AChR
Les inhibiteurs des récepteurs de l'acétylcholine (AChR) sont des composés qui bloquent l'activité des récepteurs de l'acétylcholine, essentiels pour la neurotransmission dans les systèmes nerveux central et périphérique. Les AChR jouent un rôle crucial dans la contraction musculaire, la mémoire et les fonctions cognitives. Les inhibiteurs des AChR sont utilisés pour étudier des conditions telles que la myasthénie grave, la maladie d'Alzheimer et d'autres troubles neurologiques. En modulant l'activité des AChR, ces inhibiteurs peuvent aider à démêler les complexités de la signalisation cholinergique dans le cerveau. Chez CymitQuimica, nous fournissons une gamme d'inhibiteurs des AChR pour soutenir vos recherches en neurosciences, pharmacologie et maladies neurodégénératives.
575 produits trouvés pour "AChR"
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Pozanicline hydrochloride
<p>Pozanicline hydrochloride is an oral α4β2 nAChR agonist with a 16.7 nM Ki, insignificantly binding to α7 nAChR.</p>Formule :C11H17ClN2ODegré de pureté :97.13% - 99.81%Couleur et forme :SolidMasse moléculaire :228.72AC1-IN-1
CAS :<p>AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM).</p>Formule :C18H18FN5O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :355.37Perlapine
CAS :<p>Perlapine is an effective and selective HM3DQ DREADD agonist (EC50 = 2.8 nM).</p>Formule :C19H21N3Couleur et forme :SolidMasse moléculaire :291.39M3/PDE4 modulator-1
<p>M3/PDE4 Modulator-1 (compound 10f) serves as a bifunctional entity functioning both as an M3 mAChR antagonist and a PDE4 inhibitor.</p>Formule :C38H41Cl2N3O8SCouleur et forme :SolidMasse moléculaire :770.72α-Conotoxin PIA TFA
<p>α-Conotoxin PIA TFA, targeting nicotinic acetylcholine receptor (nAChR) subtypes with α6 and α3 subunits, acts as an antagonist.</p>Formule :C81H126F3N27O27S4Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :2095.3nAChR agonist CMPI hydrochloride
CAS :<p>CMPI hydrochloride: Potent α4:α4 nAChR PAM; EC50 0.26 μM for (α4)3(β2)2 response to ACh; may aid nicotine dependence, neuropsychiatric research.</p>Formule :C18H20Cl2N4OCouleur et forme :SolidMasse moléculaire :379.29M 8218
CAS :<p>M 8218 is a bioactive chemical.</p>Formule :C20H29NO2Couleur et forme :SolidMasse moléculaire :315.45Mant-GTPγS
CAS :<p>Mant-GTPγS, an effective GTP analog, displays strong competitive inhibition of adenylyl cyclase (AC). Additionally, it acts as a potent inhibitor of YdeH.</p>Formule :C18H23N6O14P3SCouleur et forme :SolidMasse moléculaire :672.39Muscarinic toxin 3
CAS :<p>Muscarinic toxin 3 (MT3), a potent non-competitive antagonist of mAChR and adrenoceptors, exhibits pIC50 values of 6.71 for M1, 8.79 for M4, 8.86 for α1A, 7.57</p>Formule :C319H489N89O97S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :7379.35Navafenterol
CAS :<p>AZD-8871, a potential COPD and asthma treatment, may work well with ICS.</p>Formule :C38H42N6O6S2Couleur et forme :SolidMasse moléculaire :742.91Anabaseine
CAS :<p>Anabaseine is a broad nicotinic agonist, favoring alpha-7 AChRs in muscle/brain, and weakly stimulates alpha-4 beta-2 nAChRs.</p>Formule :C10H12N2Couleur et forme :SolidMasse moléculaire :160.22BTMPS
CAS :<p>BTMPS is a usage-dependent nicotinic antagonist capable of reducing acute withdrawal symptoms associated with morphine use.</p>Formule :C28H52N2O4Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :480.72Biperiden Hydrochloride
CAS :<p>Biperiden HCl is an anti-Parkinson's drug, blocks M1 receptors, manages all Parkinson's types, and is FDA-approved. Non-toxic at 0.11 mg/kg to rats' cognition.</p>Formule :C21H30ClNODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :347.92Anagyrine hydrochloride
