Récepteur activé par une protéase
Les inhibiteurs des Récepteurs Activés par les Protéases (PAR) sont des composés qui ciblent et inhibent l'activité des PARs, une famille de récepteurs couplés aux protéines G qui sont activés par clivage protéolytique. Ces récepteurs jouent un rôle dans divers processus physiologiques, notamment la coagulation, l'inflammation et la réparation tissulaire. Les inhibiteurs de PAR sont des outils précieux pour étudier les mécanismes de ces processus et leur implication dans des maladies telles que le cancer, les troubles cardiovasculaires et l'inflammation chronique. Chez CymitQuimica, nous proposons des inhibiteurs de PAR pour soutenir vos recherches en transduction du signal, réponse immunitaire et découverte thérapeutique.
54 produits trouvés pour "Récepteur activé par une protéase"
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TRAP-6 amide
CAS :<p>TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide.</p>Formule :C34H57N11O8Couleur et forme :SolidMasse moléculaire :747.899PAR-4 Agonist Peptide, amide
CAS :<p>PAR-4 Agonist Peptide, amide (AY-NH2) is an agonist of proteinase-activated receptor-4 (PAR-4).</p>Formule :C34H48N8O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :680.79Thrombin Receptor Activator for Peptide 5 (TRAP-5)
CAS :<p>Thrombin Receptor Activator for Peptide 5 (TRAP-5) is also called Coagulation Factor II Receptor (1-5), used in the research of coronary heart disease (CHD).</p>Formule :C30H50N8O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :634.77PAR650097
<p>PAR650097 is a humanized monoclonal antibody targeting PAR2, used in migraine research.</p>Degré de pureté :96.67% (SEC-HPLC) - 98.83% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.5kDaPAR-4 Agonist Peptide, amide acetate
<p>PAR-4 Agonist Peptide, amide acetate is an agonist of proteinase-activated receptor-4 (PAR-4).</p>Formule :C36H52N8O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :740.86PZ-128
CAS :<p>PZ-128, a PAR1 antagonist, is used potentially for the treatment of thrombosis.</p>Formule :C55H99N13O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1086.46Parstatin(mouse)
CAS :<p>Peptide inhibits endothelial migration/proliferation (IC50 ~20μM), induces cell cycle arrest, triggers apoptosis, and has cardioprotective effects.</p>Formule :C189H326N58O57S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4419.19AC-264613
CAS :<p>AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5.</p>Formule :C19H18BrN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.28Parstatin(human)
CAS :<p>Cell-permeable PAR1-derived peptide; inhibits endothelial migration, proliferation (IC50 ~3μM), induces apoptosis, and has cardioprotective effects.</p>Formule :C191H330N64O53S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4467.292-Furoyl-LIGRLO-amide
CAS :<p>2-Furoyl-LIGRLO-amide TFA is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.</p>Formule :C36H63N11O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :777.95Parstatin(human) TFA
<p>Parstatin(human) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, effectively inhibits angiogenesis, as indicated by studies [1] [2].</p>Formule :C193H331F3N64O55S3Couleur et forme :SolidMasse moléculaire :4581.28RAG8 peptide
<p>RAG8 peptide is an antagonist of protease-activated receptor 4 (PAR 4), which inhibits late-stage platelet activation and reduces thrombosis without altering hemostasis or increasing bleeding risk. It is applicable in atherosclerosis research.</p>Formule :C56H98N16O11Masse moléculaire :1170.7601tcY-NH2
CAS :<p>Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.</p>Formule :C40H49N7O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :739.87FSLLRY-NH2
CAS :<p>PAR2 antagonist; counters taxol effects, PKC in mice; inhibits ERK, collagen in fibroblasts; lessens dermatophyte itch in mice.</p>Formule :C39H60N10O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :796.97Protease-Activated Receptor-1, PAR-1 Agonist TFA
<p>PAR-1 Agonist TFA: Selective peptide, mimics thrombin, activates PAR-1 receptor.</p>Couleur et forme :LiquidAY 254
CAS :<p>AY 254: Potent PAR2 agonist, ERK1/2 activation (EC50=2 nM), limits caspase 3/8, aids HT29 cell healing, boosts IL-8.</p>Formule :C30H49N9O6Couleur et forme :SolidMasse moléculaire :631.779Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2
