AChR
Les inhibiteurs des récepteurs de l'acétylcholine (AChR) sont des composés qui bloquent l'activité des récepteurs de l'acétylcholine, essentiels pour la neurotransmission dans les systèmes nerveux central et périphérique. Les AChR jouent un rôle crucial dans la contraction musculaire, la mémoire et les fonctions cognitives. Les inhibiteurs des AChR sont utilisés pour étudier des conditions telles que la myasthénie grave, la maladie d'Alzheimer et d'autres troubles neurologiques. En modulant l'activité des AChR, ces inhibiteurs peuvent aider à démêler les complexités de la signalisation cholinergique dans le cerveau. Chez CymitQuimica, nous fournissons une gamme d'inhibiteurs des AChR pour soutenir vos recherches en neurosciences, pharmacologie et maladies neurodégénératives.
575 produits trouvés pour "AChR"
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Diphenmanil methylsulfate
CAS :<p>Diphenmanil methylsulfate (Diphemanil mesylate), a quaternary ammonium anticholinergic, binds muscarinic acetylcholine receptors.</p>Formule :C20H24N·CH3O4SDegré de pureté :98% - 99.27%Couleur et forme :SolidMasse moléculaire :389.51Benactyzine hydrochloride
CAS :<p>Benactyzine hydrochloride (Neuroleptone) is a centrally acting muscarinic antagonist.</p>Formule :C20H26ClNO3Degré de pureté :99.03% - 99.94%Couleur et forme :SolidMasse moléculaire :363.88Solifenacin succinate
CAS :<p>Solifenacin succinate (YM905) is a quinuclidine and tetrahydroisoquinoline derivative and selective M3 muscarinic antagonist, which is used as a urologic agent.</p>Formule :C23H26N2O2·C4H6O4Degré de pureté :99.85% - 99.98%Couleur et forme :SolidMasse moléculaire :480.56Deschloroclozapine
CAS :<p>Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist.</p>Formule :C18H20N4Degré de pureté :99.61% - 99.98%Couleur et forme :SolidMasse moléculaire :292.38Bethanechol chloride
CAS :<p>Bethanechol chloride: muscarinic agonist, boosts smooth muscle tone, used post-abdominal surgery & for urinary retention; may cause hypotension & bronchospasm.</p>Formule :C7H17N2O2·ClDegré de pureté :95% - 99.73%Couleur et forme :White CrystallineMasse moléculaire :196.68DL-trihexyphenidyl hydrochloride
CAS :<p>DL-trihexyphenidyl hydrochloride (Trihexyphenidyl HCl) is a muscarinic antagonist.</p>Formule :C20H32ClNODegré de pureté :99.63% - 99.71%Couleur et forme :SolidMasse moléculaire :337.93(Rac)-ABT-202 dihydrochloride
CAS :<p>(Rac)-ABT-202 dihydrochloride is a racemate of ABT-202. ABT-202 is an nicotinic acetylcholine receptors (nAChRs) agonist and can be used as an analgesic.</p>Formule :C9H15Cl2N3Degré de pureté :97.4%Couleur et forme :SolidMasse moléculaire :236.142Droperidol
CAS :<p>Droperidol (Dehydrobenzperidol) is a Dopamine-2 Receptor Antagonist. The mechanism of action of droperidol is as a Dopamine D2 Antagonist.</p>Formule :C22H22FN3O2Degré de pureté :97.16% - 98%Couleur et forme :SolidMasse moléculaire :379.43Nebracetam hydrochloride
CAS :<p>Nebracetam HCl (WEB 1881 FU) is an M1-muscarinic agonist nootropic, increasing intracellular Ca2+ with an EC50 of 1.59 mM.</p>Formule :C12H17ClN2ODegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :240.729(Rac)-Sabcomeline HCl
CAS :<p>Sabcomeline HCl is an M1 receptor agonist that can be used to study Alzheimer's disease.</p>Formule :C10H16ClN3ODegré de pureté :99.58%Couleur et forme :SoildMasse moléculaire :229.71Atropine methyl bromide
CAS :<p>Atropine methyl bromide (Methylatropine bromide) is a quaternary ammonium salt of atropine, characterized as a muscarinic receptor (mAChR) antagonist.</p>Formule :C18H26BrNO3Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :384.308Carbachol
CAS :<p>Carbachol (Carbamoylcholine chloride), an analog of acetylcholine, serves as a valuable tool in the investigation of various physiological responses mediated by nicotinic (nAChR) and muscarinic (mAChR) acetylcholine receptors. These responses include smooth muscle contraction, gut motility, and neuronal signaling. Known for its agonistic properties, Carbachol activates both nAChR and mAChR, with reported Ki values ranging from 10 to 10,000 nM for different receptor types and experimental preparations.</p>Formule :C6H15ClN2O2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :182.65TAK-071
