CaMK
Les inhibiteurs de la protéine kinase dépendante du calcium/calmoduline (CaMK) sont des composés spécialisés qui inhibent l'activité de la CaMK, une kinase essentielle impliquée dans une gamme de processus cellulaires, en particulier dans le système nerveux. La CaMK est cruciale pour traduire les signaux calciques en diverses réponses cellulaires, y compris la plasticité synaptique, la formation de la mémoire et l'expression génique. La dysrégulation de l'activité de la CaMK est liée à plusieurs troubles neurologiques, ce qui rend ces inhibiteurs précieux pour l'étude de la signalisation synaptique, de l'apprentissage et de la mémoire. Chez CymitQuimica, nous fournissons des inhibiteurs de CaMK de haute qualité pour soutenir vos recherches sur la plasticité synaptique, la fonction cognitive et la neuropharmacologie.
73 produits trouvés pour "CaMK"
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Elziverine
CAS :<p>Elziverine: oral calmodulin antagonist, inhibits Ca-induced acanthocyte formation, potential for neurological and cognitive disorder treatment.</p>Formule :C32H37N3O5Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :543.65Y-33075 dihydrochloride
CAS :Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).Formule :C16H18Cl2N4ODegré de pureté :98.88% - 99.89%Couleur et forme :SolidMasse moléculaire :353.25Ref: TM-T13384L
1mg35,00€5mg70,00€10mg107,00€25mg202,00€50mg360,00€100mg538,00€200mg772,00€1mL*10mM (DMSO)82,00€Trifluoperazine dihydrochloride
CAS :Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Formule :C21H26Cl2F3N3SDegré de pureté :99.57% - 99.96%Couleur et forme :Cream Fine PowderMasse moléculaire :480.43A-3 hydrochloride
CAS :<p>A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.</p>Formule :C12H14Cl2N2O2SDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :321.22Fluphenazine-N-2-chloroethane (hydrochloride)
CAS :Fluphenazine: antipsychotic, binds dopamine D2 (Ki=0.55nM), inhibits calmodulin. Its derivative adds irreversible D2 antagonism and anticancer potential.Formule :C22H27Cl3F3N3SCouleur et forme :SolidMasse moléculaire :528.89Encecalinol
CAS :Encecalinol, a compound isolated from the aerial parts of Ageratina grandifolia, acts as a potent inhibitor of calmodulin [1].Formule :C14H18O3Couleur et forme :SolidMasse moléculaire :234.29CaMKIIα-PHOTAC
CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) that specifically targets Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα).Formule :C54H58Cl2N10O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1094TAT-CN21
TatCN21, with an IC 50 of 77 nM, serves as a potent and selective inhibitor peptide of the calcium/calmodulin-dependent protein kinase II (CaMKII), a ubiquitously-expressed multifunctional serine/threonine protein kinase. It is particularly useful in research pertaining to ischemia and neurodegenerative diseases.Formule :C169H303N69O43Couleur et forme :SolidMasse moléculaire :3989.65Calmodulin Kinase IINtide, Myristoylated
Myristoylated Calmodulin Kinase IINtide (Myr-CaMKIINtide) serves as a selective and noncompetitive inhibitor of CaMKII [1].Formule :C156H275N47O43Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3497.14TAT-CN21 (scrambled)
TAT-CN21(scrambled) is a control peptide lacking specific targeting activity and serves as a negative control for TatCN21. TatCN21 is an effective and selective inhibitory peptide for calcium/calmodulin-dependent protein kinase II (CaMKII).Couleur et forme :Odour SolidAC3-I, myristoylated
