Cellules souches
Les inhibiteurs de cellules souches sont des composés qui ciblent spécifiquement les cellules souches et leurs voies de signalisation, affectant leur capacité à s'auto-renouveler et à se différencier. Ces inhibiteurs sont essentiels dans la recherche axée sur le contrôle du comportement des cellules souches, la compréhension des processus de développement et le développement de thérapies pour des maladies comme le cancer, où les cellules souches sont censées jouer un rôle clé. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de cellules souches pour soutenir vos recherches en médecine régénérative, biologie du développement et oncologie.
228 produits trouvés pour "Cellules souches"
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Mouse GDF10(GrowthDifferentiation Factor 10) Microsample ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse GDF10. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse GDF10. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse GDF10, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse GDF10 in the samples is then determined by comparing the OD of the samples to the standard curve.Simian OC/BGP(Osteocalcin) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Simian OC/BGP. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Simian OC/BGP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Simian OC/BGP, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Simian OC/BGP in the samples is then determined by comparing the OD of the samples to the standard curve.Couleur et forme :Colourless TransparentliquidTNIK-IN-5
CAS :TNIK-IN-5: strong TNIK inhibitor (IC50=0.05μM), halts Wnt signaling, effective against colorectal cancer in vitro.Formule :C22H17N3O3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :371.39Mouse sCD14(SolubleCluster of Differentiation 14) Microsample ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse sCD14. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse sCD14. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse sCD14, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse sCD14 in the samples is then determined by comparing the OD of the samples to the standard curve.Mouse sCD14(SolubleCluster of Differentiation 14) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse sCD14. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse sCD14. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse sCD14, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse sCD14 in the samples is then determined by comparing the OD of the samples to the standard curve.Couleur et forme :Colourless TransparentliquidMRT-83
CAS :MRT-83 is a potent Smo antagonist.Formule :C31H30N4O5Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :538.59Ref: TM-T12109
2mg43,00€5mg60,00€10mg96,00€25mg173,00€50mg299,00€100mg424,00€200mg595,00€1mL*10mM (DMSO)71,00€IK-930
CAS :IK-930 is an orally active TEAD inhibitor (EC50 < 0.1 µM) with potent potency.Formule :C19H19F3N4O2SDegré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :424.44Sonidegib diphosphate
CAS :Sonidegib diphosphate (LDE225 diphosphate) is a selective antagonist of Smo that inhibits murine Smo and human Smo.Cost-effective and quality-assured.Formule :C26H32F3N3O11P2Degré de pureté :99.48% - >99.99%Couleur et forme :SolidMasse moléculaire :681.49Mouse GDF10(GrowthDifferentiation Factor 10) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse GDF10. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse GDF10. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse GDF10, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse GDF10 in the samples is then determined by comparing the OD of the samples to the standard curve.Couleur et forme :Colourless TransparentliquidRat GDF10(GrowthDifferentiation Factor 10) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat GDF10. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat GDF10. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat GDF10, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat GDF10 in the samples is then determined by comparing the OD of the samples to the standard curve.Couleur et forme :Colourless TransparentliquidDog sCD14(SolubleCluster of Differentiation 14) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Dog sCD14. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Dog sCD14. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Dog sCD14, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Dog sCD14 in the samples is then determined by comparing the OD of the samples to the standard curve.Couleur et forme :Colourless TransparentliquidNimucitinib
CAS :Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.Formule :C25H26F2N6O2Degré de pureté :99.58%Couleur et forme :SoildMasse moléculaire :480.51Ref: TM-T67907
1mg96,00€2mg139,00€5mg227,00€10mg354,00€25mg653,00€50mg938,00€100mg1.454,00€500mg2.822,00€Mouse TNC(Tenascin C) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse TNC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TNC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse TNC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse TNC in the samples is then determined by comparing the OD of the samples to the standard curve.Couleur et forme :Colourless TransparentliquidRat Cys-C(Cystatin C) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat Cys-C. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat Cys-C. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat Cys-C, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat Cys-C in the samples is then determined by comparing the OD of the samples to the standard curve.Couleur et forme :Colourless TransparentliquidCCT251545
