CaMK
Les inhibiteurs de la protéine kinase dépendante du calcium/calmoduline (CaMK) sont des composés spécialisés qui inhibent l'activité de la CaMK, une kinase essentielle impliquée dans une gamme de processus cellulaires, en particulier dans le système nerveux. La CaMK est cruciale pour traduire les signaux calciques en diverses réponses cellulaires, y compris la plasticité synaptique, la formation de la mémoire et l'expression génique. La dysrégulation de l'activité de la CaMK est liée à plusieurs troubles neurologiques, ce qui rend ces inhibiteurs précieux pour l'étude de la signalisation synaptique, de l'apprentissage et de la mémoire. Chez CymitQuimica, nous fournissons des inhibiteurs de CaMK de haute qualité pour soutenir vos recherches sur la plasticité synaptique, la fonction cognitive et la neuropharmacologie.
66 produits trouvés pour "CaMK".
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A-3 hydrochloride
CAS :A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.Formule :C12H14Cl2N2O2SDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :321.22Y-33075 dihydrochloride
CAS :Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).Formule :C16H18Cl2N4ODegré de pureté :98.88% - 99.89%Couleur et forme :SolidMasse moléculaire :353.25Ref: TM-T13384L
1mg34,00€5mg66,00€1mL*10mM (DMSO)78,00€10mg102,00€25mg192,00€50mg341,00€100mg510,00€200mg732,00€Elziverine
CAS :Elziverine: oral calmodulin antagonist, inhibits Ca-induced acanthocyte formation, potential for neurological and cognitive disorder treatment.Formule :C32H37N3O5Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :543.65Trifluoperazine dihydrochloride
CAS :Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Formule :C21H26Cl2F3N3SDegré de pureté :99.57% - 99.96%Couleur et forme :SolidMasse moléculaire :480.43TAT-CN21
TAT-CN21 is a cell-permeable CaMKII inhibitory peptide used to study neuronal excitotoxicity and ischemic injury by blocking CaMKII activity.Formule :C169H303N69O43Couleur et forme :White SolidMasse moléculaire :3989.65Fluphenazine-N-2-chloroethane (hydrochloride)
CAS :Fluphenazine-N-2-chloroethane hydrochloride is a fluphenazine derivative used as a calmodulin probe.Formule :C22H27Cl3F3N3SCouleur et forme :SolidMasse moléculaire :528.89CaMKIIα-PHOTAC
CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) that specifically targets Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα).Formule :C54H58Cl2N10O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1094CALP2
CAS :CALP2 is a CaM antagonist blocking EF-hand/Ca2+ site; inhibits CaM phosphodiesterase, raises Ca2+, and activates alveolar macrophages.Formule :C68H104N14O13SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1357.72Calmodulin-Dependent Protein Kinase II 290-309 acetate
Calmodulin-Dependent Protein Kinase II 290-309 acetate is an effective antagonist of Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM).Formule :C105H189N31O26SDegré de pureté :96.7%Couleur et forme :SolidMasse moléculaire :2333.88CALP2 TFA
CALP2 TFA, a CaM antagonist with 7.9 µM Kd, blocks CaM-dependent enzymes, boosts Ca2+ levels, and activates macrophages.Formule :C70H105F3N14O15SCouleur et forme :SolidMasse moléculaire :1471.72Syntide 2 TFA
Syntide 2 (TFA) is a CaMKII substrate that selectively hinders GA response without affecting other plant processes.Formule :C70H123N20F3O20Couleur et forme :SolidMasse moléculaire :1621.84MLCK Peptide
CAS :MLCK Peptide, a high-affinity (pM), fully reversible CaM-binding peptide, is derived from smooth muscle myosin light-chain kinase [1].Formule :C91H156N36O20Couleur et forme :SolidMasse moléculaire :2074.44Calmodulin Kinase IINtide, Myristoylated
Myristoylated Calmodulin Kinase IINtide (Myr-CaMKIINtide) serves as a selective and noncompetitive inhibitor of CaMKII [1].Formule :C156H275N47O43Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3497.14Calmodulin-Dependent Protein Kinase II (281-309)
CAS :Calmodulin-Dependent Protein Kinase II (281-309) is a synthetic peptide that can be phosphorylated at Thr286 by PKC and inhibits CaM kinase II (IC50 = 80 nM).Formule :C146H254N46O39S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3374.06Fasciculic acid C
