AChR
Les inhibiteurs des récepteurs de l'acétylcholine (AChR) sont des composés qui bloquent l'activité des récepteurs de l'acétylcholine, essentiels pour la neurotransmission dans les systèmes nerveux central et périphérique. Les AChR jouent un rôle crucial dans la contraction musculaire, la mémoire et les fonctions cognitives. Les inhibiteurs des AChR sont utilisés pour étudier des conditions telles que la myasthénie grave, la maladie d'Alzheimer et d'autres troubles neurologiques. En modulant l'activité des AChR, ces inhibiteurs peuvent aider à démêler les complexités de la signalisation cholinergique dans le cerveau. Chez CymitQuimica, nous fournissons une gamme d'inhibiteurs des AChR pour soutenir vos recherches en neurosciences, pharmacologie et maladies neurodégénératives.
642 produits trouvés pour "AChR"
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Timepidium bromide
CAS :Timepidium bromide is an agent of anticholinergic.Formule :C17H22BrNOS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.4Tiotropium Bromide hydrate
CAS :Tiotropium Bromide hydrate is a potent, long-lasting anticholinergic bronchodilator for COPD, with high affinity for muscarinic receptors M1, M2, and M3.Formule :C19H24BrNO5S2Degré de pureté :98.44% - 99.41%Couleur et forme :SolidMasse moléculaire :490.43ICL-CCIC-0019
CAS :ICL-CCIC-0019 inhibits ChoKα, causes G1 arrest, ER stress, and cancer cell apoptosis.Formule :C26H44Br2N4Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :572.46Ref: TM-T27579
2mg43,00€5mg70,00€10mg92,00€25mg132,00€50mg200,00€100mg344,00€200mg505,00€1mL*10mM (DMSO)88,00€VU0453595
CAS :VU0453595 is a M1 positive allosteric modulator (PAM).
Formule :C18H15FN4ODegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :322.34N-Demethyl MK-6884
CAS :N-Demethyl MK-6884 (compound 34) is an M4 mAChR modulator for Alzheimer's and related disease research.Formule :C24H23N5OCouleur et forme :SolidMasse moléculaire :397.47Hydroxy Varenicline
CAS :Hydroxy varenicline, a metabolite of the nicotinic acetylcholine receptor (nAChR) agonist varenicline, functions within the biochemical pathway by interacting with nAChR sites.Formule :C13H13N3OCouleur et forme :SolidMasse moléculaire :227.267VU6007477
CAS :VU6007477 is a brain-penetrant M1 muscarinic receptor PAM (EC50 230 nM) used for research on CNS exposure and seizure-related models.Formule :C24H26N6O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :430.5Tolterodine Dimer
CAS :Tolterodine Dimer is a derivative of Tolterodine -- a muscarinic receptor antagonist that is used to treat patients with overactive bladder.Formule :C35H41NO2Couleur et forme :SolidMasse moléculaire :507.713-Bromocytisine
CAS :3-Bromocytisine ((-)-3-Bromocytisine) is an effective agonist of nAChR (IC50s: 0.28, 0.30 and 31.6 nM for hα4β4, hα4β2, and hα7).Formule :C11H13BrN2ODegré de pureté :99.974%Couleur et forme :SolidMasse moléculaire :269.14Ref: TM-T10108
1mg95,00€5mg202,00€10mg293,00€25mg494,00€50mg710,00€100mg973,00€200mg1.305,00€1mL*10mM (DMSO)178,00€ASP8302
CAS :ASP8302 is an allosteric potentiator of the muscarinic M3 receptor. It enhances urination efficiency and reduces residual urine volume in two rat models of voiding dysfunction. ASP8302 is useful for investigating diseases associated with bladder dysfunction.Formule :C26H32ClN7O3S2Couleur et forme :SolidMasse moléculaire :590.16Cynandione A
CAS :Cynandione A is an acetophenone derived from Cynanchum wilfordii with anti-inflammatory activity.Formule :C16H14O6Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :302.28APS3