CAS :CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).Formule :C23H24ClN5ODegré de pureté :98.29% - 98.69%Couleur et forme :SolidMasse moléculaire :421.92Mouse CC17(Clara Cell Protein) Microsample ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse CC17. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse CC17. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse CC17, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse CC17 in the samples is then determined by comparing the OD of the samples to the standard curve.Ponsegromab
CAS :Ponsegromab (PF 06946860), a humanized anti-GDF15 antibody, may treat cancer cachexia by blocking GDF15/GFRAL signaling.Degré de pureté :100% (SEC-HPLC) - > 95%Couleur et forme :LiquidMasse moléculaire :146.08 kDaRat sCD14(SolubleCluster of Differentiation 14) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat sCD14. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat sCD14. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat sCD14, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat sCD14 in the samples is then determined by comparing the OD of the samples to the standard curve.ROCK inhibitor-2
CAS :ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).Formule :C21H20N2O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :332.4Ref: TM-T12746
1mg66,00€5mg144,00€10mg216,00€25mg432,00€50mg645,00€100mg905,00€1mL*10mM (DMSO)106,00€Human ASPP1(Apoptosis-stimulating of p53 protein 1) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ASPP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ASPP1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human ASPP1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human ASPP1 in the samples is then determined by comparing the OD of the samples to the standard curve.Couleur et forme :Colourless TransparentliquidRat GDF10(GrowthDifferentiation Factor 10) Microsample ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat GDF10. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat GDF10. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat GDF10, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat GDF10 in the samples is then determined by comparing the OD of the samples to the standard curve.Mouse CC17(Clara Cell Protein) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse CC17. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse CC17. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse CC17, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse CC17 in the samples is then determined by comparing the OD of the samples to the standard curve.Couleur et forme :Colourless TransparentliquidYAP/TAZ inhibitor-4
YAP/TAZ Inhibitor-4 (Compound 45) acts as an inhibitor of YAP/TAZ, exhibiting inhibitory activity on TEAD transcriptional activation by preventing the interaction between YAP or TAZ and TEAD.Formule :C28H28F3N3O3Couleur et forme :SolidMasse moléculaire :511.54Fresolimumab
CAS :Fresolimumab (GC1008) is a human monoclonal antibody targeting active TGFβ1, TGFβ2, TGFβ3, studied for cancer and focal segmental glomerulosclerosis.Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :144.4 kDaTubastatin
CAS :Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.Formule :C21H22N2O2Degré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :334.41YAP/TEAD-IN-1
YAP/TEAD-IN-1 (compound 4) is a potent inhibitor of YAP and TEAD, exhibiting antioxidant properties. It demonstrates antiproliferative effects on tumor cells while showing minimal cytotoxic activity towards normal human cells.
Formule :C32H30N8OCouleur et forme :SolidMasse moléculaire :542.634STAT3-IN-34
STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.Formule :C19H16N2O4SCouleur et forme :SolidMasse moléculaire :368.41Wnt/β-catenin agonist 3
CAS :Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.
Formule :C16H15ClN4O2Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :330.77Casein kinase 1δ-IN-8
CAS :Casein kinase 1δ-IN-8 is an inhibitor of casein kinase 1δ and is used to treat neurodegenerative diseases such as Alzheimer's disease type.Formule :C19H14FN5OSDegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :379.41MSC-1254
MSC-1254 is a reversible, selective, and covalent inhibitor of TEAD1, primarily utilized in cancer research.Formule :C25H22F2N4O4SCouleur et forme :SolidMasse moléculaire :512.53F7H
CAS :F7H is an FZD7 antagonist, a potent ligand for the FZD7 transmembrane domain (TMD), with potential antitumor and bacteriostatic activities.
Formule :C24H18FN3O2S2Degré de pureté :99.85%Couleur et forme :SoildMasse moléculaire :463.55pan-TEAD-IN-1
CAS :pan-TEAD-IN-1 (Compound 3) is an orally active pan-inhibitor of TEAD, disrupting its interaction with coactivators YAP/TAZ by targeting the palmitoylation site of TEAD. This inhibition leads to the downregulation of oncogene transcription, such as Ctgf and Cyr61, within the Hippo signaling pathway. Demonstrating outstanding efficacy, pan-TEAD-IN-1 has an IC50 of 0.36 nM for luciferase and 1.52 nM for H226 cells, along with favorable pharmacokinetic properties (AUC0–∞= 228.7 μg/mL·min, T1/2= 183.9 min). The compound significantly inhibits tumor growth in xenograft models of TEAD-dependent cancers, indicating its potential for research in these cancer types.Formule :C19H16F3NOCouleur et forme :SolidMasse moléculaire :331.33STX-0119
CAS :STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.
