Cellules souches
Les inhibiteurs de cellules souches sont des composés qui ciblent spécifiquement les cellules souches et leurs voies de signalisation, affectant leur capacité à s'auto-renouveler et à se différencier. Ces inhibiteurs sont essentiels dans la recherche axée sur le contrôle du comportement des cellules souches, la compréhension des processus de développement et le développement de thérapies pour des maladies comme le cancer, où les cellules souches sont censées jouer un rôle clé. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de cellules souches pour soutenir vos recherches en médecine régénérative, biologie du développement et oncologie.
486 produits trouvés pour "Cellules souches"
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TNIK-IN-5
CAS :<p>TNIK-IN-5: strong TNIK inhibitor (IC50=0.05μM), halts Wnt signaling, effective against colorectal cancer in vitro.</p>Formule :C22H17N3O3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :371.39Sonidegib diphosphate
CAS :<p>Sonidegib diphosphate (LDE225 diphosphate) is a selective antagonist of Smo that inhibits murine Smo and human Smo.Cost-effective and quality-assured.</p>Formule :C26H32F3N3O11P2Degré de pureté :99.48% - >99.99%Couleur et forme :SolidMasse moléculaire :681.49Silmitasertib sodium salt
CAS :<p>Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).</p>Formule :C19H11ClN3NaO2Degré de pureté :99.49% - 99.62%Couleur et forme :SolidMasse moléculaire :371.75TAK-901
CAS :<p>TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others</p>Formule :C28H32N4O3SDegré de pureté :99.02% - 99.59%Couleur et forme :SolidMasse moléculaire :504.64WDR5-IN-6
CAS :<p>WDR5-IN-6 is a WDR5 inhibitor targeting the WBM locus.WDR5-IN-6 is highly synergistic with OICR-9429, a WDR5 inhibitor that targets the WIN locus.WDR5-IN-6</p>Formule :C13H8Cl2N2O2SDegré de pureté :99.69%Couleur et forme :SoildMasse moléculaire :327.19E 2012
CAS :<p>E2012 is a γ-secretase modulator (GSM).</p>Formule :C25H26FN3O2Degré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :419.49Cyanoacetohydrazide
CAS :<p>Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.</p>Formule :C3H5N3ODegré de pureté :99.78%Couleur et forme :Stout Prisms From Alcohol Slightly Brown PowderMasse moléculaire :99.09IK-930
CAS :<p>IK-930 is an orally active TEAD inhibitor (EC50 < 0.1 µM) with potent potency.</p>Formule :C19H19F3N4O2SDegré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :424.44CCT251545
CAS :<p>CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).</p>Formule :C23H24ClN5ODegré de pureté :98.2% - 98.69%Couleur et forme :SolidMasse moléculaire :421.92GSK-3 inhibitor 4
CAS :<p>Orally active GSK-3 inhibitor 4 targets GSK-3α/β, CDK2/5 (IC50: 0.45-0.68 μM) and may aid in Alzheimer's research by lowering Tau protein.</p>Formule :C22H15F2N5ODegré de pureté :99.41%Couleur et forme :SoildMasse moléculaire :403.38BML-286
CAS :<p>BML-286 is a WNT pathway modulator with potential anticancer activity and induces β-catenin- and TCF- dependent transcriptional activity.</p>Formule :C22H18N2O4Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :374.39Gusacitinib
CAS :<p>Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).</p>Formule :C24H28N8O2Degré de pureté :98.06% - 99.94%Couleur et forme :SolidMasse moléculaire :460.53Netarsudil Dihydrochloride
CAS :<p>Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-related protein kinase (ROCK) and norepinephrine transporter (NET) and is effective in reducing intraocular pressure (IOP).Cost-effective and quality-assured.</p>Formule :C28H29Cl2N3O3Degré de pureté :99.94% - 99.98%Couleur et forme :SolidMasse moléculaire :526.45Garetosmab
CAS :<p>Garetosmab (REGN 2477), a human IgG4 monoclonal antibody, inhibits activin A for potential cancer treatment and FOP study.</p>Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :146 kDaNGP555