CAS :APS3 is an inhibitor of GABA and nACh receptors, exhibiting an LC50 value of 7.2423 μg/mL against Plutella xylostella [1].Formule :C18H7Cl2F6N5O5S2Couleur et forme :SolidMasse moléculaire :622.31UFP-512
CAS :UFP-512 is a selective delta-opioid (DOP) receptor agonist.Formule :C31H33N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :555.62A-424274
CAS :A-424274 is a positive allosteric modulator of α4β2 neuronal nicotinic receptor.Formule :C14H15N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :225.29Tematropium
CAS :Tematropium (CDDD3602) possesses anticholinergic effects and can be used in neurological studies.Formule :C21H31NO8SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :457.54Ref: TM-T10732
1mg147,00€5mg356,00€10mg558,00€25mg880,00€50mg1.179,00€100mg1.603,00€200mg2.152,00€1mL*10mM (DMSO)413,00€(-)-Cevimeline hydrochloride hemihydrate
(-)-Cevimeline HCl hemihydrate, a muscarinic agonist, treats Sjogren's xerostomia. Quick absorption, species-dependent metabolism.Formule :C10H19ClNO1·5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :244.78Dihydro-β-erythroidine
CAS :Dihydro-β-erythroidine, a competitive nicotinic receptor antagonist, effectively blocks the discriminative stimulus properties and inhibits the anxiolyticFormule :C16H21NO3Couleur et forme :SolidMasse moléculaire :275.34TDI-11861
CAS :TDI-11861 is a second-gen sAC (ADCY10) inhibitor with an IC50 of 5.5 nM and slow dissociation.Formule :C22H25ClF2N6O3Couleur et forme :SolidMasse moléculaire :494.92VU6005806
CAS :VU6005806 is a potent M4 PAM with EC50s: 94 nM (human), 28 nM (rat), 87 nM (dog), 68 nM (cyno); studied for neuropsychiatric disorders.Formule :C17H16F3N7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :439.41Dihydro-β-erythroidine hydrobromide
CAS :Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs).Formule :C16H22BrNO3Degré de pureté :98%Couleur et forme :White SolidMasse moléculaire :356.26VU6016235
CAS :VU6016235 is a structurally unique, orally available, and highly selective tricyclic M4 muscarinic acetylcholine receptor positive allosteric modulator.Formule :C21H22N4OSCouleur et forme :SolidMasse moléculaire :378.491,9-Dideoxyforskolin
CAS :The compound is an inactive analog of forskolin(an adenylyl cyclase activator).Formule :C22H34O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.5Acetylethylcholine mustard hydrochloride
CAS :Acetylethylcholine mustard hydrochloride is a choline acetyl-transferase inhibitor that decreases muscle contraction frequency by inhibiting the synthesis of acetyl-beta-methylcholine (Ach), with a half-maximal inhibitory concentration (IC50) of 1.22 mM. It serves as an irreversible ligand for the high-affinity choline transport system and functions as a specific presynaptic long-acting cholinergic toxin. Additionally, acetylethylcholine mustard hydrochloride is a precursor to the ethylcholine mustard aziridinium ion.Formule :C8H17Cl2NO2Masse moléculaire :230.132Lu 26-046
CAS :Lu 26-046 is a muscarinic receptor agonist.Formule :C10H12N2OSCouleur et forme :SolidMasse moléculaire :208.28Metoquizine
CAS :Metoquizine is an anticholinergic compound. It is a muscarinic acetylcholine receptor antagonist that has been used to treat ulcers.Formule :C22H27N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.48VU6007496
CAS :VU6007496 is a highly selective and CNS-penetrating M1 positive allosteric modulator (PAM) that exhibits good pharmacokinetics (PK).Formule :C25H27N5O2Couleur et forme :SolidMasse moléculaire :429.51TAAR1 agonist 2