Formule :C22H14N4O3Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :382.37ROCK2-IN-9
ROCK2-IN-9 (compound 7u), a selective ROCK2 inhibitor with an IC50 value of 36.8 nM, demonstrates anticancer properties by impeding cancer cell migration and invasion. This action is achieved through the regulation of various actin cytoskeleton cellular activities. It holds potential for use in breast cancer research.Formule :C28H30N8O2Couleur et forme :SolidMasse moléculaire :510.59TEAD-IN-16
TEAD-IN-16 (compound BC-011) is a potent inhibitor of TEAD, with an IC50 of 72.43 μM. This compound plays a significant role in cancer research.
Formule :C16H14F3NO3Masse moléculaire :325.09258Plant 14-3-3-IN-1
Plant 14-3-3-IN-1 (Compound 2) is an inhibitor of the Arabidopsis thaliana 14-3-3 protein, with an IC50 of 1.21 μM. It exhibits varying inhibitory activity against different 14-3-3 isoforms and promotes the closure of leaf stomata.Formule :C22H19NO7SMasse moléculaire :441.08822VT104
CAS :VT104 is a potent and orally active YAP/TAZ inhibitor for cancer research.Cost-effective and quality-assured.Formule :C25H19F3N2ODegré de pureté :99.5% - 99.52%Couleur et forme :SolidMasse moléculaire :420.43Ref: TM-T67872
1mg79,00€5mg156,00€10mg235,00€25mg378,00€50mg540,00€100mg747,00€200mg1.035,00€1mL*10mM (DMSO)167,00€LSKL TFA
CAS :LSKL TFA (H-Leu-Ser-Lys-Leu-NH2 TFA) is a TGF-尾1 antagonist that inhibits TSP-1 binding to LAP and reduces renal interstitial fibrosis and liver fibrosis.Formule :C23H43F3N6O7Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :572.62Epigenetics Compound Library
Well-chosen 953 compounds related to epigenetic regulation for research in epigenetics, high throughput screening (HTS) and high content screening (HCS) for newCouleur et forme :Odour SolidRef: TM-L1200
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderAPTSTAT3-9R acetate
APTSTAT3-9R acetate is a selective peptide binding STAT3 with antiproliferative and antitumor activity.Formule :C225H334N80O53Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5007.56MSC-5046
MSC-5046 is a selective inhibitor of TEAD1.Formule :C24H18F3N5O3Couleur et forme :SolidMasse moléculaire :481.43CK1-IN-3
CAS :WAY-296817 inhibits CK1, potential for circadian rhythm and inflammation research.Formule :C17H16N2O3SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :328.39Ref: TM-T60005
1mg35,00€5mg74,00€10mg101,00€25mg178,00€50mg258,00€100mg354,00€200mg485,00€1mL*10mM (DMSO)82,00€Cirevetmab
CAS :Cirevetmab (ZTS-00521426), a caninized monoclonal antibody targeting Canis lupus familiaris TGFB1, is classified as an immunoglobulin G2-kappa.Couleur et forme :LiquidWnt/Hedgehog/Notch Compound Library
A unique collection of 237 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;
Couleur et forme :Odour SolidJI069
CAS :JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1.
Formule :C15H12Cl2N2O4SDegré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :387.24Ac-ESMD-CHO
CAS :Ac-ESMD-CHO functions as an inhibitor of both caspase-3 and caspase-7, specifically obstructing the proteolytic cleavage of the caspase-3 precursor peptide (
Formule :C19H30N4O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.53BAY 593
CAS :BAY 593 functions as an inhibitor of geranylgeranyltransferase-I (GGTase-I), effectively preventing the activation of Rho-GTPases and consequently inactivating YAP1/TAZ signaling pathways. It has been shown to inhibit tumor growth dose-dependently in xenograft mouse models, exhibiting IC50 values of 38.4 nM in MT-1080 cells and 564 nM in MDA-MB-231 cells, as well as in PXF 541 xenografts.Formule :C26H32ClF3N2O3Couleur et forme :SolidMasse moléculaire :512.99S-Ruxolitinib
CAS :S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.
