Cellules souche et Dérivés
Les inhibiteurs de cellules souches sont des composés qui ciblent spécifiquement les voies de signalisation et les protéines impliquées dans le maintien, la différenciation et la prolifération des cellules souches. Ces inhibiteurs sont cruciaux pour comprendre la biologie des cellules souches et pour développer des stratégies visant à manipuler les cellules souches à des fins thérapeutiques, telles que la médecine régénérative et le traitement du cancer. En contrôlant le destin des cellules souches, ces inhibiteurs peuvent aider à orienter la différenciation des cellules souches en types cellulaires spécifiques ou à prévenir une croissance cellulaire indésirable. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de cellules souches de haute qualité pour soutenir vos recherches en biologie des cellules souches, biologie du développement et médecine régénérative.
Sous-catégories appartenant à la catégorie "Cellules souche et Dérivés"
- Gamma-sécrétase(66 produits)
- Hérisson/Smoothened(49 produits)
- Voie de signalisation Hippo(7 produits)
- JAK(236 produits)
- Porc-épic(8 produits)
- ROCK(61 produits)
- STAT(102 produits)
- Cellules souches(118 produits)
- TGF-beta/Smad(68 produits)
- Wnt/beta-caténine(63 produits)
Affichez 2 plus de sous-catégories
415 produits trouvés pour "Cellules souche et Dérivés".
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BIO-013077-01
CAS :BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.Formule :C17H13N5Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :287.32Ref: TM-T8330
1mg48,00€5mg96,00€1mL*10mM (DMSO)131,00€10mg133,00€25mg259,00€50mg371,00€100mg527,00€200mg713,00€FLLL32
CAS :FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formule :C28H32O6Degré de pureté :97.90% - 99.10%Couleur et forme :SolidMasse moléculaire :464.55Ref: TM-T6838
2mg43,00€5mg63,00€1mL*10mM (DMSO)69,00€10mg88,00€25mg117,00€50mg187,00€100mg333,00€500mg797,00€Gusacitinib HCl
CAS :Gusacitinib (ASN-002/EN-3351), a potent SYK/JAK inhibitor, has strong antitumor activity in various cancers.Formule :C24H29ClN8O2Couleur et forme :SolidMasse moléculaire :497MRT-14
CAS :MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.Formule :C24H24N4O5Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :448.47Pacritinib hydrochloride
CAS :Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.Formule :C28H32N4O3·xClHCouleur et forme :Solid(E/Z)-Zotiraciclib
CAS :(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Formule :C23H24N4ODegré de pureté :97.75% - 99.92%Couleur et forme :SolidMasse moléculaire :372.46Ref: TM-T21503
1mg43,00€2mg56,00€1mL*10mM (DMSO)90,00€5mg93,00€10mg113,00€25mg200,00€50mg330,00€100mg480,00€Filgotinib
CAS :Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.Formule :C21H23N5O3SDegré de pureté :98.03% - ≥95%Couleur et forme :White SolidMasse moléculaire :425.5Baricitinib phosphate
CAS :Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.Formule :C16H20N7O6PSDegré de pureté :99.4% - 99.91%Couleur et forme :White SolidMasse moléculaire :469.41Ref: TM-T2360
5mg40,00€1mL*10mM (DMSO)46,00€10mg52,00€25mg73,00€50mg93,00€100mg105,00€200mg157,00€500mg260,00€CEP-33779
CAS :CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.Formule :C24H26N6O2SDegré de pureté :98.24% - ≥95%Couleur et forme :Yellow SolidMasse moléculaire :462.57Ref: TM-T6122
1mg43,00€2mg56,00€5mg93,00€1mL*10mM (DMSO)94,00€10mg137,00€25mg231,00€50mg356,00€100mg530,00€500mg1.153,00€WHI-P97 HCl
WHI-P97 HCl is a potent and selective JAK-3 inhibitor.Formule :C16H14Br2ClN3O3Degré de pureté :99.49%Couleur et forme :Green SolidMasse moléculaire :491.56Ref: TM-T4657L
2mg34,00€5mg48,00€1mL*10mM (DMSO)73,00€10mg86,00€25mg138,00€50mg182,00€100mg261,00€200mg371,00€Lats-IN-1
CAS :Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.Formule :C18H14N4OSDegré de pureté :97.54% - 99.79%Couleur et forme :White SolidMasse moléculaire :334.39Ref: TM-T9053
1mg50,00€2mg70,00€5mg100,00€1mL*10mM (DMSO)112,00€10mg159,00€25mg294,00€50mg394,00€100mg560,00€200mg798,00€Decernotinib
CAS :Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.Formule :C18H19F3N6ODegré de pureté :99.28% - >99.99%Couleur et forme :SolidMasse moléculaire :392.38Ref: TM-T2636
1mg34,00€2mg48,00€5mg71,00€1mL*10mM (DMSO)79,00€10mg99,00€25mg197,00€50mg295,00€100mg447,00€SJ000291942