CAS :TAAR1 agonist 2 (compound 30), a full agonist at trace amine-associated receptor 1 (TAAR1) (pEC50=7.5), also displays agonistic properties at H1 receptors and activates various muscarinic acetylcholine receptors, including the M2 receptor (pEC50=5). This compound is utilized in researching neuropsychiatric diseases.Formule :C9H11NOCouleur et forme :SolidMasse moléculaire :149.19(+)-Cevimeline hydrochloride hemihydrate
(+)-Cevimeline HCl hemihydrate is a muscarinic agonist for dry mouth in Sjogren's with rapid absorption, differing metabolism in species.Formule :C10H19ClNO1·5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :244.78WIN 62577
CAS :WIN 62577 is a species-selective tachykinin NK1 receptor antagonist and also serves as an allosteric enhancer with micromolar potency at M3 receptors. Additionally, WIN 62577 demonstrates potent antiviral activity against SARS-CoV-2.Formule :C29H31N3OCouleur et forme :SolidMasse moléculaire :437.576p-F-HHSiD hydrochloride
CAS :p-F-HHSiD (p-Fluorohexahydrosiladifenidol) hydrochloride is a selective M3mAChR antagonist. It is capable of inhibiting acetylcholine-mediated vasodilation in human umbilical vein endothelial cells (HUVEC).Formule :C20H33ClFNOSiMasse moléculaire :386.019YM-49598 iodide
CAS :YM-49598 iodide is a tachykinin NK-1 receptor antagonist. It inhibits drug-induced bladder contractions in rats with an IC50 of 11 μg/kg.Formule :C36H45Cl2IN2O2Couleur et forme :SolidMasse moléculaire :735.57LY593093
CAS :LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor.Formule :C32H30FN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :507.6CHF-6366
CAS :CHF-6366: M3 antagonist & β2 agonist (pKi 10.4/11.4), mild Ca channel blocker, used in COPD study.Formule :C42H48N6O8Couleur et forme :SolidMasse moléculaire :764.87(+)-Sparteine sulfate pentahydrate
(+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons.Formule :C15H38N2O9SCouleur et forme :SolidMasse moléculaire :422.54nAChR antagonist 1
CAS :Compound B15, a potent α7 nAChR antagonist, IC50 = 3.3 μM, promising for research on schizophrenia, Alzheimer's, and inflammation.Formule :C19H22N4O2Couleur et forme :SolidMasse moléculaire :338.4(S)-Albuterol
CAS :(S)-Albuterol functions as a muscarinic receptor and phospholipase C activator, enhancing the intracellular free calcium concentration in airway smooth muscle cells.Formule :C13H21NO3Couleur et forme :SolidMasse moléculaire :239.311UB 165
CAS :Subtype-selective nicotinic agonistFormule :C13H15ClN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :234.72AChE/BChE-IN-10
CAS :AChE/BChE-IN-10 inhibits AChE/BChE (IC50: 0.176/0.47 μM), crosses the blood-brain barrier, and prevents Aβ-aggregation.
Formule :C26H30N2O2Degré de pureté :99.55% - 99.88%Couleur et forme :SoildMasse moléculaire :402.53MG 624
CAS :neuronal α7 nAChR antagonistFormule :C22H30INOCouleur et forme :SolidMasse moléculaire :451.38VU6000918
CAS :VU6000918 is a positive allosteric modulator that targets the muscarinic acetylcholine receptor subtype M4. It exhibits a half maximal effective concentration (EC50) of 19 nM for the human M4 receptor.Formule :C18H17F2N5OSCouleur et forme :SolidMasse moléculaire :389.42Lupinine
CAS :Lupinine is an alkaloid capable of counteracting ethanol anesthesia. Lupinine is an AChE and BChE inhibitor and potential CD69 activator found in species of Loranthus, Calia, and Lupinus. It may also inhibit heparin.
Formule :C10H19NODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :169.26Ref: TM-FR16605
Produit arrêtéOxitropium Bromide
CAS :Oxitropium bromide, a mAChR blocker, treats asthma and COPD as an anticholinergic bronchodilator.Formule :C19H26BrNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :412.32
