Cystéine protéase
Les inhibiteurs de protéases à cystéine sont des composés qui ciblent et inhibent les protéases à cystéine, une classe d'enzymes qui décomposent les protéines en clivant les liaisons peptidiques dans lesquelles un résidu de cystéine agit comme nucléophile. Ces enzymes sont impliquées dans divers processus physiologiques, tels que l'apoptose, la réponse immunitaire et le renouvellement des protéines. Les inhibiteurs de protéases à cystéine sont essentiels pour l'étude de maladies telles que le cancer, les troubles neurodégénératifs et les infections parasitaires. Chez CymitQuimica, nous fournissons des inhibiteurs de protéases à cystéine pour soutenir vos recherches en protéolyse, régulation cellulaire et découverte de médicaments.
144 produits trouvés pour "Cystéine protéase".
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SmCB1-IN-1
SmCB1-IN-1 (Compound 2h) is an inhibitor of the Schistosoma mansoni cathepsin B1 (SmCB1) with a Ki of 0.05 μM. It demonstrates selectivity towards non-target human proteases, showing inhibition rates of 29% for CatB and 37% for CatL at 20 μM. At 1 μM, SmCB1-IN-1 inhibits 68% of Schistosoma mansoni.Formule :C26H25NO6SCouleur et forme :SolidMasse moléculaire :479.14026Cathepsin D and E FRET Substrate
CAS :Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.Formule :C85H122N22O19Couleur et forme :SolidMasse moléculaire :1756.046Cathepsin C-IN-6
Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastaseFormule :C24H35N5O4·xC2HF3O2Couleur et forme :SolidLeupeptin
CAS :Leupeptin, from actinomycetes, inhibits various proteases (e.g., trypsin, plasmin, kallikrein, papain, cathepsin B) but not α-chymotrypsin/thrombin.Formule :C20H38N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.562FGA146
FGA146 is a selective inhibitor of Mpro and human Cathepsin L, with Ki values of 2.19 μM for Mal-Mpro, 0.96 μM for pET21-Mpro, and 0.87 μM for Cathepsin L. It exhibits antiviral activity against SARS-CoV-2.Formule :C24H31N5O6Masse moléculaire :485.22743N-Ethylmaleimide-D5
CAS :N-Ethylmaleimide-D5 is the deuterated form of N-Ethylmaleimide (T3088) (NEM). N-Ethylmaleimide (T3088) acts as an alkylating agent for free thiol groups and serves as an inhibitor of cysteine proteinases. It specifically inhibits phosphate transport within mitochondria. Additionally, N-Ethylmaleimide (T3088) functions as an inhibitor of deubiquitinating enzymes (deubiquitinatingenzyme).Formule :C6H7NO2Masse moléculaire :130.166,6′-Dihydroxythiobinupharidine
CAS :6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-foldFormule :C30H42N2O4SCouleur et forme :SolidMasse moléculaire :526.73Acetyl-Calpastatin (184-210)(human) acetate
Acetyl-Calpastatin acetate inhibits µ-calpain (Ki=0.2nM) and cathepsin L (Ki=6μM) selectively and reversibly.Formule :C144H234N36O46SDegré de pureté :98.16% - 99.05%Couleur et forme :SolidMasse moléculaire :3237.68Cathepsin L-IN-3 TFA
CathepsinL-IN-3 (Compound cat L inh. 7) TFA is a selective, non-covalent inhibitor of cathepsin L, with a Ki value of 4.3 nM.RO5461111
CAS :RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.Formule :C27H24F6N4O4SCouleur et forme :SolidMasse moléculaire :614.56Cathepsin D and E FRET Substrate acetate
Fluorogenic substrate for cathepsins D & E, not B/H/L; useful in their mechanistic studies.Formule :C86H124N22O21Degré de pureté :96.47%Couleur et forme :Yellow SolidMasse moléculaire :1802.04N-CBZ-Phe-Arg-AMC
CAS :Z-FR-AMC substrate for serine proteases; cathepsins, kallikrein, plasmin. Substrate: 330/390 nm; Product: 342/441 nm.Formule :C33H37ClN6O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :649.136FGA145
FGA145 is a dual inhibitor of Mpro and human Cathepsin L, with Ki values of 3.71 μM for Mal-Mpro, 9.82 μM for pET21-Mpro, and 53 nM for Cathepsin L. Additionally, FGA145 exhibits multi-target antiviral activity.Formule :C23H30N4O5Masse moléculaire :442.22162SQ 32602
CAS :SQ 32602 is a cathepsin E inhibitor.Formule :C32H52N3O7PCouleur et forme :SolidMasse moléculaire :621.74Z-Phe-Tyr(tBu)-diazomethylketone
CAS :Irreversible cathepsin L inhibitor which is ca 10'000 times more effective in inactivating cathepsin L than cathepsin S.Formule :C31H34N4O5Couleur et forme :SolidMasse moléculaire :542.636Z-L(D-Val)G-CHN2
Z-L(D-Val)G-CHN2, an isoform of Z-LVG-CHN2, serves as a cell-permeable and irreversible inhibitor of cysteine proteinase.Formule :C22H31N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.51Relacatib
CAS :Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.Formule :C27H32N4O6SCouleur et forme :SolidMasse moléculaire :540.631Z-FG-NHO-Bz
CAS :Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1].Formule :C26H25N3O6Couleur et forme :SolidMasse moléculaire :475.49SARS-CoV-2-IN-77
SARS-CoV-2-IN-77 (compound 11e) is an inhibitor of cathepsin L and cathepsin S, with Ki values of 111 nM and 103 nM, respectively. It effectively inhibits SARS-CoV-2 in Calu-3 cells with an EC50 value of 38.4 nM and does not exhibit cytotoxicity.Formule :C23H25Cl2N3O3Masse moléculaire :461.1273MPI8 TFA
MPI8 (TG0205221) TFA is an inhibitor specifically designed for SARS-CoV-2 main protease (MPro), exhibiting significant antiviral activity. Its antiviral effects are achieved through the dual and selective inhibition of both SARS-CoV-2 MPro and the host cell's cysteine protease L (cathepsin L). MPI8 TFA is applicable for clinical research related to COVID-19.
