Cellules souche et Dérivés
Les inhibiteurs de cellules souches sont des composés qui ciblent spécifiquement les voies de signalisation et les protéines impliquées dans le maintien, la différenciation et la prolifération des cellules souches. Ces inhibiteurs sont cruciaux pour comprendre la biologie des cellules souches et pour développer des stratégies visant à manipuler les cellules souches à des fins thérapeutiques, telles que la médecine régénérative et le traitement du cancer. En contrôlant le destin des cellules souches, ces inhibiteurs peuvent aider à orienter la différenciation des cellules souches en types cellulaires spécifiques ou à prévenir une croissance cellulaire indésirable. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de cellules souches de haute qualité pour soutenir vos recherches en biologie des cellules souches, biologie du développement et médecine régénérative.
Sous-catégories appartenant à la catégorie "Cellules souche et Dérivés"
- Gamma-sécrétase(59 produits)
- Hérisson/Smoothened(44 produits)
- Voie de signalisation Hippo(6 produits)
- JAK(245 produits)
- Porc-épic(9 produits)
- ROCK(70 produits)
- STAT(98 produits)
- Cellules souches(486 produits)
- TGF-beta/Smad(58 produits)
- Wnt/beta-caténine(66 produits)
Affichez 2 plus de sous-catégories
695 produits trouvés pour "Cellules souche et Dérivés"
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BRD0209
CAS :<p>BRD0209 is a highly selective and potent GSK3 inhibitor.</p>Formule :C22H25N3ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :347.45JI051
CAS :<p>JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.</p>Formule :C22H24N2O3Degré de pureté :≥98% - ≥98.0%Couleur et forme :SolidMasse moléculaire :364.44SB-772077B dihydrochloride
CAS :<p>SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).</p>Formule :C15H20Cl2N8O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.28Jaspamycin
CAS :<p>Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα.</p>Formule :C12H12N4O5Couleur et forme :SolidMasse moléculaire :292.25(Rac)-SIS3 free base
CAS :<p>SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.</p>Formule :C28H27N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :453.53GSK-3β inhibitor 12
CAS :<p>GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3β</p>Formule :C14H13N3OSDegré de pureté :98.58%Couleur et forme :SolidMasse moléculaire :271.34AF-2112
<p>AF-2112, a TEAD inhibitor derived from Flufenamic acid, significantly diminishes the expression of CTGF, Cyr61, Axl, and NF2.</p>Formule :C21H18FNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.37SD-1029
CAS :<p>SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.</p>Formule :C25H32Br2Cl2N2O3Couleur et forme :SolidMasse moléculaire :639.25FzM1.8
CAS :<p>FzM1.8: allosteric FZD4 agonist, pEC50=6.4; boosts TCF/LEF, activates WNT/β-catenin with no WNT needed.</p>Formule :C18H14N2O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :322.31LEQ506
CAS :<p>LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.</p>Formule :C25H32N6ODegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :432.56JAK1-IN-8
CAS :<p>JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).</p>Formule :C22H23FN4O3SDegré de pureté :98.4%Couleur et forme :SolidMasse moléculaire :442.51SJ000063181
CAS :<p>SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.</p>Formule :C14H14ClFN2O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :296.72IHMT-MST1-58
CAS :<p>IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity.</p>Formule :C21H22N6O3SDegré de pureté :98.31% - 99.92%Couleur et forme :SolidMasse moléculaire :438.5Rho-Kinase-IN-1
CAS :<p>Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.</p>Formule :C20H24N4SDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :352.5Butyzamide
CAS :<p>Butyzamide: oral Mpl activator, non-peptide, antagonizes TPO receptors, boosts hMpl, Ba/F3 cells, and enhances platelets in mice.</p>Formule :C29H32Cl2N2O5SDegré de pureté :99.51% - 99.83%Couleur et forme :SoildMasse moléculaire :591.55PI-828
CAS :<p>PI-828 (LY 294002), a PI3K inhibitor, researches PI3K function and aids stem cell differentiation into mesoderm.</p>Formule :C19H18N2O3Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :322.36CRT0066854 hydrochloride
CAS :<p>CRT0066854 HCl inhibits atypical PKCs; IC50: PKCι 132 nM, PKCζ 639 nM, ROCK-II 620 nM.</p>Formule :C24H27Cl2N5SDegré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :488.48DIF-3
CAS :<p>DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.</p>Formule :C13H17ClO4Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :272.72CID-5056270
CAS :<p>CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma</p>Formule :C17H13N3O3SDegré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :339.37EHT 1610
CAS :<p>EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.</p>Formule :C18H14FN5O2SDegré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :383.4BIP-135
