COX
Les inhibiteurs de la cyclooxygénase (COX) sont des composés qui bloquent l'activité des enzymes COX, impliquées dans la production de prostaglandines, des médiateurs clés de l'inflammation et de la douleur. En neurosciences, les inhibiteurs de la COX sont étudiés pour leur potentiel à réduire la neuroinflammation, qui est impliquée dans diverses maladies neurodégénératives telles que la maladie d'Alzheimer, la maladie de Parkinson et la sclérose en plaques. En inhibant la COX, ces composés peuvent aider à atténuer les processus inflammatoires dans le cerveau et à protéger contre les lésions neuronales. Chez CymitQuimica, nous fournissons une gamme d'inhibiteurs de la COX pour soutenir vos recherches sur la neuroinflammation, la gestion de la douleur et les maladies neurodégénératives.
601 produits trouvés pour "COX"
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COX-2-IN-7
COX-2-IN-7: potent, orally active COX-2 inhibitor with higher selectivity than Celecoxib, IC50 6.585 uM, anti-inflammatory, low ulcer risk.Formule :C15H13N3O2S2Couleur et forme :SolidMasse moléculaire :331.41COX-2-IN-51
CAS :COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.Formule :C23H18F4O3SCouleur et forme :SolidMasse moléculaire :450.446XO/COX/LOX-IN-1
XO/COX/LOX-IN-1 targets XO/COX/LOX, used in research of inflammation, cancer, and metabolic disorders.Formule :C24H20N4O2SCouleur et forme :SolidMasse moléculaire :428.51COX-2-IN-13
COX-2-IN-13 is a potent, selective COX-2 inhibitor with 0.98 μM IC50; shows strong anti-inflammatory properties and low acute toxicity.Formule :C19H18N2O5SCouleur et forme :SolidMasse moléculaire :386.42COX-2-IN-29
COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).Formule :C22H23FN2O6S2Couleur et forme :SolidMasse moléculaire :494.56Neral
CAS :Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.Formule :C10H16OCouleur et forme :SolidMasse moléculaire :152.23COX-2-IN-6
CAS :COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.Formule :C20H27NO6SDegré de pureté :99.29% - 99.32%Couleur et forme :SoildMasse moléculaire :409.5COX-2-IN-9
COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.Formule :C25H23N5O4S2Couleur et forme :SolidMasse moléculaire :521.61Anti-inflammatory agent 9
Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.Formule :C18H15N5O2SCouleur et forme :SolidMasse moléculaire :365.41Ambuic acid
CAS :Ambuic acid: cyclohexanone with antifungal, quorum-inhibiting, antibacterial properties, blocks cyclic peptides; reduces MRSA abscesses in mice.Formule :C19H26O6Couleur et forme :SolidMasse moléculaire :350.41COX-1/2-IN-2
COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.Formule :C15H10ClIN2OCouleur et forme :SolidMasse moléculaire :396.61Anti-inflammatory agent 10
Tilomisole-derived benzimidazole-thiazole, orally active, favors COX-2 inhibition over COX-1.Formule :C17H13BrN4O3S2Couleur et forme :SolidMasse moléculaire :465.34Soquelitinib
CAS :Soquelitinib (CPI-818) is a selective ITK inhibitor， inhibits tumor growth,T-cell, up-regulatCXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells.Formule :C25H30N4O4S2Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :514.66Ref: TM-T87429
1mg170,00€5mg411,00€10mg677,00€25mg1.349,00€50mg2.023,00€100mg2.745,00€200mg3.695,00€1mL*10mM (DMSO)465,00€NLRP3-IN-69
CAS :NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.Formule :C25H24O7Couleur et forme :SolidMasse moléculaire :436.454COX-2/NO-IN-1
COX-2/NO-IN-1: oral iNOS & NO blocker (IC50=3.52μM), COX-2 supressor, anti-inflammatory, protects kidneys.Formule :C15H15NO3Couleur et forme :SolidMasse moléculaire :257.28COX-2/15-LOX-IN-5
CAS :COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.Formule :C25H21N3O3SCouleur et forme :SolidMasse moléculaire :443.52COX-2-IN-10
COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.Formule :C31H32FN5O2SCouleur et forme :SolidMasse moléculaire :557.68COX-2/PI3K-IN-2
COX-2/PI3K-IN-2 (5f): anti-inflammatory & anti-cancer, selectively inhibits COX-2 (Ki=3.02nM), potently blocks PI3K (IC50=2.78nM).Formule :C16H17N5O2Couleur et forme :SolidMasse moléculaire :311.34ODN 2088
CAS :ODN 2088 is a potent inhibitor of TLR3, TLR7 and TLR9 that is non-cytotoxic and shows inhibition of the release of IFN-α and IL-6.Couleur et forme :Solid(R)-Ketoprofen
CAS :(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.Formule :C16H14O3Couleur et forme :SolidMasse moléculaire :254.28