CAS :<p>Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biologically active peptide functioning as a selective agonist for Protease Activated Receptor 1 (PAR-1), a subtype</p>Formule :C42H63FN12O8Couleur et forme :SolidMasse moléculaire :883.02PAR-2 (1-6) (human)
CAS :<p>PAR-2 (1-6) (human) (SLIGKV), a peptide ligand, is a PAR-2 agonist [1] .</p>Formule :C28H53N7O8Couleur et forme :SolidMasse moléculaire :615.76SFNGGP-NH2
CAS :<p>SFNGGP-NH2 is a biologically active peptide that interacts with Protease-Activated Receptor 3 (PAR-3), a high-affinity thrombin receptor.</p>Formule :C25H36N8O8Couleur et forme :SolidMasse moléculaire :576.6Protease-Activated Receptor-1, PAR-1 Agonist
CAS :<p>Selective peptide agonist that mimics thrombin to activate PAR-1 receptor, enabling targeted receptor activation.</p>Formule :C35H58N10O9Couleur et forme :SolidMasse moléculaire :762.91FLLRN
CAS :<p>FLLRN is a biologically active peptide serving as a PAR1-specific antagonist.</p>Formule :C31H51N9O7Couleur et forme :SolidMasse moléculaire :661.79YFLLRNP
CAS :<p>YFLLRNP is a biologically active peptide functioning as a partial agonist of PAR-1, selectively activating the G12/13 signaling pathway.</p>Formule :C45H67N11O10Couleur et forme :SolidMasse moléculaire :922.08TRAP-5 amide
CAS :<p>TRAP-5 amide is a peptide agonist for protease-activated receptor 1 (PAR 1) [1].</p>Formule :C30H51N9O6Couleur et forme :SolidMasse moléculaire :633.78PAR 4 (1-6) (TFA)
<p>PAR 4 (1-6) TFA (GYPGQV TFA), a hexapeptide derived from protease-activated receptor 4 (PAR 4), serves as a specific agonist for PAR 4.</p>Formule :C28H41N7O9·xC2HF3O2Couleur et forme :SolidP4pal10 TFA
<p>P4pal10 TFA, the TFA salt form of P4pal10, serves as an antagonist of the protease-activated receptor 4 (PAR4). This compound inhibits platelet aggregation and thrombin generation induced by tissue factor (TF), exhibiting anticoagulant and antithrombotic activities. Additionally, P4pal10 TFA alleviates carrageenan-induced edema and neutrophil infiltration, and ameliorates damage in rat myocardial ischemia/reperfusion (I/R) models.</p>Couleur et forme :Odour SolidTRAP-6 amide TFA
CAS :<p>TRAP-6 amide TFA is a PAR-1 thrombin receptor agonist peptide.</p>Formule :C36H58F3N11O10Couleur et forme :SolidMasse moléculaire :861.922TFLLR-NH2(TFA)
CAS :<p>TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM. EC50: 1.9 μM (PAR1)</p>Formule :C33H54F3N9O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :761.83SLIGRL-NH2
CAS :<p>SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is a PAR-2 agonist that induces non-histaminergic pruritus.</p>Formule :C29H56N10O7Degré de pureté :98.29%Couleur et forme :SolidMasse moléculaire :656.82Protease-Activated Receptor-2, amide
CAS :<p>Protease-Activated Receptor-2, amide (SLIGKV-NH2) is an agonist of PAR2 (IC50 : 10.4 M)</p>Formule :C28H54N8O7Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :614.78PAR-2-IN-1
CAS :<p>PAR-2-IN-1 (IUN76750) is a PAR- 2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.</p>Formule :C12H14ClN3O2Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :267.71Vorapaxar
CAS :<p>Vorapaxar (MK-5348) (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).</p>Formule :C29H33FN2O4Degré de pureté :98.77% - 99.93%Couleur et forme :SolidMasse moléculaire :492.58Vorapaxar sulfate
CAS :<p>Vorapaxar sulfate (Zontivity) is a potent and orally active thrombin receptor (PAR-1) antagonist.</p>Formule :C29H35FN2O8SDegré de pureté :99.9% - >99.99%Couleur et forme :SolidMasse moléculaire :590.66I-191
CAS :<p>I-191 is a potent antagonist of protease-activated receptor 2 (PAR2), inhibits multiple signaling functions in human cancer cells.</p>Formule :C23H26FN5O2Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :423.48TRAP-6
CAS :<p>TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1).</p>Formule :C34H56N10O9Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :748.87PAR-4 Agonist Peptide, amide TFA
CAS :<p>PAR-4 agonist peptide doesn't affect PAR-1/PAR-2; blocked by PAR-4 antagonist.</p>Formule :C36H49F3N8O9Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :794.82Protease-Activated Receptor-1, PAR-1 Agonist acetate