CAS :<p>BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.</p>Formule :C21H13BrN2O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :421.24JAK-STAT-IN-1
CAS :<p>JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.</p>Formule :C21H21N5O2Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :375.42GSK-3β inhibitor 11
CAS :<p>GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.</p>Formule :C20H15N3O4SDegré de pureté :97.33%Couleur et forme :SolidMasse moléculaire :393.42Miclxin
CAS :<p>Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent</p>Formule :C26H27N5O2Degré de pureté :99.17% - 99.99%Couleur et forme :SolidMasse moléculaire :441.52Wnt/β-catenin agonist 4
CAS :<p>Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling.</p>Formule :C16H15FN4O2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :314.31LM-41
CAS :<p>LM-41 is a TEAD binding agent with potential anticancer activity for the study of breast cancer.</p>Formule :C19H14FNO2Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :307.32Casein kinase 1δ-IN-1
CAS :<p>Casein kinase 1δ-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δ (CK1δ), which inhibits CK1δ.</p>Formule :C11H7N3OSDegré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :229.26GSK-3 Inhibitor XIII
CAS :<p>GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.</p>Formule :C18H15N5Degré de pureté :99.85% - 99.86%Couleur et forme :SolidMasse moléculaire :301.35ARN25068
CAS :<p>ARN25068 inhibits GSK-3β, FYN, DYRK1A kinases; acts in sub-micromolar range; combats tau hyperphosphorylation.</p>Formule :C19H18N6SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :362.45GSK-3β inhibitor 2
CAS :<p>GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50</p>Formule :C14H14N4O3SDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :318.35Rhodblock 6
CAS :<p>Rhodblock 6 is a Rho kinase inhibitor, blocking phosphorylated MRLC localization by targeting ROCK activity.</p>Formule :C12H13N3ODegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :215.25XL413 xHCl
CAS :<p>BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215</p>Formule :C14H12ClN3O2·xHClDegré de pureté :99.37% - 99.67%Couleur et forme :SolidMasse moléculaire :326.18STS-E412
CAS :<p>STS-E412 is a tissue-protective and selective EPOR/CD131 receptor activator for the study of neurological disorders.</p>Formule :C15H15ClN4O2Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :318.76AS 1892802
CAS :<p>AS 1892802, a ROCK inhibitor: IC50 - 52nM (hROCK2), 57nM (rROCK2), 122nM (hROCK1). Fast antinociceptive effect similar to Tramadol, Diclofenac.</p>Formule :C20H19N3O2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :333.38ABC1183
CAS :<p>ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.</p>Formule :C18H14N4OSDegré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :334.39Izencitinib
CAS :<p>Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.</p>Formule :C22H26N8Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :402.50TT-10
CAS :<p>TT-10 (TAZ-K) activates YAP-TEAD; useful in heart disease with cardiomyocyte loss research.</p>Formule :C11H10FN3OS2Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :283.35FzM1
CAS :<p>FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)</p>Formule :C21H16N2O2SDegré de pureté :99.37% - 99.89%Couleur et forme :SolidMasse moléculaire :360.43MSC-4106
CAS :<p>MSC-4106, an oral YAP/TAZ-TEAD inhibitor, blocks TEAD1/3 auto-palmitoylation and suppresses NCI-H226 tumors.</p>Formule :C18H12F3N3O2Degré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :359.3A 1070722
CAS :<p>A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.</p>Formule :C17H13F3N4O2Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :362.31STAT6-IN-3
CAS :<p>STAT6-IN-3 (Compound 18a) serves as an inhibitor of STAT6 with an IC50 value of 44 nM, specifically targeting the Src Homology 2 (SH2) domain.</p>Formule :C32H35IN3O7PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :731.51Antitumor agent-73
CAS :<p>Antitumor Agent-73, derived from Diosgenin, blocks STAT3 and activates Pdia3, showing strong cancer cell line efficacy.</p>Formule :C50H82BrO4PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :858.06Casein kinase 1δ-IN-5
CAS :<p>Casein kinase 1δ-IN-5 is a potent and selective CK-1δ inhibitor, exhibiting an IC50 of 47 nM, and demonstrates neuroprotective and anti-inflammatory effects in</p>Formule :C16H11F3N2OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.33YAP-TEAD-IN-2
CAS :<p>YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50)</p>Formule :C25H24ClFN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :470.92JAK-IN-31
CAS :<p>JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2,</p>Formule :C21H19N7O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :465.55Ginsenoside Rk1
