Cellules souche et Dérivés
Les inhibiteurs de cellules souches sont des composés qui ciblent spécifiquement les voies de signalisation et les protéines impliquées dans le maintien, la différenciation et la prolifération des cellules souches. Ces inhibiteurs sont cruciaux pour comprendre la biologie des cellules souches et pour développer des stratégies visant à manipuler les cellules souches à des fins thérapeutiques, telles que la médecine régénérative et le traitement du cancer. En contrôlant le destin des cellules souches, ces inhibiteurs peuvent aider à orienter la différenciation des cellules souches en types cellulaires spécifiques ou à prévenir une croissance cellulaire indésirable. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de cellules souches de haute qualité pour soutenir vos recherches en biologie des cellules souches, biologie du développement et médecine régénérative.
Sous-catégories appartenant à la catégorie "Cellules souche et Dérivés"
- Gamma-sécrétase(59 produits)
- Hérisson/Smoothened(44 produits)
- Voie de signalisation Hippo(6 produits)
- JAK(245 produits)
- Porc-épic(9 produits)
- ROCK(70 produits)
- STAT(98 produits)
- Cellules souches(486 produits)
- TGF-beta/Smad(58 produits)
- Wnt/beta-caténine(66 produits)
Affichez 2 plus de sous-catégories
695 produits trouvés pour "Cellules souche et Dérivés"
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NMS-P715
CAS :<p>NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).</p>Formule :C35H39F3N8O3Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :676.73IK-930
CAS :<p>IK-930 is an orally active TEAD inhibitor (EC50 < 0.1 µM) with potent potency.</p>Formule :C19H19F3N4O2SDegré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :424.44Ilginatinib maleate
CAS :<p>Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.</p>Formule :C25H24FN7O4Degré de pureté :99.74% - 99.82%Couleur et forme :SolidMasse moléculaire :505.5Sonidegib diphosphate
CAS :<p>Sonidegib diphosphate (LDE225 diphosphate) is a selective antagonist of Smo that inhibits murine Smo and human Smo.Cost-effective and quality-assured.</p>Formule :C26H32F3N3O11P2Degré de pureté :99.48% - >99.99%Couleur et forme :SolidMasse moléculaire :681.49Garetosmab
CAS :<p>Garetosmab (REGN 2477), a human IgG4 monoclonal antibody, inhibits activin A for potential cancer treatment and FOP study.</p>Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :146 kDaBRD0705
CAS :<p>BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.</p>Formule :C20H23N3ODegré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :321.42CB-103
CAS :<p>CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.</p>Formule :C15H18N2ODegré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :242.32Demcizumab
CAS :<p>Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo or with chemo.</p>Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :145.34 kDaRovalpituzumab
CAS :<p>Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.</p>Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :145.02 kDaN-(3-Aminopropyl)cyclohexylamine
CAS :<p>N-(3-Aminopropyl)cyclohexylamine inhibits spermine synthase; used in neuro disease research.</p>Formule :C9H20N2Degré de pureté :98.05% - 98.82%Couleur et forme :Pale Yellow Clear LiquidMasse moléculaire :156.2685Netarsudil Dihydrochloride
CAS :<p>Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-related protein kinase (ROCK) and norepinephrine transporter (NET) and is effective in reducing intraocular pressure (IOP).Cost-effective and quality-assured.</p>Formule :C28H29Cl2N3O3Degré de pureté :99.94% - 99.98%Couleur et forme :SolidMasse moléculaire :526.45MRT-83
CAS :<p>MRT-83 is a potent Smo antagonist.</p>Formule :C31H30N4O5Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :538.59ROCK inhibitor-2
CAS :<p>ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).</p>Formule :C21H20N2O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :332.4JW74
CAS :<p>JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).</p>Formule :C24H20N6O2SDegré de pureté :95.00%Couleur et forme :SolidMasse moléculaire :456.52GSK-3 inhibitor 4
CAS :<p>Orally active GSK-3 inhibitor 4 targets GSK-3α/β, CDK2/5 (IC50: 0.45-0.68 μM) and may aid in Alzheimer's research by lowering Tau protein.</p>Formule :C22H15F2N5ODegré de pureté :99.41%Couleur et forme :SoildMasse moléculaire :403.38Nimucitinib