<p>PAR-1 Agonist acetate is a selective PAR-1 agonist that mimics thrombin action.</p>Formule :C37H62N10O11Degré de pureté :98.1800%Couleur et forme :SolidMasse moléculaire :822.95PAR-2 Activating Peptide acetate
<p>PAR-2 Activating Peptide acetate (SLIGRL-NH2 acetate) is an agonist of Protease-Activated Receptor-2 (PAR-2).</p>Formule :C31H60N10O9Degré de pureté :98.5% - 99.92%Couleur et forme :SolidMasse moléculaire :716.88AC-55541
CAS :<p>AC-55541 (AOB2796), a PAR2 agonist, activates PAR2 in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays.</p>Formule :C25H20BrN5O3Degré de pureté :98% - 99.33%Couleur et forme :SolidMasse moléculaire :518.36VKGILS-NH2 Acetate
<p>VKGILS-NH2 Acetate is a reversed amino acid sequence control peptide for SLIGKV-NH2, a protease-activated receptor 2 (PAR2) agonist.</p>Formule :C30H58N8O9Degré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :674.83LRGILS-NH2 acetate
<p>LRGILS-NH2 acetate is a PAR-2-inactive reversed peptide.</p>Formule :C29H56N10O7Degré de pureté :96.65%Couleur et forme :SolidMasse moléculaire :656.82FSLLRY-NH2 TFA(245329-02-6 free base)
<p>FSLLRY-NH2 TFA inhibits PAR2, reverses taxol-induced pain, and reduces itch in mice; blocks ERK and collagen in fibroblasts.</p>Formule :C41H61F3N10O10Degré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :910.99tcY-NH2 TFA(327177-34-4 free base)
<p>tcY-NH2 TFA is a selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.</p>Formule :C42H50F3N7O9Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :853.9Thrombin Receptor Activator for Peptide
<p>Thrombin Receptor Activator (TRAP) or Coagulation Factor II (1-5), used in CHD research.</p>Formule :C32H51F3N8O9Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :748.79Parmodulin 2
CAS :<p>ML161 (Parmodulin 2) inhibits PAR1, blocking platelet activation and thrombin-induced activity (IC50: 0.26μM).</p>Formule :C17H17BrN2O2Degré de pureté :97.35% - 99.95%Couleur et forme :SolidMasse moléculaire :361.23AZ3451
CAS :<p>AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).</p>Formule :C30H27BrN4O3Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :571.46Protease-Activated Receptor-4 diTFA
<p>Protease-Activated Receptor-4 diTFA,2454 is the proteinase-activated receptor-4 (PAR4)agonist</p>Formule :C37H48F6N8O11Degré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :894.812-Furoyl-LIGRLO-amide TFA(729589-58-6 free base)
<p>2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base) is a potent and selective protease-activated receptor 2 (PAR2) agonist.</p>Formule :C38H64F3N11O10Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :891.98ML-354
CAS :<p>ML354 is a selective antagonist of PAR4 with an IC 50 of 140 nM [1].</p>Formule :C16H14N2O3Degré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :282.29iso-TRAP-6
CAS :<p>iso-TRAP-6 (iso-SFLLRN), a hexapeptide made from isoserine instead of serine, is a PAR1 agonist that activates platelets via PAR-1.</p>Formule :C34H56N10O9Degré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :748.87PAR4 antagonist 3
CAS :<p>PAR4 antagonist3 (Compound 36) is a selective antagonist of protease-activated receptor 4 (PAR4). It exhibits antiplatelet activity with an IC50 of 26.1 nM and enhances metabolic stability in human liver microsomes, with a half-life (T1/2) of 97.6 minutes.</p>Formule :C22H16FN3O5SMasse moléculaire :453.44PAR-2-IN-2
CAS :<p>PAR-2-IN-2 (compound P-596) is an inhibitor of protease-activated receptor 2 (PAR-2), with an IC50 of 10.79 μM for SLIGKV and an IC50 greater than 200 μM for trypsin.</p>Formule :C25H20F3N5O2Couleur et forme :SolidMasse moléculaire :479.454BMS-986141
CAS :<p>BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614</p>Formule :C27H23N5O5S2Degré de pureté :98.43% - 99.26%Couleur et forme :SolidMasse moléculaire :561.63Protease-Activated Receptor-4
CAS :<p>Protease-Activated Receptor-4 (PAR4) is a proteinase-activated receptor-4 agonist used in antiplatelet therapy.</p>Formule :C33H46N8O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :666.77TFLLR-NH2 2TFA(197794-83-5(free base))
<p>TFLLR-NH2 2TFA(197794-83-5(free base)) is an agonist of PAR1 (EC50 :1.9 μM).</p>Formule :C35H55F6N9O10Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :875.87