CAS :<p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>Formule :C42H70O12Degré de pureté :98.46% - 99.13%Couleur et forme :SolidMasse moléculaire :7673,7-DMF
CAS :<p>3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.</p>Formule :C17H14O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.29BRD5648
CAS :<p>BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.</p>Formule :C20H23N3ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :321.42JAK-IN-17
<p>"JAK-IN-17: Potent JAK inhibitor for studying ocular, skin, and respiratory diseases."</p>Formule :C33H38F2N6O8Couleur et forme :SolidMasse moléculaire :684.69Tyk2-IN-9
CAS :<p>Tyk2-IN-9: selective Tyk-2 inhibitor, IC50 of 0.076 nM (TYK2-JH2), 1.8 nM (JAK1-JH2), for inflammation/autoimmune research.</p>Formule :C20H17N9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :383.41inS3-54A18
CAS :<p>inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.</p>Formule :C23H16ClNO2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :373.83TCJL37
CAS :<p>TCJL37: potent, selective TYK2 inhibitor (K i 1.6 nM), oral, for IBD research.</p>Formule :C17H11ClF2N4O2Couleur et forme :SolidMasse moléculaire :376.74JAK-IN-24
CAS :<p>JAK-IN-24: JAK inhibitor, IC50: 0.534 nM (4 μM ATP), 24 nM (1mM ATP), STAT5 phosphorylation IC50: 86.171 nM.</p>Formule :C20H25N5O2Couleur et forme :SolidMasse moléculaire :367.44Upadacitinib tartrate
CAS :<p>Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.</p>Formule :C21H33F3N6O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.521JAK-IN-25
CAS :<p>JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3.</p>Formule :C19H17N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :379.37BT-GSI
<p>BT-GSI: γ-secretase inhibitor targeting Notch, anti-myeloma & anti-resorptive for multiple myeloma/bone disease research.</p>Formule :C26H46BrN5O10P2Couleur et forme :SolidMasse moléculaire :730.52JAK-IN-1
CAS :<p>JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.</p>Formule :C20H24N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.44Tubulin/JAK2-IN-1
CAS :<p>Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significant</p>Formule :C22H20N6O3Couleur et forme :SolidMasse moléculaire :416.43Yhhu-3792 hydrochloride
CAS :<p>Yhhu-3792 hydrochloride is a compound that bolsters the self-renewal capacity of neural stem cells (NSCs), catalyzes the Notch signaling pathway, and upregulates expression of Hes3 and Hes5. It augments the NSC pool, stimulates endogenous neurogenesis in the mouse hippocampal dentate gyrus (DG), and enhances mice's spatial and episodic memory skills. This compound shows promise for researching learning and memory impairments linked to DG dysfunction [1].</p>Formule :C24H25ClN4O2Couleur et forme :SolidMasse moléculaire :436.93JW 67
CAS :<p>JW 67 is an inhibitor of canonical Wnt pathway signaling.</p>Formule :C21H18N2O6Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :394.38TCS 21311
CAS :<p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.</p>Formule :C27H25F3N4O4Degré de pureté :99.39% - ≥98%Couleur et forme :SolidMasse moléculaire :526.51Lepzacitinib
CAS :<p>Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.</p>Formule :C18H21N5O3Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :355.39ROCK2-IN-6 hydrochloride
CAS :<p>ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。</p>Formule :C26H22ClF2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.95TGFβ-IN-5
CAS :<p>TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.</p>Formule :C20H16N4Degré de pureté :99.29% - 99.5%Couleur et forme :SolidMasse moléculaire :312.37ROCK-IN-8
CAS :<p>ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research,</p>Formule :C30H25FN4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.61Nezulcitinib
CAS :<p>Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.</p>Formule :C30H37N7O2Couleur et forme :SolidMasse moléculaire :527.66Chroman 1
CAS :<p>Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).</p>Formule :C24H28N4O4Degré de pureté :99.67% - 99.84%Couleur et forme :SolidMasse moléculaire :436.5BMS-932481
CAS :<p>BMS-932481 is a γ-secretase modulator.</p>Formule :C24H24FN7OCouleur et forme :SolidMasse moléculaire :445.49GSK-3β inhibitor 8
CAS :<p>GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine</p>Formule :C20H20ClN5OSDegré de pureté :98.46%Couleur et forme :SolidMasse moléculaire :413.92JAK-IN-4
CAS :<p>JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.</p>Formule :C18H21N4Na2O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :466.341ROCK2-IN-2
CAS :<p>ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).</p>Formule :C18H12N6OSDegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :360.39Casein kinase 1δ-IN-10
CAS :<p>Casein kinase 1δ-IN-10 is an inhibitor of casein kinase 1δ (CK1δ).</p>Formule :C21H17N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :359.38FM-479
