Ketoprofen lysine salt
CAS :<p>Ketoprofen lysine salt is a lysine salt of ketoprofen, a Non-Steroidal Anti-Inflammatory Drug</p>Formule :C22H28N2O5Couleur et forme :SolidMasse moléculaire :400.48Fentiazac
CAS :<p>Fentiazac (BR-700) is an oral NSAID for pain, inflammation, fever, studied for arthritis and tendonitis.</p>Formule :C17H12ClNO2SDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :329.8COX-2-IN-35
<p>COX-2-IN-35 (compound 7) is a selective inhibitor of COX-2, demonstrating anti-inflammatory activity, with an inhibitory concentration (IC 50) of 4.37 nM [1].</p>Formule :C22H19NO2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :393.52COX-2/15-LOX-IN-3
<p>COX-2/15-LOX-IN-3 (compound 5k) serves as a dual inhibitor for COX-2 and 15-LOX, demonstrating inhibitory concentrations (IC50) of 0.075 μM and 1.97 μM,</p>Formule :C25H24FN3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :465.54MCI
<p>MCI, a chemical compound demonstrating significant anti-inflammatory effects, particularly in collagen-induced arthritis (CIA) models, modulates inflammation</p>Formule :C45H52ClN7O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :934.391-Hydroxy-ibuprofen
CAS :<p>1-Hydroxy Ibuprofen, a metabolite in P. australis, targets COX-1/COX-2 with IC50s: 13 μM/370 μM.</p>Formule :C13H18O3Couleur et forme :SolidMasse moléculaire :222.28025-LOX/sEH-IN-1
<p>Compound 8o (5-LOX/sEH-IN-1) is a dual inhibitor with cardioprotective properties, targeting both 5-LOX and sEH with IC50 values of 3.05 μM and 2.20 nM respectively. It also inhibits the activity of COX-2 (IC50=10.50 μM). Possessing analgesic and anti-inflammatory properties, 5-LOX/sEH-IN-1 reduces ulcerogenicity, making it a potential candidate for developing anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects.</p>Couleur et forme :Odour SolidAkt/NF-κB/MAPK-IN-1
<p>Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity.</p>Formule :C38H56N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :604.86Guaiacol-d3
CAS :<p>Guaiacol-d3 is a deuterated form of Guaiacol, which is a phenolic compound known for its ability to inhibit COX-2 expression and NF-κB activation in response to LPS stimulation, exhibiting anti-inflammatory properties.</p>Formule :C7H8O2Couleur et forme :SolidMasse moléculaire :127.16Vedaprofen
CAS :<p>Vedaprofen (PM 150) is a COX-1 inhibitor with anti-inflammatory effects, blocking E. coli clamp at IC50 222 μM, Ki 131 μM.</p>Formule :C19H22O2Degré de pureté :99.24% - 99.70%Couleur et forme :SolidMasse moléculaire :282.38COX-2-IN-46
<p>COX-2-IN-46 (compound 5m) serves as a potent anti-inflammatory and analgesic agent. It demonstrates a significant inhibitory action on COX-2, with an IC 50 value of 87.74 nM.</p>Formule :C28H19F2N3SCouleur et forme :SolidMasse moléculaire :467.53COX-2-IN-34
CAS :<p>COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.</p>Formule :C13H11NO4Degré de pureté :98.08%Couleur et forme :SoildMasse moléculaire :245.23COX-1-IN-2
<p>COX-1-IN-2 (compound 5h) serves as a potent anti-inflammatory and analgesic agent. This compound demonstrates a significant inhibitory effect on COX-1, with an IC 50 value of 38.76 nM.</p>Formule :C29H22FN3OSCouleur et forme :SolidMasse moléculaire :479.572-(Phosphonooxy)benzoic acid
CAS :<p>2-(Phosphonooxy)benzoic acid (Fosfosal), used as the anti-inflammatory agent, has the anti-bacterial effect.</p>Formule :C7H7O6PDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :218.1SARS-CoV-2 Mpro-IN-41
<p>SARS-CoV-2 Mpro-IN-41 (Compound 7e) is an orally active inhibitor targeting COX-2 and SARS-CoV-2 Mpro, with respective IC50 values of 9.66 μM and 13.24 μM. It also demonstrates inhibitory activity against COX-1 (IC50: 46.11 μM). This compound significantly suppresses the expression of inflammation-related cytokines such as TNF-α, IL-6, and IL-1β, exhibiting anti-inflammatory properties. By selectively inhibiting COX-2 and SARS-CoV-2 Mpro, SARS-CoV-2 Mpro-IN-41 exerts both anti-inflammatory and antiviral effects, making it a potential candidate for research in inflammation and COVID-19 treatment.</p>Formule :C27H23ClN4O3SCouleur et forme :SolidMasse moléculaire :518.11794COX-1/2-IN-9