CAS :<p>NGP555 is a modulator of γ-secretase.</p>Formule :C23H23FN4SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :406.52Nefopam hydrochloride
CAS :<p>Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.</p>Formule :C17H20ClNODegré de pureté :99.32% - 99.85%Couleur et forme :SolidMasse moléculaire :289.8Golidocitinib
CAS :<p>Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).</p>Formule :C25H31N9O2Degré de pureté :98.87% - 99.88%Couleur et forme :SolidMasse moléculaire :489.57JAK2 Inhibitor V
CAS :<p>JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.</p>Formule :C23H24N2ODegré de pureté :98.36% - 99.15%Couleur et forme :SolidMasse moléculaire :344.45Nimucitinib
CAS :<p>Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.</p>Formule :C25H26F2N6O2Degré de pureté :98.71%Couleur et forme :SoildMasse moléculaire :480.51NMS-P715
CAS :<p>NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).</p>Formule :C35H39F3N8O3Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :676.73Brepocitinib P-Tosylate
CAS :<p>Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).</p>Formule :C25H29F2N7O4SDegré de pureté :99.82% - 99.97%Couleur et forme :SolidMasse moléculaire :561.6JW74
CAS :<p>JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).</p>Formule :C24H20N6O2SDegré de pureté :95.00%Couleur et forme :SolidMasse moléculaire :456.52KY1220
CAS :<p>KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.</p>Formule :C14H10N4O3SDegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :314.32CWP232228
CAS :<p>CWP232228 is a selective Wnt/β-catenin pathway inhibitor targeting β-catenin/TCF binding, halting breast/liver CSC growth and metastasis safely.</p>Formule :C33H34N7Na2O7PDegré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :717.63MRT-83
CAS :<p>MRT-83 is a potent Smo antagonist.</p>Formule :C31H30N4O5Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :538.59BRD0705
CAS :<p>BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.</p>Formule :C20H23N3ODegré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :321.42Ponsegromab
CAS :<p>Ponsegromab (PF 06946860), a humanized anti-GDF15 antibody, may treat cancer cachexia by blocking GDF15/GFRAL signaling.</p>Degré de pureté :100% (SEC-HPLC) - > 95%Couleur et forme :LiquidMasse moléculaire :146.08 kDaROCK inhibitor-2
CAS :<p>ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).</p>Formule :C21H20N2O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :332.4ROCK2-IN-9
<p>ROCK2-IN-9 (compound 7u), a selective ROCK2 inhibitor with an IC50 value of 36.8 nM, demonstrates anticancer properties by impeding cancer cell migration and invasion. This action is achieved through the regulation of various actin cytoskeleton cellular activities. It holds potential for use in breast cancer research.</p>Formule :C28H30N8O2Couleur et forme :SolidMasse moléculaire :510.591(R),2(S)-epoxy Cannabidiol
CAS :<p>1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analog of phytocannabinoids, exhibiting significant inhibitory activity on the Wnt/β-catenin pathway. It holds potential for research as a neuroprotective agent.</p>Formule :C21H30O3Couleur et forme :SolidMasse moléculaire :330.46MeBIO
CAS :<p>MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.</p>Formule :C17H12BrN3O2Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :370.2YAP/TAZ inhibitor-4
<p>YAP/TAZ Inhibitor-4 (Compound 45) acts as an inhibitor of YAP/TAZ, exhibiting inhibitory activity on TEAD transcriptional activation by preventing the interaction between YAP or TAZ and TEAD.</p>Formule :C28H28F3N3O3Couleur et forme :SolidMasse moléculaire :511.54CSNK2-IN-2
<p>CSNK2-IN-2 (compound 2) is an orally active inhibitor of CSNK2. It is utilized in antiviral research.</p>Formule :C25H30FN9OCouleur et forme :SolidMasse moléculaire :491.56MSC-1254