CAS :<p>FM-479, a structural analog of FM-381, lacks inhibition of JAK3/kinases within 100-300 nM, serving as FM-381's negative control.</p>Formule :C25H26N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.523STAT3-IN-B9
CAS :<p>STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.</p>Formule :C20H13NO5SDegré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :379.39TP0427736
CAS :<p>TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x > ALK3 selectivity; counters TGF-β in human cells, extends anagen in mice.</p>Formule :C14H10N4S2Degré de pureté :97.26%Couleur et forme :SolidMasse moléculaire :298.39ML115
CAS :<p>ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.</p>Formule :C15H15ClN2O4Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :322.74MRK-560
CAS :<p>MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.</p>Formule :C19H17ClF5NO4S2Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :517.92LX7101
CAS :<p>LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).</p>Formule :C23H29N7O3Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :451.52Itacnosertib (hydrocholide)
CAS :<p>Itacnosertib hydrochloride acts as an inhibitor targeting JAK2, ACVR1 (ALK2), and ALK5 [1].</p>Formule :C26H29ClN8OCouleur et forme :SolidMasse moléculaire :505.01BMS-983970
CAS :<p>BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.</p>Formule :C26H26F4N4O3Couleur et forme :SolidMasse moléculaire :518.5Stafib-2
CAS :<p>Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,</p>Formule :C28H26N2O12P2Degré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :644.46GSM-1
CAS :<p>GSM-1 is a modulator of γ-Secretase.</p>Formule :C26H31ClF3NO2Couleur et forme :SolidMasse moléculaire :481.98ABBV-712
CAS :<p>ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseases</p>Formule :C24H28N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.5SWTX-143
CAS :<p>SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptional</p>Formule :C19H18F3N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :361.36DT-6
CAS :<p>DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing</p>Formule :C89H130N20O29S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2008.23QL-1200186
CAS :<p>QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production following</p>Formule :C26H27N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :485.54JAK kinase-IN-1
CAS :<p>JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32</p>Formule :C17H19F2N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.44Casein kinase 1δ-IN-4
CAS :<p>"Casein kinase 1δ-IN-4 (compound 567) is a potent inhibitor of casein kinase 1δ with potential application in Alzheimer's disease research [1]."</p>Formule :C16H12N6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :320.37Myristoyl tetrapeptide-12
CAS :<p>Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].</p>Formule :C32H63N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :625.89ROCK-IN-7
CAS :<p>ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].</p>Formule :C17H17N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :327.4Brepocitinib
CAS :<p>Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).</p>Formule :C18H21F2N7ODegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :389.4JAK-IN-26
CAS :<p>JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency in</p>Formule :C22H24N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.46JAK-IN-5
CAS :<p>JAK-IN-5 is a JAK inhibitor.</p>Formule :C27H31FN6ODegré de pureté :98.1% - 99.37%Couleur et forme :SolidMasse moléculaire :474.57Casein Kinase II Inhibitor IV
CAS :<p>Casein kinase II inhibitor IV is an effective small molecule inducer, which can be used to induce epidermal keratinocyte differentiation.</p>Formule :C24H23N5O3Degré de pureté :99.65% - 99.75%Couleur et forme :SolidMasse moléculaire :429.47JAK2-IN-4
CAS :<p>JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.</p>Formule :C23H27N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.56STAT3-IN-20
CAS :<p>STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclear</p>Formule :C30H27F4N7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.64STAT6-IN-2
CAS :<p>STAT6-IN-2(R)-84 is a STAT6 inhibitor that inhibits the secretion of eotaxin-3 and the tyrosine phosphorylation of STAT6.</p>Formule :C28H31N5O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :469.58H-1152 dihydrochloride
CAS :<p>H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.</p>Formule :C16H23Cl2N3O2SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :392.34GNE-7883
CAS :<p>GNE-7883 is an inhibitor targeting TEAD transcription factor, inhibits cell proliferation and suppresses YAP/TAZ activation, and can be used to study YAP/TAZ-dependent tumors.</p>Formule :C28H29FN6O2Degré de pureté :97.61%Couleur et forme :SolidMasse moléculaire :500.57Gossypolone
CAS :<p>Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.</p>Formule :C30H26O10Degré de pureté :96.66%Couleur et forme :SolidMasse moléculaire :546.52
