Glutaminase
Les inhibiteurs de la glutaminase sont des composés qui inhibent la glutaminase, une enzyme qui catalyse la conversion de la glutamine en glutamate, une étape cruciale dans le métabolisme cellulaire, en particulier dans les cellules cancéreuses. La glutaminase joue un rôle clé dans l'apport d'énergie et de précurseurs biosynthétiques pour les cellules en prolifération rapide. Les inhibiteurs de la glutaminase sont essentiels pour explorer les dépendances métaboliques des cellules cancéreuses et développer des stratégies thérapeutiques potentielles. Chez CymitQuimica, nous fournissons des inhibiteurs de la glutaminase pour soutenir vos recherches en métabolisme du cancer, bioénergétique cellulaire et découverte thérapeutique.
43 produits trouvés pour "Glutaminase"
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LDN-27219
CAS :LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.Formule :C20H16N4O2S2Degré de pureté :99.01% - 99.38%Couleur et forme :SolidMasse moléculaire :408.5BJJF078
CAS :BJJF078, an aminopiperidine, inhibits human/mouse TG2 (IC50: 41/54 nM) and TG1 (IC50: 0.16 μM), may be used in MS studies.Formule :C27H29N3O6SDegré de pureté :99.56%Couleur et forme :SoildMasse moléculaire :523.6PROTAC TG2 degrader-2
PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2), exhibiting a dissociation constant (Kd) greater than 100 μM.Formule :C47H57N9O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :876.08GLS1 Inhibitor-7
GLS1 Inhibitor-7 (compound 4d) serves as a GLS1 antagonist with an IC50 value of 46.7 μM, demonstrating potential applications in anticancer, antiaging, andFormule :C20H17F3N4O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :482.5LM11
<p>LM11 is a transglutaminase 2 (TG2) inhibitor that exhibits activity against glioblastoma cells by maintaining TG2 in a cytotoxic conformational state.</p>Formule :C26H18Cl2N4O5Masse moléculaire :536.065436-Diazo-5-oxo-L-nor-Leucine
CAS :6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is an antagonist of glutaminases (Ki : 6 μM).Formule :C6H9N3O3Degré de pureté :98.04% - 98.93%Couleur et forme :SolidMasse moléculaire :171.15PROTAC TG2 degrader-1
PROTAC TG2 Degrader-1 (Compound 11) is a VHL-based PROTAC that targets tissue transglutaminase (TG2) and exhibits a binding affinity with a K D of 68.9 μM.Formule :C55H73N9O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1052.29Glutaminase C-IN-2
<p>Glutaminase C-IN-2 (compound 11), an allosteric inhibitor of glutaminase C (GAC), exhibits potent inhibitory activity with an IC50 of 10.64 nM.</p>Formule :C24H23N7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.55HB-2-30
CAS :HB-2-30 is a far-red fluorescent transglutaminase 2 (TG2) probe for in vitro and in vivo endocytosis imaging. HB-2-30 complexes with TG2 and α2-macroglobulin for efficient endocytosis via the LRP1 pathway.Formule :C66H86N10O14S2Masse moléculaire :1307.58Trivalent hydroxyarsinothricn
Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible inhibitor of kidney-type glutaminase (KGA). It binds to the glutamine binding site and forms a covalent bond with the cysteine residue at the active site. This compound selectively kills triple-negative breast cancer (TNBC) cells without being cytotoxic to control cell lines. KGA is an enzyme that regulates glutamine metabolism and is associated with tumor malignancy.Formule :C4H10AsNO4Masse moléculaire :210.98258L-Methionine-DL-sulfoximine