CAS :<p>Anagyrine hydrochloride, a quinolizidine from Lupinus albus, targets muscarinic/nicotinic receptors; IC50: 132/2096 µM. It desensitizes nAChR directly.</p>Formule :C15H21ClN2OCouleur et forme :SolidMasse moléculaire :280.79DSPE-PEG1000-RVG29
<p>DSPE-PEG1000-RVG29 is a PEG compound composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 can specifically bind to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB) and cross the BBB.</p>Couleur et forme :Odour SolidEmraclidine
CAS :<p>Emraclidine (CVL-231) is a novel, highly selective allosteric modulator of the muscarinic M4 receptor positive receptor.Cost-effective and quality-assured.</p>Formule :C20H21F3N4ODegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :390.4TIP 39, Tuberoinfundibular Neuropeptide
CAS :<p>TIP39 is a synthetic neuropeptide agonist for human and rat PTH2 receptors from the hypothalamus.</p>Formule :C202H325N61O54SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :4504.2Destomycin A
CAS :<p>Destomycin A, an aminoglycoside antibiotic, exhibits activity against bacterial (Gram-positive and Gram-negative), antifungal, and anthelmintic agents. It inhibits peptide synthesis in Escherichia coli cells and stimulates adenylate cyclase in animal tissues.</p>Formule :C20H37N3O13Couleur et forme :SolidMasse moléculaire :527.52PDE4-IN-4
CAS :<p>PDE4-IN-4 is a compound acting as both a potent M3 antagonist (p IC 50 = 10.2) and a PDE4 inhibitor (p IC 50 = 8.8), designed for inhalation-based treatment of</p>Formule :C36H37Cl2N3O7SCouleur et forme :SolidMasse moléculaire :726.67MK-0969
CAS :<p>MK-0969 (J-104135) is a possible M3 antagonist for the treatment of chronic obstructive pulmonary disease.</p>Formule :C24H30F2N4O2Couleur et forme :SolidMasse moléculaire :444.52Fentonium bromide
CAS :<p>Fentonium bromide is a biochemical.</p>Formule :C31H34BrNO4Couleur et forme :SolidMasse moléculaire :564.51[D-Trp7,9,10]-Substance P
CAS :<p>Substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.</p>Formule :C79H105N21O13SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1588.89Small Cardioactive Peptide B (SCPB)
CAS :<p>SCPB: neurally active peptide, boosts adenylate cyclase in heart/gills, EC50s: 0.1 μM (heart), 1.0 μM (gills).</p>Formule :C52H80N14O11S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1141.41TDI-10229
CAS :<p>TDI-10229: potent oral sAC inhibitor, IC50=195 nM. Good mouse pharmacokinetics for in vivo use.</p>Formule :C16H16ClN5Degré de pureté :99.85% - 99.89%Couleur et forme :SoildMasse moléculaire :313.78DSPE-PEG5000-RVG29
<p>DSPE-PEG5000-RVG29 is a PEG compound comprised of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB) and facilitates passage through the BBB.</p>Couleur et forme :Odour SolidAceclidine (hydrochloride)
CAS :<p>agonist of muscarinic receptors</p>Formule :C9H16ClNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :205.68Ebiratide
CAS :<p>Ebiratide is an analog of ACTH 4-9.</p>Formule :C48H73N11O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :996.23R-(+)-Cotinine
CAS :<p>R-(+)-Cotinine, an inactive nicotine metabolite, boosts Ach-induced current in human α7 nAChRs.</p>Formule :C10H12N2OCouleur et forme :SolidMasse moléculaire :176.22VU6028418
CAS :<p>VU6028418 is a highly selective, potent, orally active M4mAChR antagonist that acts on hM4 (IC50: 4.1 nM).</p>Couleur et forme :SolidThiothixene
CAS :<p>Thiothixene has a wide range of applications in life science related research.</p>Formule :C23H29N3O2S2Couleur et forme :SolidMasse moléculaire :443.62Epiboxidine hydrochloride
CAS :<p>Epiboxidine HCl: potent α4β2 nAChR agonist; Ki 0.46 nM (rat), 1.2 nM (human); Epibatidine analog.</p>Formule :C10H15ClN2OCouleur et forme :SolidMasse moléculaire :214.69Dicloromezotiaz
CAS :<p>Dicloromezotiaz: Potent insecticide targeting nAChRs, controls various lepidoptera.</p>Formule :C19H12Cl3N3O2SCouleur et forme :SolidMasse moléculaire :452.74Proadrenomedullin (1-20), human