CAS :SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.Formule :C16H15FN2O4Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :318.3Ref: TM-T4662
1mg34,00€2mg44,00€5mg63,00€1mL*10mM (DMSO)71,00€10mg100,00€25mg205,00€50mg349,00€100mg557,00€200mg790,00€SC99
CAS :SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formule :C15H8Cl2FN3ODegré de pureté :99.56%Couleur et forme :Yellow SolidMasse moléculaire :336.15WP1066
CAS :WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.Formule :C17H14BrN3ODegré de pureté :98.59% - 99.73%Couleur et forme :SolidMasse moléculaire :356.22SHR0302
CAS :SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,Formule :C18H22N8O2SDegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :414.48Ref: TM-T9195
1mg75,00€1mL*10mM (DMSO)164,00€5mg173,00€10mg281,00€25mg485,00€50mg773,00€100mg1.243,00€γ-secretase modulator 1 hydrochloride
CAS :gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].Formule :C24H25ClN4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :453(E)-SIS3
CAS :(E)-SIS3 (SIS3) is a Smad3 inhibitor (IC50=3 μM) selective.inhibits the differentiation of fibroblasts into myofibroblasts via TGF-β1. High-Quality, Low-Cost!Formule :C28H27N3O3·HClDegré de pureté :95.64% - 98%Couleur et forme :Yellow SolidMasse moléculaire :489.99Ref: TM-T3636
1mg40,00€2mg54,00€5mg105,00€1mL*10mM (DMSO)114,00€10mg164,00€25mg326,00€50mg485,00€100mg692,00€500mg1.395,00€Curculigoside
CAS :1.Formule :C22H26O11Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :466.44AMG-47a
CAS :AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.Formule :C29H28F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :535.56RGB-286638 free base
CAS :RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formule :C29H35N7O4Degré de pureté :98% - 99.91%Couleur et forme :SolidMasse moléculaire :545.63MYF-01-37
CAS :MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.Formule :C15H17F3N2ODegré de pureté :99.46% - 99.5%Couleur et forme :SolidMasse moléculaire :298.3Ref: TM-T22372
2mg38,00€5mg57,00€1mL*10mM (DMSO)63,00€10mg90,00€25mg166,00€50mg281,00€100mg421,00€500mg888,00€Gandotinib
CAS :LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).Formule :C23H25ClFN7ODegré de pureté :99.33% - 99.86%Couleur et forme :SolidMasse moléculaire :469.94WHI-P97
CAS :WHI-P97 is a rationally designed potent inhibitor of JAK-3.Formule :C16H13Br2N3O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :455.1JAK3-IN-6
CAS :JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nMFormule :C19H18N4O3Degré de pureté :99.94% - 99.94%Couleur et forme :SolidMasse moléculaire :350.37Pyridone 6
CAS :Pyridone 6, a selective JAK1/2/3 and Tyk2 inhibitor with IC50s: JAK1=15 nM, JAK2=1 nM, JAK3 (Ki=5 nM), Tyk2=1 nM; weakly binds other kinases (130 nM-10 μM).Formule :C18H16FN3ODegré de pureté :97.1% - 98.74%Couleur et forme :SolidMasse moléculaire :309.34Ref: TM-T3080
1mg50,00€2mg71,00€5mg105,00€1mL*10mM (DMSO)110,00€10mg173,00€25mg358,00€50mg587,00€100mg888,00€200mg1.198,00€WHI-P154
CAS :WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.Formule :C16H14BrN3O3Degré de pureté :98% - 99.67%Couleur et forme :SolidMasse moléculaire :376.2AT9283
CAS :AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).Formule :C19H23N7O2Degré de pureté :99.83% - 99.98%Couleur et forme :White SolidMasse moléculaire :381.43Ref: TM-T3068
2mg39,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg111,00€25mg231,00€50mg371,00€100mg595,00€200mg833,00€Tofacitinib Citrate
CAS :Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).Formule :C22H28N6O8Degré de pureté :99.19% - 99.75%Couleur et forme :White SolidMasse moléculaire :504.49Upadacitinib
CAS :Upadacitinib (ABT-494), a selective JAK1 inhibitor, is researched for autoimmune diseases; IC50: 43 nM.Formule :C17H19F3N6ODegré de pureté :98.96% - 99.94%Couleur et forme :SolidMasse moléculaire :380.37Ref: TM-T7503
1mL*10mM (DMSO)44,00€2mg55,00€5mg89,00€10mg116,00€25mg198,00€50mg276,00€100mg389,00€200mg595,00€Momelotinib
CAS :Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.Formule :C23H22N6O2Degré de pureté :97.07% - 99.56%Couleur et forme :Yellow SolidMasse moléculaire :414.46Ref: TM-T1849
1mg35,00€2mg50,00€5mg77,00€1mL*10mM (DMSO)84,00€10mg89,00€25mg158,00€50mg245,00€100mg385,00€200mg592,00€LGK974