<p>MSC-1254 is a reversible, selective, and covalent inhibitor of TEAD1, primarily utilized in cancer research.</p>Formule :C25H22F2N4O4SCouleur et forme :SolidMasse moléculaire :512.53Disitertide acetate
<p>Disitertide acetate: a TGF-β1 and PI3K blocker, promotes apoptosis; inhibits receptor interaction.</p>Formule :C70H113N17O24S2Degré de pureté :95.11%Couleur et forme :SoildMasse moléculaire :1640.88MSC-5046
<p>MSC-5046 is a selective inhibitor of TEAD1.</p>Formule :C24H18F3N5O3Couleur et forme :SolidMasse moléculaire :481.43Casein kinase 1δ-IN-7
CAS :<p>Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.</p>Formule :C17H14N4O2SDegré de pureté :98.6%Couleur et forme :SolidMasse moléculaire :338.38ALK5-IN-83
<p>ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.</p>Formule :C20H23N7O2SCouleur et forme :SolidMasse moléculaire :425.51JAK/HDAC-IN-4
<p>JAK/HDAC-IN-4 (compound 11 i) is a dual inhibitor targeting both JAK2 and HDAC6, with IC50 values of 0.49 nM and 12 nM respectively. It inhibits cell proliferation and the production of nitric oxide. In a mouse model induced by Imiquimod, JAK/HDAC-IN-4 ameliorates psoriasiform skin lesions with low toxicity.</p>Formule :C30H32N8O5SCouleur et forme :SolidMasse moléculaire :616.69Ripasudil free base
CAS :<p>Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.</p>Formule :C15H18FN3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :323.39JAK3-IN-15
<p>JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.</p>Couleur et forme :Odour SolidEmugrobart
<p>Emugrobart is a humanized IgG1κ antibody targeted at GDF8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Couleur et forme :Odour LiquidSTAT3 HiBiT degrader 1
CAS :<p>STAT3HiBiT degrader 1 is a potent degrader of STAT3HiBiT, exhibiting a DC50 of less than 0.05 μM in A549 cells.</p>Formule :C58H63F4N10O14PSCouleur et forme :SolidMasse moléculaire :1263.21Wnt/β-catenin agonist 2
CAS :<p>Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist.</p>Formule :C13H12N4O3Degré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :272.26Linavonkibart
CAS :<p>Linavonkibart (SRK181) is a humanized antibody targeting TGFβ1 that blocks the release of TGF-β1 protein by specifically binding latent TGF-β1.</p>Degré de pureté :97.4% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.4% (SDS-PAGE); 99.4% (SEC-HPLC)Couleur et forme :LiquidCCT 031374 hydrobromide
CAS :<p>CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.</p>Formule :C23H20BrN3ODegré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :434.33WAY-656935
CAS :<p>WAY-656935 inhibits ROCK.</p>Formule :C20H28ClN3O3SDegré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :425.97Foxy-5 Ammonium Salt
<p>Foxy-5 Ammonium Salt, a WNT5A mimetic, blocks epithelial cancer cell migration without β-catenin impact and curbs prostate cancer spread.</p>Formule :C26H46N7O12S2Degré de pureté :97.70%Couleur et forme :SolidMasse moléculaire :712.26YAP-TEAD-IN-1 acetate
<p>YAP-TEAD-IN-1 acetate is an effective and competitive inhibitor of YAP–TEAD interaction with an IC50 of 25 nM.</p>Formule :C95H148ClN23O23S2Degré de pureté :98.11% - 99.57%Couleur et forme :SoildMasse moléculaire :2079.92MR24
<p>MR24 is a derivative of G-5555 and acts as an inhibitor of mammalian STE20-like (MST) kinases. It selectively targets MST3 and MST4, with EC50 values of 57 nM and 583 nM, respectively.</p>Formule :C26H29ClN6O3Masse moléculaire :508.19897STX-0119
CAS :<p>STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.</p>Formule :C22H14N4O3Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :382.37Casein kinase 1δ-IN-8