CAS :<p>Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.</p>Formule :C25H26F2N6O2Degré de pureté :98.71%Couleur et forme :SoildMasse moléculaire :480.51NGP555
CAS :<p>NGP555 is a modulator of γ-secretase.</p>Formule :C23H23FN4SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :406.52Delgocitinib
CAS :<p>Delgocitinib is a potent JAK inhibitor (IC50: 2.8-58 nM), treats inflammatory diseases, and is the first topical drug for atopic dermatitis.</p>Formule :C16H18N6ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :310.35TAK-901
CAS :<p>TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others</p>Formule :C28H32N4O3SDegré de pureté :99.02% - 99.59%Couleur et forme :SolidMasse moléculaire :504.64CWP232228
CAS :<p>CWP232228 is a selective Wnt/β-catenin pathway inhibitor targeting β-catenin/TCF binding, halting breast/liver CSC growth and metastasis safely.</p>Formule :C33H34N7Na2O7PDegré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :717.63Brepocitinib P-Tosylate
CAS :<p>Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).</p>Formule :C25H29F2N7O4SDegré de pureté :99.82% - 99.97%Couleur et forme :SolidMasse moléculaire :561.6BML-286
CAS :<p>BML-286 is a WNT pathway modulator with potential anticancer activity and induces β-catenin- and TCF- dependent transcriptional activity.</p>Formule :C22H18N2O4Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :374.39WDR5-IN-6
CAS :<p>WDR5-IN-6 is a WDR5 inhibitor targeting the WBM locus.WDR5-IN-6 is highly synergistic with OICR-9429, a WDR5 inhibitor that targets the WIN locus.WDR5-IN-6</p>Formule :C13H8Cl2N2O2SDegré de pureté :99.69%Couleur et forme :SoildMasse moléculaire :327.19Gusacitinib
CAS :<p>Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).</p>Formule :C24H28N8O2Degré de pureté :98.06% - 99.94%Couleur et forme :SolidMasse moléculaire :460.53Golidocitinib
CAS :<p>Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).</p>Formule :C25H31N9O2Degré de pureté :98.87% - 99.88%Couleur et forme :SolidMasse moléculaire :489.57CCT251545
CAS :<p>CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).</p>Formule :C23H24ClN5ODegré de pureté :98.2% - 98.69%Couleur et forme :SolidMasse moléculaire :421.92Ilginatinib hydrochloride
CAS :<p>Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.</p>Formule :C21H21ClFN7Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :425.89TNIK-IN-5
CAS :<p>TNIK-IN-5: strong TNIK inhibitor (IC50=0.05μM), halts Wnt signaling, effective against colorectal cancer in vitro.</p>Formule :C22H17N3O3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :371.39KY1220
CAS :<p>KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.</p>Formule :C14H10N4O3SDegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :314.32E 2012
CAS :<p>E2012 is a γ-secretase modulator (GSM).</p>Formule :C25H26FN3O2Degré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :419.49Silmitasertib sodium salt
CAS :<p>Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).</p>Formule :C19H11ClN3NaO2Degré de pureté :99.49% - 99.62%Couleur et forme :SolidMasse moléculaire :371.75Ilginatinib
CAS :<p>Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.</p>Formule :C21H20FN7Degré de pureté :98.4% - 99.01%Couleur et forme :SolidMasse moléculaire :389.43Cyanoacetohydrazide
CAS :<p>Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.</p>Formule :C3H5N3ODegré de pureté :99.78%Couleur et forme :Stout Prisms From Alcohol Slightly Brown PowderMasse moléculaire :99.09JAK2 Inhibitor V
CAS :<p>JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.</p>Formule :C23H24N2ODegré de pureté :98.36% - 99.15%Couleur et forme :SolidMasse moléculaire :344.45Brontictuzumab
CAS :<p>Brontictuzumab (OMP 52M5) is an anti-Notch1 monoclonal antibody with antitumor activity that inhibits tumor cell proliferation.</p>Degré de pureté :98.1% (SDS-PAGE); 97.6% (SEC-HPLC) - 98.1% (SDS-PAGE); 97.6% (SEC-HPLC)Couleur et forme :LiquidNefopam hydrochloride
CAS :<p>Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.</p>Formule :C17H20ClNODegré de pureté :99.32% - 99.85%Couleur et forme :SolidMasse moléculaire :289.8Ponsegromab
CAS :<p>Ponsegromab (PF 06946860), a humanized anti-GDF15 antibody, may treat cancer cachexia by blocking GDF15/GFRAL signaling.</p>Degré de pureté :100% (SEC-HPLC) - > 95%Couleur et forme :LiquidMasse moléculaire :146.08 kDaSuper-TDU (1-31) (TFA)