CAS :MSO blocks glutamine synthetase, impacts astroglia, and is used in convulsant research.Formule :C5H12N2O3SDegré de pureté :99.56% - ≥98%Couleur et forme :White Crystalline PowderMasse moléculaire :180.23Glutaminase-IN-1
CAS :Glutaminase-IN-1 (CB839 derivative), a glutaminase (KGA) inhibitor, has antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.Formule :C26H24F3N7O3SeDegré de pureté :98.65% - 98.65%Couleur et forme :SolidMasse moléculaire :618.47Glutaminase-IN-3
CAS :<p>Glutaminase-IN-3 is a potent Glutaminase 1 inhibitor with potential antitumor activity and inhibits GLS1 for cancer research.</p>Formule :C19H19F3N6O2SDegré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :452.45Telaglenastat
CAS :Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.Formule :C26H24F3N7O3SDegré de pureté :97.57% - 99.89%Couleur et forme :SolidMasse moléculaire :571.57L-Albizziin
CAS :L-Albizziin (L-beta-Ureidoalanine) is a glutamase inhibitor and is a glutaminyl-tRNA synthetase inhibitor.Formule :C4H9N3O3Degré de pureté :99.98%Couleur et forme :White PowderMasse moléculaire :147.13Glutaminase C-IN-1
CAS :Glutaminase C-IN-1 (Compound 968) is a Glutaminase C allosteric inhibitor.Formule :C27H27BrN2ODegré de pureté :99.68% - >99.99%Couleur et forme :SolidMasse moléculaire :475.42GK921
CAS :GK921 is a transglutaminase 2 (TGase) inhibitor.Formule :C21H20N4ODegré de pureté :97.44% - 99.49%Couleur et forme :SolidMasse moléculaire :344.41BPTES
CAS :<p>BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.</p>Formule :C24H24N6O2S3Degré de pureté :95.83% - 99.64%Couleur et forme :SolidMasse moléculaire :524.68Zampilimab
CAS :<p>Zampilimab (UCB-7858) is a humanised monoclonal antibody targeting TGM2, inhibits the cross-linking transamidase activity of TG2, renal fibrosis.</p>Degré de pureté :95%Couleur et forme :LiquidIrbesartan-d4
CAS :Irbesartan-d4 (Irbesartan D4), a deuterated compound of Irbesartan, is an angiotensin receptor blocker and is used in the study of cardiovascular disease.Formule :C25H28N6ODegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :432.55Duazomycin
CAS :Duazomycin, an antitumor substance and glutamine antagonist, is used as a chemotherapeutic agent.Formule :C8H11N3O4Couleur et forme :SolidMasse moléculaire :213.19JHU-083
CAS :JHU-083 is a glutaminase antagonist that improves cognition and normalizes aberrant hippocampal glutaminase activity in APOE4 mice.Formule :C14H24N4O4Degré de pureté :97.89% - 99.53%Couleur et forme :SolidMasse moléculaire :312.37GLS1 Inhibitor
CAS :GLS1 inhibitor blocks glutaminase 1 (IC50=0.021 μM), hinders NCI H1703 NSCLC cell growth in vitro (GI50=0.011 μM), and suppresses tumors in mice.Formule :C19H21N7O2SCouleur et forme :SolidMasse moléculaire :411.48NC9 TG2 inhibitor
CAS :NC9 is an irreversible inhibitor of transglutaminase 2 (TG2) and also inhibits Factor XIIIA (FXIIIA).Formule :C35H47N5O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :697.84AA9 TG2 inhibitor
CAS :<p>AA9 is a novel transglutaminase (TG2) inhibitor.</p>Formule :C32H36N4O5Couleur et forme :SolidMasse moléculaire :556.65AA10 TG2 inhibitor
CAS :<p>AA10 is an irreversible inhibitor of transglutaminase 2 (TG2).</p>Formule :C32H36N4O5Couleur et forme :SolidMasse moléculaire :556.65GLS1 Inhibitor-3
CAS :GLS1 Inhibitor-3 (compound C147) is a potent inhibitor of GLS1 (IC50: 27.98 nM) and exhibits anti-proliferative effects.Formule :C30H32N10O2SCouleur et forme :SolidMasse moléculaire :596.71VA4 TG2 inhibitor