CAS :<p>Casein kinase 1δ-IN-8 is an inhibitor of casein kinase 1δ and is used to treat neurodegenerative diseases such as Alzheimer's disease type.</p>Formule :C19H14FN5OSDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :379.41YAP/TEAD-IN-1
<p>YAP/TEAD-IN-1 (compound 4) is a potent inhibitor of YAP and TEAD, exhibiting antioxidant properties. It demonstrates antiproliferative effects on tumor cells while showing minimal cytotoxic activity towards normal human cells.</p>Formule :C32H30N8OCouleur et forme :SolidMasse moléculaire :542.634LP-922056
CAS :<p>LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.</p>Formule :C11H9ClN2O2S2Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :300.78BAY 593
CAS :<p>BAY 593 functions as an inhibitor of geranylgeranyltransferase-I (GGTase-I), effectively preventing the activation of Rho-GTPases and consequently inactivating YAP1/TAZ signaling pathways. It has been shown to inhibit tumor growth dose-dependently in xenograft mouse models, exhibiting IC50 values of 38.4 nM in MT-1080 cells and 564 nM in MDA-MB-231 cells, as well as in PXF 541 xenografts.</p>Formule :C26H32ClF3N2O3Couleur et forme :SolidMasse moléculaire :512.99JAK2-IN-6
CAS :<p>JAK2-IN-6: A potent JAK2-specific inhibitor (IC50=22.86μg/mL), blocks JAK2 signaling, has anticancer properties, and is inactive against JAK1/3.</p>Formule :C14H10ClN3OS2Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :335.83Wnt/β-catenin agonist 3
CAS :<p>Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.</p>Formule :C16H15ClN4O2Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :330.77Sotatercept
CAS :<p>Sotatercept (ACE-011) is an ActRIIA-Fc fusion protein and an inhibitor of activin signaling.</p>Degré de pureté :97% (SDS-PAGE); 97.8% (SEC-HPLC) - 97% (SDS-PAGE); 97.8% (SEC-HPLC)Couleur et forme :LiquidWIC1
CAS :<p>2H-1-Benzopyran-3-carboxamide, N-[4-(4-ethyl-1-piperazinyl)phenyl]-2-oxo- is a compound that is potential for the treatment of tumours.</p>Formule :C22H23N3O3Degré de pureté :99.82%Couleur et forme :SoildMasse moléculaire :377.44RhoA-ROCK-IN-1
<p>RhoA-ROCK-IN-1 (Compound b19) is an inhibitor of the RhoA/ROCK pathway. It significantly inhibits cell proliferation, migration, and invasion, while promoting cell apoptosis (apoptosis). RhoA-ROCK-IN-1 exhibits strong anticancer activities by inhibiting the RhoA/ROCK pathway.</p>Formule :C24H23N3O4SCouleur et forme :SolidMasse moléculaire :449.52LX-7101 hydrochloride
CAS :<p>LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.</p>Formule :C23H29N7O3xHClDegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :487.99GSK3-IN-4
CAS :<p>GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay.</p>Formule :C18H20N4ODegré de pureté :98.33%Couleur et forme :SoildMasse moléculaire :308.38Povorcitinib phosphate
CAS :<p>Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.</p>Formule :C23H25F5N7O5PDegré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :605.45Tubastatin
CAS :<p>Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.</p>Formule :C21H22N2O2Degré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :334.41Plant 14-3-3-IN-1
<p>Plant 14-3-3-IN-1 (Compound 2) is an inhibitor of the Arabidopsis thaliana 14-3-3 protein, with an IC50 of 1.21 μM. It exhibits varying inhibitory activity against different 14-3-3 isoforms and promotes the closure of leaf stomata.</p>Formule :C22H19NO7SMasse moléculaire :441.08822(R)-Lisofylline
CAS :<p>(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM).</p>Formule :C13H20N4O3Degré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :280.32S-Ruxolitinib
CAS :<p>S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.</p>Formule :C17H18N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.37GSK3-IN-1
CAS :<p>GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.</p>Formule :C14H10ClN3OSDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :303.77YAP-TEAD-IN-3