<p>Myristoylated AC3-I is a biologically active peptide and a myristoylated variant of the Autocamtide-3-Derived Inhibitory Peptide (AC3-I).</p>Formule :C78H137N21O20Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1689.05Beauverolide Ja
CAS :Beauverolide Ja: cyclotetradepsipeptide, CaM inhibitor; Kd 0.078 μM, Ki 0.39 μM; from Isaria fumosorosea.Formule :C35H46N4O5Couleur et forme :SolidMasse moléculaire :602.76CALP2
CAS :CALP2 is a CaM antagonist blocking EF-hand/Ca2+ site; inhibits CaM phosphodiesterase, raises Ca2+, and activates alveolar macrophages.Formule :C68H104N14O13SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1357.72Calmodulin-Dependent Protein Kinase II (281-309)
CAS :Calmodulin-Dependent Protein Kinase II (281-309) is a synthetic peptide that can be phosphorylated at Thr286 by PKC and inhibits CaM kinase II (IC50 = 80 nM).Formule :C146H254N46O39S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3374.06Acremonidin A
CAS :Acremonidin A, from Purpureocillium lilacinum, is a strong CaM inhibitor binding to hCaM M124C-mBBr with a Kd of 19.40 nM.Formule :C33H26O12Couleur et forme :SolidMasse moléculaire :614.55Fasciculic acid C
CAS :Fasciculic acid C is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.Formule :C38H63NO11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :709.91Cloxacepride
CAS :cloxacepride is a CaM antagonist that is used to treat asthma disease.Formule :C22H27Cl2N3O4Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :468.37Fasciculic acid A
CAS :Fasciculic acid A is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.Formule :C36H60O8Couleur et forme :SolidMasse moléculaire :620.868Syntide 2 TFA
Syntide 2 (TFA) is a CaMKII substrate that selectively hinders GA response without affecting other plant processes.Formule :C70H123N20F3O20Couleur et forme :SolidMasse moléculaire :1621.84Fasciculic acid B
CAS :Fasciculic acid B: ester of fasciculol B, 3-hydroxy-methylglutaric acid; a calmodulin antagonist from Naematoloma fasciculare.Formule :C36H60O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :636.86CALP2 TFA
CALP2 TFA, a CaM antagonist with 7.9 µM Kd, blocks CaM-dependent enzymes, boosts Ca2+ levels, and activates macrophages.Formule :C70H105F3N14O15SCouleur et forme :SolidMasse moléculaire :1471.72Calmodulin-Dependent Protein Kinase II 290-309 acetate
Calmodulin-Dependent Protein Kinase II 290-309 acetate is an effective antagonist of Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM).Formule :C105H189N31O26SDegré de pureté :96.7%Couleur et forme :SolidMasse moléculaire :2333.88Calmodulin Binding Peptide 1
CAS :Calmodulin Binding Peptide 1, a high-affinity MLCK-derived inhibitor, blocks IP3-induced Ca2+ release.Formule :C231H373N69O70S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5301.1MLCK Peptide
CAS :MLCK Peptide, a high-affinity (pM), fully reversible CaM-binding peptide, is derived from smooth muscle myosin light-chain kinase [1].Formule :C91H156N36O20Couleur et forme :SolidMasse moléculaire :2074.44Purine riboside triphosphate
CAS :Purine riboside triphosphate resembles adenosine; inhibits cancer cell growth by blocking RNA/DNA synthesis.Formule :C10H15N4O13P3Couleur et forme :SolidMasse moléculaire :492.17Purine riboside-5'-O-triphosphate sodium
CAS :Purine riboside-5'-O-triphosphate sodium is an active metabolite of Nebularine (HY-103694) and acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM, respectively. It also inhibits calmodulin-dependent protein kinase II (CaMKII), with a Ki value of 590 µM.Formule :C10H11N4Na4O13P3Masse moléculaire :580.09RA306