CAS :<p>Endogenous peptide; agonist of MRGPRX2 (EC50=251 nM); noncompetitive inhibitor of nicotinic receptors; reduces catecholamine secretion; antihypertensive.</p>Formule :C112H178N36O27Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2460.84(+)-Coclaurine hydrochloride
CAS :<p>(+)-Coclaurine hydrochloride, also known as (+)-(R)-Coclaurine, is a benzyltetrahydroisoquinoline alkaloid extracted from multiple plant species.</p>Formule :C17H20ClNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :321.8LtIA-F
<p>LtIA-F, a fluorescent LtIA derivative, aids study of α3β2 nAChR's structure, distribution, and binding domain.</p>Formule :C86H121N25O22S4Couleur et forme :SolidMasse moléculaire :1985.31(S)-Dinotefuran
CAS :<p>(S)-Dinotefuran, a neonicotinoid, more toxic to bees than its R-isomer, targets α8 nAChR.</p>Formule :C7H14N4O3Couleur et forme :SolidMasse moléculaire :202.21nAChR agonist 2
CAS :<p>Compound 8, identified as a selective alpha4beta2 (α4β2) neuronal acetylcholine receptor (nAChR) agonist, demonstrates a dissociation constant (Kd) of 26 nM,</p>Formule :C11H16N2Couleur et forme :SolidMasse moléculaire :176.263M4 mAChR agonist-1
CAS :<p>M4 mAChR agonist-1 (4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-) is an effective agonist of M4 mAChR (EC50 >10 μM).</p>Formule :C14H18N4OSDegré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :290.38ANQ-9040
CAS :<p>ANQ-9040 is a nondepolarizing neuromuscular relaxant of the steroid class.</p>Formule :C36H58N2O5SCouleur et forme :SolidMasse moléculaire :630.92Oxotremorine
CAS :<p>Oxotremorine acts as an agonist of mAChR, specifically activating the M1 and M3 acetylcholine receptors. In drug discrimination experiments with macaques, it exhibits effects similar to nicotine.</p>Formule :C12H18N2OCouleur et forme :SolidMasse moléculaire :206.28Br-PBTC
CAS :<p>Br-PBTC modulates nAChRs; targets α2/β2,4 subtypes; potent with 0.1-0.6 μM EC50; binds α subunit c-tail.</p>Formule :C14H15BrN2OSCouleur et forme :SolidMasse moléculaire :339.25Guanylyl Imidodiphosphate (lithium salt)
CAS :<p>Guanylyl Imidodiphosphate (lithium salt) is a non-hydrolyzable GTP analog that increases adenylate cyclase activity.</p>Formule :C10H13Li4N6O13P3Couleur et forme :SolidMasse moléculaire :545.93nAChR modulator-2
CAS :<p>nAChR modulator-2, a insecticide, is a insect nAChR orthosteric modulator [1] .</p>Formule :C12H8ClN3O2Couleur et forme :SolidMasse moléculaire :261.66Irsogladine maleate
CAS :<p>Compound PDK0375, with CAS No. 84504-69-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0375 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formule :C9H7Cl2N5Couleur et forme :SolidMasse moléculaire :256.09trans-Cevimeline hydrochloride
CAS :<p>AF 102A hydrochloride is a biochemical.</p>Formule :C10H18ClNOSCouleur et forme :SolidMasse moléculaire :235.77Albanin A
<p>Albanin A is a useful organic compound for research related to life sciences and the catalog number is T124310.</p>Formule :C20H18O6Couleur et forme :SolidMasse moléculaire :354.358Hydroxybupropion
CAS :<p>Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM).</p>Formule :C13H18ClNO2Degré de pureté :99.73%Couleur et forme :Off-White SolidMasse moléculaire :255.74nAChR modulator-1
CAS :<p>nAChR modulator-1, a insecticide, is a insect nAChR orthosteric modulator [1] .</p>Formule :C12H8ClN3O2Couleur et forme :SolidMasse moléculaire :261.66bPiDDB
CAS :<p>bPiDDB (N,N'-Dodecylbis-Picolinium Bromide) is a nicotinic receptor (nAChR) antagonist.</p>Formule :C24H38Br2N2Degré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :514.38Octamylamine
CAS :<p>Octamylamine is a bioactive chemical.</p>Formule :C13H29NCouleur et forme :SolidMasse moléculaire :199.3761
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