CAS :<p>TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520 nM).</p>Formule :C24H24FN3O3Degré de pureté :98.02%Couleur et forme :SolidMasse moléculaire :421.46Acetamiprid
CAS :<p>Acetamiprid: nAChR agonist, global neonicotinoid insecticide linked to neuromuscular/reproductive issues.</p>Formule :C10H11ClN4Degré de pureté :99.66%Couleur et forme :White PowderMasse moléculaire :222.67Rocuronium bromide
CAS :<p>Rocuronium bromide (ORG 9426) is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker, which is used to provide skeletal muscle relaxation.</p>Formule :C32H53BrN2O4Degré de pureté :99.77% - >99.99%Couleur et forme :White Or Off-White PowderMasse moléculaire :609.68Procainamide hydrochloride
CAS :<p>Procainamide Hydrochloride (Procapan) is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog</p>Formule :C13H21N3O·HClDegré de pureté :99.83% - 99.97%Couleur et forme :White To Slightly Yellow PowderMasse moléculaire :271.79Benzethonium chloride
CAS :<p>Benzethonium chloride (Quatrachlor) is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.</p>Formule :C27H42ClNO2Degré de pureté :99.91%Couleur et forme :White To Off-White Solid Solid Particulate/PowderMasse moléculaire :448.09Methylatropine (nitrate)
CAS :<p>Methylatropine: Muscarinic antagonist, <0.1 nM IC50, atropine derivative, lowers ACh's effect on BP, affects salivation, pupil dilation, heart rate.</p>Formule :C18H26N2O6Couleur et forme :SolidMasse moléculaire :366.414β2AR/M-receptor agonist-1
CAS :<p>β2AR/M-receptor agonist-1 (example 131), a muscarinic antagonist and β2 adrenoceptor agonist (MABA), exhibits dual potency towards β2 adrenoceptor and</p>Formule :C43H56BrN3O7Couleur et forme :SolidMasse moléculaire :806.82Perindoprilat
CAS :<p>Perindoprilat (Perindoprilate) is an angiotensin-converting enzyme inhibitor.</p>Formule :C17H28N2O5Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :340.41DSPE-PEG1000-RVG29
<p>DSPE-PEG1000-RVG29 is a PEG compound composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 can specifically bind to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB) and cross the BBB.</p>Couleur et forme :Odour SolidTC-2559 difumarate
CAS :<p>TC-2559 difumarate: Oral α4β2 nAChR partial agonist, CNS-selective, EC50 0.18 μM, prefers α4β2 over α2β4/α4β4/α3β4, antinociceptive.</p>Formule :C20H26N2O9Couleur et forme :SolidMasse moléculaire :438.43Navafenterol saccharinate
CAS :<p>AZD-8871 saccharinate is a dual-acting bronchodilator which may be useful in the treatment of Chronic Obstructive Pulmonary Disease (COPD).</p>Formule :C45H47N7O9S3Couleur et forme :SolidMasse moléculaire :926.09Lobeline sulfate
CAS :<p>Lobeline sulfate, an alkaloid like nicotine, aids in smoking cessation, insomnia, and respiratory issues. Less potent on nicotinic receptors.</p>Formule :C22H29NO6SDegré de pureté :98%Couleur et forme :White PowderMasse moléculaire :435.54(Rac)-5-Hydroxymethyl Tolterodine hydrochloride
CAS :<p>(Rac)-5-Hydroxymethyl Tolterodine HCl, or (Rac)-Desfesoterodine HCl, is a potent mAChR blocker researched for overactive bladder.</p>Formule :C22H32ClNO2Couleur et forme :SolidMasse moléculaire :377.95Epiboxidine
CAS :<p>Epiboxidine: Potent, selective nAChR agonist; Ki 0.46/1.2 nM for rat/human α4β2; analogous to Epibatidine and ABT 418.</p>Formule :C10H14N2OCouleur et forme :SolidMasse moléculaire :178.23Lupanine hydrochloride
CAS :<p>Lupanine hydrochloride, a Sparteine derivative, binds to nAChR with a Ki of 500 nM and has ganglioplegic properties.</p>Formule :C15H25ClN2OCouleur et forme :SolidMasse moléculaire :284.83MK-0969
CAS :<p>MK-0969 (J-104135) is a possible M3 antagonist for the treatment of chronic obstructive pulmonary disease.</p>Formule :C24H30F2N4O2Couleur et forme :SolidMasse moléculaire :444.52Muscarine
CAS :<p>Muscarine is a toxic alkaloid found in Amanita muscaria and other fungi of the Inocybe species.</p>Formule :C9H20NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :174.26Anagyrine hydrochloride