RA306 is an orally active CAMK2 inhibitor that effectively disrupts the PEAK1/CAMK2 signaling pathway. It demonstrates anti-tumor activity by inhibiting proliferation, migration, and invasion of breast cancer cells. Additionally, RA306 shows potential in cardiac disease research, as it improves dilated cardiomyopathy in mice.Couleur et forme :Odour SolidCAMKIV Protein, Human, Recombinant (GST)
CAMKIV Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag.Couleur et forme :Lyophilized PowderMasse moléculaire :79 kDa (predicted); 100 kDa (reducing conditions)KN-62
CAS :KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.Formule :C38H35N5O6S2Degré de pureté :99.80% - >99.99%Couleur et forme :White SolidMasse moléculaire :721.84Ref: TM-T2694
1mg34,00€2mg49,00€5mg71,00€10mg105,00€25mg207,00€50mg404,00€100mg592,00€1mL*10mM (DMSO)105,00€CALP2 acetate(261969-04-4 free base)
CALP2 acetate is an antagonist of calmodulin showing high affinity for binding to the CaM EF-hand/Ca2+-binding site with a Kd of 7.9 µM.Formule :C68H104N14O13SDegré de pureté :97.43%Couleur et forme :SolidMasse moléculaire :1357.7Syntide 2 acetate(108334-68-5 free base)
Syntide-2 acetate is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 μM).Formule :C70H126N20O20Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :1567.85Autocamtide-2-related inhibitory peptide
CAS :Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.Formule :C64H116N22O19Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :1497.74Autocamtide 2 TFA(129198-88-5 free base)
Autocamtide 2 TFA, selective CaMKII peptide substrate, used in its activity assay.Formule :C67H119F3N22O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1641.79CaMKP Inhibitor
CAS :<p>CaMKP Inhibitor can inhibit CaMKP.</p>Formule :C10H8NNaO7S2Degré de pureté :96.55% - 99.98%Couleur et forme :SolidMasse moléculaire :341.28GSK3i XIII
CAS :GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor.Formule :C18H19N5Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :305.38Ref: TM-T24111
1mg66,00€5mg120,00€10mg175,00€25mg295,00€50mg429,00€100mg605,00€1mL*10mM (DMSO)135,00€IGS-1.76
CAS :IGS-1.76 binds strongly to hNCS-1, modulates its Ric8a interaction, and inhibits the hNCS-1/Ric8a complex.Formule :C22H18N2OSDegré de pureté :98.18% - 98.56%Couleur et forme :SolidMasse moléculaire :358.46KN-92
CAS :KN-92 is an inactive analog of the CaM kinase II inhibitor KN 93.Formule :C24H25ClN2O3SCouleur et forme :SolidMasse moléculaire :456.98KN-93
CAS :KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.Formule :C26H29ClN2O4SDegré de pureté :99.56% - 99.86%Couleur et forme :White SolidMasse moléculaire :501.04Ref: TM-T2697
1mg57,00€2mg79,00€5mg113,00€10mg155,00€25mg305,00€50mg378,00€100mg552,00€1mL*10mM (DMSO)127,00€Trifluoperazine
CAS :Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Formule :C21H24F3N3SDegré de pureté :98.3% - 99.46%Couleur et forme :White To Yellowish Crystalline PowderMasse moléculaire :407.5NH125
CAS :NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.Formule :C27H45IN2Degré de pureté :98.60%Couleur et forme :SolidMasse moléculaire :524.56Ref: TM-T6605
1mg40,00€2mg52,00€5mg88,00€10mg119,00€25mg264,00€50mg454,00€100mg655,00€1mL*10mM (DMSO)87,00€CALP1 acetate
<p>CALP1 acetate is a calmodulin (CaM) agonist (Kd of 88 µM) that binds to the CaM EF-hand/Ca2+-binding site.</p>Formule :C42H79N9O12Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :902.13CaMKII-IN-1