Formule :C17H18N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.37YAP-TEAD-IN-1 acetate
YAP-TEAD-IN-1 acetate is an effective and competitive inhibitor of YAP–TEAD interaction with an IC50 of 25 nM.Formule :C95H148ClN23O23S2Degré de pureté :98.11% - 99.57%Couleur et forme :SoildMasse moléculaire :2079.92Jagged-1 (188-204)
CAS :Jagged-1 （188-204）is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin.Formule :C93H127N25O26S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2107.4TBCA
CAS :TBCA: selective CK2 inhibitor, IC50=110 nM, Ki=77 nM, favors CK2 over CK1, DYRK1A, and 27 other kinases.Formule :C9H4Br4O2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :463.74WIC1
CAS :2H-1-Benzopyran-3-carboxamide, N-[4-(4-ethyl-1-piperazinyl)phenyl]-2-oxo- is a compound that is potential for the treatment of tumours.
Formule :C22H23N3O3Degré de pureté :99.82%Couleur et forme :SoildMasse moléculaire :377.44P17 Peptide
CAS :P17 Peptide, a human TGF-β1 inhibitory peptide, effectively blocks the activity of woodchuck TGF-β1.Formule :C95H139N27O21Couleur et forme :SolidMasse moléculaire :1995.29MR24
CAS :MR24 is a derivative of G-5555 and acts as an inhibitor of mammalian STE20-like (MST) kinases. It selectively targets MST3 and MST4, with EC50 values of 57 nM and 583 nM, respectively.Formule :C26H29ClN6O3Masse moléculaire :509.00SLLK, Control Peptide for TSP1 Inhibitor(TFA)
CAS :SLLK is a control peptide for LSKL.
Formule :C21H41N5O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.58Emugrobart
Emugrobart is a humanized IgG1κ antibody targeted at GDF8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Couleur et forme :Odour LiquidYAP-IN-1
YAP-IN-1 (Compound (+)-1) is an autophagy inhibitor specifically targeting YAP1. It binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM, promoting its degradation through the chaperone-mediated autophagy (CMA) pathway. This process inhibits the Rab7-mediated fusion of autophagosomes with lysosomes and decreases autophagy levels without affecting lysosomal function. YAP-IN-1 shows potential for cancer research, including in hepatocellular carcinoma and breast cancer.Couleur et forme :Odour SolidDC-TEADin02
CAS :DC-TEADin02 is an inhibitor of TEAD auto palmitoylation (IC50 = 197 nM). DC-TEADin02 can be in studies about development, regeneration, and tissue homeostasis.
Formule :C19H17NO2SDegré de pureté :99.83%Couleur et forme :SoildMasse moléculaire :323.41HC-258
CAS :HC-258 is a direct TEAD inhibitor covalent Cys380, and reduces the transcriptional levels and inhibits the migration of CTGF, CYR61, AXL and NF2 MDA-MB-231.Formule :C20H24N2O2Couleur et forme :SolidMasse moléculaire :324.42ALK5-IN-83
ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.Formule :C20H23N7O2SCouleur et forme :SolidMasse moléculaire :425.51JAK2-IN-6
CAS :JAK2-IN-6: A potent JAK2-specific inhibitor (IC50=22.86μg/mL), blocks JAK2 signaling, has anticancer properties, and is inactive against JAK1/3.Formule :C14H10ClN3OS2Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :335.83Prafnosbart
CAS :Prafnosbart (DS-6016A) is a humanized IgG1-kappa monoclonal antibody targeting ACVR1 (activin A receptor type 1, ACVRLK2, ALK2, ACVR1A, SKR1), utilized inCouleur et forme :LiquidLX-7101 hydrochloride
CAS :LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.
Formule :C23H29N7O3xHClDegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :487.99TGFβRI-IN-7
TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.Formule :C27H32N6O2Couleur et forme :SolidMasse moléculaire :472.582YAP-TEAD-IN-3
CAS :YAP-TEAD-IN-3 inhibitor YAP/TAZ-TEAD interactions Avi-human TEAD (4217-434) YAP-TEAD-IN-3 inhibits YAP reporter gene expression and NCI-H2052 cell proliferationFormule :C27H26ClF2N3O4Degré de pureté :97.55% - 98.71%Couleur et forme :SoildMasse moléculaire :529.96Disitertide acetate
Disitertide acetate: a TGF-β1 and PI3K blocker, promotes apoptosis; inhibits receptor interaction.Formule :C70H113N17O24S2Degré de pureté :95.11%Couleur et forme :SoildMasse moléculaire :1640.88LP-922056
CAS :LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.