CAS :LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.Formule :C23H20N6ODegré de pureté :99.04% - >99.99%Couleur et forme :SolidMasse moléculaire :396.44Ref: TM-T2618
1mg46,00€2mg62,00€5mg90,00€1mL*10mM (DMSO)90,00€10mg156,00€25mg288,00€50mg515,00€100mg737,00€Ruxolitinib (S enantiomer)
CAS :Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.Formule :C17H18N6Degré de pureté :99.37% - 99.79%Couleur et forme :SolidMasse moléculaire :306.36Delgocitinib EtOH
CAS :Delgocitinib (LEO-124249/JTE052) is a selective JAK inhibitor used for reducing skin inflammation and treating chronic dermatitis.Formule :C18H24N6O2Couleur et forme :SolidMasse moléculaire :356.43Deucravacitinib
CAS :Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.Formule :C20H19D3N8O3Degré de pureté :98.52% - >99.99%Couleur et forme :SolidMasse moléculaire :425.46Ref: TM-T14687
1mg56,00€5mg137,00€1mL*10mM (DMSO)149,00€10mg248,00€25mg389,00€50mg575,00€100mg817,00€(Z)-LFM-A13
CAS :(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.Formule :C11H8Br2N2O2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :360Atractylenolide I
CAS :Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Formule :C15H18O2Degré de pureté :97.55% - 99.92%Couleur et forme :White SolidMasse moléculaire :230.30Fedratinib
CAS :Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Formule :C27H36N6O3SDegré de pureté :97.31% - 99.96%Couleur et forme :SolidMasse moléculaire :524.68Ref: TM-T1995
5mg50,00€1mL*10mM (DMSO)54,00€10mg65,00€50mg107,00€100mg127,00€200mg205,00€500mg447,00€1g592,00€Brevilin A
CAS :Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.Formule :C20H26O5Degré de pureté :99.97% - >99.99%Couleur et forme :SolidMasse moléculaire :346.42Ref: TM-T4672
1mg90,00€5mg203,00€1mL*10mM (DMSO)224,00€10mg350,00€25mg578,00€50mg797,00€100mg1.071,00€500mg2.187,00€BD750
CAS :BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM inFormule :C14H13N3OSDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :271.34Cerdulatinib
CAS :Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.Formule :C20H27N7O3SDegré de pureté :98.74% - 99.49%Couleur et forme :SolidMasse moléculaire :445.54Ref: TM-T2487
1mg42,00€2mg52,00€5mg74,00€1mL*10mM (DMSO)81,00€10mg101,00€25mg175,00€50mg268,00€100mg409,00€200mg573,00€500mg888,00€RO8191
CAS :RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.Formule :C14H5F6N5ODegré de pureté :98.15% - 98.85%Couleur et forme :Yellow SolidMasse moléculaire :373.21Ref: TM-T22142
1mg43,00€2mg55,00€5mg93,00€10mg137,00€25mg254,00€50mg380,00€100mg573,00€500mg1.189,00€G5-7
CAS :G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Formule :C22H19F2NO3Degré de pureté :97.3%Couleur et forme :Yellow SolidMasse moléculaire :383.39Ref: TM-T8742
1mg35,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg96,00€25mg172,00€50mg248,00€100mg348,00€200mg470,00€Fedratinib hydrochloride hydrate
CAS :Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.Formule :C27H40Cl2N6O4SDegré de pureté :98.96% - 99.87%Couleur et forme :SolidMasse moléculaire :615.61BMS986260
CAS :BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).Formule :C18H12ClFN6ODegré de pureté :97.67%Couleur et forme :SolidMasse moléculaire :382.78RO495
CAS :RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assaysFormule :C17H14Cl2N6ODegré de pureté :97.94%Couleur et forme :SolidMasse moléculaire :389.24ITD-1
CAS :ITD-1 is a potent and highly selective TGFβ pathway inhibitor.Formule :C27H29NO3Degré de pureté :99.89% - >99.99%Couleur et forme :Yellow SolidMasse moléculaire :415.52AZ960
CAS :AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).Formule :C18H16F2N6Degré de pureté :96.02% - 99.88%Couleur et forme :SolidMasse moléculaire :354.36WDR5-0103 hydrochloride[890190-22-4(free base)]
WDR5-0103 hydrochloride[890190-22-4(free base)] (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd:Formule :C21H26ClN3O4Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :419.9BMP signaling agonist sb4
CAS :BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)Formule :C14H10BrNOSDegré de pureté :99.48% - 99.80%Couleur et forme :SolidMasse moléculaire :320.2Ref: TM-T7799
5mg44,00€1mL*10mM (DMSO)48,00€10mg57,00€25mg94,00€50mg119,00€100mg177,00€200mg268,00€500mg465,00€
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