CAS :<p>YAP-TEAD-IN-3 inhibitor YAP/TAZ-TEAD interactions Avi-human TEAD (4217-434) YAP-TEAD-IN-3 inhibits YAP reporter gene expression and NCI-H2052 cell proliferation</p>Formule :C27H26ClF2N3O4Degré de pureté :97.55% - 98.71%Couleur et forme :SoildMasse moléculaire :529.96GSK-3β inhibitor 19
<p>GSK-3β Inhibitor 19 (compound 36) is an inhibitor of GSK-3β with an IC50 value of 70 nM. It is applicable in research related to anti-inflammatory and Alzheimer's disease.</p>Formule :C15H12N4O2SCouleur et forme :SolidMasse moléculaire :312.35STAT3-IN-34
<p>STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.</p>Formule :C19H16N2O4SCouleur et forme :SolidMasse moléculaire :368.41Super-TDU (1-31) (TFA)
<p>Super-TDU (1-31) TFA, a peptide, inhibits YAP-TEAD; it has strong anti-tumor effects in gastric cancer models.</p>Formule :C141H218N40O48·C2HF3O2Couleur et forme :SolidMasse moléculaire :3355.5Pumecitinib
CAS :<p>Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.</p>Formule :C17H20N8O2SDegré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :400.46PROTAC YAP degrader-1
<p>PROTAC YAP degrader-1, a targeted proteolysis promoting chimeric molecule, both degrades the YAP protein and inhibits its nuclear localization. This compound is formulated with Demethyl-NSC682769 as the target protein ligand, and utilizes (R,S,R)-AHPC-PEG2-C2-boc, which is the E3 ubiquitin ligase ligand + Linker conjugate. The linker incorporated in the design is Acid-PEG2-C2-Boc.</p>Formule :C56H62N6O9SCouleur et forme :SolidMasse moléculaire :995.19HC-258
CAS :<p>HC-258 is a direct TEAD inhibitor covalent Cys380, and reduces the transcriptional levels and inhibits the migration of CTGF, CYR61, AXL and NF2 MDA-MB-231.</p>Formule :C20H24N2O2Couleur et forme :SolidMasse moléculaire :324.42Cirevetmab
CAS :<p>Cirevetmab (ZTS-00521426), a caninized monoclonal antibody targeting Canis lupus familiaris TGFB1, is classified as an immunoglobulin G2-kappa.</p>Couleur et forme :LiquidLerdelimumab
CAS :<p>Lerdelimumab (CAT-152) is an IgG4 monoclonal antibody targeting TGF-β2, used in glaucoma scarring research.</p>Couleur et forme :LiquidP17 Peptide
CAS :<p>P17 Peptide, a human TGF-β1 inhibitory peptide, effectively blocks the activity of woodchuck TGF-β1.</p>Formule :C95H139N27O21Couleur et forme :SolidMasse moléculaire :1995.29CBT-295
<p>CBT-295, an orally active autotaxin (ATX) inhibitor, effectively decreases inflammatory cytokines including TGF-β, TNF-α, and IL-6, along with the bile duct proliferation marker CK-19, and ameliorates liver fibrosis. The compound's ability to reverse liver fibrosis contributes to lowered ammonia levels in the blood and brain, which in turn reduces ammonia-induced neuroinflammation. CBT-295 shows potential for the study of liver cirrhosis and related encephalopathy.</p>Formule :C18H20ClN3OCouleur et forme :SolidMasse moléculaire :329.82TGFβRI-IN-7
<p>TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.</p>Formule :C27H32N6O2Couleur et forme :SolidMasse moléculaire :472.582STAT3-IN-31
<p>STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).</p>Formule :C16H15NO3SCouleur et forme :SolidMasse moléculaire :301.36WAY-297174
CAS :<p>WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.</p>Formule :C11H12N2O2S2Degré de pureté :99.53%Couleur et forme :SoildMasse moléculaire :268.36TEAD-IN-19
<p>TEAD-IN-19 (Compound 1l) is a transcriptional inhibitor of TEAD, showing inhibition rates of 38.5%, 36.2%, 57.8%, and 71.3% for TEAD1, TEAD2, TEAD3, and TEAD4, respectively, at 10 μM. It exhibits strong antiproliferative and antimigratory effects on prostate cancer cell lines and significantly reduces the expression of TEAD-regulated downstream genes. TEAD-IN-19 holds potential for research in the field of cancer therapeutics.</p>Couleur et forme :Odour SolidWnt pathway inhibitor 3