Formule :C11H9ClN2O2S2Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :300.78TEAD-IN-19
TEAD-IN-19 (Compound 1l) is a transcriptional inhibitor of TEAD, showing inhibition rates of 38.5%, 36.2%, 57.8%, and 71.3% for TEAD1, TEAD2, TEAD3, and TEAD4, respectively, at 10 μM. It exhibits strong antiproliferative and antimigratory effects on prostate cancer cell lines and significantly reduces the expression of TEAD-regulated downstream genes. TEAD-IN-19 holds potential for research in the field of cancer therapeutics.Couleur et forme :Odour SolidWAY-297174
CAS :WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.
Formule :C11H12N2O2S2Degré de pureté :99.53%Couleur et forme :SoildMasse moléculaire :268.36Pumecitinib
CAS :Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.
Formule :C17H20N8O2SDegré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :400.461(R),2(S)-epoxy Cannabidiol
CAS :1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analog of phytocannabinoids, exhibiting significant inhibitory activity on the Wnt/β-catenin pathway. It holds potential for research as a neuroprotective agent.Formule :C21H30O3Couleur et forme :SolidMasse moléculaire :330.46Rilogrotug
CAS :Rilogrotug is a humanized IgG1κ monoclonal antibody targeting GDF15, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Couleur et forme :SoildNIBR-LTSi
NIBR-LTSi is a selective LATS kinase inhibitor that also activates YAP signaling, promotes tissue stem cell expansion and tissue regeneration in vitro/vivo.Formule :C18H20N4ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :308.38CCT 031374 hydrobromide
CAS :CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.Formule :C23H20BrN3ODegré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :434.33Ref: TM-T21685
1mg38,00€5mg71,00€10mg105,00€25mg207,00€50mg329,00€100mg472,00€200mg620,00€1mL*10mM (DMSO)87,00€Super-TDU (1-31) (TFA)
Super-TDU (1-31) TFA, a peptide, inhibits YAP-TEAD; it has strong anti-tumor effects in gastric cancer models.Formule :C141H218N40O48·C2HF3O2Couleur et forme :SolidMasse moléculaire :3355.5BAY-593
CAS :BAY-593 is an orally active GGTase-I inhibitor capable of blocking YAP1/TAZ signaling in vivo, exhibiting antitumor activity.Formule :C26H31F3N2O3Couleur et forme :SolidMasse moléculaire :476.53YAP/TAZ inhibitor-1
CAS :YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor (IC50 <0.100 μΜ) for the study of abnormal immune function and cancer.Formule :C33H39N3O5S2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :621.81Anti-GPC3 Antibody (4L576)
Anti-GPC3 Antibody (4L576) is an antibody targeting GPC3. Anti-GPC3 Antibody (4L576) can be used in ELISA, WB, IF.Couleur et forme :Odour LiquidAnti-SOST Antibody (3R170)
Anti-SOST Antibody (3R170) is an antibody targeting SOST. Anti-SOST Antibody (3R170) can be used in ELISA, IHC.Couleur et forme :Odour LiquidIBS008738
CAS :IBS008738 is a TAZ activator that stabilises TAZ and increases unphosphorylated TAZ levels in C2C12 cells, upregulates MyoD-dependent gene transcription.Formule :C22H22N4O2Degré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :374.44Anti-NANOG Antibody (1M448)
Anti-NANOG Antibody (1M448) is a Mouse antibody targeting NANOG. Anti-NANOG Antibody (1M448) can be used in ELISA, WB, ICC, IF, FCM.Degré de pureté :>95%Couleur et forme :Odour LiquidAnti-5T4/TPBG Antibody (9P872)
Anti-5T4/TPBG Antibody (9P872) is an antibody targeting 5T4/TPBG. Anti-5T4/TPBG Antibody (9P872) can be used in ELISA, FCM.Couleur et forme :Odour LiquidCotosudil
CAS :Cotosudil is a ROCK kinase inhibitor with antihypertensive activity used to treat or prevent neurodegenerative diseases.Formule :C16H21N3O2SDegré de pureté :98.41%Couleur et forme :SolidMasse moléculaire :319.42Thiazovivin
CAS :Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.Formule :C15H13N5OSDegré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :311.36Ref: TM-T2155