<p>Super-TDU (1-31) TFA, a peptide, inhibits YAP-TEAD; it has strong anti-tumor effects in gastric cancer models.</p>Formule :C141H218N40O48·C2HF3O2Couleur et forme :SolidMasse moléculaire :3355.5PSEN1-IN-1
<p>PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50</p>Formule :C20H19ClF3NO3SCouleur et forme :SolidMasse moléculaire :445.88GSK3-IN-4
CAS :<p>GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay.</p>Formule :C18H20N4ODegré de pureté :98.33%Couleur et forme :SoildMasse moléculaire :308.38JAK-2/3-IN-1
CAS :<p>JAK-2/3-IN-1 inhibits JAK-2/3 isoforms with sub-250 nM Ki; from US patent US8163732B2.</p>Formule :C20H12ClN3OCouleur et forme :SolidMasse moléculaire :345.79HAT-SIL-TG-1&AT
<p>HAT-SIL-TG-1&AT: a hypoxia-activated JAK inhibitor that curbs HEL cell growth & STAT3/5 phosphorylation in tumors.</p>Formule :C60H69N17O11SCouleur et forme :SolidMasse moléculaire :1236.36SPL-707
CAS :<p>SPL-707 is an effective and selective signal peptide peptidase-like 2a inhibitor (IC50: 80 nM).</p>Formule :C27H28FN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.54Tubastatin
CAS :<p>Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.</p>Formule :C21H22N2O2Degré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :334.41Navicixizumab
CAS :<p>Navicixizumab, a bispecific VEGF/DLL4 inhibitor, pairs with Paclitaxel in ovarian and other cancer research.</p>Couleur et forme :LiquidTGFβRI-IN-7
<p>TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.</p>Formule :C27H32N6O2Couleur et forme :SolidMasse moléculaire :472.582STX-0119
CAS :<p>STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.</p>Formule :C22H14N4O3Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :382.37PROTAC TYK2 degradation agent1
CAS :<p>PROTAC TYK2 Agent1 selectively degrades TYK2, with a 14 nM DC50, for autoimmune research.</p>Formule :C55H69N13O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1056.28LH168
<p>LH168 is a potent and selective probe for WDR5, with a SPR Kd value of 13 nM.</p>Formule :C29H31F3N6O2SCouleur et forme :SolidMasse moléculaire :584.66Lerdelimumab
CAS :<p>Lerdelimumab (CAT-152) is an IgG4 monoclonal antibody targeting TGF-β2, used in glaucoma scarring research.</p>Couleur et forme :LiquidLX-7101 hydrochloride
CAS :<p>LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.</p>Formule :C23H29N7O3xHClDegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :487.99ABC99
CAS :<p>ABC99 irreversibly inhibits wnt-deacylating enzyme NOTUM (IC50: 13 nM) with high serine hydrolase family selectivity.</p>Formule :C22H21ClN4O5Degré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :456.88Cirevetmab
CAS :<p>Cirevetmab (ZTS-00521426), a caninized monoclonal antibody targeting Canis lupus familiaris TGFB1, is classified as an immunoglobulin G2-kappa.</p>Couleur et forme :Liquidγ-Secretase modulator 10
CAS :<p>γ-Secretase modulator 10 is a novel γ-secretase modulator.</p>Formule :C25H23F3N4O2Couleur et forme :SolidMasse moléculaire :468.48AS2553627
CAS :<p>AS2553627 is a JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts.</p>Formule :C18H19N5OCouleur et forme :SolidMasse moléculaire :321.38HC-258
CAS :<p>HC-258 is a direct TEAD inhibitor covalent Cys380, and reduces the transcriptional levels and inhibits the migration of CTGF, CYR61, AXL and NF2 MDA-MB-231.</p>Formule :C20H24N2O2Couleur et forme :SolidMasse moléculaire :324.42JAK2-IN-10
CAS :<p>JAK2-IN-10 (compound 5) is a potent inhibitor of JAK2v617f, with an IC50 value of ≤10 nM.</p>Formule :C33H33D3FN9O2Couleur et forme :SolidMasse moléculaire :612.71Casein kinase 1δ-IN-6
CAS :<p>CK1δ-IN-6: potent, selective CK-1δ inhibitor, IC50 23 nM, neuroprotective, anti-inflammatory, for neurodegenerative research.</p>Formule :C16H10ClF3N2OSDegré de pureté :99%Couleur et forme :SoildMasse moléculaire :370.78JAK-IN-15
CAS :<p>JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).</p>Formule :C22H23FN4O3SCouleur et forme :SolidMasse moléculaire :442.51Povorcitinib phosphate
CAS :<p>Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.</p>Formule :C23H25F5N7O5PDegré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :605.45JAK1/TYK2-IN-1
CAS :<p>JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).</p>Formule :C18H20F3N7OCouleur et forme :SolidMasse moléculaire :407.401WAY-656935
