Cystéine protéase
Les inhibiteurs de protéases à cystéine sont des composés qui ciblent et inhibent les protéases à cystéine, une classe d'enzymes qui décomposent les protéines en clivant les liaisons peptidiques dans lesquelles un résidu de cystéine agit comme nucléophile. Ces enzymes sont impliquées dans divers processus physiologiques, tels que l'apoptose, la réponse immunitaire et le renouvellement des protéines. Les inhibiteurs de protéases à cystéine sont essentiels pour l'étude de maladies telles que le cancer, les troubles neurodégénératifs et les infections parasitaires. Chez CymitQuimica, nous fournissons des inhibiteurs de protéases à cystéine pour soutenir vos recherches en protéolyse, régulation cellulaire et découverte de médicaments.
96 produits trouvés pour "Cystéine protéase"
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VEL-0230
CAS :<p>VEL-0230 (NC-2300) is a cathespin K inhibitor boosting bone growth and reducing loss, targeting bone diseases and developed by Velcura Therapeutics.</p>Formule :C14H24NNaO5Couleur et forme :SolidMasse moléculaire :309.33ASPER-29
CAS :<p>ASPER-29, an Asperphenamate analog, inhibits cathepsins L/S with IC50s of 6.03/5.02 μM, useful in cancer migration/invasion research.</p>Formule :C31H29BrN2O5SCouleur et forme :SolidMasse moléculaire :621.54L-873724
CAS :<p>L-873724: Selective, reversible cathepsin K inhibitor; IC50s—cat K: 0.2 nM, cat S: 178 nM, cat L: 264 nM, cat B: 5239 nM; inhibits bone resorption.</p>Formule :C23H26F3N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :481.53CAA0225
CAS :<p>CAA0225 is a selective inhibitor of cathepsin L. CAA0225 is a probe for autophagic proteolysis.</p>Formule :C28H29N3O5Couleur et forme :SolidMasse moléculaire :487.55MDL 27399
CAS :<p>MDL 27399 suppresses human neutrophil cathepsin G.</p>Formule :C26H36N4O8Couleur et forme :SolidMasse moléculaire :532.59AM 4299 B
CAS :<p>AM 4299 B is a novel inhibitor of a thiol protease.</p>Formule :C16H27N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :373.4Cysteine Protease inhibitor hydrochloride
CAS :<p>Cysteine Protease inhibitor hydrochloride is a cysteine protease inhibitor.</p>Formule :C18H15ClN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :338.79NAAA-IN-2
CAS :<p>NAAA-IN-2, a selective inhibitor with 50 nM IC50, targets NAAA, an enzyme hydrolyzing PEA/OEA, and may aid inflammation and pain studies.</p>Formule :C11H13N3O2SCouleur et forme :SolidMasse moléculaire :251.3SSAA09E1
CAS :<p>SSAA09E1 blocks SARS-CoV entry, lowers ACE2-mediated HEK293T cell infection (EC50 = 6.7 μM), and inhibits cathepsin L (IC50 = 5.33 μM).</p>Formule :C7H9N3S2Couleur et forme :SolidMasse moléculaire :199.3SQ 32602
CAS :<p>SQ 32602 is a cathepsin E inhibitor.</p>Formule :C32H52N3O7PCouleur et forme :SolidMasse moléculaire :621.74Dutacatib
CAS :<p>Dutacatib is an inhibitor of SARS-CoV-2 3CLpro and cathepsin K, offering antiviral properties and potential benefits in treating cancer-induced bone disease.</p>Formule :C23H31N7OCouleur et forme :SolidMasse moléculaire :421.54Cysteine protease inhibitor-2
CAS :<p>Cysteine protease inhibitor from US20070032499A1; halts DCT116 at 6.5μM, PC3 at 4.4μM.</p>Formule :C13H5N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :247.21Kgp-IN-1
CAS :<p>Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor.</p>Formule :C19H24F4N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.41LHVS
CAS :<p>LHVS effectively blocks T.</p>Formule :C28H37N3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.68CA 074
CAS :<p>CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates</p>Formule :C18H29N3O6Degré de pureté :97.80%Couleur et forme :SolidMasse moléculaire :383.44Cathepsin X-IN-1
CAS :<p>Cathepsin X-IN-1 (compound 25) reduces the migration of PC-3 cell with low cytotoxic that is a potent inhibitor of Cathepsin X (IC 50 = 7.13 μM) [1].</p>Formule :C15H13N3O3SDegré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :315.35JNJ-10311795
CAS :<p>JNJ-10311795 (RWJ-355871) is an inhibitor of neutrophil elastase G and mast cell chymase, demonstrating significant anti-inflammatory effects.</p>Formule :C40H35N2O6PDegré de pureté :97.43%Couleur et forme :SolidMasse moléculaire :670.69SPR38
<p>SPR38: SARS-CoV-2 protease inhibitor with Ki 0.260 μM; also blocks hCatL (Ki 1.92 μM) and hCatB (Ki 11.1 μM).</p>Formule :C24H33N3O5Couleur et forme :SolidMasse moléculaire :443.54Cathepsin K inhibitor 3
CAS :<p>Cathepsin K inhibitor 3: Selective, IC50 of 0.5 nM, good pharmacokinetics, potential for OA research.</p>Formule :C30H31FN4O4SCouleur et forme :SolidMasse moléculaire :562.65ABP 25
CAS :<p>ABP 25 is a highly potent and selective activity-based probe (ABP) for cathepsin K imaging.</p>Formule :C55H66ClN5O3Couleur et forme :SolidMasse moléculaire :880.6SQ 32056
CAS :<p>SQ 32056 is a cathepsin E inhibitor.</p>Formule :C37H56N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :636.86Cathepsin Inhibitor 2