CAS :Fasciculic acid C is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.Formule :C38H63NO11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :709.91Cloxacepride
CAS :cloxacepride is a CaM antagonist that is used to treat asthma disease.Formule :C22H27Cl2N3O4Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :468.37TAT-CN21 (scrambled)
TAT-CN21(scrambled) is a control peptide lacking specific targeting activity and serves as a negative control for TatCN21. TatCN21 is an effective and selective inhibitory peptide for calcium/calmodulin-dependent protein kinase II (CaMKII).Couleur et forme :Odour SolidBeauverolide Ja
CAS :Beauverolide Ja: cyclotetradepsipeptide, CaM inhibitor; Kd 0.078 μM, Ki 0.39 μM; from Isaria fumosorosea.Formule :C35H46N4O5Couleur et forme :SolidMasse moléculaire :602.76RA306
RA306 is an orally active CAMK2 inhibitor that effectively disrupts the PEAK1/CAMK2 signaling pathway. It demonstrates anti-tumor activity by inhibiting proliferation, migration, and invasion of breast cancer cells. Additionally, RA306 shows potential in cardiac disease research, as it improves dilated cardiomyopathy in mice.Couleur et forme :Odour SolidAC3-I, myristoylated
Myristoylated AC3-I is a biologically active peptide and a myristoylated variant of the Autocamtide-3-Derived Inhibitory Peptide (AC3-I).Formule :C78H137N21O20Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1689.05Calmodulin Binding Peptide 1
CAS :Calmodulin Binding Peptide 1, a high-affinity MLCK-derived inhibitor, blocks IP3-induced Ca2+ release.Formule :C231H373N69O70S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5301.1CAMKIV Protein, Human, Recombinant (GST)
CAMKIV Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag.Couleur et forme :Lyophilized PowderMasse moléculaire :79 kDa (predicted); 100 kDa (reducing conditions)A-484954
CAS :A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.Formule :C13H15N5O3Degré de pureté :97.47% - 99.86%Couleur et forme :SolidMasse moléculaire :289.29Ref: TM-TQ0137
1mg40,00€2mg52,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg137,00€25mg289,00€50mg515,00€100mg733,00€KN-92 hydrochloride
CAS :KN-92 hydrochloride is an inactive derivative of KN-93.Formule :C24H26Cl2N2O3SDegré de pureté :99.68%Couleur et forme :White SolidMasse moléculaire :493.45KN-92
CAS :KN-92 is an inactive analog of the CaM kinase II inhibitor KN 93.Formule :C24H25ClN2O3SCouleur et forme :SolidMasse moléculaire :456.98KN-93
CAS :KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.Formule :C26H29ClN2O4SDegré de pureté :99.56% - 99.95%Couleur et forme :White SolidMasse moléculaire :501.04Ref: TM-T2697
1mg54,00€2mg74,00€5mg107,00€1mL*10mM (DMSO)120,00€10mg146,00€25mg289,00€50mg358,00€100mg523,00€Trifluoperazine
CAS :Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Formule :C21H24F3N3SDegré de pureté :98.3% - 99.46%Couleur et forme :SolidMasse moléculaire :407.5NH125
CAS :NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.Formule :C27H45IN2Degré de pureté :98.60%Couleur et forme :SolidMasse moléculaire :524.56Ref: TM-T6605
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg113,00€25mg250,00€50mg430,00€100mg620,00€KN-62
CAS :KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.Formule :C38H35N5O6S2Degré de pureté :99.80% - >99.99%Couleur et forme :SolidMasse moléculaire :721.84Ref: TM-T2694
1mg34,00€2mg49,00€5mg71,00€10mg105,00€1mL*10mM (DMSO)105,00€25mg207,00€50mg404,00€100mg592,00€CaMKII-IN-1
CAS :CaMKII-IN-1 is a potent and highly selective inhibitor of CaMKII (IC50 = 63 nM).Formule :C29H30ClN5O2SDegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :548.1Ref: TM-T14860
1mg50,00€2mg71,00€5mg113,00€1mL*10mM (DMSO)137,00€10mg166,00€25mg334,00€50mg520,00€100mg750,00€lavendustin C
CAS :lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.Formule :C14H13NO5Degré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :275.26Ref: TM-T4185
1mg42,00€2mg55,00€1mL*10mM (DMSO)90,00€5mg93,00€10mg152,00€25mg330,00€50mg492,00€100mg707,00€STO-609