CAS :CaMKII-IN-1 is a potent and highly selective inhibitor of CaMKII (IC50 = 63 nM).Formule :C29H30ClN5O2SDegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :548.1Ref: TM-T14860
1mg50,00€2mg71,00€5mg113,00€10mg166,00€25mg334,00€50mg520,00€100mg750,00€1mL*10mM (DMSO)137,00€lavendustin C
CAS :lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.Formule :C14H13NO5Degré de pureté :98.06%Couleur et forme :Yellow To Tan PowderMasse moléculaire :275.26Ref: TM-T4185
1mg44,00€2mg58,00€5mg87,00€10mg160,00€25mg349,00€50mg518,00€100mg747,00€1mL*10mM (DMSO)95,00€STO-609
CAS :<p>STO-609 inhibits CaM-KKα/KKβ (Ki: 80/15 ng/mL), is specific, cell-permeable, and targets Ca2+/calmodulin-dependent protein kinase kinase.</p>Formule :C19H10N2O3Degré de pureté :97.14% - 98.8%Couleur et forme :SolidMasse moléculaire :314.29KN-92 hydrochloride
CAS :KN-92 hydrochloride is an inactive derivative of KN-93.Formule :C24H26Cl2N2O3SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :493.45A-484954
CAS :A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.Formule :C13H15N5O3Degré de pureté :97.47% - 99.86%Couleur et forme :SolidMasse moléculaire :289.29Ref: TM-TQ0137
1mg43,00€2mg56,00€5mg88,00€10mg144,00€25mg305,00€50mg543,00€100mg775,00€1mL*10mM (DMSO)103,00€CaM kinase II inhibitor TFA salt
<p>CaM kinase II inhibitor TFA salt (Autocamtide-2-related inhibitory peptide (TFA)) is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.</p>Formule :C66H117F3N22O21Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :1611.77L-6355
CAS :L-6355 is an agent of bioactive chemicals.Formule :C25H30INO3Couleur et forme :SolidMasse moléculaire :519.42Zaldaride maleate
CAS :Zaldaride maleate blocks Ca2+, Na+, K+ currents, and nAChR; inhibits CaM cAMP PDE (IC50: 3.3 nM) and estrogen signaling.Formule :C30H32N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :544.6CK59
CAS :CK59 inhibits CaMKII and several voltage-gated calcium channels, with an IC50 of ~50 μM.Formule :C21H37N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.56Prenylamine lactate
CAS :Prenylamine lactate, an ex-angina drug, depletes heart catecholamines and blocks calcium channels.Formule :C27H33NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.56W-5 hydrochloride
CAS :W-5 hydrochloride (N-(6-Aminohexyl)-1-naphthalenesulfonamide HCl) is a potent calmodulin antagonist.Formule :C16H23ClN2O2SDegré de pureté :99.35%Couleur et forme :Off-White Crystalline SolidMasse moléculaire :342.88W-13 hydrochloride
CAS :W-13 hydrochloride (W-13 HCl) is a calmodulin antagonist.Formule :C14H18Cl2N2O2SDegré de pureté :98.51%Couleur et forme :White PowderMasse moléculaire :349.28CV-159
CAS :CV-159 is a unique dihydropyridine Ca2+ antagonist with antiinflammatory activities. It has an anti-calmodulin (CaM) action.Formule :C31H34N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :574.62A-7 hydrochloride
CAS :<p>A-7 hydrochloride is a calmodulin antagonist and causes alterations in the subpopulation of CD44+CD24- in MDA-MB-231 cells.</p>Formule :C20H30Cl2N2O2SDegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :433.44TX-1123
CAS :TX-1123: PTK/COX inhibitor, Src/eEF2-K/PKA/EGFR-K/PKC targeted, IC50 of 1.16μM(COX2), 15.7μM(COX1), low mitochondrial toxicity.Formule :C20H24O3Couleur et forme :SolidMasse moléculaire :312.4CBP501
CAS :CBP501 peptide inhibits kinases like MAPKAP-K2/C-Tak1/CHK1, preventing Cdc25C function and blocking the entry into mitosis.Formule :C86H122F5N29O17Couleur et forme :SolidMasse moléculaire :1929.06Ph-HTBA