CAS :<p>Anagyrine hydrochloride, a quinolizidine from Lupinus albus, targets muscarinic/nicotinic receptors; IC50: 132/2096 µM. It desensitizes nAChR directly.</p>Formule :C15H21ClN2OCouleur et forme :SolidMasse moléculaire :280.79AC1-IN-1
CAS :<p>AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM).</p>Formule :C18H18FN5O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :355.37(rel)-Asperparaline A
CAS :<p>Aspergillimide, from A. japonicus, inhibits silkworm neuron nAChRs (IC50s: 20.2/39.6 nM), not affecting chicken nAChRs, and paralyzes silkworm larvae.</p>Formule :C20H29N3O3Couleur et forme :SolidMasse moléculaire :359.47Perlapine
CAS :<p>Perlapine is an effective and selective HM3DQ DREADD agonist (EC50 = 2.8 nM).</p>Formule :C19H21N3Couleur et forme :SolidMasse moléculaire :291.39TMPH
CAS :<p>TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.</p>Formule :C16H31NO2Degré de pureté :99.78%Couleur et forme :SoildMasse moléculaire :269.428-Aminoadenine
CAS :<p>8-Aminoadenine (7H-purine-6,8-diamine) is a ligand for Adenine Receptor with Ki of 0.0341 μM.</p>Formule :C5H6N6Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :150.14TDI-10229
CAS :<p>TDI-10229: potent oral sAC inhibitor, IC50=195 nM. Good mouse pharmacokinetics for in vivo use.</p>Formule :C16H16ClN5Degré de pureté :99.85% - 99.89%Couleur et forme :SoildMasse moléculaire :313.78M3/PDE4 modulator-1
<p>M3/PDE4 Modulator-1 (compound 10f) serves as a bifunctional entity functioning both as an M3 mAChR antagonist and a PDE4 inhibitor.</p>Formule :C38H41Cl2N3O8SCouleur et forme :SolidMasse moléculaire :770.72(R)-Dinotefuran
CAS :<p>(R)-Dinotefuran, a neonicotinoid, is 1.7-2.4x more effective against pests like Aphis gossypii and safer for bees.</p>Formule :C7H14N4O3Couleur et forme :SolidMasse moléculaire :202.21nAChR modulator-1
CAS :<p>nAChR modulator-1, a insecticide, is a insect nAChR orthosteric modulator [1] .</p>Formule :C12H8ClN3O2Couleur et forme :SolidMasse moléculaire :261.66nAChR agonist CMPI hydrochloride
CAS :<p>CMPI hydrochloride: Potent α4:α4 nAChR PAM; EC50 0.26 μM for (α4)3(β2)2 response to ACh; may aid nicotine dependence, neuropsychiatric research.</p>Formule :C18H20Cl2N4OCouleur et forme :SolidMasse moléculaire :379.29Dicloromezotiaz
CAS :<p>Dicloromezotiaz: Potent insecticide targeting nAChRs, controls various lepidoptera.</p>Formule :C19H12Cl3N3O2SCouleur et forme :SolidMasse moléculaire :452.74Navafenterol
CAS :<p>AZD-8871, a potential COPD and asthma treatment, may work well with ICS.</p>Formule :C38H42N6O6S2Couleur et forme :SolidMasse moléculaire :742.91α-Conotoxin PIA TFA
<p>α-Conotoxin PIA TFA, targeting nicotinic acetylcholine receptor (nAChR) subtypes with α6 and α3 subunits, acts as an antagonist.</p>Formule :C81H126F3N27O27S4Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :2095.3α-Conotoxin imi
CAS :<p>alpha-Conotoxin imi is a nicotinic acetylcholine receptor ligand.</p>Formule :C52H78N20O15S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1351.56α-Bungarotoxin
CAS :<p>Neurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs).</p>Formule :C338H529N97O105S11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :7984.14Doxacurium Chloride
CAS :<p>Doxacurium Chloride is a muscarinic acetylcholine receptor M2 antagonist.</p>Formule :C56H78ClN2O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1070.69G-Protein antagonist peptide
CAS :<p>Peptide inhibits G protein-receptor binding; competitively blocks M2 and β-adrenoceptor-induced Gs/Gi/Go activation.</p>Formule :C57H64N12O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1093.27Heliosupine N-oxide
<p>Heliosupine N-oxide is a useful organic compound for research related to life sciences and the catalog number is T125058.</p>Formule :C20H31NO8Couleur et forme :SolidMasse moléculaire :413.467rac-Desethyl Oxybutynin (hydrochloride)
CAS :<p>rac-Desethyl oxybutynin, active oxybutynin metabolite, binds to mAChRs; K_i values 3.12-16 nM; lowers rat micturition pressure.</p>Formule :C20H28ClNO3Couleur et forme :SolidMasse moléculaire :365.89α-Conotoxin AuIB
CAS :<p>Selective antagonist of α3β4 nicotinic acetylcholine receptors.</p>Formule :C65H89N17O21S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1572.76