CAS :STO-609 inhibits CaM-KKα/KKβ (Ki: 80/15 ng/mL), is specific, cell-permeable, and targets Ca2+/calmodulin-dependent protein kinase kinase.Formule :C19H10N2O3Degré de pureté :97.14% - 99.35%Couleur et forme :SolidMasse moléculaire :314.29Ref: TM-T3546
1mg39,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg120,00€25mg250,00€50mg400,00€100mg620,00€200mg873,00€CaMKP Inhibitor
CAS :CaMKP Inhibitor can inhibit CaMKP.Formule :C10H8NNaO7S2Degré de pureté :99.91% - 99.98%Couleur et forme :SolidMasse moléculaire :341.28Ref: TM-T2159
1mg39,00€5mg82,00€1mL*10mM (DMSO)102,00€10mg120,00€25mg227,00€50mg334,00€100mg460,00€500mg1.035,00€Stains-All
CAS :Stains-All is a cationic dye of carbocyanine.Formule :C30H27BrN2S2Degré de pureté :98.85% - 99.71%Couleur et forme :Black SolidMasse moléculaire :559.58CALP2 acetate(261969-04-4 free base)
CALP2 acetate is an antagonist of calmodulin showing high affinity for binding to the CaM EF-hand/Ca2+-binding site with a Kd of 7.9 µM.Formule :C68H104N14O13SDegré de pureté :99.91%Couleur et forme :White SolidMasse moléculaire :1357.7Syntide 2 acetate(108334-68-5 free base)
Syntide-2 acetate is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 μM).Formule :C70H126N20O20Degré de pureté :99.87%Couleur et forme :Purple LiquidMasse moléculaire :1567.85Autocamtide-2-related inhibitory peptide TFA salt
Autocamtide-2-related inhibitory peptide TFA salt(CaM kinase II inhibitor TFA salt) is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.Formule :C66H117F3N22O21Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :1611.77Autocamtide-2-related inhibitory peptide
CAS :Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.Formule :C64H116N22O19Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :1497.74Autocamtide 2 TFA(129198-88-5 free base)
Autocamtide 2 TFA, selective CaMKII peptide substrate, used in its activity assay.Formule :C67H119F3N22O22Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :1641.79GSK3i XIII
CAS :GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor.Formule :C18H19N5Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :305.38Ref: TM-T24111
1mg63,00€5mg114,00€1mL*10mM (DMSO)128,00€10mg172,00€25mg279,00€50mg406,00€100mg572,00€IGS-1.76
CAS :IGS-1.76 binds strongly to hNCS-1, modulates its Ric8a interaction, and inhibits the hNCS-1/Ric8a complex.Formule :C22H18N2OSDegré de pureté :98.18% - 98.56%Couleur et forme :SolidMasse moléculaire :358.46L-6355
CAS :L-6355 is an agent of bioactive chemicals.Formule :C25H30INO3Couleur et forme :SolidMasse moléculaire :519.42W-5 hydrochloride
CAS :W-5 hydrochloride (N-(6-Aminohexyl)-1-naphthalenesulfonamide HCl) is a potent calmodulin antagonist.Formule :C16H23ClN2O2SDegré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :342.88A-7 hydrochloride
CAS :A-7 hydrochloride is a calmodulin antagonist and causes alterations in the subpopulation of CD44+CD24- in MDA-MB-231 cells.Formule :C20H30Cl2N2O2SDegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :433.44Prenylamine lactate
CAS :Prenylamine lactate, an ex-angina drug, depletes heart catecholamines and blocks calcium channels.Formule :C27H33NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.56Zaldaride maleate
CAS :Zaldaride maleate blocks Ca2+, Na+, K+ currents, and nAChR; inhibits CaM cAMP PDE (IC50: 3.3 nM) and estrogen signaling.Formule :C30H32N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :544.6TX-1123
CAS :TX-1123: PTK/COX inhibitor, Src/eEF2-K/PKA/EGFR-K/PKC targeted, IC50 of 1.16μM(COX2), 15.7μM(COX1), low mitochondrial toxicity.Formule :C20H24O3Couleur et forme :SolidMasse moléculaire :312.4CV-159
CAS :CV-159 is a unique dihydropyridine Ca2+ antagonist with antiinflammatory activities. It has an anti-calmodulin (CaM) action.Formule :C31H34N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :574.62CK59
CAS :CK59 inhibits CaMKII and several voltage-gated calcium channels, with an IC50 of ~50 μM.Formule :C21H37N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.56Bisindolylmaleimide VII
CAS :Bisindolylmaleimide VII is a selective inhibitor of protein kinase C.Formule :C27H27N5O2Couleur et forme :SolidMasse moléculaire :453.54