CAS :<p>WAY-656935 inhibits ROCK.</p>Formule :C20H28ClN3O3SDegré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :425.97GSK3-IN-1
CAS :<p>GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.</p>Formule :C14H10ClN3OSDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :303.77TEAD-IN-19
<p>TEAD-IN-19 (Compound 1l) is a transcriptional inhibitor of TEAD, showing inhibition rates of 38.5%, 36.2%, 57.8%, and 71.3% for TEAD1, TEAD2, TEAD3, and TEAD4, respectively, at 10 μM. It exhibits strong antiproliferative and antimigratory effects on prostate cancer cell lines and significantly reduces the expression of TEAD-regulated downstream genes. TEAD-IN-19 holds potential for research in the field of cancer therapeutics.</p>Couleur et forme :Odour SolidPROTAC YAP degrader-1
<p>PROTAC YAP degrader-1, a targeted proteolysis promoting chimeric molecule, both degrades the YAP protein and inhibits its nuclear localization. This compound is formulated with Demethyl-NSC682769 as the target protein ligand, and utilizes (R,S,R)-AHPC-PEG2-C2-boc, which is the E3 ubiquitin ligase ligand + Linker conjugate. The linker incorporated in the design is Acid-PEG2-C2-Boc.</p>Formule :C56H62N6O9SCouleur et forme :SolidMasse moléculaire :995.19RBPJ Inhibitor-1
CAS :<p>RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell</p>Formule :C17H14FN3O2Degré de pureté :99.58%Couleur et forme :SoildMasse moléculaire :311.31S-Ruxolitinib
CAS :<p>S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.</p>Formule :C17H18N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.37SJ10542
CAS :<p>SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.</p>Formule :C41H46N12O5SCouleur et forme :SolidMasse moléculaire :818.95FRM-024
CAS :<p>FRM-024 is a powerful gamma secretase modulator with the ability to penetrate the central nervous system (CNS), designed specifically for the treatment of</p>Formule :C22H22ClN5O2Couleur et forme :SolidMasse moléculaire :423.9CIA-1 (Free base)
CAS :<p>CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.</p>Formule :C17H19N3O2SDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :329.42WDR5 ligand 2
CAS :<p>WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.</p>Formule :C29H31F3N4O4Couleur et forme :SolidMasse moléculaire :556.576Notch 1 TFA
<p>Notch 1 TFA encodes a member of the NOTCH family of proteins.</p>Formule :C64H98N15F3O25S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1614.81Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)
CAS :<p>Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.</p>Formule :C88H138N20O34P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2082.1Fasudil
CAS :<p>Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.</p>Formule :C14H17N3O2SDegré de pureté :99.79% - 99.84%Couleur et forme :SolidMasse moléculaire :291.37JAK3-IN-15
<p>JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.</p>Couleur et forme :Odour SolidSJ1008030 formic
<p>SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with an</p>Formule :C43H45N13O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :919.96TYK2 activator-1
<p>TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.</p>Formule :C23H21FN4O2Couleur et forme :SolidMasse moléculaire :404.16485Axltide
CAS :<p>Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.</p>Formule :C63H107N19O20S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1514.77Wnt/β-catenin agonist 3
CAS :<p>Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.</p>Formule :C16H15ClN4O2Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :330.77Sotatercept
CAS :<p>Sotatercept (ACE-011) is an ActRIIA-Fc fusion protein and an inhibitor of activin signaling.</p>Degré de pureté :97% (SDS-PAGE); 97.8% (SEC-HPLC) - 97% (SDS-PAGE); 97.8% (SEC-HPLC)Couleur et forme :LiquidTYD-68
<p>TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.</p>Couleur et forme :Odour SolidSJ988497
CAS :<p>SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.</p>Formule :C36H36N10O5Couleur et forme :SolidMasse moléculaire :688.74JAK1/STAT3-IN-1