CAS :<p>Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studies</p>Formule :C21H17BrN2O5Degré de pureté :99.69%Couleur et forme :SoildMasse moléculaire :457.27Fasudil
CAS :<p>Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.</p>Formule :C14H17N3O2SDegré de pureté :99.79% - 99.84%Couleur et forme :SolidMasse moléculaire :291.37NIBR-LTSi
<p>NIBR-LTSi is a selective LATS kinase inhibitor that also activates YAP signaling, promotes tissue stem cell expansion and tissue regeneration in vitro/vivo.</p>Formule :C18H20N4ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :308.38ABC99
CAS :<p>ABC99 irreversibly inhibits wnt-deacylating enzyme NOTUM (IC50: 13 nM) with high serine hydrolase family selectivity.</p>Formule :C22H21ClN4O5Degré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :456.88GSK-3β inhibitor 1
CAS :<p>GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.</p>Formule :C14H10N2ODegré de pureté :99.40%Couleur et forme :SolidMasse moléculaire :222.24Casein kinase 1δ-IN-6
CAS :<p>CK1δ-IN-6: potent, selective CK-1δ inhibitor, IC50 23 nM, neuroprotective, anti-inflammatory, for neurodegenerative research.</p>Formule :C16H10ClF3N2OSDegré de pureté :99%Couleur et forme :SoildMasse moléculaire :370.78TEAD-IN-16
<p>TEAD-IN-16 (compound BC-011) is a potent inhibitor of TEAD, with an IC50 of 72.43 μM. This compound plays a significant role in cancer research.</p>Formule :C16H14F3NO3Masse moléculaire :325.09258Wnt/Hedgehog/Notch Compound Library
<p>A unique collection of 237 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;</p>Couleur et forme :Odour SolidSLLK, Control Peptide for TSP1 Inhibitor(TFA)
CAS :<p>SLLK is a control peptide for LSKL.</p>Formule :C21H41N5O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.58Jagged-1 (188-204)
CAS :<p>Jagged-1 （188-204）is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin.</p>Formule :C93H127N25O26S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2107.4Epigenetics Compound Library
<p>Well-chosen 953 compounds related to epigenetic regulation for research in epigenetics, high throughput screening (HTS) and high content screening (HCS) for new</p>Couleur et forme :Odour SolidRBPJ Inhibitor-1
CAS :<p>RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell</p>Formule :C17H14FN3O2Degré de pureté :99.58%Couleur et forme :SoildMasse moléculaire :311.31YAP-IN-1
<p>YAP-IN-1 (Compound (+)-1) is an autophagy inhibitor specifically targeting YAP1. It binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM, promoting its degradation through the chaperone-mediated autophagy (CMA) pathway. This process inhibits the Rab7-mediated fusion of autophagosomes with lysosomes and decreases autophagy levels without affecting lysosomal function. YAP-IN-1 shows potential for cancer research, including in hepatocellular carcinoma and breast cancer.</p>Couleur et forme :Odour SolidFresolimumab
CAS :<p>Fresolimumab (GC1008) is a human monoclonal antibody targeting active TGFβ1, TGFβ2, TGFβ3, studied for cancer and focal segmental glomerulosclerosis.</p>Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :144.4 kDaYW2036
CAS :<p>YW2036 is an inhibitor of Wnt signaling pathway.</p>Formule :C20H16N4ODegré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :328.37Carboxylesterase-IN-2
CAS :<p>Carboxylesterase-IN-2 is a potent Carboxylesterase Notum inhibitor (IC50 <= 10 nM).Carboxylesterase-IN-2 has potential for the study of cancer diseases.</p>Formule :C13H12N4OSDegré de pureté :99.92%Couleur et forme :SoildMasse moléculaire :272.33Casein kinase 1δ-IN-3
CAS :<p>Casein kinase 1δ-IN-3 (Casein kinase 1δ-IN-3) (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC50 of 6.5376 M.</p>Formule :C17H16N2O2SDegré de pureté :98.94%Couleur et forme :SoildMasse moléculaire :312.39