1mg35,00€2mg48,00€5mg67,00€10mg103,00€25mg190,00€50mg321,00€100mg469,00€1mL*10mM (DMSO)73,00€GSK429286A
CAS :GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).Formule :C21H16F4N4O2Degré de pureté :97.68% - 98.49%Couleur et forme :SolidMasse moléculaire :432.37AZD1080
CAS :AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.Formule :C19H18N4O2Degré de pureté :97.72% - 99.75%Couleur et forme :SolidMasse moléculaire :334.37Ref: TM-T1741
1mg43,00€2mg56,00€5mg85,00€10mg124,00€25mg219,00€50mg350,00€100mg429,00€1mL*10mM (DMSO)63,00€Galunisertib
CAS :Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.Formule :C22H19N5ODegré de pureté :97.09% - 99.98%Couleur et forme :SolidMasse moléculaire :369.42Ref: TM-T2510
1g657,00€5mg46,00€10mg52,00€25mg84,00€50mg114,00€100mg178,00€200mg269,00€500mg442,00€1mL*10mM (DMSO)52,00€SB 216763
CAS :SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).Formule :C19H12Cl2N2O2Degré de pureté :98.9% - 99.13%Couleur et forme :SolidMasse moléculaire :371.22Ref: TM-T3077
2mg39,00€5mg52,00€10mg79,00€25mg131,00€50mg197,00€100mg334,00€500mg803,00€1mL*10mM (DMSO)52,00€Tegatrabetan
CAS :Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.Formule :C28H36N4O6S2Degré de pureté :98.01% - 99.18%Couleur et forme :SolidMasse moléculaire :588.74Ref: TM-T5642
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg210,00€50mg334,00€100mg565,00€1mL*10mM (DMSO)96,00€IWP-O1
CAS :IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.Formule :C26H20N6ODegré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :432.48Ref: TM-T5342
2mg39,00€5mg64,00€10mg101,00€25mg163,00€50mg226,00€100mg320,00€200mg459,00€1mL*10mM (DMSO)70,00€VP3.15 dihydrobromide
CAS :VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.Formule :C20H24Br2N4OSDegré de pureté :99.67% - ≥95%Couleur et forme :SolidMasse moléculaire :528.3Fosciclopirox
CAS :Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entireFormule :C13H20NO6PDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :317.27Ref: TM-T9422
2mg35,00€5mg52,00€10mg90,00€25mg170,00€50mg259,00€100mg383,00€200mg545,00€1mL*10mM (DMSO)58,00€XMU-MP-1
CAS :XMU-MP-1 is a reversible and selective MST1/2 kinase inhibitor, IC50 values for MST1 and MST2 are 71.1 nM and 38.1 nM, respectively. High-Quality, Low-Cost!Formule :C17H16N6O3S2Degré de pureté :99.68% - 99.86%Couleur et forme :SolidMasse moléculaire :416.48Ref: TM-T4212
1mg52,00€2mg79,00€5mg97,00€10mg153,00€25mg305,00€50mg512,00€100mg663,00€1mL*10mM (DMSO)95,00€BIO-013077-01
CAS :BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.Formule :C17H13N5Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :287.32Ref: TM-T8330
1mg50,00€5mg92,00€10mg140,00€25mg273,00€50mg393,00€100mg557,00€200mg753,00€1mL*10mM (DMSO)138,00€ITD-1
CAS :ITD-1 is a potent and highly selective TGFβ pathway inhibitor.Formule :C27H29NO3Degré de pureté :99.89% - >99.99%Couleur et forme :SolidMasse moléculaire :415.52MYF-01-37
CAS :MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.Formule :C15H17F3N2ODegré de pureté :99.46% - 99.5%Couleur et forme :SolidMasse moléculaire :298.3Ref: TM-T22372
2mg38,00€5mg57,00€10mg90,00€25mg166,00€50mg281,00€100mg421,00€500mg888,00€1mL*10mM (DMSO)63,00€Porcn-IN-1
CAS :Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).Formule :C25H19FN4ODegré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :410.44Adavivint
CAS :Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.
Formule :C29H24FN7ODegré de pureté :98.27% - 98.6%Couleur et forme :SolidMasse moléculaire :505.55LY3200882
CAS :LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).Formule :C24H29N5O3Degré de pureté :99.46% - 99.63%Couleur et forme :SolidMasse moléculaire :435.52PF-670462
CAS :PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.Formule :C19H22Cl2FN5Degré de pureté :99.42% - 99.72%Couleur et forme :SolidMasse moléculaire :410.32