<p>JAK1/STAT3-IN-1 (compound 4f) functions as an anti-atopic dermatitis (AD) agent by inhibiting the JAK1/STAT3 signaling pathway. It has an IC50 value of 2.17 μM for inhibiting NO production. Additionally, JAK1/STAT3-IN-1 improves skin conditions in AD-like mice by reducing inflammatory infiltration, suppressing the expression of p-JAK1/JAK1 and p-STAT3/STAT3, and alleviating the hyperimmune response induced by MC903 (Calcipotriol).</p>Formule :C30H33FN4O3SCouleur et forme :SolidMasse moléculaire :548.67YAP-IN-1
<p>YAP-IN-1 (Compound (+)-1) is an autophagy inhibitor specifically targeting YAP1. It binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM, promoting its degradation through the chaperone-mediated autophagy (CMA) pathway. This process inhibits the Rab7-mediated fusion of autophagosomes with lysosomes and decreases autophagy levels without affecting lysosomal function. YAP-IN-1 shows potential for cancer research, including in hepatocellular carcinoma and breast cancer.</p>Couleur et forme :Odour SolidCBT-295
<p>CBT-295, an orally active autotaxin (ATX) inhibitor, effectively decreases inflammatory cytokines including TGF-β, TNF-α, and IL-6, along with the bile duct proliferation marker CK-19, and ameliorates liver fibrosis. The compound's ability to reverse liver fibrosis contributes to lowered ammonia levels in the blood and brain, which in turn reduces ammonia-induced neuroinflammation. CBT-295 shows potential for the study of liver cirrhosis and related encephalopathy.</p>Formule :C18H20ClN3OCouleur et forme :SolidMasse moléculaire :329.82P17 Peptide
CAS :<p>P17 Peptide, a human TGF-β1 inhibitory peptide, effectively blocks the activity of woodchuck TGF-β1.</p>Formule :C95H139N27O21Couleur et forme :SolidMasse moléculaire :1995.29WAY-297174
CAS :<p>WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.</p>Formule :C11H12N2O2S2Degré de pureté :99.53%Couleur et forme :SoildMasse moléculaire :268.36STAT3-IN-31
<p>STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).</p>Formule :C16H15NO3SCouleur et forme :SolidMasse moléculaire :301.36SJ1008030
CAS :<p>SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.</p>Formule :C42H43N13O7SCouleur et forme :SolidMasse moléculaire :873.94STAT3-IN-34
<p>STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.</p>Formule :C19H16N2O4SCouleur et forme :SolidMasse moléculaire :368.41Epigenetics Compound Library
<p>Well-chosen 953 compounds related to epigenetic regulation for research in epigenetics, high throughput screening (HTS) and high content screening (HCS) for new</p>Couleur et forme :Odour SolidGSK-3β inhibitor 19
<p>GSK-3β Inhibitor 19 (compound 36) is an inhibitor of GSK-3β with an IC50 value of 70 nM. It is applicable in research related to anti-inflammatory and Alzheimer's disease.</p>Formule :C15H12N4O2SCouleur et forme :SolidMasse moléculaire :312.355β-Cholanic acid
CAS :<p>5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.</p>Formule :C24H40O2Degré de pureté :98.91% - 99.89%Couleur et forme :SoildMasse moléculaire :360.57ROCK2-IN-9
<p>ROCK2-IN-9 (compound 7u), a selective ROCK2 inhibitor with an IC50 value of 36.8 nM, demonstrates anticancer properties by impeding cancer cell migration and invasion. This action is achieved through the regulation of various actin cytoskeleton cellular activities. It holds potential for use in breast cancer research.</p>Formule :C28H30N8O2Couleur et forme :SolidMasse moléculaire :510.59Ripasudil free base
CAS :<p>Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.</p>Formule :C15H18FN3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :323.39Wnt/Hedgehog/Notch Compound Library
<p>A unique collection of 237 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;</p>Couleur et forme :Odour SolidFDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Couleur et forme :LiquidPSEN1-IN-2
<p>PSEN1-IN-2 (Compound 13K) is a potent inhibitor of both PSEN1-APH1A and PSEN1-APH1B complexes, exhibiting IC50 values of 6.9 nM and 2.4 nM, respectively.</p>Formule :C20H18ClFN2O3SCouleur et forme :SolidMasse moléculaire :420.88NIBR-LTSi
<p>NIBR-LTSi is a selective LATS kinase inhibitor that also activates YAP signaling, promotes tissue stem cell expansion and tissue regeneration in vitro/vivo.</p>Formule :C18H20N4ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :308.38Fresolimumab
CAS :<p>Fresolimumab (GC1008) is a human monoclonal antibody targeting active TGFβ1, TGFβ2, TGFβ3, studied for cancer and focal segmental glomerulosclerosis.</p>Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :144.4 kDa