CAS :<p>Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).</p>Formule :C19H21F6N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.38MPI8
CAS :<p>MPI8 is a SARS-CoV-2 Protease inhibitor (IC50 = 105 nM).</p>Formule :C32H48N4O7Couleur et forme :SolidMasse moléculaire :600.75Z-DEVD-CMK
CAS :<p>Z-DEVD-CMK irreversibly inhibits various cathepsins in vitro [1].</p>Formule :C27H35ClN4O12Couleur et forme :SolidMasse moléculaire :643.04Petesicatib
CAS :<p>Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.</p>Formule :C25H23F6N5O4SDegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :603.54MeOSuc-AAPV-CMK
CAS :<p>MeOSuc-AAPV-CMK (Elastase Inhibitor III) serves as an inhibitor of elastase, as well as cathepsin G and proteinase 3, and impedes leukocyte elastase-mediated</p>Formule :C22H35ClN4O7Couleur et forme :SolidMasse moléculaire :502.99Z-FG-NHO-BzOME
CAS :<p>Z-FG-NHO-BzOME is a chemical compound functioning as a cysteine protease inhibitor, selectively targeting and inhibiting cathepsin B, cathepsin L, cathepsin S,</p>Formule :C27H27N3O7Couleur et forme :SolidMasse moléculaire :505.52SID 26681509
CAS :<p>SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).</p>Formule :C27H33N5O5SDegré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :539.65MK-0674
CAS :<p>MK-0674 is a cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S for metabolism-related diseases.</p>Formule :C26H27F6N3O2Degré de pureté :97.3% - 99.91%Couleur et forme :SolidMasse moléculaire :527.5VBY-825
CAS :<p>VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.</p>Formule :C23H29F4N3O5SDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :535.55GB111-NH2
CAS :<p>GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].</p>Formule :C33H39N3O6Couleur et forme :SolidMasse moléculaire :573.68Verducatib
CAS :<p>Verducatib is an inhibitor of cathepsins (cathepsin).</p>Formule :C31H35FN4O3Couleur et forme :SolidMasse moléculaire :530.633Cathepsin K inhibitor 2
CAS :<p>Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.</p>Formule :C30H33F4N5O3Couleur et forme :SolidMasse moléculaire :587.61BI-1915
CAS :<p>BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.</p>Formule :C21H37N5O3Couleur et forme :SolidMasse moléculaire :407.55Cathepsin C-IN-3
<p>Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).</p>Formule :C28H21F3N6OSCouleur et forme :SolidMasse moléculaire :546.57RO5461111
CAS :<p>RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.</p>Formule :C27H24F6N4O4SCouleur et forme :SolidMasse moléculaire :614.56SID 26681509 quarterhydrate
<p>SID 26681509 is a selective inhibitor of cathepsin L (IC50: 56 nM) and blocks Plasmodium falciparum (IC50: 15.4 μM) and Leishmania major (IC50: 12.5 μM).</p>Formule :C27H35N5O6SCouleur et forme :SolidMasse moléculaire :544.16Dual Cathepsin L/JAK-IN-1
CAS :<p>DualCathepsinL/JAK-IN-1 (Compound A8) serves as a dual inhibitor of Cathepsin L (CTSL) and JAK, exhibiting IC50 values of 0.68 μM for CTSL and 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for JAK1/2/3 and TYK2, respectively. This compound effectively prevents the activation of MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. DualCathepsinL/JAK-IN-1 is applicable in research on acute lung injury (ALI).</p>Formule :C19H18ClN5Couleur et forme :SolidMasse moléculaire :351.833Cathepsin C-IN-5
CAS :<p>Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.</p>Formule :C21H17ClN6OSCouleur et forme :SolidMasse moléculaire :436.92Z-FY-CHO
CAS :<p>Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.</p>Formule :C26H26N2O5Degré de pureté :95.88%Couleur et forme :SolidMasse moléculaire :446.5CTSL/CAPN1-IN-2
CAS :<p>CTSL/CAPN1-IN-2 (Compound 14b) serves as an orally active inhibitor targeting both CTSL and CAPN1, manifesting IC50 values of 6.88 nM for CTSL and 347.6 nM for CAPN1 respectively. This compound not only displays anti-inflammatory attributes but also features favorable pharmacokinetic properties. Moreover, CTSL/CAPN1-IN-2 shows extensive antiviral effects against coronaviruses by inhibiting viral entry [1].</p>Formule :C34H40N4O6Couleur et forme :SolidMasse moléculaire :600.7CatD-IN-1
CAS :<p>CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.</p>Formule :C18H18Cl2N4O5Couleur et forme :SolidMasse moléculaire :441.265Cathepsin C-IN-4
<p>Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).</p>Formule :C21H14ClF3N4SCouleur et forme :SolidMasse moléculaire :446.88MIV-247
CAS :<p>MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.</p>Formule :C17H24F3N3O4Degré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :391.39PD 151746
CAS :<p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>Formule :C11H8FNO2SDegré de pureté :98.63% - ≥95%Couleur et forme :SolidMasse moléculaire :237.25ALLM
CAS :<p>ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].</p>Formule :C19H35N3O4SDegré de pureté :98%Couleur et forme :White PowderMasse moléculaire :401.56