CAS :VA4 is a novel irreversible TG2 transamidase site-specific inhibitor.Formule :C33H41N5O6SCouleur et forme :SolidMasse moléculaire :635.77α-Glucosidase-IN-5
CAS :α-Glucosidase-IN-5 (compound 8) is isolated from a twig extract of Polyalthia cinnamomea which is a potent α-glucosidase inhibitor with an IC50 of 57.9 µM.Formule :C15H13NO3Couleur et forme :SolidMasse moléculaire :255.27Glutaminase-IN-4
CAS :<p>Glutaminase-IN-4 (compound 2a) is a glutaminase (GLS) inhibitor (IC50: 2.3 μM).</p>Formule :C23H22N6O2S2Couleur et forme :SolidMasse moléculaire :478.59CP4d inhibitor
CAS :CP4d is a novel reversible tg2 transamidase site-specific inhibitorFormule :C18H13N5O5Couleur et forme :SolidMasse moléculaire :379.33THDP-17
CAS :THDP-17 is a inhibitor of glutaminase. THDP-17 shows a partial uncompetitive inhibition in vitro.Formule :C12H16N2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :220.33UPGL00004
CAS :<p>UPGL00004: potent GAC inhibitor, IC50=29 nM, Kd=27 nM, suppresses triple-negative breast cancer cell growth.</p>Formule :C25H26N8O2S2Degré de pureté :97.93%Couleur et forme :SolidMasse moléculaire :534.66IPN60090
CAS :IPN60090: potent oral GLS1 inhibitor, IC50 of 31 nM, potential for anticancer and immunomodulation.Formule :C24H27F3N8O3Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :532.52Sirpiglenastat
CAS :<p>Sirpiglenastat (DRP-104) is a glutamine antagonist, a prodrug of DON, with antitumor activity that acts by suppressing the adaptive immune system.</p>Formule :C22H27N5O5Degré de pureté :98.01% - 98.37%Couleur et forme :SolidMasse moléculaire :441.48TG2-IN-3h
CAS :TG2-IN-3h is a highly selective, potent, cell-permeable fluorescent irreversible tissue transglutaminase (tg2) inhibitorFormule :C21H26N4O4SDegré de pureté :99.34% - 99.76%Couleur et forme :SolidMasse moléculaire :430.52TG-2-IN-1
CAS :TG-2-IN-1 (Compound D003) is a transglutaminase-2 ( TGM-2 ) inhibitor. TG-2-IN-1 can be used in myopia research[1].Formule :C8H13ClN2OSDegré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :220.72KCC009
CAS :KCC009 is a potent and selective Transglutaminase 2 Inhibitor.Formule :C21H22BrN3O5Couleur et forme :SolidMasse moléculaire :476.32ZED-1227
CAS :<p>ZED-1227 (TAK-227) is a TG2 inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Diseas</p>Formule :C26H36N6O6Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :528.6TGase2-IN-1
CAS :TGase2-IN-1 (Compound 22) is an orally effective TGase2 inhibitor with an IC50 of 1.12 µM. It inhibits TGase2 in human retinal microvascular endothelial cells with a strikingly lower IC50 of 0.07 µM. The oral bioavailability of TGase2-IN-1 is 74.6%. Additionally, it can suppress retinal vascular leakage in a mouse model of diabetes induced by Streptozotocin.Formule :C23H25N3O3Couleur et forme :SolidMasse moléculaire :391.46TG-2-IN-4
CAS :TG-2-IN-4 (compound 8), an inhibitor of transglutaminase 2 (TG2) with an IC 50 value of less than 0.5 mM, is utilized in the study of inflammatory disorders [1].Formule :C34H40N6O5Couleur et forme :SolidMasse moléculaire :612.72GLS-1-IN-1
<p>GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.</p>Formule :C26H25FN4OSCouleur et forme :SolidMasse moléculaire :460.57IPN60090 dihydrochloride
CAS :IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.Formule :C24H29Cl2F3N8O3Couleur et forme :SolidMasse moléculaire :605.44