CAS :Ph-HTBA: high-affinity CaMKIIα modulator, brain-penetrant, Kd 757 nM, used in ischemia/neurodegeneration research.Formule :C19H18O3Couleur et forme :SolidMasse moléculaire :294.34TIM-063
CAS :TIM-063: ATP-competitive CaMKKα/β inhibitor, cell-permeable, Ki: 0.35/0.2 μM, IC50: 0.63/0.96 μM.Formule :C18H9N3O4Couleur et forme :SolidMasse moléculaire :331.28Bisindolylmaleimide VII
CAS :Bisindolylmaleimide VII is a selective inhibitor of protein kinase C.Formule :C27H27N5O2Couleur et forme :SolidMasse moléculaire :453.54RU 45144
CAS :RU 45144 is an estradiol derivative with antiestrogenic activity.Formule :C28H37NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.6HOCPCA
CAS :HOCPCA: potent, selective GHB site ligand; 27x higher affinity than GHB; crosses blood-brain barrier.Formule :C6H8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :128.13W-9 hydrochloride
CAS :W-9 hydrochloride is a calmodulin antagonist.Formule :C16H22Cl2N2O2SDegré de pureté :98.9%Couleur et forme :SolidMasse moléculaire :377.33Ref: TM-T23525
1mg35,00€2mg44,00€5mg64,00€10mg96,00€25mg183,00€50mg284,00€100mg411,00€500mgÀ demander1mL*10mM (DMSO)70,00€Calmidazolium chloride
CAS :Calmidazolium chloride blocks calmodulin, hinders phosphodiesterase (IC50=0.15µM), Ca2+-ATPase (IC50=0.35µM), and can induce cancer cell apoptosis.Formule :C31H23Cl7N2ODegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :687.7Ref: TM-T10667
5mg63,00€10mg87,00€25mg145,00€50mg215,00€100mg320,00€200mg467,00€1mL*10mM (DMSO)95,00€Zaldaride (free base)
CAS :Zaldaride (free base) is a calmodulin antagonist.Formule :C26H28N4O2Couleur et forme :SolidMasse moléculaire :428.53MCB-22-174
CAS :MCB-22-174 is a potent agonist of Piezo1 with an EC50 value of 6.28 µM. It activates Ca2+-related extracellular signal-regulated kinase and calcium-calmodulin (CaM)-dependent protein kinase II (CaMKII) pathways, and it promotes mesenchymal stem cell osteogenic differentiation, indicating its potential application in the study of disuse osteoporosis (OP).Formule :C16H14DCl2N5OS2Masse moléculaire :429.37PTCA
CAS :PTCA is a potent ligand for Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα), with a pKi value of 7.2.Formule :C10H5Cl2NO2SCouleur et forme :SolidMasse moléculaire :274.123CaMKK2-IN-1
CAS :CaMKK2-IN-1 is a selective and potent inhibitor of CaMKK2, exhibiting an IC50 of 7 nM.Formule :C22H22N2O3Masse moléculaire :362.42BRD0418
CAS :BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.Formule :C29H32N2O5Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :488.57CaMKIIα-IN-1
CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.Formule :C14H11ClO4Couleur et forme :SolidMasse moléculaire :278.69FO-4-15
CAS :FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.Formule :C18H20N4O4SCouleur et forme :SolidMasse moléculaire :388.44Aprindine
CAS :Aprindine, an arrhythmia inhibitor, stabilizes the cell membranes of heart muscle cells to prevent abnormal electrical impulses and irregular heartbeats. In hematological toxicity studies, aprindine demonstrated potential inhibitory effects on the replicative capacity of mouse and human blood cells at specific concentrations [1].Formule :C22H30N2Masse moléculaire :322.49Calmodulin antagonist-1
CAS :Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist that effectively inhibits calmodulin-activated Ca 2+ -phosphodiesterase (PDE) with an IC 50 of 28 μM. This compound also competitively inhibits trypsin-treated Ca 2+ -PDE with respect to cyclic GMP, exhibiting an IC 50 of 375 μM and a K i value of 300 μM.Formule :C14H18Cl2N2O2SCouleur et forme :SolidMasse moléculaire :349.27
