COX
Les inhibiteurs de la cyclooxygénase (COX) sont des composés qui bloquent l'activité des enzymes COX, impliquées dans la production de prostaglandines, des médiateurs clés de l'inflammation et de la douleur. En neurosciences, les inhibiteurs de la COX sont étudiés pour leur potentiel à réduire la neuroinflammation, qui est impliquée dans diverses maladies neurodégénératives telles que la maladie d'Alzheimer, la maladie de Parkinson et la sclérose en plaques. En inhibant la COX, ces composés peuvent aider à atténuer les processus inflammatoires dans le cerveau et à protéger contre les lésions neuronales. Chez CymitQuimica, nous fournissons une gamme d'inhibiteurs de la COX pour soutenir vos recherches sur la neuroinflammation, la gestion de la douleur et les maladies neurodégénératives.
561 produits trouvés pour "COX"
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1-Hydroxy-ibuprofen
CAS :<p>1-Hydroxy Ibuprofen, a metabolite in P. australis, targets COX-1/COX-2 with IC50s: 13 μM/370 μM.</p>Formule :C13H18O3Couleur et forme :SolidMasse moléculaire :222.2802COX-2/15-LOX-IN-3
<p>COX-2/15-LOX-IN-3 (compound 5k) serves as a dual inhibitor for COX-2 and 15-LOX, demonstrating inhibitory concentrations (IC50) of 0.075 μM and 1.97 μM,</p>Formule :C25H24FN3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :465.54MCI
<p>MCI, a chemical compound demonstrating significant anti-inflammatory effects, particularly in collagen-induced arthritis (CIA) models, modulates inflammation</p>Formule :C45H52ClN7O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :934.395-LOX/sEH-IN-1
<p>Compound 8o (5-LOX/sEH-IN-1) is a dual inhibitor with cardioprotective properties, targeting both 5-LOX and sEH with IC50 values of 3.05 μM and 2.20 nM respectively. It also inhibits the activity of COX-2 (IC50=10.50 μM). Possessing analgesic and anti-inflammatory properties, 5-LOX/sEH-IN-1 reduces ulcerogenicity, making it a potential candidate for developing anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects.</p>Couleur et forme :Odour SolidAkt/NF-κB/MAPK-IN-1
<p>Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity.</p>Formule :C38H56N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :604.86M-5011
CAS :<p>M-5011: NSAID and immunomodulator for pain and inflammation; ED50 0.63mg/kg; reduces bone loss in arthritis; low ulcer risk.</p>Formule :C14H14O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :246.32SARS-CoV-2 Mpro-IN-41
<p>SARS-CoV-2 Mpro-IN-41 (Compound 7e) is an orally active inhibitor targeting COX-2 and SARS-CoV-2 Mpro, with respective IC50 values of 9.66 μM and 13.24 μM. It also demonstrates inhibitory activity against COX-1 (IC50: 46.11 μM). This compound significantly suppresses the expression of inflammation-related cytokines such as TNF-α, IL-6, and IL-1β, exhibiting anti-inflammatory properties. By selectively inhibiting COX-2 and SARS-CoV-2 Mpro, SARS-CoV-2 Mpro-IN-41 exerts both anti-inflammatory and antiviral effects, making it a potential candidate for research in inflammation and COVID-19 treatment.</p>Formule :C27H23ClN4O3SCouleur et forme :SolidMasse moléculaire :518.11794COX-2-IN-46
<p>COX-2-IN-46 (compound 5m) serves as a potent anti-inflammatory and analgesic agent. It demonstrates a significant inhibitory action on COX-2, with an IC 50 value of 87.74 nM.</p>Formule :C28H19F2N3SCouleur et forme :SolidMasse moléculaire :467.53COX-2-IN-34
CAS :<p>COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.</p>Formule :C13H11NO4Degré de pureté :98.08%Couleur et forme :SoildMasse moléculaire :245.23COX-1-IN-2
<p>COX-1-IN-2 (compound 5h) serves as a potent anti-inflammatory and analgesic agent. This compound demonstrates a significant inhibitory effect on COX-1, with an IC 50 value of 38.76 nM.</p>Formule :C29H22FN3OSCouleur et forme :SolidMasse moléculaire :479.572-(Phosphonooxy)benzoic acid
CAS :<p>2-(Phosphonooxy)benzoic acid (Fosfosal), used as the anti-inflammatory agent, has the anti-bacterial effect.</p>Formule :C7H7O6PDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :218.1NF157
CAS :<p>NF157, a selective P2Y11 antagonist with pKi 7.35, lowers MMP-3/MMP-13, aiding OA treatment; IC50s: P2Y11 463 nM, P2Y1 1811 μM, P2Y2 170 μM.</p>Formule :C49H28F2N6Na6O23S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1437.1Feladilimab
CAS :<p>Feladilimab (GSK3359609) is an IgG4 monoclonal antibody that is an ICOS agonist.</p>Degré de pureté :SDS-PAGE:95% SEC-HPLC:98%Couleur et forme :LiquidMasse moléculaire :145.24 kDaCOX-2/15-LOX-IN-2
<p>COX-2/15-LOX-IN-2 is a potent inhibitor of both COX-2 and 15-LOX, demonstrating IC50 values of 0.065 μM for COX-2 and 1.86 μM for 15-LOX.</p>Formule :C27H26N6OS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.66COX-2-IN-49
<p>COX-2-IN-49 (compound 6c) is a potent inhibitor of cyclooxygenase-2 (COX-2), displaying an IC50 value of 2.671 µM. This compound exhibits anti-proliferative properties and holds potential for use in cancer research.</p>Couleur et forme :Odour SolidCOX-2-IN-33
<p>COX-2-IN-33 (compound 5f) is a selective COX-2 inhibitor with an IC50 value of 45.5 nM and exhibits potential as an anti-inflammatory agent.</p>Formule :C20H13ClF3N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :479.8Anti-inflammatory agent 52
<p>Anti-inflammatory agent 52 (compound 7j) is an orally active, selective COX-2 inhibitor with the capability to induce G2/M phase arrest and exhibit anti-HT29</p>Formule :C24H21ClN2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.952-O-Sinapoyl makisterone A
<p>Compound 2, formally known as 2-O-Sinapoyl makisterone A, is a sinapinic acid-ecdysterone hybrid that acts as a selective inhibitor of COX-2, effectively</p>Formule :C39H56O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :700.864-Methylamino antipyrine hydrochloride
CAS :<p>4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole.</p>Formule :C12H16ClN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :253.73COX-1/2-IN-5
<p>COX-1/2-IN-5 (compound 2a) functions as a dual inhibitor of COX1/2, demonstrating inhibitory concentrations (IC50) of 2.650 μM and 0.958 μM, respectively, and</p>Formule :C21H22N2O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.47