<p>COX-1/2-IN-9 (Compound 3n) serves as a selective and potent inhibitor of both COX-1 and COX-2, demonstrating IC 50 values of 0.031 µM for COX-1 and 0.01 µM for COX-2. This compound exhibits antibacterial and anti-inflammatory properties, effectively targeting MRSA 1478 (MIC=50 μg/mL) and multidrug-resistant S. lentus (MIC=50 μg/mL). Furthermore, COX-1/2-IN-9 shows promise in relieving MRSA-induced pneumonia in conditions of compromised immunity.</p>Formule :C30H20IN9O13S2Couleur et forme :SolidMasse moléculaire :905.57COX-2/15-LOX-IN-2
<p>COX-2/15-LOX-IN-2 is a potent inhibitor of both COX-2 and 15-LOX, demonstrating IC50 values of 0.065 μM for COX-2 and 1.86 μM for 15-LOX.</p>Formule :C27H26N6OS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.66COX-2-IN-49
<p>COX-2-IN-49 (compound 6c) is a potent inhibitor of cyclooxygenase-2 (COX-2), displaying an IC50 value of 2.671 µM. This compound exhibits anti-proliferative properties and holds potential for use in cancer research.</p>Couleur et forme :Odour SolidBMP-4
CAS :<p>BMP-4, a heparin-binding peptide, exhibits anti-inflammatory and anti-chondrogenic properties. In murine chondrocytes and macrophages, it effectively mitigates inflammation and alleviates symptoms of various arthritides by dose-dependently suppressing the expression of inflammatory proteins such as iNOS, COX2, IFN, and IL6 through modulation of the iNOS-IFN-IL6 signaling pathway.</p>Formule :C52H93N25O13SCouleur et forme :SolidMasse moléculaire :1308.52NF157
CAS :<p>NF157, a selective P2Y11 antagonist with pKi 7.35, lowers MMP-3/MMP-13, aiding OA treatment; IC50s: P2Y11 463 nM, P2Y1 1811 μM, P2Y2 170 μM.</p>Formule :C49H28F2N6Na6O23S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1437.14-Methylamino antipyrine hydrochloride
CAS :<p>4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole.</p>Formule :C12H16ClN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :253.73Multinoside A
CAS :<p>Multinoside A is a useful organic compound for research related to life sciences. The catalog number is T124593 and the CAS number is 59262-54-3.</p>Formule :C27H30O16Couleur et forme :SolidMasse moléculaire :610.521Lobuprofen
CAS :<p>Lobuprofen is a small molecule COX inhibitor that is used to treat neurological disorders.</p>Formule :C25H33ClN2O2Degré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :428.99Anti-inflammatory agent 50
<p>Anti-inflammatory agent 50 (compound a1), a derivative of Fusidic acid, exerts its effects through inhibition of inflammatory mediators including NO, IL-6, and</p>Formule :C40H55N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.88Hamaline
CAS :<p>Hamaline (9-(4-chlorobenzyl)-6-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole) is a substrate-selective cyclooxygenase-2 (COX-2) inhibitor.</p>Formule :C20H19ClN2ODegré de pureté :99.88%Couleur et forme :SoildMasse moléculaire :338.83COX-1/2-IN-5
<p>COX-1/2-IN-5 (compound 2a) functions as a dual inhibitor of COX1/2, demonstrating inhibitory concentrations (IC50) of 2.650 μM and 0.958 μM, respectively, and</p>Formule :C21H22N2O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.47COX-2-IN-52
<p>COX-2-IN-52 (Compound 5l) is an orally active and selective COX-2 inhibitor with an IC50 of 54 nM. It can suppress the release of NO in cells, exhibiting anti-inflammatory properties. COX-2-IN-52 offers high gastrointestinal safety and is suitable for research on oral anti-inflammatory drugs.</p>Formule :C16H13IN4O4S2Couleur et forme :SolidMasse moléculaire :516.333
